Prpic-Schäper, Nikola-Michael

[["dc.bibliographiccitation.firstpage","4921"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","4926"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T09:12:10Z"],["dc.date.available","2018-11-07T09:12:10Z"],["dc.date.issued","2012"],["dc.description.abstract","Evolution often results in morphologically similar solutions in different organisms, a phenomenon known as convergence. However, there is little knowledge of the processes that lead to convergence at the genetic level. The genes of the Hox cluster control morphology in animals. They may also be central to the convergence of morphological traits, but whether morphological similarities also require similar changes in Hox gene function is disputed. In arthropods, body subdivision into a region with locomotory appendages (\"thorax\") and a region with reduced appendages (\"abdomen\") has evolved convergently in several groups, e. g., spiders and insects. In insects, legs develop in the expression domain of the Hox gene Antennapedia (Antp), whereas the Hox genes Ultrabithorax (Ubx) and abdominal-A mediate leg repression in the abdomen. Here, we show that, unlike Antp in insects, the Antp gene in the spider Achaearanea tepidariorum represses legs in the first segment of the abdomen (opisthosoma), and that Antp and Ubx are redundant in the following segment. The down-regulation of Antp in A. tepidariorum leads to a striking 10-legged phenotype. We present evidence from ectopic expression of the spider Antp gene in Drosophila embryos and imaginal tissue that this unique function of Antp is not due to changes in the Antp protein, but likely due to divergent evolution of cofactors, Hox collaborators or target genes in spiders and flies. Our results illustrate an interesting example of convergent evolution of abdominal leg repression in arthropods by altering the role of distinct Hox genes at different levels of their action."],["dc.identifier.doi","10.1073/pnas.1116421109"],["dc.identifier.isi","000302164200046"],["dc.identifier.pmid","22421434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26887"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Divergent role of the Hox gene Antennapedia in spiders is responsible for the convergent evolution of abdominal limb repression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","109"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular Biology and Evolution"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schomburg, Christoph"],["dc.contributor.author","Schneider, Julia"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T10:21:03Z"],["dc.date.available","2018-11-07T10:21:03Z"],["dc.date.issued","2016"],["dc.description.abstract","The acquisition of a novel function, or neofunctionalization, protects duplicated genes from redundancy and subsequent loss, and is a major force that drives adaptive evolution. Neofunctionalization has been inferred for many duplicated genes based on differences in regulation between the parental gene and its duplicate. However, only few studies actually link the new function of a duplicated gene to a novel morphological or physiological character of the organism. Here we show that the duplication of dachshund (dac) in arachnids (spiders and allies) is linked with the evolution of a novel leg segment, the patella. We have studied dac genes in two distantly related spider species, the entelegyne spider Parasteatoda tepidariorum and the haplogyne spider Pholcus phalangioides. Both species possess two paralogous dac genes that duplicated before the split between entelegyne and haplogyne spiders. In contrast to the evolutionarily highly conserved dac1, its duplicate dac2 is strongly expressed in the patella leg segment during embryogenesis in both species. Using parental RNA interference in P. tepidariorum we show that dac2 is required for the development of the patella segment. If dac2 function is impaired, then the patella is fused with the tibia into a single leg segment. Thus, removing the function of dac2 experimentally reverts P. tepidariorum leg morphology into a stage before the duplication of dac and the evolution of the patella segment. Our results indicate that the origin of the patella is the result of the duplication and subsequent neofunctionalization of dac in the arachnid lineage."],["dc.identifier.doi","10.1093/molbev/msv200"],["dc.identifier.isi","000369992600008"],["dc.identifier.pmid","26443673"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42012"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1537-1719"],["dc.relation.issn","0737-4038"],["dc.title","Neofunctionalization of a Duplicate dachshund Gene Underlies the Evolution of a Novel Leg Segment in Arachnids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","389"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","400"],["dc.bibliographiccitation.volume","227"],["dc.contributor.author","Königsmann, Tatiana"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Prpic-Schäper, Nikola-Michael"],["dc.date.accessioned","2020-12-10T14:10:36Z"],["dc.date.available","2020-12-10T14:10:36Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00427-017-0595-2"],["dc.identifier.eissn","1432-041X"],["dc.identifier.issn","0949-944X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70812"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Expression and function of the zinc finger transcription factor Sp6–9 in the spider Parasteatoda tepidariorum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","413"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","422"],["dc.bibliographiccitation.volume","226"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T10:06:24Z"],["dc.date.available","2018-11-07T10:06:24Z"],["dc.date.issued","2016"],["dc.description.abstract","Most recent studies of spider embryonic development have focused on representatives of the species-rich group of entelegyne spiders (over 80 % of all extant species). Embryogenesis in the smaller spider groups, however, is less well studied. Here, we describe the development of the germ band in the spider species Pholcus phalangioides, a representative of the haplogyne spiders that are phylogenetically the sister group of the entelegyne spiders. We show that the transition from radially symmetric embryonic anlage to the bilaterally symmetric germ band involves the accumulation of cells in the centre of the embryonic anlage (primary thickening). These cells then disperse all across the embryonic anlage. A secondary thickening of cells then appears in the centre of the embryonic anlage, and this thickening expands and forms the segment addition zone. We also confirm that the major part of the opisthosoma initially develops as a tube shaped structure, and its segments are then sequentially folded down on the yolk during inversion. This special mode of opisthosoma formation has not been reported for entelegyne spiders, but a more comprehensive sampling of this diverse group is necessary to decide whether this peculiarity is indeed lacking in the entelegyne spiders."],["dc.identifier.doi","10.1007/s00427-016-0562-3"],["dc.identifier.isi","000387595500004"],["dc.identifier.pmid","27581033"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39088"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1432-041X"],["dc.relation.issn","0949-944X"],["dc.title","Observations on germ band development in the cellar spider Pholcus phalangioides"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","20151162"],["dc.bibliographiccitation.firstpage","206"],["dc.bibliographiccitation.issue","1814"],["dc.bibliographiccitation.journal","Proceedings of The Royal Society B Biological Sciences"],["dc.bibliographiccitation.lastpage","211"],["dc.bibliographiccitation.volume","282"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T09:51:46Z"],["dc.date.available","2018-11-07T09:51:46Z"],["dc.date.issued","2015"],["dc.description.abstract","The intercalary segment is a limbless version of the tritocerebral segment and is present in the head of all insects, whereas other extant arthropods have retained limbs on their tritocerebral segment (e.g. the pedipalp limbs in spiders). The evolutionary origin of limb loss on the intercalary segment has puzzled zoologists for over a century. Here we show that an intercalary segment-like phenotype can be created in spiders by interfering with the function of the Hox gene labial. This links the origin of the intercalary segment to a functional change in labial. We show that in the spider Parasteatoda tepidariorum the labial gene has two functions: one function in head tissue maintenance that is conserved between spiders and insects, and a second function in pedipalp limb promotion and specification, which is only present in spiders. These results imply that labial was originally crucial for limb formation on the tritocerebral segment, but that it has lost this particular subf unction in the insect ancestor, resulting in limb loss on the intercalary segment. Such loss of a sub-function is a way to avoid adverse pleiotropic effects normally associated with mutations in developmental genes, and may thus be a common mechanism to accelerate regressive evolution."],["dc.identifier.doi","10.1098/rspb.2015.1162"],["dc.identifier.isi","000363361800025"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35976"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1471-2954"],["dc.relation.issn","0962-8452"],["dc.title","Regressive evolution of the arthropod tritocerebral segment linked to functional divergence of the Hox gene"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2240"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Molecular Biology and Evolution"],["dc.bibliographiccitation.lastpage","2253"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Leite, Daniel J"],["dc.contributor.author","Baudouin-Gonzalez, Luís"],["dc.contributor.author","Iwasaki-Yokozawa, Sawa"],["dc.contributor.author","Lozano-Fernandez, Jesus"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Akiyama-Oda, Yasuko"],["dc.contributor.author","Prpic-Schäper, Nikola-Michael"],["dc.contributor.author","Pisani, Davide"],["dc.contributor.author","Oda, Hiroki"],["dc.contributor.author","Sharma, Prashant P"],["dc.contributor.author","McGregor, Alistair P"],["dc.contributor.editor","O’Connell, Mary J"],["dc.date.accessioned","2020-12-10T18:19:33Z"],["dc.date.available","2020-12-10T18:19:33Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1093/molbev/msy125"],["dc.identifier.eissn","1537-1719"],["dc.identifier.issn","0737-4038"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75290"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Homeobox Gene Duplication and Divergence in Arachnids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]