Options
Quintel, Michael I.
Loading...
Preferred name
Quintel, Michael I.
Official Name
Quintel, Michael I.
Alternative Name
Quintel, M.
Quintel, M. I.
Quintel, Michael
Quintel, Michel
Main Affiliation
Now showing 1 - 10 of 309
2018Journal Article [["dc.bibliographiccitation.firstpage","788"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Chest"],["dc.bibliographiccitation.lastpage","791"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Brodie, Daniel"],["dc.contributor.author","Vincent, Jean-Louis"],["dc.contributor.author","Brochard, Laurent J."],["dc.contributor.author","Combes, Alain"],["dc.contributor.author","Ferguson, Niall D."],["dc.contributor.author","Hodgson, Carol L."],["dc.contributor.author","Laffey, John G."],["dc.contributor.author","Mercat, Alain"],["dc.contributor.author","Pesenti, Antonio"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Slutsky, Arthur S."],["dc.contributor.author","Ranieri, V. Marco"],["dc.contributor.author","Bakker, Jan"],["dc.contributor.author","Broome, Michael"],["dc.contributor.author","Creteur, Jacques"],["dc.contributor.author","De Backer, Daniel"],["dc.contributor.author","Gattinoi, Luciano"],["dc.contributor.author","Lorusso, Roberto"],["dc.contributor.author","Nava, Stefano"],["dc.contributor.author","Papazian, Laurent"],["dc.contributor.author","Rimensberger, Peter"],["dc.contributor.author","Ronco, Claudio"],["dc.contributor.author","Sladen, Robert"],["dc.contributor.author","Staudinger, Thomas"],["dc.contributor.author","Taccone, Fabio"],["dc.date.accessioned","2020-12-10T14:23:05Z"],["dc.date.available","2020-12-10T14:23:05Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.chest.2017.12.024"],["dc.identifier.issn","0012-3692"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71829"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Research in Extracorporeal Life Support"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]Details DOI2018Journal Article [["dc.bibliographiccitation.firstpage","413"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Critical Care Clinics"],["dc.bibliographiccitation.lastpage","422"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Duscio, Eleonora"],["dc.contributor.author","Cipulli, Francesco"],["dc.contributor.author","Romitti, Federica"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2020-12-10T14:22:56Z"],["dc.date.available","2020-12-10T14:22:56Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.ccc.2018.03.011"],["dc.identifier.issn","0749-0704"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71782"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Extracorporeal Gas Exchange"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]Details DOI2012Journal Article [["dc.bibliographiccitation.firstpage","194"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","International Journal of Pharmaceutics"],["dc.bibliographiccitation.lastpage","201"],["dc.bibliographiccitation.volume","422"],["dc.contributor.author","Tsagogiorgas, Charalambos"],["dc.contributor.author","Jung, Tobias"],["dc.contributor.author","Krebs, J."],["dc.contributor.author","Theisinger, B."],["dc.contributor.author","Beck, G."],["dc.contributor.author","Yard, Benito A."],["dc.contributor.author","Quintel, M."],["dc.date.accessioned","2018-11-07T09:14:20Z"],["dc.date.available","2018-11-07T09:14:20Z"],["dc.date.issued","2012"],["dc.description.abstract","Semifluorinated alkanes (SFAs) have been described as potential excipients for pulmonary drug delivery, but proof of their efficacy is still lacking. We tested whether SFA formulations with the test drug ibuprofen can be nebulised and evaluated their pharmacokinetics. Physico-chemical properties of five different ibuprofen formulations were evaluated: an aqueous solution (H2O), two different SFAs (perfluorohexyloctane (F6H8), perfluorobutylpentane (F4H5)) with and without ethanol (SFA/EtOH). Nebulisation was performed with a jet catheter system. Inhalative characteristics were evaluated by laser diffraction. A confirmative animal study with an inhalative single-dose (6 mg/kg) of ibuprofen with each formulation was performed in anaesthetised healthy rabbits. Plasma samples at defined time points and lung tissue harvested after the 6-h study period were analyzed by HPLC-MS/MS. Pharmacokinetics were calculated using a non-compartment model. All formulations were nebulisable. No differences in aerodynamic diameters (MMAD) were detected between SFA and SFA/EtOH. The ibuprofen plasma concentration-time curve (AUC) was highest with F4H5/EtOH. In contrast, F6H8/EtOH had the highest deposition of ibuprofen into lung tissue but the lowest AUC. All tested SFA and SFA/EtOH formulations are suitable for inhalation. F4H5/EtOH formulations might be used for rapid systemic availability of drugs. F6H8/EtOH showed intrapulmonary deposition of the test drug. (C) 2011 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Novaliq GmbH, Heidelberg, Germany"],["dc.identifier.doi","10.1016/j.ijpharm.2011.10.051"],["dc.identifier.isi","000302398700024"],["dc.identifier.pmid","22079720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27385"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0378-5173"],["dc.title","Aerosolized semifluorinated alkanes as excipients are suitable for inhalative drug delivery-A pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2014Journal Article [["dc.bibliographiccitation.firstpage","252"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","264"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Chiumello, Davide"],["dc.contributor.author","Cressoni, Massimo"],["dc.contributor.author","Carlesso, Eleonora"],["dc.contributor.author","Caspani, Maria L."],["dc.contributor.author","Marino, Antonella"],["dc.contributor.author","Gallazzi, Elisabetta"],["dc.contributor.author","Caironi, Pietro"],["dc.contributor.author","Lazzerini, Marco"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2018-11-07T09:44:43Z"],["dc.date.available","2018-11-07T09:44:43Z"],["dc.date.issued","2014"],["dc.description.abstract","Objective: Positive end-expiratory pressure exerts its effects keeping open at end-expiration previously collapsed areas of the lung; consequently, higher positive end-expiratory pressure should be limited to patients with high recruitability. We aimed to determine which bedside method would provide positive end-expiratory pressure better related to lung recruitability. Design: Prospective study performed between 2008 and 2011. Setting: Two university hospitals (Italy and Germany). Patients: Fifty-one patients with acute respiratory distress syndrome. Interventions: Whole lung CT scans were taken in static conditions at 5 and 45 cm H2O during an end-expiratory/end-inspiratory pause to measure lung recruitability. To select individual positive end-expiratory pressure, we applied bedside methods based on lung mechanics (ExPress, stress index), esophageal pressure, and oxygenation (higher positive end-expiratory pressure table of lung open ventilation study). Measurements and Main Results: Patients were classified in mild, moderate and severe acute respiratory distress syndrome. Positive end-expiratory pressure levels selected by the ExPress, stress index, and absolute esophageal pressures methods were unrelated with lung recruitability, whereas positive end-expiratory pressure levels selected by the lung open ventilation method showed a weak relationship with lung recruitability (r(2) = 0.29; p < 0.0001). When patients were classified according to the acute respiratory distress syndrome Berlin definition, the lung open ventilation method was the only one which gave lower positive end-expiratory pressure levels in mild and moderate acute respiratory distress syndrome compared with severe acute respiratory distress syndrome (8 2 and 11 +/- 3 cm H2O vs 15 +/- 3 cm H2O; p < 0.05), whereas ExPress, stress index, and esophageal pressure methods gave similar positive end-expiratory pressure values in mild, moderate, and severe acute respiratory distress syndrome. The positive end-expiratory pressure selected by the different methods were unrelated to each other with the exception of the two methods based on lung mechanics (ExPress and stress index). Conclusions: Bedside positive end-expiratory pressure selection methods based on lung mechanics or absolute esophageal pressures provide positive end-expiratory pressure levels unrelated to lung recruitability and similar in mild, moderate, and severe acute respiratory distress syndrome, whereas the oxygenation-based method provided positive end-expiratory pressure levels related with lung recruitability progressively increasing from mild to moderate and severe acute respiratory distress syndrome."],["dc.identifier.doi","10.1097/CCM.0b013e3182a6384f"],["dc.identifier.isi","000329863400020"],["dc.identifier.pmid","24196193"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34453"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1530-0293"],["dc.relation.issn","0090-3493"],["dc.title","Bedside Selection of Positive End-Expiratory Pressure in Mild, Moderate, and Severe Acute Respiratory Distress Syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2010Journal Article [["dc.bibliographiccitation.firstpage","842"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","850"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Waeschle, Reiner M."],["dc.contributor.author","Heise, Daniel"],["dc.contributor.author","Perl, Tal Naggan"],["dc.contributor.author","Hinz, Jose Maria"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Bauer, M."],["dc.date.accessioned","2018-11-07T08:39:25Z"],["dc.date.available","2018-11-07T08:39:25Z"],["dc.date.issued","2010"],["dc.description.abstract","Despite the broad application of intraoperative warming new studies still show a high incidence of perioperative hypothermia. Therefore a prewarming program in the preoperative holding area was started. The efficacy of the prewarming program was assessed with an accompanying quality assurance check sheet over a period of 3 months. During the 3 month test period 127 patients were included. The median length from arrival in the holding area to beginning prewarming was 6 min and the average duration of prewarming was 46 +/- 38 min. During prewarming the core temperature rose by 0.3 +/- 0.4A degrees C to 37.1 +/- 0.5A degrees C and decreased to 36.3 +/- 0.5A degrees C after induction of anesthesia. At the end of the operation the core temperature was 36.4 +/- 0.5A degrees C and 14% of the patients were hypothermic. These data allow 2 conclusions: 1. Prewarming in the holding area is possible with a sufficient duration. 2. Prewarming is highly efficient even when performed over a relatively short duration."],["dc.identifier.doi","10.1007/s00101-010-1772-0"],["dc.identifier.isi","000281844600007"],["dc.identifier.pmid","20703440"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18992"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0003-2417"],["dc.title","Preoperative prewarming as a routine measure. First experiences"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2017Journal Article [["dc.bibliographiccitation.firstpage","76"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","78"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Tonetti, Tommaso"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2020-12-10T14:08:46Z"],["dc.date.available","2020-12-10T14:08:46Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00134-017-4770-8"],["dc.identifier.eissn","1432-1238"],["dc.identifier.issn","0342-4642"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70555"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Intensive care medicine in 2050: ventilator-induced lung injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]Details DOI2010Conference Abstract [["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Raymondos, Konstantinos"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Dirks, T."],["dc.contributor.author","Ahrens, J."],["dc.contributor.author","Molitoris, Ulrich"],["dc.contributor.author","Dieck, Thorben"],["dc.contributor.author","Johanning, Kai"],["dc.contributor.author","Henzler, Dietrich"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Putensen, Christian"],["dc.contributor.author","Wrigge, Hermann"],["dc.contributor.author","Wittich, Ralph"],["dc.contributor.author","Ragaller, Maximilian"],["dc.contributor.author","Bein, Thomas"],["dc.contributor.author","Schneider, M."],["dc.contributor.author","Rabe, Christian"],["dc.contributor.author","Schlechtweg, Joern"],["dc.contributor.author","Holler, Monika"],["dc.contributor.author","Frutos-Vivar, Fernando"],["dc.contributor.author","Esteban, Andres"],["dc.contributor.author","Rosseau, Simone"],["dc.contributor.author","Koppert, W."],["dc.contributor.author","Hecker, Hartmut"],["dc.contributor.author","Spies, C."],["dc.contributor.author","Weber-Carstens, Steffen"],["dc.date.accessioned","2018-11-07T08:39:44Z"],["dc.date.available","2018-11-07T08:39:44Z"],["dc.date.issued","2010"],["dc.format.extent","S227"],["dc.identifier.isi","000281679500565"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19067"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","23rd Annual Meeting of the European-Society-of-Intensive-Care-Medicine"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","1432-1238"],["dc.relation.issn","0342-4642"],["dc.title","HOSPITAL LEVEL AND OUTCOME OF MECHANICALLY VENTILATED PATIENTS WITH AND WITHOUT ARDS IN GERMANY"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2013Journal Article [["dc.bibliographiccitation.firstpage","148"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Journal of Primatology"],["dc.bibliographiccitation.lastpage","156"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Hoeing, Andrea"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Indrawati, Yohana Maria"],["dc.contributor.author","Cheyne, Susan M."],["dc.contributor.author","Waltert, Matthias"],["dc.date.accessioned","2018-11-07T09:28:47Z"],["dc.date.available","2018-11-07T09:28:47Z"],["dc.date.issued","2013"],["dc.description.abstract","Estimating population densities of key species is crucial for many conservation programs. Density estimates provide baseline data and enable monitoring of population size. Several different survey methods are available, and the choice of method depends on the species and study aims. Few studies have compared the accuracy and efficiency of different survey methods for large mammals, particularly for primates. Here we compare estimates of density and abundance of Kloss' gibbons (Hylobates klossii) using two of the most common survey methods: line transect distance sampling and triangulation. Line transect surveys (survey effort: 155.5 km) produced a total of 101 auditory and visual encounters and a density estimate of 5.5 gibbon clusters (groups or subgroups of primate social units)/km(2). Triangulation conducted from 12 listening posts during the same period revealed a similar density estimate of 5.0 clusters/km(2). Coefficients of variation of cluster density estimates were slightly higher from triangulation (0.24) than from line transects (0.17), resulting in a lack of precision in detecting changes in cluster densities of < 66 % for triangulation and < 47 % for line transect surveys at the 5 % significance level with a statistical power of 50 %. This case study shows that both methods may provide estimates with similar accuracy but that line transects can result in more precise estimates and allow assessment of other primate species. For a rapid assessment of gibbon density under time and financial constraints, the triangulation method also may be appropriate."],["dc.identifier.doi","10.1007/s10764-012-9655-7"],["dc.identifier.isi","000314048600010"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8852"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30860"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1573-8604"],["dc.relation.issn","0164-0291"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Line Transect and Triangulation Surveys Provide Reliable Estimates of the Density of Kloss' Gibbons (Hylobates klossii) on Siberut Island, Indonesia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]Details DOI WOS2016Journal Article [["dc.bibliographiccitation.artnumber","36"],["dc.bibliographiccitation.journal","CRITICAL CARE"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Fanelli, Vito"],["dc.contributor.author","Ranieri, Marco V."],["dc.contributor.author","Mancebo, Jordi"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Morley, Scott"],["dc.contributor.author","Moran, Indalecio"],["dc.contributor.author","Parrilla, Francisco"],["dc.contributor.author","Costamagna, Andrea"],["dc.contributor.author","Gaudiosi, Marco"],["dc.contributor.author","Combes, Alain"],["dc.date.accessioned","2018-11-07T10:18:16Z"],["dc.date.available","2018-11-07T10:18:16Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Mechanical ventilation with a tidal volume (V-T) of 6 mL/kg/predicted body weight (PBW), to maintain plateau pressure (P-plat) lower than 30 cmH(2)O, does not completely avoid the risk of ventilator induced lung injury (VILI). The aim of this study was to evaluate safety and feasibility of a ventilation strategy consisting of very low VT combined with extracorporeal carbon dioxide removal (ECCO2R). Methods: In fifteen patients with moderate ARDS, VT was reduced from baseline to 4 mL/kg PBW while PEEP was increased to target a plateau pressure - (Pplat) between 23 and 25 cmH(2)O. Low-flow ECCO2R was initiated when respiratory acidosis developed (pH < 7.25, PaCO2 > 60 mmHg). Ventilation parameters (VT, respiratory rate, PEEP), respiratory compliance (C-RS), driving pressure (DeltaP = V-T/C-RS), arterial blood gases, and ECCO2R system operational characteristics were collected during the period of ultra-protective ventilation. Patients were weaned from ECCO2R when PaO2/FiO(2) was higher than 200 and could tolerate conventional ventilation settings. Complications, mortality at day 28, need for prone positioning and extracorporeal membrane oxygenation, and data on weaning from both MV and ECCO2R were also collected. Results: During the 2 h run in phase, VT reduction from baseline (6.2 mL/kg PBW) to approximately 4 mL/kg PBW caused respiratory acidosis (pH < 7.25) in all fifteen patients. At steady state, ECCO2R with an average blood flow of 435 mL/min and sweep gas flow of 10 L/min was effective at correcting pH and PaCO2 to within 10 % of baseline values. PEEP values tended to increase at V-T of 4 mL/kg from 12.2 to 14.5 cmH(2)O, but this change was not statistically significant. Driving pressure was significantly reduced during the first two days compared to baseline (from 13.9 to 11.6 cmH(2)O; p < 0.05) and there were no significant differences in the values of respiratory system compliance. Rescue therapies for life threatening hypoxemia such as prone position and ECMO were necessary in four and two patients, respectively. Only two study-related adverse events were observed (intravascular hemolysis and femoral catheter kinking). Conclusions: The low-flow ECCO2R system safely facilitates a low volume, low pressure ultra-protective mechanical ventilation strategy in patients with moderate ARDS."],["dc.description.sponsorship","ALung Technologies, Inc."],["dc.identifier.doi","10.1186/s13054-016-1211-y"],["dc.identifier.isi","000369912900002"],["dc.identifier.pmid","26861596"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13484"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41401"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1364-8535"],["dc.relation.issn","1466-609X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2016Journal Article [["dc.bibliographiccitation.artnumber","86"],["dc.bibliographiccitation.journal","CRITICAL CARE"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Gattinoni, Luciano"],["dc.contributor.author","Quintel, Michael"],["dc.date.accessioned","2018-11-07T10:15:38Z"],["dc.date.available","2018-11-07T10:15:38Z"],["dc.date.issued","2016"],["dc.description.abstract","The Berlin definition criteria applied at positive end-expiratory pressure (PEEP) 5 cm H2O reasonably predict lung edema and recruitabilty. To maintain viable gas exchange, the mechanical ventilation becomes progressively more risky going from mild to severe acute respiratory distress syndrome (ARDS). Tidal volume, driving pressure, flow, and respiratory rate have been identified as causes of ventilation-induced lung injury. Taken together, they represent the mechanical power applied to the lung parenchyma. In an inhomogeneous lung, stress risers locally increase the applied mechanical power. Increasing lung homogeneity by PEEP and prone position decreases the harm of mechanical ventilation, particularly in severe ARDS."],["dc.identifier.doi","10.1186/s13054-016-1268-7"],["dc.identifier.isi","000373669800001"],["dc.identifier.pmid","27048605"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13487"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40846"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1364-8535"],["dc.relation.issn","1466-609X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","How ARDS should be treated"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS