Olthoff, Arno

[["dc.bibliographiccitation.firstpage","556"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","NERVENHEILKUNDE"],["dc.bibliographiccitation.lastpage","559"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T08:48:12Z"],["dc.date.available","2018-11-07T08:48:12Z"],["dc.date.issued","2010"],["dc.description.abstract","A focal laryngeal dystonia might cause dysphonia, dysphagia or dyspnea. These dysorders can appear discrete or combined. The treatment with botulinum toxin is a symptomatic off-label-use that has to be repetitive every three to six months to conserve a positive outcome. In case of dysphonia and dyspnea the laryngeal muscles and in case of dysphagia the cricopharyngeal muscle and the salivary glands are injected. For a selective indication an interdisciplinary diagnostic is essential."],["dc.identifier.isi","000282799000008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21153"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0722-1541"],["dc.title","Treatment of dysphonia, dysphagia and dyspnea with botulinum toxin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","450"],["dc.bibliographiccitation.issue","08"],["dc.bibliographiccitation.journal","Fortschritte der Neurologie · Psychiatrie"],["dc.bibliographiccitation.lastpage","462"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Grosheva, Maria"],["dc.contributor.author","Reichel, Gerhard"],["dc.contributor.author","Volk, Gerd Fabian"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2020-12-10T18:12:26Z"],["dc.date.available","2020-12-10T18:12:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-115644"],["dc.identifier.eissn","1439-3522"],["dc.identifier.issn","0720-4299"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74374"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Die Behandlung der laryngealen Dystonie mit Botulinumtoxin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1045"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","1050"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Rohrbach, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Giefer, B."],["dc.contributor.author","Gotz, W."],["dc.date.accessioned","2018-11-07T11:25:23Z"],["dc.date.available","2018-11-07T11:25:23Z"],["dc.date.issued","2001"],["dc.description.abstract","Nasal hypersecretion is predominantly caused by overaction of nasal glands, which are mainly under cholinergic control. In this work, we investigated the influence of botulinum toxin A (BTA) on the nasal mucosal tissue of the maxillary sinus turbinates of guinea pigs (n = 10) that were painlessly sacrificed 10 days (short-term group) or 3 months (long-term group) after local treatment with 20 units of BTA (Botox) or 0.2 mL of 0.9% sodium chloride (control). Histologic investigation of the nasal mucosal tissue of the BTA-treated animals (short-term group) showed degeneration of glands and ducts and apoptotic nuclei on TUNEL staining of these structures. The control animals revealed normal glandular tissue and no apoptosis. The animals of the long-term group showed almost normal glandular tissue and only a few apoptotic nuclei, In conclusion, BTA induces temporary apoptosis in the nasal glandular compartment of guinea pigs."],["dc.identifier.isi","000172151800010"],["dc.identifier.pmid","11713916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56607"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.relation.issn","0003-4894"],["dc.title","Botulinum toxin type a induces apoptosis in nasal glands of guinea pigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","599"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","604"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Zeiss, D."],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Kruse, Eberhard"],["dc.contributor.author","Steiner, W."],["dc.date.accessioned","2018-11-07T10:56:55Z"],["dc.date.available","2018-11-07T10:56:55Z"],["dc.date.issued","2005"],["dc.description.abstract","Objectives: We performed a prospective study to assess respiratory function and voice quality before and after laser microsurgical bilateral posterior cordectonly performed for chronic airway obstruction in patients with bilateral vocal fold paralysis. Methods: In 17 patients a laser microsurgical posterior cordectomy was performed as an immediate bilateral approach. Roughness, breathiness, hoarseness, and dyspnea were evaluated both subjectively (on a scale from 0 to 3) and objectively (body plethysmography, computerized voice analysis: Gottingen Hoarseness Diagram). Results: After laser surgery, the patients ' respiratory function was significantly increased and was sufficient for all activities of daily living. The body plethysmographic measure of airway resistance had superior descriptive power and correlated significantly with the clinical degree of dyspnea (scale 0 to 3). Pretreatment and posttreatment impairment of voice quality was objectively documented with the Gottingen Hoarseness Diagram; the phonatory results measured with it correlated significantly with the subjective clinical evaluation of hoarseness. Aphonia did not occur. Conclusions: A bilateral approach for laser microsurgical posterior cordectomy combines excellent airway improvement and satisfactory voice preservation. In bilateral vocal fold paralysis, pretreatment and posttreatment clinical data should be evaluated by objective measures."],["dc.identifier.isi","000231228800004"],["dc.identifier.pmid","16190092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50129"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.publisher.place","St louis"],["dc.relation.conference","Annual Scientific Meeting of the German-Society-of-Phoniatrics and Pedaudiology"],["dc.relation.eventlocation","Tubingen, GERMANY"],["dc.relation.issn","0003-4894"],["dc.title","Laser microsurgical bilateral posterior cordectomy for the treatment of bilateral vocal fold paralysis"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","475"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","HNO"],["dc.bibliographiccitation.lastpage","478"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T09:09:48Z"],["dc.date.available","2018-11-07T09:09:48Z"],["dc.date.issued","2012"],["dc.description.abstract","Dystonias of the oral, pharyngeal and laryngeal muscles are potential causes of deglutitive, respiratory and communicative disorders. In addition to functional deficits such as dysphagia, dysarthria and dysphonia, social disadvantages may arise from the visible or audible manifestations. Treatment with botulinum toxin offers symptomatic and temporary therapeutic effects. Examples of applications in oromandibular dystonia, palatoclonus, dysphagia and laryngeal dystonia (e.g., spasmodic dysphonia) are described."],["dc.identifier.doi","10.1007/s00106-011-2477-7"],["dc.identifier.isi","000304876600002"],["dc.identifier.pmid","22669434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26344"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-6192"],["dc.title","The application of botulinum toxin in oromandibular, pharyngeal and laryngeal dystonia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","994"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY"],["dc.bibliographiccitation.lastpage","999"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Mrugalla, S."],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Frohlich, M."],["dc.contributor.author","Stuermer, Ingo W."],["dc.contributor.author","Kruse, Eberhard"],["dc.contributor.author","Ambrosch, Petra"],["dc.contributor.author","Steiner, W."],["dc.date.accessioned","2018-11-07T10:36:16Z"],["dc.date.available","2018-11-07T10:36:16Z"],["dc.date.issued","2003"],["dc.description.abstract","Objectives: To assess the merits of computer-aided voice analysis procedures for very irregular voices of patients after total and laser surgical partial laryngectomy, and to characterize, qualitative differences in speech and voice function between these 2 groups of patients. Design: Cross-sectional study. Setting: University hospital in Gottingen, Germany. Patients: Twenty-nine patients with advanced laryngeal carcinomas (T3-T4; according to the Union Internationale Contre le Cancer, TNM staging system, stages III-IVa) were examined: 18 patients with tracheoesophageal speech (voice prosthesis) after total laryngectomy and 11 patients who underwent partial transoral resection of the larynx (by means of laser microsurgery without surgical voice rehabilitation). Main Outcome Measures: Speech intelligibility was measured by a standardized and validated telephone test, and voice quality was determined by 2 computerized voice analysis systems (multidimensional voice program and Gottingen hoarseness diagram). Results: The telephone test demonstrated A significantly better speech performance of the patients who had undergone organ-preserving surgery. The voices of both patient groups were too irregular for a qualitative differentiation with the multidimensional voice program. The multidimensional voice program results also failed to show significant correlations to speech intelligibility. The Gottingen hoarseness diagram showed significantly more regular voices in patients with partial laryngectomy than total laryngectomy. These results were correlated with speech intelligibility. Conclusions: The Gottingen hoarseness diagram is suitable for a qualitative assessment even of irregular voices. Voice prosthesis offers a voice quality that at best approaches that of patients with partial laryngectomy."],["dc.identifier.doi","10.1001/archotol.129.9.994"],["dc.identifier.isi","000185220400015"],["dc.identifier.pmid","12975275"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45285"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Medical Assoc"],["dc.relation.issn","0886-4470"],["dc.title","Assessment of irregular voices after total and laser surgical partial laryngectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","594"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","598"],["dc.bibliographiccitation.volume","116"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Kruse, Eberhard"],["dc.date.accessioned","2018-11-07T10:59:45Z"],["dc.date.available","2018-11-07T10:59:45Z"],["dc.date.issued","2007"],["dc.description.abstract","Objectives: We sought to treat autophonia due to a patulous eustachian tube using botulinum toxin. Methods: Because we assumed that the patulous eustachian tube was caused by abnormal activity of paratubal muscles (tensor and levator veli palatini muscles and salpingopharyngeus muscle), paralysis was performed via injection of botulinum toxin type A in a 45-year-old female professional musician who had had chronic unilateral autophonia for 20 years. In addition to a patient interview, an endoscopic examination of the nasopharynx (posterior rhinoscopy), ear microscopy, and impedance audiometry were performed to verify the diagnosis and the outcome after treatment. Results: The autophonia disappeared 1 week after treatment. Normalized tympanic ventilation was verified by impedance audiometry after 8 weeks. The period of symptom relief was 9 months. Conclusions: The administration of botulinum toxin type A provides a new option in the treatment of patulous eustachian tube. The reliability of this method and the effect of repeated injections remains to be proved in future studies."],["dc.identifier.isi","000248962300007"],["dc.identifier.pmid","17847727"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50773"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.relation.issn","0003-4894"],["dc.title","Successful treatment of autophonia with botulinum toxin: Case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","330"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES"],["dc.bibliographiccitation.lastpage","334"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Rohrbach, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Gotz, W."],["dc.date.accessioned","2018-11-07T10:08:13Z"],["dc.date.available","2018-11-07T10:08:13Z"],["dc.date.issued","2002"],["dc.description.abstract","The influence of botulinum toxin type A (BTA) on cellular mechanisms has not been studied in much detail. Since nitric oxide (NO) is of increasing interest as a neuromodulator in the innervation of the nose, its localization was examined in the nasal mucosa of guinea pigs treated with BTA or saline. Neuronal nitric oxide synthase-immunoreactivity (nNOS-IR) was found around vessels and nasal glands. Immunoreactivity was seen in the respiratory epithelium, in the periost and the osteocytes of the turbinate bone. A distinct interindividual difference in the strength of nNOS-IR was obvious among the animals, but there was no difference in the strength of immunoreactivity between the animals treated with BTA or saline. NO might therefore contribute to the regulation of vascular tone, glandular function, respiratory epithelial cell function and bone metabolism. BTA does not seem to influence the processes regulated and modulated by NO. This may represent a benefit for the application of BTA. Copyright (C) 2002 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000066087"],["dc.identifier.isi","000179464000007"],["dc.identifier.pmid","12417774"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39430"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0301-1569"],["dc.title","Neuronal nitric oxide synthase-immunoreactivity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","180"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES"],["dc.bibliographiccitation.lastpage","185"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Rohrbach, S."],["dc.contributor.author","Faber, M."],["dc.contributor.author","Gotz, W."],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T10:30:24Z"],["dc.date.available","2018-11-07T10:30:24Z"],["dc.date.issued","2002"],["dc.description.abstract","The localization of neuronal nitric oxide synthase (nNOS) in the mucosa of the inferior and middle turbinates of 30 patients with and without allergic rhinitis was examined by immunohistochemical methods. Staining of paraffin sections from allergic and nonallergic patients revealed nNOS immuncreactivity, (nNOS-IR) in the muscular layer of vessels, in the basal portion of submucosal glands and in the periost and the osteocytes of the turbinate bones. In contrast to earlier investigations, nNOS-IR was also seen in the nasal respiratory epithelium of allergic and nonallergic patients. The immunostaining of sections of submucosal glands from allergic patients was stronger than that of sections from patients with idiopathic rhinitis or patients with no nasal obstruction. The present result - nNOS-IR around glands is elevated in patients with allergic rhinitis - could indicate that this enzyme is involved in the pathogenesis and symptornatology of allergic rhinitis. Copyright (C) 2002 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000058022"],["dc.identifier.isi","000176049500003"],["dc.identifier.pmid","12037384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43859"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0301-1569"],["dc.title","Neuronal nitric oxide synthase immunoreactivity in the nasal mucosa of patients with idiopathic and allergic rhinitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","859"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","HNO"],["dc.bibliographiccitation.lastpage","870"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Laskawi, R."],["dc.contributor.author","Olthoff, A."],["dc.date.accessioned","2020-12-10T14:08:12Z"],["dc.date.available","2020-12-10T14:08:12Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00106-017-0409-x"],["dc.identifier.eissn","1433-0458"],["dc.identifier.issn","0017-6192"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70406"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Botulinumtoxin in der HNO‑Heilkunde – ein Update"],["dc.title.alternative","Botulinum toxin in otorhinolaryngology – an update"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]