Keppeler, Daniel

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","EMBO Molecular Medicine"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Dieter, Alexander"],["dc.contributor.author","Keppeler, Daniel"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2021-04-14T08:27:00Z"],["dc.date.available","2021-04-14T08:27:00Z"],["dc.date.issued","2020"],["dc.description.abstract","Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss. By electrically stimulating the auditory nerve, CIs constitute an interface re-connecting the brain and the auditory scene, providing the patient with information regarding the latter. However, since electric current is hard to focus in conductive environments such as the cochlea, the precision of electrical sound encoding—and thus quality of artificial hearing—is limited. Recently, optogenetic stimulation of the cochlea has been suggested as an alternative approach for hearing restoration. Cochlear optogenetics promises increased spectral selectivity of artificial sound encoding, hence improved hearing, as light can conveniently be confined in space to activate the auditory nerve within smaller tonotopic ranges. In this review, we discuss the latest experimental and technological developments of cochlear optogenetics and outline the remaining challenges on the way to clinical translation."],["dc.identifier.doi","10.15252/emmm.201911618"],["dc.identifier.pmid","32227585"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82138"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/190"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1757-4684"],["dc.relation.issn","1757-4676"],["dc.relation.workinggroup","RG Moser (Molecular Anatomy, Physiology and Pathology of Sound Encoding)"],["dc.rights","CC BY 4.0"],["dc.title","Towards the optical cochlear implant: optogenetic approaches for hearing restoration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","EMBO Molecular Medicine"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Dieter, Alexander"],["dc.contributor.author","Klein, Eric"],["dc.contributor.author","Keppeler, Daniel"],["dc.contributor.author","Jablonski, Lukasz"],["dc.contributor.author","Harczos, Tamas"],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Rankovic, Vladan"],["dc.contributor.author","Paul, Oliver"],["dc.contributor.author","Jeschke, Marcus"],["dc.contributor.author","Ruther, Patrick"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2021-04-14T08:25:11Z"],["dc.date.available","2021-04-14T08:25:11Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re‐connecting deaf patients to the auditory scene surrounding them. Yet, eCIs suffer from limited spectral selectivity, resulting from current spread around each electrode contact and causing poor speech recognition in the presence of background noise. Optogenetic stimulation of the auditory nerve might overcome this limitation as light can be conveniently confined in space. Here, we combined virus‐mediated optogenetic manipulation of cochlear spiral ganglion neurons (SGNs) and microsystems engineering to establish acute multi‐channel optical cochlear implant (oCI) stimulation in adult Mongolian gerbils. oCIs based on 16 microscale thin‐film light‐emitting diodes (μLEDs) evoked tonotopic activation of the auditory pathway with high spectral selectivity and modest power requirements in hearing and deaf gerbils. These results prove the feasibility of μLED‐based oCIs for spectrally selective activation of the auditory nerve."],["dc.description.abstract","Synopsis image Electrical cochlear implants effectiveness in individuals remains limited by the spread of the electric current in the cochlea. This study explores the potential of optogenetics for hearing restoration through combining optogenetic manipulation of the auditory nerve with microsystems engineering. μLED‐based optical cochlear implants (oCI) enable stimulation of the rodent auditory nerve. The strength of induced responses scales with the number of recruited emitters. μLED‐evoked neural responses are tonotopic and spectrally selective. The combination of gene therapy and microsystems engineering enables optical activation of the auditory nerve with higher spectral precision in gerbils."],["dc.description.abstract","Electrical cochlear implants effectiveness in individuals remains limited by the spread of the electric current in the cochlea. This study explores the potential of optogenetics for hearing restoration through combining optogenetic manipulation of the auditory nerve with microsystems engineering. image"],["dc.description.sponsorship","H2020 European Research Council (ERC) http://dx.doi.org/10.13039/100010663"],["dc.description.sponsorship","Bundesministerium für Bildung und Forschung (BMBF) http://dx.doi.org/10.13039/501100002347"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG) http://dx.doi.org/10.13039/501100001659"],["dc.identifier.doi","10.15252/emmm.202012387"],["dc.identifier.pmid","32596983"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81549"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/52"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1757-4684"],["dc.relation.issn","1757-4676"],["dc.relation.workinggroup","RG Moser (Molecular Anatomy, Physiology and Pathology of Sound Encoding)"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]