Andreas, Stefan

[["dc.bibliographiccitation.artnumber","7"],["dc.bibliographiccitation.journal","Respiratory Research"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Raupach, Tobias"],["dc.contributor.author","Michels, Hellmuth"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Koegler, Harald"],["dc.contributor.author","Andreas, Stefan"],["dc.date.accessioned","2017-09-07T11:47:34Z"],["dc.date.available","2017-09-07T11:47:34Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Systemic effects of chronic obstructive pulmonary disease (COPD) significantly contribute to severity and mortality of the disease. We aimed to develop a COPD/emphysema model exhibiting systemic manifestations of the disease. Methods: Female NMRI mice were treated 5 times intratracheally with porcine pancreatic elastase (emphysema) or phosphate-buffered saline (control). Emphysema severity was quantified histologically by mean linear intercept, exercise tolerance by treadmill running distance, diaphragm dysfunction using isolated muscle strips, pulmonary hypertension by measuring right ventricular pressure, and neurohumoral activation by determining urinary norepinephrine concentration. Results: Mean linear intercept was higher in emphysema (260.7 +/- 26.8 mu m) than in control lungs (24.7 +/- 1.7 mu m). Emphysema mice lost body weight, controls gained weight. Running distance was shorter in emphysema than in controls. Diaphragm muscle length was shorter in controls compared to emphysema. Fatigue tests of muscle strips revealed impaired relaxation in emphysema diaphragms. Maximum right ventricular pressure and norepinephrine were elevated in emphysema compared to controls. Linear correlations were observed between running distance changes and intercept, right ventricular weight, norepinephrine, and diaphragm length. Conclusion: The elastase mouse model exhibited severe emphysema with consecutive exercise limitation, and neurohumoral activation. The model may deepen our understanding of systemic aspects of COPD."],["dc.identifier.doi","10.1186/1465-9921-10-7"],["dc.identifier.gro","3143160"],["dc.identifier.isi","000263727200001"],["dc.identifier.pmid","19175913"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13854"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/643"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1465-9921"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","273"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","280"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Luethje, Lars"],["dc.contributor.author","Renner, Bernd"],["dc.contributor.author","Kessels, Roger"],["dc.contributor.author","Vollmann, Dirk"],["dc.contributor.author","Raupach, Tobias"],["dc.contributor.author","Gerritse, Bart"],["dc.contributor.author","Tasci, Selcuk"],["dc.contributor.author","Schwab, Joerg O."],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Zenker, Dieter"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Andreas, Stefan"],["dc.date.accessioned","2017-09-07T11:47:31Z"],["dc.date.available","2017-09-07T11:47:31Z"],["dc.date.issued","2009"],["dc.description.abstract","Aims The combined therapeutic impact of atrial overdrive pacing (ACIP) and cardiac resynchronization therapy (CRT) on central steep apnoea (CSA) in chronic heart failure (CHF) so far has not been investigated. We aimed to evaluate the effect of CRT alone and CRT + AOP on CSA in CHF patients and to compare the influence of CRT on CHF between CSA positive and CSA negative patients. Methods and results Thirty patients with CRT indication underwent full night polysomnography, echocardiography, exercise testing, and neurohumoral evaluation before and 3 months after CRT implantation. In CSA positive patients (60%), two additional steep studies were conducted after 3 months of CRT, with CRT alone or CRT + ACIP, in random order. Cardiac resynchronization therapy resulted in significant improvements of NYHA class, left ventricular ejection fraction, N-terminal pro-brain natriuretic peptide, VO(2)max, and quality of life irrespective of the presence of CSA. Cardiac resynchronization therapy also reduced the central apnoea-hypopnoea index (AHI) (33.6 +/- 14.3 vs. 23.8 +/- 16.9 h(-1); P < 0.01) and central apnoea index (17.3 +/- 14.1 vs. 10.9 +/- 13.9 h(-1); P < 0.01) without altering steep stages. Cardiac resynchronization therapy with atrial overdrive pacing resulted in a small but significant additional decrease of the central AHI (23.8 +/- 16.9 vs. 21.5 +/- 16.9 h(-1); P < 0.01). Conclusion In this study, CRT significantly improved CSA without altering sleep stages. Cardiac resynchronization therapy with atrial. overdrive pacing resulted in a significant but minor additional improvement of CSA. Positive effects of CRT were irrespective of the presence of CSA."],["dc.identifier.doi","10.1093/eurjhf/hfn042"],["dc.identifier.gro","3143143"],["dc.identifier.isi","000265845700008"],["dc.identifier.pmid","19147446"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/625"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Bakken Research Center, Maastricht, Netherlands"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1388-9842"],["dc.title","Cardiac resynchronization therapy and atrial overdrive pacing for the treatment of central sleep apnoea"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","776"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","786"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Omlor, Albert J."],["dc.contributor.author","Trudzinski, Franziska C."],["dc.contributor.author","Alqudrah, Mohamad"],["dc.contributor.author","Seiler, Frederik"],["dc.contributor.author","Biertz, Frank"],["dc.contributor.author","Vogelmeier, Claus F."],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Watz, Henrik"],["dc.contributor.author","Waschki, Benjamin"],["dc.contributor.author","Brinker, Titus J."],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Fähndrich, Sebastian"],["dc.contributor.author","Alter, Peter"],["dc.contributor.author","Jörres, Rudolf A."],["dc.contributor.author","Böhm, Michael"],["dc.contributor.author","Bals, Robert"],["dc.date.accessioned","2020-12-10T14:10:23Z"],["dc.date.available","2020-12-10T14:10:23Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00392-019-01572-1"],["dc.identifier.eissn","1861-0692"],["dc.identifier.issn","1861-0684"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70745"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Time-updated resting heart rate predicts mortality in patients with COPD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","RCT210"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Testa, Marco"],["dc.contributor.author","Boyer, Laurent"],["dc.contributor.author","Brusselle, Guy"],["dc.contributor.author","Janssens, Wim"],["dc.contributor.author","Kerwin, Edward"],["dc.contributor.author","Papi, Alberto"],["dc.contributor.author","Pek, Bonavuth"],["dc.contributor.author","Puente-Maestu, Luis"],["dc.contributor.author","Saralaya, Dinesh"],["dc.contributor.author","Watz, Henrik"],["dc.contributor.author","Wilkinson, Tom Ma"],["dc.contributor.author","Casula, Daniela"],["dc.contributor.author","Di Maro, Gennaro"],["dc.contributor.author","Lattanzi, Maria"],["dc.contributor.author","Moraschini, Luca"],["dc.contributor.author","Schoonbroodt, Sonia"],["dc.contributor.author","Tasciotti, Annaelisa"],["dc.contributor.author","Arora, Ashwani K"],["dc.contributor.author","Maltais, François"],["dc.date.accessioned","2022-04-01T10:03:05Z"],["dc.date.available","2022-04-01T10:03:05Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1183/13993003.congress-2021.RCT210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106081"],["dc.notes.intern","DOI-Import GROB-530"],["dc.notes.preprint","yes"],["dc.publisher","European Respiratory Society"],["dc.relation.conference","ERS International Congress 2021 abstracts"],["dc.relation.iserratumof","yes"],["dc.title","Late Breaking Abstract - First-time assessment of efficacy of candidate vaccine to prevent acute exacerbations of chronic obstructive pulmonary disease (AECOPD): multicentre, randomised, controlled, observer-blind phase 2b trial"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Pulmonary Pharmacology and Therapeutics"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Bothner, Ulrich"],["dc.contributor.author","Trampisch, Matthias"],["dc.contributor.author","Haensel, Michaela"],["dc.contributor.author","Buhl, Roland"],["dc.contributor.author","Alter, Peter"],["dc.date.accessioned","2020-12-10T15:20:58Z"],["dc.date.available","2020-12-10T15:20:58Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.pupt.2018.08.002"],["dc.identifier.issn","1094-5539"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72872"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Effect of long-acting β2-agonists olodaterol and formoterol on heart rate and blood pressure in chronic obstructive pulmonary disease patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","589"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","COPD: Journal of Chronic Obstructive Pulmonary Disease"],["dc.bibliographiccitation.lastpage","594"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Haarmann, Helge"],["dc.contributor.author","Folle, Jan"],["dc.contributor.author","Xuan Phuc Nguyen, Xuan Phuc Nguyen"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Heusser, Karsten"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Raupach, Tobias"],["dc.date.accessioned","2017-09-07T11:54:43Z"],["dc.date.available","2017-09-07T11:54:43Z"],["dc.date.issued","2016"],["dc.description.abstract","Exercise intolerance, skeletal muscle dysfunction, and reduced daily activity are central in COPD patients and closely related to quality of life and prognosis. Studies assessing muscle exercise have revealed an increase in sympathetic outflow as a link to muscle hypoperfusion and exercise limitation. Our primary hypothesis was that muscle sympathetic nerve activity (MSNA) correlates with exercise limitation in COPD. MSNA was evaluated at rest and during dynamic or static handgrip exercise. Additionally, we assessed heart rate, blood pressure, CO2 tension, oxygen saturation (SpO(2)), and breathing frequency. Ergospirometry was performed to evaluate exercise capacity. We assessed MSNA of 14 COPD patients and 8 controls. In patients, MSNA was negatively correlated with peak oxygen uptake (VO2 % pred) (r = -0.597; p = 0.040). During dynamic or static handgrip exercise, patients exhibited a significant increase in MSNA, which was not observed in the control group. The increase in MSNA during dynamic handgrip was highly negatively correlated with peak exercise capacity in Watts (w) and peak oxygen uptake (VO2/kg) (r = -0.853; p = 0.002 and r = -0.881; p = 0.002, respectively). Our study reveals an association between increased MSNA and limited exercise capacity in patients with COPD. Furthermore, we found an increased sympathetic response to moderate physical exercise (handgrip), which may contribute to exercise intolerance in COPD."],["dc.identifier.doi","10.3109/15412555.2015.1136272"],["dc.identifier.gro","3141749"],["dc.identifier.isi","000381997300009"],["dc.identifier.pmid","26829234"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/646"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Taylor & Francis Inc"],["dc.relation.eissn","1541-2563"],["dc.relation.issn","1541-2555"],["dc.title","Sympathetic Activation is Associated with Exercise Limitation in COPD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Lung Cancer"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Griesinger, Frank"],["dc.contributor.author","Overbeck, Tobias R."],["dc.contributor.author","Schondube, F."],["dc.contributor.author","Schmidtberger, H."],["dc.contributor.author","Andreas, S."],["dc.contributor.author","Schirren, J."],["dc.contributor.author","Hemmerlein, Bernhard"],["dc.contributor.author","Keppler, U."],["dc.contributor.author","Leupold, H."],["dc.contributor.author","Baum, R."],["dc.date.accessioned","2018-11-07T09:26:18Z"],["dc.date.available","2018-11-07T09:26:18Z"],["dc.date.issued","2005"],["dc.format.extent","S26"],["dc.identifier.doi","10.1016/S0169-5002(05)80201-6"],["dc.identifier.isi","000231307800076"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30268"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.publisher.place","Clare"],["dc.relation.conference","11th World Conference on Lung Cancer"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","0169-5002"],["dc.title","Phase II induction therapy with docetaxel and carboplatin in NSCLC IIIA/IIIB: FDG-PET response predicts overall and disease free survival"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","769"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Immunotherapy"],["dc.bibliographiccitation.lastpage","782"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Schiwitza, Annett"],["dc.contributor.author","Schildhaus, Hans-Ulrich"],["dc.contributor.author","Zwerger, Birgit"],["dc.contributor.author","Rüschoff, Josef"],["dc.contributor.author","Reinhardt, Christian"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Rittmeyer, Achim"],["dc.date.accessioned","2020-12-10T18:43:39Z"],["dc.date.available","2020-12-10T18:43:39Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.2217/imt-2019-0039"],["dc.identifier.eissn","1750-7448"],["dc.identifier.issn","1750-743X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78202"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Monitoring efficacy of checkpoint inhibitor therapy in patients with non-small-cell lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1945"],["dc.bibliographiccitation.journal","The International Journal of Chronic Obstructive Pulmonary Disease"],["dc.bibliographiccitation.lastpage","1953"],["dc.bibliographiccitation.volume","Volume 15"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Bothner, Ulrich"],["dc.contributor.author","de la Hoz, Alberto"],["dc.contributor.author","Kloer, Isabel"],["dc.contributor.author","Trampisch, Matthias"],["dc.contributor.author","Alter, Peter"],["dc.date.accessioned","2021-04-14T08:27:23Z"],["dc.date.available","2021-04-14T08:27:23Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.2147/COPD.S246350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82273"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1178-2005"],["dc.title","No Influence on Cardiac Arrhythmia or Heart Rate from Long-Term Treatment with Tiotropium/Olodaterol versus Monocomponents by Holter ECG Analysis in Patients with Moderate-to-Very-Severe COPD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","61"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Respiratory Journal"],["dc.bibliographiccitation.lastpage","79"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Jimenez-Ruiz, Carlos A."],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Lewis, Keir E."],["dc.contributor.author","Tonnesen, Philip"],["dc.contributor.author","van Schayck, C. P."],["dc.contributor.author","Hajek, Peter"],["dc.contributor.author","Tonstad, Serena"],["dc.contributor.author","Dautzenberg, Bertrand"],["dc.contributor.author","Fletcher, Monica"],["dc.contributor.author","Masefield, Sarah"],["dc.contributor.author","Powell, Pippa"],["dc.contributor.author","Hering, Thomas"],["dc.contributor.author","Nardini, Stefano"],["dc.contributor.author","Tonia, Thomy"],["dc.contributor.author","Gratziou, Christina"],["dc.date.accessioned","2018-11-07T09:55:15Z"],["dc.date.available","2018-11-07T09:55:15Z"],["dc.date.issued","2015"],["dc.description.abstract","Chronic obstructive pulmonary disease (COPD), lung cancer, asthma and pulmonary tuberculosis are common pulmonary diseases that are caused or worsened by tobacco smoking. Growing observational evidence suggests that symptoms and prognosis of these conditions improve upon smoking cessation. Despite increasing numbers of (small) randomised controlled trials suggesting intensive smoking cessation treatments work in people with pulmonary diseases many patients are not given specific advice on the benefits or referred for intensive cessation treatments and, therefore, continue smoking. This is a qualitative review regarding smoking cessation in patients with COPD and other pulmonary disorders, written by a group of European Respiratory Society experts. We describe the epidemiological links between smoking and pulmonary disorders, the evidence for benefits of stopping smoking, how best to assess tobacco dependence and what interventions currently work best to help pulmonary patients quit. Finally, we describe characteristics and management of any \"hardcore\" smoker who finds it difficult to quit with standard approaches."],["dc.identifier.doi","10.1183/09031936.00092614"],["dc.identifier.isi","000357137300011"],["dc.identifier.pmid","25882805"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36704"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","European Respiratory Soc Journals Ltd"],["dc.relation.issn","1399-3003"],["dc.relation.issn","0903-1936"],["dc.title","Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]