Brunner, Edgar

[["dc.bibliographiccitation.firstpage","63"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The International Journal of Biostatistics"],["dc.bibliographiccitation.lastpage","73"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Boesiger, Sandra"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Hothorn, Ludwig A."],["dc.date.accessioned","2018-11-07T09:24:47Z"],["dc.date.available","2018-11-07T09:24:47Z"],["dc.date.issued","2013"],["dc.description.abstract","Multiple contrast tests can be used to test arbitrary linear hypotheses by providing local and global test decisions as well as simultaneous confidence intervals. The ANOVA-F-test on the contrary can be used to test the global null hypothesis of no treatment effect. Thus, multiple contrast tests provide more information than the analysis of variance (ANOVA) by offering which levels cause the significance. We compare the exact powers of the ANOVA-F-test and multiple contrast tests to reject the global null hypothesis. Hereby, we compute their least favorable configurations (LFCs). It turns out that both procedures have the same LFCs under certain conditions. Exact power investigations show that their powers are equal to detect their LFCs."],["dc.description.sponsorship","German Research Foundation [DFG-Br 655/16-1, Ho 1687/9-1]"],["dc.identifier.doi","10.1515/ijb-2012-0020"],["dc.identifier.isi","000329433300005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29910"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Walter De Gruyter Gmbh"],["dc.relation.issn","1557-4679"],["dc.relation.issn","2194-573X"],["dc.title","Are Multiple Contrast Tests Superior to the ANOVA?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","423"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","METHODS OF INFORMATION IN MEDICINE"],["dc.bibliographiccitation.lastpage","430"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Bretz, F."],["dc.contributor.author","Landgrebe, J."],["dc.contributor.author","Brunner, E."],["dc.date.accessioned","2018-11-07T08:43:42Z"],["dc.date.available","2018-11-07T08:43:42Z"],["dc.date.issued","2005"],["dc.description.abstract","Objectives: A variety of linear models have recently been proposed for the design and analysis of microarray experiments. This article gives an introduction to the most common models and describes their respective characteristics. Methods: We focus on the application of linear models to logarithmized and normalized microarray data from two-color arrays. Linear models can be applied at different stages of evaluating microarray experiments, such as experimental design, background correction, normalization and hypothesis testing. Both one-stage and two-stage linear models including technical and possibly biological replicates are described. Issues related to selecting robust and efficient microorray designs are also discussed. Results: Linear models provide flexible and powerful tools, which are easily implemented and interpreted. The methods are illustrated with an experiment performed in our laboratory, which demonstrates the value of using linear models for the evaluation of current microarray experiments. Conclusions: Linear models provide a flexible approach to properly account for variability, both across and within genes. This allows the experimenter to adequately model the sources of variability, which are assumed to be of major influence on the final measurements. In addition, design considerations essential for any well-planned microarray experiments are best incorporated using linear models. Results from such experimental design investigations show that the widely used common reference design is often substantially less efficient than alternative designs and its use is therefore not recommended."],["dc.identifier.isi","000230734600013"],["dc.identifier.pmid","16113768"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20035"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0026-1270"],["dc.title","Design and analysis of two-color microarray experiments using linear models"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","191"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","British Journal of Dermatology"],["dc.bibliographiccitation.lastpage","192"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Gutgesell, C."],["dc.contributor.author","Heise, S."],["dc.contributor.author","Seubert, S."],["dc.contributor.author","Seubert, A."],["dc.contributor.author","Domhof, S."],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:19:45Z"],["dc.date.available","2018-11-07T10:19:45Z"],["dc.date.issued","2002"],["dc.identifier.isi","000176634300041"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41728"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.issn","0007-0963"],["dc.title","Atopic dermatitis and house dust mite control measures: reply from author"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","17"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Biometrical Journal"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Munzel, U."],["dc.date.accessioned","2018-11-07T11:01:27Z"],["dc.date.available","2018-11-07T11:01:27Z"],["dc.date.issued","2000"],["dc.description.abstract","A generalization of the Behrens-Fisher problem for two samples is examined in a nonparametric model. It is not assumed that the underlying distribution functions are continuous so that data with arbitrary ties can be handled. A rank rest is considered where the asymptotic variance is estimated consistently by using the ranks over all observations as well as the ranks within each sample. The consistency of the estimator is derived in the appendix. For small samples (n(1), n(2) greater than or equal to 10), a simple approximation by a central t-distribution is suggested where the degrees of freedom are taken from the Satterthwaite-Smith-Welch approximation in the parametric Behrens-Fisher problem. It is demonstrated by means of a simulation study that the Wilcoxon-Mann-Whitney-test may be conservative or liberal depending on the ratio of the sample sizes and the variances of the underlying distribution functions. For the suggested approximation, however, it turns out that the nominal level is maintained rather accurately. The suggested nonparametric procedure is applied to a data set from a clinical trial. Moreover, a confidence interval for the nonparametric treatment effect is given."],["dc.identifier.doi","10.1002/(SICI)1521-4036(200001)42:1<17::AID-BIMJ17>3.0.CO;2-U"],["dc.identifier.isi","000085627900002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51150"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Akademie Verlag Gmbh"],["dc.relation.issn","0323-3847"],["dc.title","The nonparametric Behrens-Fisher problem: Asymptotic theory and a small-sample approximation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","McCoy, Jonathan H."],["dc.contributor.author","Brunner, Will"],["dc.contributor.author","Pesch, Werner"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.date.accessioned","2022-06-08T07:59:46Z"],["dc.date.available","2022-06-08T07:59:46Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1103/PhysRevLett.101.254102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110856"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.title","Self-Organization of Topological Defects due to Applied Constraints"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","DRUG INFORMATION JOURNAL"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Munk, A."],["dc.contributor.author","Brunner, E."],["dc.date.accessioned","2018-11-07T08:54:34Z"],["dc.date.available","2018-11-07T08:54:34Z"],["dc.date.issued","2001"],["dc.format.extent","863"],["dc.identifier.isi","000170617400024"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22695"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Drug Information Association"],["dc.relation.issn","0092-8615"],["dc.title","Guest editors' note"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Journal of Immunology"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Ferrari, David M."],["dc.contributor.author","Schwarz, Herbert"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Latif, A. H. M. Mahbub"],["dc.contributor.author","Neumann, Christine"],["dc.contributor.author","Soruri, Afsaneh"],["dc.date.accessioned","2018-11-07T11:14:25Z"],["dc.date.available","2018-11-07T11:14:25Z"],["dc.date.issued","2008"],["dc.format.extent","1767"],["dc.identifier.doi","10.1002/eji.200737800"],["dc.identifier.isi","000256762400030"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54117"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.haserratum","/handle/2/97655"],["dc.relation.issn","0014-2980"],["dc.title","CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response (vol 38, pg 1024, 2008)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","733"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Arthritis & Rheumatism"],["dc.bibliographiccitation.lastpage","743"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Scheel, Alexander Konrad"],["dc.contributor.author","Hermann, Kay Geert A."],["dc.contributor.author","Kahler, Elke"],["dc.contributor.author","Pasewaldt, Daniel"],["dc.contributor.author","Fritz, Jacqueline"],["dc.contributor.author","Hamm, Bernd"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Burmester, Gerd-Ruediger"],["dc.contributor.author","Backhaus, Marina"],["dc.date.accessioned","2018-11-07T11:17:58Z"],["dc.date.available","2018-11-07T11:17:58Z"],["dc.date.issued","2005"],["dc.description.abstract","Objective. To develop an ultrasonographic (US) synovitis scoring system suitable for evaluation of ringer joint inflammation in patients with active rheumatoid arthritis (RA) and to compare semiquantitative US scoring with quantitative US measurements. Methods. US was performed at the palmar and dorsal sides of the second through fifth metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in 10 healthy subjects and in the clinically more affected hand in 46 RA patients. Ten patients additionally underwent magnetic resonance imaging (MRI). Synovitis was measured, standardized, and scored according to a semiquantitative method. The 2 methods (semiquantitative US scoring, quantitative US) were compared and statistical cutoffs were identified using receiver operating characteristic (ROC) curve analysis. MRI results were compared with semiquantitative US scoring and quantitative US results. The optimal US scoring method from 6 joint combinations was identified (ROC curve analysis). Results. Synovitis was most frequently detected in the palmar proximal area (86% of affected joints). We found no significant differences between individual PIP joints or between individual MCP joints, indicating that all fingers within each of these joint groups should be treated equally for statistical calculations, although each joint group as a whole should be treated separately. The optimal cutoff point to distinguish between \"health\" and \"pathology\" was 0.6 min both for MCP joints (sensitivity 94%, specificity 89%) and for PIP joints (sensitivity 90%, specificity 88%). There was no significant difference between semiquantitative US scores and quantitative US measurements. The best results for joint combinations were achieved using the \"sum of 4 fingers\" (second through fifth MCP and PIP joints) and \"sum of 3 fingers\" (second through fourth MCP and PIP joints) methods. Comparison of MRI results with semiquantitative US scores revealed high concordance. Conclusion. US evaluation of finger joint synovitis call be considerably simplified by focusing on the palmar side and by applying semiquantitative grading instead of quantitative measurements. For evaluation of treatment efficacy based on synovitis in RA patients, we recommend using the \"sum of 3 fingers\" method in longitudinal trials."],["dc.description.sponsorship","Rheumatology Competence Network; George-August University"],["dc.identifier.doi","10.1002/art.20939"],["dc.identifier.isi","000227570600009"],["dc.identifier.pmid","15751062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54937"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0004-3591"],["dc.title","A Novel Ultrasonographic Synovitis Scoring System Suitable for Analyzing Finger Joint Inflammation in Rheumatoid Arthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Zachmann, Karolin"],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Lafti, A. H."],["dc.contributor.author","Ferrari, David M."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Soruri, Afsaneh"],["dc.date.accessioned","2018-11-07T10:56:17Z"],["dc.date.available","2018-11-07T10:56:17Z"],["dc.date.issued","2005"],["dc.format.extent","A49"],["dc.identifier.isi","000231862600286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49976"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.conference","35th Annual Meeting of the European-Society-for-Dermatological-Research"],["dc.relation.eventlocation","Tubingen, GERMANY"],["dc.relation.issn","0022-202X"],["dc.title","CD137 ligand mediated differentiation of immature human dendritic cells is associated with enhanced (antigen specific) T cell activation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5523"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","5533"],["dc.bibliographiccitation.volume","179"],["dc.contributor.author","Elsner, Leslie"],["dc.contributor.author","Muppala, Vijayakumar"],["dc.contributor.author","Gehrmann, Mathias"],["dc.contributor.author","Lozano, Jingky"],["dc.contributor.author","Malzahn, Dörthe"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Zientkowska, Marta"],["dc.contributor.author","Herrmann, Thomas"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Dressel, Ralf"],["dc.date.accessioned","2022-06-08T07:57:36Z"],["dc.date.available","2022-06-08T07:57:36Z"],["dc.date.issued","2007"],["dc.description.abstract","The stress-inducible heat shock protein (HSP) 70 is known to function as an endogenous danger signal that can increase the immunogenicity of tumors and induce CTL responses. We show in this study that HSP70 also activates mouse NK cells that recognize stress-inducible NKG2D ligands on tumor cells. Tumor size and the rate of metastases derived from HSP70-overexpressing human melanoma cells were found to be reduced in T and B cell-deficient SCID mice, but not in SCID/beige mice that lack additionally functional NK cells. In the SCID mice with HSP70-overexpressing tumors, NK cells were activated so that they killed ex vivo tumor cells that expressed NKG2D ligands. In the tumors, the MHC class I chain-related (MIC) A and B molecules were found to be expressed. Interestingly, a counter selection was observed against the expression of MICA/B in HSP70-overexpressing tumors compared with control tumors in SCID, but not in SCID/beige mice, suggesting a functional relevance of MICA/B expression. The melanoma cells were found to release exosomes. HSP70-positive exosomes from the HSP70-overexpressing cells, in contrast to HSP70-negative exosomes from the control cells, were able to activate mouse NK cells in vitro to kill YAC-1 cells, which express NKG2D ligands constitutively, or the human melanoma cells, in which MICA/B expression was induced. Thus, HSP70 and inducible NKG2D ligands synergistically promote the activation of mouse NK cells resulting in a reduced tumor growth and suppression of metastatic disease."],["dc.identifier.doi","10.4049/jimmunol.179.8.5523"],["dc.identifier.isi","000250099400061"],["dc.identifier.pmid","17911639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110150"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.eissn","1550-6606"],["dc.relation.issn","0022-1767"],["dc.title","The Heat Shock Protein HSP70 Promotes Mouse NK Cell Activity against Tumors That Express Inducible NKG2D Ligands"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]