Grosse, Christian

[["dc.bibliographiccitation.firstpage","3708"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","Organometallics"],["dc.bibliographiccitation.lastpage","3725"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Stollenz, Michael"],["dc.contributor.author","Gehring, Henrike"],["dc.contributor.author","Konstanzer, Vera"],["dc.contributor.author","Fischer, Stefan"],["dc.contributor.author","Dechert, Sebastian"],["dc.contributor.author","Grosse, Christian"],["dc.contributor.author","Meyer, Franc"],["dc.date.accessioned","2018-11-07T08:54:12Z"],["dc.date.available","2018-11-07T08:54:12Z"],["dc.date.issued","2011"],["dc.description.abstract","The synthesis of a series of new pyrazole-based binucleating compartmental ligands, 3,5-bis((RRN)-R-2-N-3)-(4-R-1)-pyrazoles (LH)-H-1-(LH)-H-6 ((LH)-H-1, R-1 = H, R-2 = Me, R-3 = 2-py(CH2); (LH)-H-2, R-1 = Ph, R-2 = Me, R-3 = 2-py(CH2); (LH)-H-3, R-1 = H, R-2 = Cy, R-3 = 2-py(CH2); (LH)-H-4, R-1 = Ph, R-2 = Cy, R-3 = 2-py(CH2); (LH)-H-5, R-1 = Ph, R-2, R-3 = 2-py(CH2), L6H, R-1 = Ph, R-2 = Me, R-3 = 8-quin), together with the X-ray crystal structure of (LH)-H-3 is reported. After deprotonation and subsequent reaction with 2 equiv of [Cu-I(CH3CN)(4)](BF4) and PMe3, (LH)-H-3 forms the stable binuclear Cu-I complex [L-3{Cu(PMe3)}(2)](BF4) (1). The analogous reaction with (LH)-H-6 and 2 equiv of tert-butyl isonitrile affords [L-6{Cu(CNtBu)}(2)](BF4) (2), 1 and 2 represent the first examples of binuclear Cu-I-pyrazolate complexes of the type [LCu21]X that have been characterized by their X-ray crystal structures. With respect to the planes spanned by the pyrazolate backbone, 1 shows a cis orientation of the PMe3 ligands, whereas 2 exhibits a trans arrangement of the tBuNC ligands. (LH)-H-1-(LH)-H-6 are shown to react with 4 equiv of mesitylcopper and stoichiometric amounts of dioxygen, leading to the formation of the unusually stable organocopper frameworks 3-8. These complexes follow a general structural principle that is best described by the heteroleptic O-centered cuprate anion [(MesCu(I))(4) (mu(4)-O)](2-) linked via four trans-oriented sigma-mesityl bridges to two flanking binuclear Cu-I-pyrazolates [(L-1-L-6)Cu-2(I)](+). Thus, 1 and 2 can also be viewed as capping binuclear Cu-I-complex units that are concealed by two ancillary PMe3 and tBuNC ligands, respectively. The exemplary reaction of 4 with an excess of dimethyl acetylenedicarboxylate (DMDAC) supports the observed cuprate features of 3-8, since after hydrolysis the corresponding (syn-)addition product MesC(CO2Me)=C(CO2Me)H (9) and the free ligand (LH)-H-2 are found as major products."],["dc.description.sponsorship","Fonds der Chemischen Industrie"],["dc.identifier.doi","10.1021/om100836j"],["dc.identifier.isi","000292847900006"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8936"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22617"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0276-7333"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","From Pyrazolate-Based Binuclear Copper(I) Complexes to Octanuclear sigma-Mesityl-Bridged mu(4)-Oxo-Cuprocuprates: Controlled Dioxygen Splitting by Organocopper Scaffolds"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","10428"],["dc.bibliographiccitation.issue","37"],["dc.bibliographiccitation.journal","Chemical Communications"],["dc.bibliographiccitation.lastpage","10430"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Burger, Boris"],["dc.contributor.author","Dechert, Sebastian"],["dc.contributor.author","Grosse, Christian"],["dc.contributor.author","Demeshko, Serhiy"],["dc.contributor.author","Meyer, Franc"],["dc.date.accessioned","2018-11-07T09:00:57Z"],["dc.date.available","2018-11-07T09:00:57Z"],["dc.date.issued","2011"],["dc.description.abstract","A novel pyrazolate-based diiron(II) complex shows five different binding modes of exogenous carboxylate ligands in a single crystal structure. Temperature dependent X-ray data reveal thermally induced disorder due to carboxylate dynamics that resemble the carboxylate shift, as it is known from various diiron enzyme active sites."],["dc.description.sponsorship","DFG [IRTG 1422]; Evonik Foundation"],["dc.identifier.doi","10.1039/c1cc13756e"],["dc.identifier.isi","000294500600072"],["dc.identifier.pmid","21842055"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8677"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24289"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1364-548X"],["dc.relation.issn","1359-7345"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Visualising the carboxylate shift at a bioinspired diiron(II) site in the solid state"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Biomolecular NMR"],["dc.bibliographiccitation.lastpage","119"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Gruene, Tim"],["dc.contributor.author","Cho, Min-Kyu"],["dc.contributor.author","Karyagina, Irina"],["dc.contributor.author","Kim, Hai-Young"],["dc.contributor.author","Grosse, Christian"],["dc.contributor.author","Giller, Karin"],["dc.contributor.author","Zweckstetter, Markus"],["dc.contributor.author","Becker, Stefan"],["dc.date.accessioned","2018-11-07T08:59:23Z"],["dc.date.available","2018-11-07T08:59:23Z"],["dc.date.issued","2011"],["dc.description.abstract","Long-range structural information derived from paramagnetic relaxation enhancement observed in the presence of a paramagnetic nitroxide radical is highly useful for structural characterization of globular, modular and intrinsically disordered proteins, as well as protein protein and protein-DNA complexes. Here we characterized the conformation of a spin-label attached to the homodimeric protein CylR2 using a combination of X-ray crystallography, electron paramagnetic resonance (EPR) and NMR spectroscopy. Close agreement was found between the conformation of the spin label observed in the crystal structure with interspin distances measured by EPR and signal broadening in NMR spectra, suggesting that the conformation seen in the crystal structure is also preferred in solution. In contrast, conformations of the spin label observed in crystal structures of T4 lysozyme are not in agreement with the paramagnetic relaxation enhancement observed for spin-labeled CylR2 in solution. Our data demonstrate that accurate positioning of the paramagnetic center is essential for high-resolution structure determination."],["dc.description.sponsorship","Max Planck Society; Fonds der Chemischen Industrie; DFG [ZW 71/2-2, 3-2]"],["dc.identifier.doi","10.1007/s10858-011-9471-y"],["dc.identifier.isi","000288768700006"],["dc.identifier.pmid","21271275"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6660"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23880"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0925-2738"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Integrated analysis of the conformation of a protein-linked spin label by crystallography, EPR and NMR spectroscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2844"],["dc.bibliographiccitation.journal","Beilstein Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","2857"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Kozhushkov, Sergei I."],["dc.contributor.author","Yufit, Dmitry S."],["dc.contributor.author","Grosse, Christian"],["dc.contributor.author","Kaiser, Marcel"],["dc.contributor.author","Raev, Vitaly A."],["dc.date.accessioned","2018-11-07T09:31:31Z"],["dc.date.available","2018-11-07T09:31:31Z"],["dc.date.issued","2014"],["dc.description.abstract","Efficient and scalable syntheses of enantiomerically pure (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl]alanines 9a-c, as well as allo-D-threonine (4) and (2S,3R)-beta-methylphenylalanine (3), using the Belokon' approach with (S)- and (R)-2-[(N-benzylprolyl)amino]benzophenone [(S)- and (R)-10] as reusable chiral auxiliaries have been developed. Three new fluoromethyl analogues of the naturally occurring octadepsipeptide hormaomycin (1) with (fluoromethylcyclopropyl)alanine moieties have been synthesized and subjected to preliminary tests of their antibiotic activity."],["dc.description.sponsorship","Land Niedersachsen"],["dc.identifier.doi","10.3762/bjoc.10.302"],["dc.identifier.isi","000346467000001"],["dc.identifier.pmid","25550751"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11913"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31547"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Beilstein-institut"],["dc.relation.issn","1860-5397"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","(2R,1 ' S,2 ' R)- and (2S,1 ' S,2 ' R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]