Simultaneous localization of labelled macrophages and structural analysis of asthmatic mice by phase contrast CT

We successfully applied synchrotron in-line phase contrast CT in combination with single distance phase retrieval to image lungs of asthmatic and healthy mice in high resolution in situ. The increased image quality in phase contrast CT added functional contrast to CT which enabled simultaneous i\) anatomical imaging for the discrimination of asthmatic from healthy mice based on alterations of their lung structure as well as ii\) functional imaging to track the location of barium sulfate loaded intratracheally instilled alveolar macrophages. Link to fulltext: http://www.elettra.eu/images/Documents/SCIENCE/Elettra%20HL%202015.pdf