Prpic-Schäper, Nikola-Michael

[["dc.bibliographiccitation.firstpage","487"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","BioEssays"],["dc.bibliographiccitation.lastpage","498"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","McGregor, Alistair P."],["dc.contributor.author","Hilbrant, Maarten"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Damen, Wim G. M."],["dc.date.accessioned","2018-11-07T11:15:20Z"],["dc.date.available","2018-11-07T11:15:20Z"],["dc.date.issued","2008"],["dc.description.abstract","The spiders Cupiennius salei and Achaearanea tepidariorum are firmly established laboratory models that have already contributed greatly to answering evolutionary developmental questions. Here we appraise why these animals are such useful models from phylogeny, natural history and embryogenesis to the tools available for their manipulation. We then review recent studies of axis formation, segmentation, appendage development and neurogenesis in these spiders and how this has contributed to understanding the evolution of these processes. Furthermore, we discuss the potential of comparisons of silk production between Cupiennius and Achaearanea to investigate the origins and diversification of this evolutionary innovation. We suggest that further comparisons between these two spiders and other chelicerates will prove useful for understanding the evolution of development in metazoans."],["dc.identifier.doi","10.1002/bies.20744"],["dc.identifier.isi","000255621200010"],["dc.identifier.pmid","18404731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54345"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Inc"],["dc.relation.issn","0265-9247"],["dc.title","Cupiennius salei and Achaearanea tepidariorum: spider models for investigating evolution and development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4921"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","4926"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T09:12:10Z"],["dc.date.available","2018-11-07T09:12:10Z"],["dc.date.issued","2012"],["dc.description.abstract","Evolution often results in morphologically similar solutions in different organisms, a phenomenon known as convergence. However, there is little knowledge of the processes that lead to convergence at the genetic level. The genes of the Hox cluster control morphology in animals. They may also be central to the convergence of morphological traits, but whether morphological similarities also require similar changes in Hox gene function is disputed. In arthropods, body subdivision into a region with locomotory appendages (\"thorax\") and a region with reduced appendages (\"abdomen\") has evolved convergently in several groups, e. g., spiders and insects. In insects, legs develop in the expression domain of the Hox gene Antennapedia (Antp), whereas the Hox genes Ultrabithorax (Ubx) and abdominal-A mediate leg repression in the abdomen. Here, we show that, unlike Antp in insects, the Antp gene in the spider Achaearanea tepidariorum represses legs in the first segment of the abdomen (opisthosoma), and that Antp and Ubx are redundant in the following segment. The down-regulation of Antp in A. tepidariorum leads to a striking 10-legged phenotype. We present evidence from ectopic expression of the spider Antp gene in Drosophila embryos and imaginal tissue that this unique function of Antp is not due to changes in the Antp protein, but likely due to divergent evolution of cofactors, Hox collaborators or target genes in spiders and flies. Our results illustrate an interesting example of convergent evolution of abdominal leg repression in arthropods by altering the role of distinct Hox genes at different levels of their action."],["dc.identifier.doi","10.1073/pnas.1116421109"],["dc.identifier.isi","000302164200046"],["dc.identifier.pmid","22421434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26887"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Divergent role of the Hox gene Antennapedia in spiders is responsible for the convergent evolution of abdominal limb repression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","341"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","350"],["dc.bibliographiccitation.volume","223"],["dc.contributor.author","Schaeper, Nina D."],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T09:18:17Z"],["dc.date.available","2018-11-07T09:18:17Z"],["dc.date.issued","2013"],["dc.description.abstract","Arthropod appendages are among the most diverse animal organs and have been adapted to a variety of functions. Due to this diversity, it can be difficult to recognize homologous parts in different appendage types and different species. Gene expression patterns of appendage development genes have been used to overcome this problem and to identify homologous limb portions across different species and their appendages. However, regarding the largest arthropod group, the hexapods, most of these studies focused on members of the winged insects (Pterygota), but primitively wingless groups like the springtails (Collembola) or silverfish and allies (Zygentoma) are underrepresented. We have studied the expression of a set of appendage patterning genes in the firebrat Thermobia domestica and the white springtail Folsomia candida. The expressions of Distal-less (Dll) and dachshund (dac) are generally similar to the patterns reported for pterygote insects. Modifications of gene regulation, for example, the lack of Dll expression in the palp of F. candida mouthparts, however, point to changes in gene function that can make the use of single genes and specific expression domains problematic for homology inference. Such hypotheses should therefore not rely on a small number of genes and should ideally also include information about gene function. The expression patterns of homothorax (hth) and extradenticle (exd) in both species are similar to the patterns of crustaceans and pterygote insects, but differ from those in chelicerates and myriapods. The proximal specificity of hth thus appears to trace from a common hexapod ancestor and also provides a link to the regulation of this gene in crustaceans."],["dc.identifier.doi","10.1007/s00427-013-0449-5"],["dc.identifier.isi","000325810600001"],["dc.identifier.pmid","23873479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-041X"],["dc.relation.issn","0949-944X"],["dc.title","Appendage patterning in the primitively wingless hexapods Thermobia domestica (Zygentoma: Lepismatidae) and Folsomia candida (Collembola: Isotomidae)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","109"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular Biology and Evolution"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schomburg, Christoph"],["dc.contributor.author","Schneider, Julia"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T10:21:03Z"],["dc.date.available","2018-11-07T10:21:03Z"],["dc.date.issued","2016"],["dc.description.abstract","The acquisition of a novel function, or neofunctionalization, protects duplicated genes from redundancy and subsequent loss, and is a major force that drives adaptive evolution. Neofunctionalization has been inferred for many duplicated genes based on differences in regulation between the parental gene and its duplicate. However, only few studies actually link the new function of a duplicated gene to a novel morphological or physiological character of the organism. Here we show that the duplication of dachshund (dac) in arachnids (spiders and allies) is linked with the evolution of a novel leg segment, the patella. We have studied dac genes in two distantly related spider species, the entelegyne spider Parasteatoda tepidariorum and the haplogyne spider Pholcus phalangioides. Both species possess two paralogous dac genes that duplicated before the split between entelegyne and haplogyne spiders. In contrast to the evolutionarily highly conserved dac1, its duplicate dac2 is strongly expressed in the patella leg segment during embryogenesis in both species. Using parental RNA interference in P. tepidariorum we show that dac2 is required for the development of the patella segment. If dac2 function is impaired, then the patella is fused with the tibia into a single leg segment. Thus, removing the function of dac2 experimentally reverts P. tepidariorum leg morphology into a stage before the duplication of dac and the evolution of the patella segment. Our results indicate that the origin of the patella is the result of the duplication and subsequent neofunctionalization of dac in the arachnid lineage."],["dc.identifier.doi","10.1093/molbev/msv200"],["dc.identifier.isi","000369992600008"],["dc.identifier.pmid","26443673"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42012"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1537-1719"],["dc.relation.issn","0737-4038"],["dc.title","Neofunctionalization of a Duplicate dachshund Gene Underlies the Evolution of a Novel Leg Segment in Arachnids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","453"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Arthropod Structure & Development"],["dc.bibliographiccitation.lastpage","467"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Sprenger, Frederik"],["dc.contributor.author","Prpic, Nikola Michael"],["dc.date.accessioned","2018-11-07T08:37:17Z"],["dc.date.available","2018-11-07T08:37:17Z"],["dc.date.issued","2010"],["dc.description.abstract","The prosoma of spiders bears different gnathal (labrum, chelicerae, pedipalps) and locomotory appendages (legs). In most species these appendages are also used for additional functions, e.g. sensing, mating, and courtship. The opisthosoma is equipped with four pairs of highly specialized appendages. Two pairs of spinnerets are used for silk production and manipulation. The other two pairs of appendages are internalized during development and give rise to a complex respiratory system of book lungs and tracheae. Thus spiders have a number of different appendage types with radically different adult morphologies. Furthermore, all these appendage types display significant additional species specific diversity correlating with a large spectrum of functions of the appendages. Despite this importance of appendage diversity for the evolution of the spiders we know relatively little about the genetic patterning mechanisms producing this diversity of morphology. We review recent advances concerning the developmental genetics of spider appendage diversification, mainly concentrating on open questions and future directions of research. We conclude that the deeper understanding of appendage development and diversity in spiders can contribute significantly not only to evolutionary developmental biology, but also to behavioral biology, speciation research and population genetics, and the study of sexually dimorphic traits. (C) 2010 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.asd.2010.07.007"],["dc.identifier.isi","000285819100007"],["dc.identifier.pmid","20696272"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18496"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1467-8039"],["dc.title","Patterning mechanisms and morphological diversity of spider appendages and their importance for spider evolution"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","53"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","58"],["dc.bibliographiccitation.volume","219"],["dc.contributor.author","Toegel, Jane Patricia"],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T08:34:23Z"],["dc.date.available","2018-11-07T08:34:23Z"],["dc.date.issued","2009"],["dc.description.abstract","The Drosophila spineless (ss) gene is regulated downstream of the appendage gene Distal-less (Dll) and is involved in leg and antenna development. Specifically, loss of ss leads to the homeotic transformation of the arista, the distalmost antennal segment, into tarsal identity, and the loss or fusion of distal leg segments. Here we show that the ss homolog from the red flour beetle Tribolium castaneum also homeotically transforms the beetle antenna into leg, but the extent of the transformation is significantly larger than in Drosophila, as the entire antenna (except for the basal antennifer) is transformed into pretarsal, tibiotarsal, and femoral identity; i.e., the transformation comprises the Dll positive area in both appendages. We interpret the antennal phenotype in Tribolium as evidence for a more exclusive role of ss in antennal determination downstream of Dll in the beetle. By contrast, the fact that, in Drosophila ss mutants, only a small portion of the Dll positive area in the antenna is homeotically transformed indicates that Dll uses additional targets to govern the development of the other antennal segments in the fly."],["dc.identifier.doi","10.1007/s00427-008-0265-5"],["dc.identifier.isi","000261787900007"],["dc.identifier.pmid","19030876"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3537"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17796"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0949-944X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Loss of spineless function transforms the Tribolium antenna into a thoracic leg with pretarsal, tibiotarsal, and femoral identity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","716"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Research Notes"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Quade, Felix S. C."],["dc.contributor.author","Preitz, Beate"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2019-07-09T11:45:59Z"],["dc.date.available","2019-07-09T11:45:59Z"],["dc.date.issued","2018"],["dc.description.abstract","Objective The bleaching, clearing and handling of tiny specimens with soft tissue and cuticular components for confocal laser scanning microscopy is difficult, because after cuticle bleaching and tissue clearing the specimens are virtually invisible. We have adjusted the design of the specimen container described by Smolla et al. (Arthropod Struct Dev 43:175–81, 2014) to handle tiny specimens. Results We describe a perforated and anodised aluminium slide that was designed to hold the distal tips of the pedipalp appendages of the spider Parasteatoda tepidariorum during clearing, and that can then be used directly for confocal laser scanning microscopy. We believe that this slide design will be helpful for others who want to visualise specimens between 500 and 800 µm with confocal laser scanning microscopy."],["dc.identifier.doi","10.1186/s13104-018-3826-3"],["dc.identifier.pmid","30305162"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59353"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A perforated anodised aluminium slide for improved specimen clearing and imaging for confocal laser scanning microscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","389"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","400"],["dc.bibliographiccitation.volume","227"],["dc.contributor.author","Königsmann, Tatiana"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Prpic-Schäper, Nikola-Michael"],["dc.date.accessioned","2020-12-10T14:10:36Z"],["dc.date.available","2020-12-10T14:10:36Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00427-017-0595-2"],["dc.identifier.eissn","1432-041X"],["dc.identifier.issn","0949-944X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70812"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Expression and function of the zinc finger transcription factor Sp6–9 in the spider Parasteatoda tepidariorum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","62"],["dc.bibliographiccitation.journal","BMC Biology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Sharma, Prashant P."],["dc.contributor.author","Clark, Thomas"],["dc.contributor.author","Leite, Daniel J."],["dc.contributor.author","Wierschin, Torsten"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Akiyama-Oda, Yasuko"],["dc.contributor.author","Esposito, Lauren"],["dc.contributor.author","Bechsgaard, Jesper"],["dc.contributor.author","Bilde, Trine"],["dc.contributor.author","Buffry, Alexandra D."],["dc.contributor.author","Chao, Hsu"],["dc.contributor.author","Huyen, Dinh"],["dc.contributor.author","Doddapaneni, Harshavardhan"],["dc.contributor.author","Dugan, Shannon"],["dc.contributor.author","Eibner, Cornelius"],["dc.contributor.author","Extavour, Cassandra G."],["dc.contributor.author","Funch, Peter"],["dc.contributor.author","Garb, Jessica"],["dc.contributor.author","Gonzalez, Luis B."],["dc.contributor.author","Gonzalez, Vanessa L."],["dc.contributor.author","Griffiths-Jones, Sam"],["dc.contributor.author","Han, Yi"],["dc.contributor.author","Hayashi, Cheryl"],["dc.contributor.author","Hilbrant, Maarten"],["dc.contributor.author","Hughes, Daniel S. T."],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Lee, Sandra L."],["dc.contributor.author","Maeso, Ignacio"],["dc.contributor.author","Murali, Shwetha C."],["dc.contributor.author","Muzny, Donna M."],["dc.contributor.author","Nunes da Fonseca, Rodrigo"],["dc.contributor.author","Paese, Christian L. B."],["dc.contributor.author","Qu, Jiaxin"],["dc.contributor.author","Ronshaugen, Matthew"],["dc.contributor.author","Schomburg, Christoph"],["dc.contributor.author","Schönauer, Anna"],["dc.contributor.author","Stollewerk, Angelika"],["dc.contributor.author","Torres-Oliva, Montserrat"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Vanthournout, Bram"],["dc.contributor.author","Werren, John H."],["dc.contributor.author","Wolff, Carsten"],["dc.contributor.author","Worley, Kim C."],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Gibbs, Richard A."],["dc.contributor.author","Coddington, Jonathan"],["dc.contributor.author","Oda, Hiroki"],["dc.contributor.author","Stanke, Mario"],["dc.contributor.author","Ayoub, Nadia A."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Flot, Jean-Francois"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Richards, Stephen"],["dc.contributor.author","McGregor, Alistair P."],["dc.date.accessioned","2019-07-09T11:44:25Z"],["dc.date.available","2019-07-09T11:44:25Z"],["dc.date.issued","2017"],["dc.description.abstract","The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication. Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes."],["dc.identifier.doi","10.1186/s12915-017-0399-x"],["dc.identifier.pmid","28756775"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15127"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59010"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/14757 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The house spider genome reveals an ancient whole-genome duplication during arachnid evolution"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","370"],["dc.bibliographiccitation.volume","218"],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Budd, Graham E."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T11:13:19Z"],["dc.date.available","2018-11-07T11:13:19Z"],["dc.date.issued","2008"],["dc.description.abstract","The correlation between dorsal and ventral segmental units in diplopod myriapods is complex and disputed. Recent results with engrailed (en), hedgehog (hh), wingless (wg), and cubitus-interruptus (ci) have shown that the dorsal segments are patterned differently from the ventral segments. Ventrally, gene expression is compatible with the classical autoregulatory loop known from Drosophila to specify the parasegment boundary. In the dorsal segments, however, this Wg/Hh autoregulatory loop cannot be present because the observed gene expression patterns argue against the involvement of Wg signalling. In this paper, we present further evidence against an involvement of Wg signalling in dorsal segmentation and propose a hypothesis about how dorsal segmental boundaries may be controlled in a wg-independent way. We find that (1) the Notum gene, a modulator of the Wg gradient in Drosophila, is not expressed in the dorsal segments. (2) The H15/midline gene, a repressor of Wg action in Drosophila, is not expressed in the dorsal segments, except for future heart tissue. (3) The patched (ptc) gene, which encodes a Hh receptor, is strongly expressed in the dorsal segments, which is incompatible with Wg-Hh autoregulation. The available data suggest that anterior-posterior (AP) boundary formation in dorsal segments could instead rely on Dpp signalling rather than Wg signalling. We present a hypothesis that relies on Hh-mediated activation of Dpp signalling and optomotor-blind (omb) expression to establish the dorsal AP boundary (the future tergite boundary). The proposed mechanism is similar to the mechanism used to establish the AP boundary in Drosophila wings and ventral pleura."],["dc.identifier.doi","10.1007/s00427-008-0231-2"],["dc.identifier.isi","000257395200003"],["dc.identifier.pmid","18592266"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53865"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0949-944X"],["dc.title","Evidence for Wg-independent tergite boundary formation in the millipede Glomeris marginata"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]