Prpic-Schäper, Nikola-Michael

[["dc.bibliographiccitation.firstpage","487"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","BioEssays"],["dc.bibliographiccitation.lastpage","498"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","McGregor, Alistair P."],["dc.contributor.author","Hilbrant, Maarten"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Damen, Wim G. M."],["dc.date.accessioned","2018-11-07T11:15:20Z"],["dc.date.available","2018-11-07T11:15:20Z"],["dc.date.issued","2008"],["dc.description.abstract","The spiders Cupiennius salei and Achaearanea tepidariorum are firmly established laboratory models that have already contributed greatly to answering evolutionary developmental questions. Here we appraise why these animals are such useful models from phylogeny, natural history and embryogenesis to the tools available for their manipulation. We then review recent studies of axis formation, segmentation, appendage development and neurogenesis in these spiders and how this has contributed to understanding the evolution of these processes. Furthermore, we discuss the potential of comparisons of silk production between Cupiennius and Achaearanea to investigate the origins and diversification of this evolutionary innovation. We suggest that further comparisons between these two spiders and other chelicerates will prove useful for understanding the evolution of development in metazoans."],["dc.identifier.doi","10.1002/bies.20744"],["dc.identifier.isi","000255621200010"],["dc.identifier.pmid","18404731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54345"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Inc"],["dc.relation.issn","0265-9247"],["dc.title","Cupiennius salei and Achaearanea tepidariorum: spider models for investigating evolution and development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4921"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","4926"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T09:12:10Z"],["dc.date.available","2018-11-07T09:12:10Z"],["dc.date.issued","2012"],["dc.description.abstract","Evolution often results in morphologically similar solutions in different organisms, a phenomenon known as convergence. However, there is little knowledge of the processes that lead to convergence at the genetic level. The genes of the Hox cluster control morphology in animals. They may also be central to the convergence of morphological traits, but whether morphological similarities also require similar changes in Hox gene function is disputed. In arthropods, body subdivision into a region with locomotory appendages (\"thorax\") and a region with reduced appendages (\"abdomen\") has evolved convergently in several groups, e. g., spiders and insects. In insects, legs develop in the expression domain of the Hox gene Antennapedia (Antp), whereas the Hox genes Ultrabithorax (Ubx) and abdominal-A mediate leg repression in the abdomen. Here, we show that, unlike Antp in insects, the Antp gene in the spider Achaearanea tepidariorum represses legs in the first segment of the abdomen (opisthosoma), and that Antp and Ubx are redundant in the following segment. The down-regulation of Antp in A. tepidariorum leads to a striking 10-legged phenotype. We present evidence from ectopic expression of the spider Antp gene in Drosophila embryos and imaginal tissue that this unique function of Antp is not due to changes in the Antp protein, but likely due to divergent evolution of cofactors, Hox collaborators or target genes in spiders and flies. Our results illustrate an interesting example of convergent evolution of abdominal leg repression in arthropods by altering the role of distinct Hox genes at different levels of their action."],["dc.identifier.doi","10.1073/pnas.1116421109"],["dc.identifier.isi","000302164200046"],["dc.identifier.pmid","22421434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26887"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Divergent role of the Hox gene Antennapedia in spiders is responsible for the convergent evolution of abdominal limb repression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","341"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","350"],["dc.bibliographiccitation.volume","223"],["dc.contributor.author","Schaeper, Nina D."],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T09:18:17Z"],["dc.date.available","2018-11-07T09:18:17Z"],["dc.date.issued","2013"],["dc.description.abstract","Arthropod appendages are among the most diverse animal organs and have been adapted to a variety of functions. Due to this diversity, it can be difficult to recognize homologous parts in different appendage types and different species. Gene expression patterns of appendage development genes have been used to overcome this problem and to identify homologous limb portions across different species and their appendages. However, regarding the largest arthropod group, the hexapods, most of these studies focused on members of the winged insects (Pterygota), but primitively wingless groups like the springtails (Collembola) or silverfish and allies (Zygentoma) are underrepresented. We have studied the expression of a set of appendage patterning genes in the firebrat Thermobia domestica and the white springtail Folsomia candida. The expressions of Distal-less (Dll) and dachshund (dac) are generally similar to the patterns reported for pterygote insects. Modifications of gene regulation, for example, the lack of Dll expression in the palp of F. candida mouthparts, however, point to changes in gene function that can make the use of single genes and specific expression domains problematic for homology inference. Such hypotheses should therefore not rely on a small number of genes and should ideally also include information about gene function. The expression patterns of homothorax (hth) and extradenticle (exd) in both species are similar to the patterns of crustaceans and pterygote insects, but differ from those in chelicerates and myriapods. The proximal specificity of hth thus appears to trace from a common hexapod ancestor and also provides a link to the regulation of this gene in crustaceans."],["dc.identifier.doi","10.1007/s00427-013-0449-5"],["dc.identifier.isi","000325810600001"],["dc.identifier.pmid","23873479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-041X"],["dc.relation.issn","0949-944X"],["dc.title","Appendage patterning in the primitively wingless hexapods Thermobia domestica (Zygentoma: Lepismatidae) and Folsomia candida (Collembola: Isotomidae)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","109"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular Biology and Evolution"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schomburg, Christoph"],["dc.contributor.author","Schneider, Julia"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T10:21:03Z"],["dc.date.available","2018-11-07T10:21:03Z"],["dc.date.issued","2016"],["dc.description.abstract","The acquisition of a novel function, or neofunctionalization, protects duplicated genes from redundancy and subsequent loss, and is a major force that drives adaptive evolution. Neofunctionalization has been inferred for many duplicated genes based on differences in regulation between the parental gene and its duplicate. However, only few studies actually link the new function of a duplicated gene to a novel morphological or physiological character of the organism. Here we show that the duplication of dachshund (dac) in arachnids (spiders and allies) is linked with the evolution of a novel leg segment, the patella. We have studied dac genes in two distantly related spider species, the entelegyne spider Parasteatoda tepidariorum and the haplogyne spider Pholcus phalangioides. Both species possess two paralogous dac genes that duplicated before the split between entelegyne and haplogyne spiders. In contrast to the evolutionarily highly conserved dac1, its duplicate dac2 is strongly expressed in the patella leg segment during embryogenesis in both species. Using parental RNA interference in P. tepidariorum we show that dac2 is required for the development of the patella segment. If dac2 function is impaired, then the patella is fused with the tibia into a single leg segment. Thus, removing the function of dac2 experimentally reverts P. tepidariorum leg morphology into a stage before the duplication of dac and the evolution of the patella segment. Our results indicate that the origin of the patella is the result of the duplication and subsequent neofunctionalization of dac in the arachnid lineage."],["dc.identifier.doi","10.1093/molbev/msv200"],["dc.identifier.isi","000369992600008"],["dc.identifier.pmid","26443673"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42012"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1537-1719"],["dc.relation.issn","0737-4038"],["dc.title","Neofunctionalization of a Duplicate dachshund Gene Underlies the Evolution of a Novel Leg Segment in Arachnids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","453"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Arthropod Structure & Development"],["dc.bibliographiccitation.lastpage","467"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Sprenger, Frederik"],["dc.contributor.author","Prpic, Nikola Michael"],["dc.date.accessioned","2018-11-07T08:37:17Z"],["dc.date.available","2018-11-07T08:37:17Z"],["dc.date.issued","2010"],["dc.description.abstract","The prosoma of spiders bears different gnathal (labrum, chelicerae, pedipalps) and locomotory appendages (legs). In most species these appendages are also used for additional functions, e.g. sensing, mating, and courtship. The opisthosoma is equipped with four pairs of highly specialized appendages. Two pairs of spinnerets are used for silk production and manipulation. The other two pairs of appendages are internalized during development and give rise to a complex respiratory system of book lungs and tracheae. Thus spiders have a number of different appendage types with radically different adult morphologies. Furthermore, all these appendage types display significant additional species specific diversity correlating with a large spectrum of functions of the appendages. Despite this importance of appendage diversity for the evolution of the spiders we know relatively little about the genetic patterning mechanisms producing this diversity of morphology. We review recent advances concerning the developmental genetics of spider appendage diversification, mainly concentrating on open questions and future directions of research. We conclude that the deeper understanding of appendage development and diversity in spiders can contribute significantly not only to evolutionary developmental biology, but also to behavioral biology, speciation research and population genetics, and the study of sexually dimorphic traits. (C) 2010 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.asd.2010.07.007"],["dc.identifier.isi","000285819100007"],["dc.identifier.pmid","20696272"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18496"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1467-8039"],["dc.title","Patterning mechanisms and morphological diversity of spider appendages and their importance for spider evolution"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","389"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","400"],["dc.bibliographiccitation.volume","227"],["dc.contributor.author","Königsmann, Tatiana"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Prpic-Schäper, Nikola-Michael"],["dc.date.accessioned","2020-12-10T14:10:36Z"],["dc.date.available","2020-12-10T14:10:36Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00427-017-0595-2"],["dc.identifier.eissn","1432-041X"],["dc.identifier.issn","0949-944X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70812"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Expression and function of the zinc finger transcription factor Sp6–9 in the spider Parasteatoda tepidariorum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","370"],["dc.bibliographiccitation.volume","218"],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Budd, Graham E."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T11:13:19Z"],["dc.date.available","2018-11-07T11:13:19Z"],["dc.date.issued","2008"],["dc.description.abstract","The correlation between dorsal and ventral segmental units in diplopod myriapods is complex and disputed. Recent results with engrailed (en), hedgehog (hh), wingless (wg), and cubitus-interruptus (ci) have shown that the dorsal segments are patterned differently from the ventral segments. Ventrally, gene expression is compatible with the classical autoregulatory loop known from Drosophila to specify the parasegment boundary. In the dorsal segments, however, this Wg/Hh autoregulatory loop cannot be present because the observed gene expression patterns argue against the involvement of Wg signalling. In this paper, we present further evidence against an involvement of Wg signalling in dorsal segmentation and propose a hypothesis about how dorsal segmental boundaries may be controlled in a wg-independent way. We find that (1) the Notum gene, a modulator of the Wg gradient in Drosophila, is not expressed in the dorsal segments. (2) The H15/midline gene, a repressor of Wg action in Drosophila, is not expressed in the dorsal segments, except for future heart tissue. (3) The patched (ptc) gene, which encodes a Hh receptor, is strongly expressed in the dorsal segments, which is incompatible with Wg-Hh autoregulation. The available data suggest that anterior-posterior (AP) boundary formation in dorsal segments could instead rely on Dpp signalling rather than Wg signalling. We present a hypothesis that relies on Hh-mediated activation of Dpp signalling and optomotor-blind (omb) expression to establish the dorsal AP boundary (the future tergite boundary). The proposed mechanism is similar to the mechanism used to establish the AP boundary in Drosophila wings and ventral pleura."],["dc.identifier.doi","10.1007/s00427-008-0231-2"],["dc.identifier.isi","000257395200003"],["dc.identifier.pmid","18592266"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53865"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0949-944X"],["dc.title","Evidence for Wg-independent tergite boundary formation in the millipede Glomeris marginata"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","262"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","271"],["dc.bibliographiccitation.volume","326"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Damen, Wim G. M."],["dc.date.accessioned","2018-11-07T08:32:57Z"],["dc.date.available","2018-11-07T08:32:57Z"],["dc.date.issued","2009"],["dc.description.abstract","Arthropod limbs are arguably the most diverse organs in the animal kingdom. Morphological diversity of the limbs is largely based on their segmentation, because this divides the limbs into modules that can evolve separately for new morphologies and functions. Limb segmentation also distinguishes the arthropods from related phyla (e.g. onychophorans) and thus forms an important evolutionary innovation in arthropods. Understanding the genetic basis of limb segmentation in arthropods can thus shed light onto the mechanisms of macroevolution and the origin of a character (articulated limbs) that defines a new phylum (arthropods). In the fly Drosophila limb segmentation and limb growth are controlled by the Notch signaling pathway. Here we show that the Notch pathway also controls limb segmentation and growth in the spider Cupiennius salei, a representative of the most basally branching arthropod group Chelicerata, and thus this function must trace from the last common ancestor of all arthropods. The similarities of Notch and Serrate function between Drosophila and Cupiennius are extensive and also extend to target genes like odd-skipped, nubbin, AP-2 and hairy related genes. Our data confirm that the jointed appendages, which are a morphological phylotypic trait of the arthropods and the basis for naming the phylum, have a common developmental genetic basis. Notch-mediated limb segmentation is thus a molecular phylotypic trait of the arthropods. (C) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2008.10.049"],["dc.identifier.isi","000263141100023"],["dc.identifier.pmid","19046962"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17457"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Notch-mediated segmentation of the appendages is a molecular phylotypic trait of the arthropods"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","413"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","422"],["dc.bibliographiccitation.volume","226"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T10:06:24Z"],["dc.date.available","2018-11-07T10:06:24Z"],["dc.date.issued","2016"],["dc.description.abstract","Most recent studies of spider embryonic development have focused on representatives of the species-rich group of entelegyne spiders (over 80 % of all extant species). Embryogenesis in the smaller spider groups, however, is less well studied. Here, we describe the development of the germ band in the spider species Pholcus phalangioides, a representative of the haplogyne spiders that are phylogenetically the sister group of the entelegyne spiders. We show that the transition from radially symmetric embryonic anlage to the bilaterally symmetric germ band involves the accumulation of cells in the centre of the embryonic anlage (primary thickening). These cells then disperse all across the embryonic anlage. A secondary thickening of cells then appears in the centre of the embryonic anlage, and this thickening expands and forms the segment addition zone. We also confirm that the major part of the opisthosoma initially develops as a tube shaped structure, and its segments are then sequentially folded down on the yolk during inversion. This special mode of opisthosoma formation has not been reported for entelegyne spiders, but a more comprehensive sampling of this diverse group is necessary to decide whether this peculiarity is indeed lacking in the entelegyne spiders."],["dc.identifier.doi","10.1007/s00427-016-0562-3"],["dc.identifier.isi","000387595500004"],["dc.identifier.pmid","27581033"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39088"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1432-041X"],["dc.relation.issn","0949-944X"],["dc.title","Observations on germ band development in the cellar spider Pholcus phalangioides"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","21"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Evolution & Development"],["dc.bibliographiccitation.lastpage","33"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Jørgensen, Mette Christine"],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Budd, Graham E."],["dc.date.accessioned","2018-11-07T10:03:41Z"],["dc.date.available","2018-11-07T10:03:41Z"],["dc.date.issued","2015"],["dc.description.abstract","Onychophorans (velvet worms) are closely related to the arthropods, but their limb morphology represents a stage before arthropodization (i.e., the segmentation of the limbs). We investigated the expression of onychophoran homologs of genes that are involved in dorso-ventral (DV) and proximo-distal (PD) limb patterning in arthropods. We find that the two onychophoran optomotor-blind (omb) genes, omb-1 and omb-2, are both expressed in conserved patterns in the dorsal ectoderm of the limbs, including the onychophoran antennae (the frontal appendages). Surprisingly, the expression of decapentaplegic (dpp), which acts upstream of omb in Drosophila, is partially reversed in onychophoran limbs compared to its expression in arthropods. A conserved feature of dpp expression in arthropods and onychophorans, however, is the prominent expression of dpp in the tips of developing limbs, which, therefore, may represent the ancestral pattern. The expression patterns of wingless (wg) and H15 are very diverged in onychophorans. The wg gene is only expressed in the limb tips and the single H15 gene is expressed in a few dorsal limb cells, but not on the ventral side. The expression of wg and dpp at the limb tips is one of the three possible alternatives predicted by the topology model of arthropod limb patterning and is, thus, compatible with a conserved function of wg and dpp in the patterning of the PD axis. On the other hand, DV limb gene expression is less conserved, and the specification of ventral fate appears to involve neither wg nor H15 expression."],["dc.identifier.doi","10.1111/ede.12107"],["dc.identifier.isi","000349042300003"],["dc.identifier.pmid","25627711"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38530"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1525-142X"],["dc.relation.issn","1520-541X"],["dc.title","Aspects of dorso-ventral and proximo-distal limb patterning in onychophorans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]