Prpic-Schäper, Nikola-Michael

[["dc.bibliographiccitation.firstpage","487"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","BioEssays"],["dc.bibliographiccitation.lastpage","498"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","McGregor, Alistair P."],["dc.contributor.author","Hilbrant, Maarten"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Damen, Wim G. M."],["dc.date.accessioned","2018-11-07T11:15:20Z"],["dc.date.available","2018-11-07T11:15:20Z"],["dc.date.issued","2008"],["dc.description.abstract","The spiders Cupiennius salei and Achaearanea tepidariorum are firmly established laboratory models that have already contributed greatly to answering evolutionary developmental questions. Here we appraise why these animals are such useful models from phylogeny, natural history and embryogenesis to the tools available for their manipulation. We then review recent studies of axis formation, segmentation, appendage development and neurogenesis in these spiders and how this has contributed to understanding the evolution of these processes. Furthermore, we discuss the potential of comparisons of silk production between Cupiennius and Achaearanea to investigate the origins and diversification of this evolutionary innovation. We suggest that further comparisons between these two spiders and other chelicerates will prove useful for understanding the evolution of development in metazoans."],["dc.identifier.doi","10.1002/bies.20744"],["dc.identifier.isi","000255621200010"],["dc.identifier.pmid","18404731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54345"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Inc"],["dc.relation.issn","0265-9247"],["dc.title","Cupiennius salei and Achaearanea tepidariorum: spider models for investigating evolution and development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4921"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","4926"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T09:12:10Z"],["dc.date.available","2018-11-07T09:12:10Z"],["dc.date.issued","2012"],["dc.description.abstract","Evolution often results in morphologically similar solutions in different organisms, a phenomenon known as convergence. However, there is little knowledge of the processes that lead to convergence at the genetic level. The genes of the Hox cluster control morphology in animals. They may also be central to the convergence of morphological traits, but whether morphological similarities also require similar changes in Hox gene function is disputed. In arthropods, body subdivision into a region with locomotory appendages (\"thorax\") and a region with reduced appendages (\"abdomen\") has evolved convergently in several groups, e. g., spiders and insects. In insects, legs develop in the expression domain of the Hox gene Antennapedia (Antp), whereas the Hox genes Ultrabithorax (Ubx) and abdominal-A mediate leg repression in the abdomen. Here, we show that, unlike Antp in insects, the Antp gene in the spider Achaearanea tepidariorum represses legs in the first segment of the abdomen (opisthosoma), and that Antp and Ubx are redundant in the following segment. The down-regulation of Antp in A. tepidariorum leads to a striking 10-legged phenotype. We present evidence from ectopic expression of the spider Antp gene in Drosophila embryos and imaginal tissue that this unique function of Antp is not due to changes in the Antp protein, but likely due to divergent evolution of cofactors, Hox collaborators or target genes in spiders and flies. Our results illustrate an interesting example of convergent evolution of abdominal leg repression in arthropods by altering the role of distinct Hox genes at different levels of their action."],["dc.identifier.doi","10.1073/pnas.1116421109"],["dc.identifier.isi","000302164200046"],["dc.identifier.pmid","22421434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26887"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Divergent role of the Hox gene Antennapedia in spiders is responsible for the convergent evolution of abdominal limb repression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","370"],["dc.bibliographiccitation.volume","218"],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Budd, Graham E."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T11:13:19Z"],["dc.date.available","2018-11-07T11:13:19Z"],["dc.date.issued","2008"],["dc.description.abstract","The correlation between dorsal and ventral segmental units in diplopod myriapods is complex and disputed. Recent results with engrailed (en), hedgehog (hh), wingless (wg), and cubitus-interruptus (ci) have shown that the dorsal segments are patterned differently from the ventral segments. Ventrally, gene expression is compatible with the classical autoregulatory loop known from Drosophila to specify the parasegment boundary. In the dorsal segments, however, this Wg/Hh autoregulatory loop cannot be present because the observed gene expression patterns argue against the involvement of Wg signalling. In this paper, we present further evidence against an involvement of Wg signalling in dorsal segmentation and propose a hypothesis about how dorsal segmental boundaries may be controlled in a wg-independent way. We find that (1) the Notum gene, a modulator of the Wg gradient in Drosophila, is not expressed in the dorsal segments. (2) The H15/midline gene, a repressor of Wg action in Drosophila, is not expressed in the dorsal segments, except for future heart tissue. (3) The patched (ptc) gene, which encodes a Hh receptor, is strongly expressed in the dorsal segments, which is incompatible with Wg-Hh autoregulation. The available data suggest that anterior-posterior (AP) boundary formation in dorsal segments could instead rely on Dpp signalling rather than Wg signalling. We present a hypothesis that relies on Hh-mediated activation of Dpp signalling and optomotor-blind (omb) expression to establish the dorsal AP boundary (the future tergite boundary). The proposed mechanism is similar to the mechanism used to establish the AP boundary in Drosophila wings and ventral pleura."],["dc.identifier.doi","10.1007/s00427-008-0231-2"],["dc.identifier.isi","000257395200003"],["dc.identifier.pmid","18592266"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53865"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0949-944X"],["dc.title","Evidence for Wg-independent tergite boundary formation in the millipede Glomeris marginata"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","262"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","271"],["dc.bibliographiccitation.volume","326"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Damen, Wim G. M."],["dc.date.accessioned","2018-11-07T08:32:57Z"],["dc.date.available","2018-11-07T08:32:57Z"],["dc.date.issued","2009"],["dc.description.abstract","Arthropod limbs are arguably the most diverse organs in the animal kingdom. Morphological diversity of the limbs is largely based on their segmentation, because this divides the limbs into modules that can evolve separately for new morphologies and functions. Limb segmentation also distinguishes the arthropods from related phyla (e.g. onychophorans) and thus forms an important evolutionary innovation in arthropods. Understanding the genetic basis of limb segmentation in arthropods can thus shed light onto the mechanisms of macroevolution and the origin of a character (articulated limbs) that defines a new phylum (arthropods). In the fly Drosophila limb segmentation and limb growth are controlled by the Notch signaling pathway. Here we show that the Notch pathway also controls limb segmentation and growth in the spider Cupiennius salei, a representative of the most basally branching arthropod group Chelicerata, and thus this function must trace from the last common ancestor of all arthropods. The similarities of Notch and Serrate function between Drosophila and Cupiennius are extensive and also extend to target genes like odd-skipped, nubbin, AP-2 and hairy related genes. Our data confirm that the jointed appendages, which are a morphological phylotypic trait of the arthropods and the basis for naming the phylum, have a common developmental genetic basis. Notch-mediated limb segmentation is thus a molecular phylotypic trait of the arthropods. (C) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2008.10.049"],["dc.identifier.isi","000263141100023"],["dc.identifier.pmid","19046962"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17457"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Notch-mediated segmentation of the appendages is a molecular phylotypic trait of the arthropods"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e104885"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Zeng, Victor"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Hilbrant, Maarten"],["dc.contributor.author","Keefe, Joseph D."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","McGregor, Alistair P."],["dc.contributor.author","Extavour, Cassandra G."],["dc.date.accessioned","2018-11-07T09:36:37Z"],["dc.date.available","2018-11-07T09:36:37Z"],["dc.date.issued","2014"],["dc.description.abstract","Parasteatoda tepidariorum is an increasingly popular model for the study of spider development and the evolution of development more broadly. However, fully understanding the regulation and evolution of P. tepidariorum development in comparison to other animals requires a genomic perspective. Although research on P. tepidariorum has provided major new insights, gene analysis to date has been limited to candidate gene approaches. Furthermore, the few available EST collections are based on embryonic transcripts, which have not been systematically annotated and are unlikely to contain transcripts specific to post-embryonic stages of development. We therefore generated cDNA from pooled embryos representing all described embryonic stages, as well as post-embryonic stages including nymphs, larvae and adults, and using Illumina HiSeq technology obtained a total of 625,076,514 100-bp paired end reads. We combined these data with 24,360 ESTs available in GenBank, and 1,040,006 reads newly generated from 454 pyrosequencing of a mixed-stage embryo cDNA library. The combined sequence data were assembled using a custom de novo assembly strategy designed to optimize assembly product length, number of predicted transcripts, and proportion of raw reads incorporated into the assembly. The de novo assembly generated 446,427 contigs with an N50 of 1,875 bp. These sequences obtained 62,799 unique BLAST hits against the NCBI non-redundant protein data base, including putative orthologs to 8,917 Drosophila melanogaster genes based on best reciprocal BLAST hit identity compared with the D. melanogaster proteome. Finally, we explored the utility of the transcriptome for RNA-Seq studies, and showed that this resource can be used as a mapping scaffold to detect differential gene expression in different cDNA libraries. This resource will therefore provide a platform for future genomic, gene expression and functional approaches using P. tepidariorum."],["dc.description.sponsorship","Open Access Publikationsfonds 2014"],["dc.identifier.doi","10.1371/journal.pone.0104885"],["dc.identifier.isi","000340900600099"],["dc.identifier.pmid","25118601"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10635"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32658"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","A Comprehensive Reference Transcriptome Resource for the Common House Spider Parasteatoda tepidariorum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","5"],["dc.bibliographiccitation.journal","EvoDevo"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Budd, Graham E."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Damen, Wim G. M."],["dc.date.accessioned","2018-11-07T09:00:09Z"],["dc.date.available","2018-11-07T09:00:09Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Segmentation is a hallmark of the arthropods; most knowledge about the molecular basis of arthropod segmentation comes from work on the fly Drosophila melanogaster. In this species a hierarchic cascade of segmentation genes subdivides the blastoderm stepwise into single segment wide regions. However, segmentation in the fly is a derived feature since all segments form virtually simultaneously. Conversely, in the vast majority of arthropods the posterior segments form one at a time from a posterior pre-segmental zone. The pair rule genes (PRGs) comprise an important level of the Drosophila segmentation gene cascade and are indeed the first genes that are expressed in typical transverse stripes in the early embryo. Information on expression and function of PRGs outside the insects, however, is scarce. Results: Here we present the expression of the pair rule gene orthologs in the pill millipede Glomeris marginata (Myriapoda: Diplopoda). We find evidence that these genes are involved in segmentation and that components of the hierarchic interaction of the gene network as found in insects may be conserved. We further provide evidence that segments are formed in a single-segment periodicity rather than in pairs of two like in another myriapod, the centipede Strigamia maritima. Finally we show that decoupling of dorsal and ventral segmentation in Glomeris appears already at the level of the PRGs. Conclusions: Although the pair rule gene network is partially conserved among insects and myriapods, some aspects of PRG interaction are, as suggested by expression pattern analysis, convergent, even within the Myriapoda. Conserved expression patterns of PRGs in insects and myriapods, however, may represent ancestral features involved in segmenting the arthropod ancestor."],["dc.identifier.doi","10.1186/2041-9139-2-5"],["dc.identifier.isi","000310693900005"],["dc.identifier.pmid","21352542"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5995"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24084"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","2041-9139"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Expression of myriapod pair rule gene orthologs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","374"],["dc.bibliographiccitation.journal","BMC Evolutionary Biology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Le Gouar, Martine"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Poulin, Francis"],["dc.contributor.author","Bolognesi, Renata"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Hopfen, Corinna"],["dc.contributor.author","Colbourne, John K."],["dc.contributor.author","Budd, Graham E."],["dc.contributor.author","Brown, Susan J."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Kosiol, Carolin"],["dc.contributor.author","Vervoort, Michel"],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Balavoine, Guillaume"],["dc.contributor.author","McGregor, Alistair P."],["dc.date.accessioned","2018-11-07T08:36:03Z"],["dc.date.available","2018-11-07T08:36:03Z"],["dc.date.issued","2010"],["dc.description.abstract","Background: The Wnt genes encode secreted glycoprotein ligands that regulate a wide range of developmental processes, including axis elongation and segmentation. There are thirteen subfamilies of Wnt genes in metazoans and this gene diversity appeared early in animal evolution. The loss of Wnt subfamilies appears to be common in insects, but little is known about the Wnt repertoire in other arthropods, and moreover the expression and function of these genes have only been investigated in a few protostomes outside the relatively Wnt-poor model species Drosophila melanogaster and Caenorhabditis elegans. To investigate the evolution of this important gene family more broadly in protostomes, we surveyed the Wnt gene diversity in the crustacean Daphnia pulex, the chelicerates Ixodes scapularis and Achaearanea tepidariorum, the myriapod Glomeris marginata and the annelid Platynereis dumerilii. We also characterised Wnt gene expression in the latter three species, and further investigated expression of these genes in the beetle Tribolium castaneum. Results: We found that Daphnia and Platynereis both contain twelve Wnt subfamilies demonstrating that the common ancestors of arthropods, ecdysozoans and protostomes possessed all members of all Wnt subfamilies except Wnt3. Furthermore, although there is striking loss of Wnt genes in insects, other arthropods have maintained greater Wnt gene diversity. The expression of many Wnt genes overlap in segmentally reiterated patterns and in the segment addition zone, and while these patterns can be relatively conserved among arthropods and the annelid, there have also been changes in the expression of some Wnt genes in the course of protostome evolution. Nevertheless, our results strongly support the parasegment as the primary segmental unit in arthropods, and suggest further similarities between segmental and parasegmental regulation by Wnt genes in annelids and arthropods respectively. Conclusions: Despite frequent losses of Wnt gene subfamilies in lineages such as insects, nematodes and leeches, most protostomes have probably maintained much of their ancestral repertoire of twelve Wnt genes. The maintenance of a large set of these ligands could be in part due to their combinatorial activity in various tissues"],["dc.identifier.doi","10.1186/1471-2148-10-374"],["dc.identifier.isi","000287576000002"],["dc.identifier.pmid","21122121"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18218"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2148"],["dc.title","Conservation, loss, and redeployment of Wnt ligands in protostomes: implications for understanding the evolution of segment formation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","363"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","376"],["dc.bibliographiccitation.volume","344"],["dc.contributor.author","Schaeper, Nina D."],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Wimmer, Ernst A."],["dc.date.accessioned","2018-11-07T08:40:43Z"],["dc.date.available","2018-11-07T08:40:43Z"],["dc.date.issued","2010"],["dc.description.abstract","The insect intercalary segment represents a small and appendage-less head segment that is homologous to the second antennal segment of Crustacea and the pedipalpal segment in Chelicerata, which are generally referred to as \"tritocerebral segment\" In Drosophila, the gene collier (col) has an important role for the formation of the intercalary segment Here we show that in the beetle Tribolium castaneum col is required for the activation of the segment polarity genes hedgehog (hh), engrailed (en) and wingless (wg) in the intercalary segment, and is a regulatory target of the intercalary segment specific Hox gene labial (lab) Loss of Tc col function leads to increased cell death in the intercalary segment In the milkweed bug Oncopeltus fasciatus, the loss of col function has a more severe effect in lacking the intercalary segment and also affecting the adjacent mandibular and antenna! segments By contrast, col is not expressed early in the second antennal segment in the crustacean Parhyale hawarensis or in the pedipalpal segment of the spider Achaearanea tepidariorum This suggests that the early expression of col in a stripe and its role in tritocerebral segment development is insect-specific and might correlate with the appendage-less morphology of the intercalary segment. (C) 2010 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2010.05.001"],["dc.identifier.isi","000280426400032"],["dc.identifier.pmid","20457148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19296"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Evolutionary plasticity of collier function in head development of diverse arthropods"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","143"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Evolution & Development"],["dc.bibliographiccitation.lastpage","154"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Feitosa, Natalia M."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T11:17:35Z"],["dc.date.available","2018-11-07T11:17:35Z"],["dc.date.issued","2008"],["dc.description.abstract","Dorsoventral axis formation in the legs of the fly Drosophila melanogaster requires the T-box genes optomotor-blind (omb) and H15. Evolutionary conservation of the patterning functions of these genes is unclear, because data on H15 expression in the spider Cupiennius salei did not support a general role of H15 in ventral fate specification. However, H15 has a paralogous gene, midline (mid) in Drosophila and H15 duplicates are also present in Cupiennius and the millipede Glomeris marginata. H15 therefore seems to have been subject to gene duplication opening the possibility that the previous account on Cupiennius has overlooked one or several paralogs. We have studied omb- and H15-related genes in two additional spider species, Tegenaria atrica and Achearanea tepidariorum and show that in both species one of the H15 genes belongs to a third group of spider H15 genes that has an expression pattern very similar to the H15 pattern in Drosophila. The expression patterns of all omb-related genes are also very similar to the omb expression pattern in Drosophila. These data suggest that the dorsoventral patterning functions of omb and H15 are conserved in the arthropods and that the previous conclusions were based on an incomplete data set in Cupiennius. Our results emphasize the importance of a broad taxon sampling in comparative studies."],["dc.identifier.isi","000253707300003"],["dc.identifier.pmid","18315808"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54840"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","1520-541X"],["dc.title","The T-box genes H15 and optomotor-blind in the spiders Cupiennius salei, Tegenaria atrica and Achaearanea tepidariorum and the dorsoventral axis of arthropod appendages"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1002342"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","McGregor, Alistair P."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T08:51:00Z"],["dc.date.available","2018-11-07T08:51:00Z"],["dc.date.issued","2011"],["dc.description.abstract","Despite many aspects of the regulation of segmentation being conserved among arthropods, the evolution of novel gene functions has played an important role in the evolution of developmental regulation and the emergence of new segmental structures. Moreover the study of such novel gene functions can be informative with respect to the patterns and direction of evolutionary changes in developmental programs. The homeobox gene Distal-less (Dll) is known for its conserved function in appendage development in metazoans. In arthropods, Dll is required for the specification of distal appendage structures. Here we describe a novel and unexpected role of Dll in the spider Achaearanea tepidariorum. We detect At-Dll transcripts not only in the appendages, but unexpectedly also in an anterior domain during early development, prior to the specification of the limb primordia. A similar early Dll domain is present in the distantly related spider Pholcus phalangioides. In A. tepidariorum this early At-Dll expression is required for head segmentation. RNA interference results in spiders that lack either the first or the first and the second walking leg segments. The early At-Dll expression is also required for the activation of the segment polarity genes engrailed and hedgehog in this region. Our work identifies the Distal-less gene as a novel factor in anterior spider segmentation with a gap gene-like function. This novel role of Dll is interesting because Dll expression is reduced in this region in crustaceans and the homologous insect segment, the mandible segment, does not express Dll and does not require this gene for patterning. We therefore discuss the possible implications of our results for understanding the evolution and diversification of the mandible segment."],["dc.identifier.doi","10.1371/journal.pgen.1002342"],["dc.identifier.isi","000296665400041"],["dc.identifier.pmid","22028676"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8016"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21829"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7390"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Novel Function of Distal-less as a Gap Gene during Spider Segmentation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]