Al Ghazal, Philipp

[["dc.bibliographiccitation.firstpage","595"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","EUROPEAN JOURNAL OF DERMATOLOGY"],["dc.bibliographiccitation.lastpage","601"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Erfurt-Berge, Cornelia"],["dc.contributor.author","Dissemond, Joachim"],["dc.contributor.author","Schwede, Katharina"],["dc.contributor.author","Seitz, Anna-Theresa"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Wollina, Uwe"],["dc.contributor.author","Renner, Regina"],["dc.date.accessioned","2018-11-07T09:49:08Z"],["dc.date.available","2018-11-07T09:49:08Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Necrobiosis lipoidica (NL) is a rare granulomatous disorder of unknown aetiology which can manifest in ulcerative skin lesions and is widely recognised in association with diabetes. We evaluated in total 100 patients to improve knowledge about the epidemiology and clinical course of NL. Additionally we focused on treatment options according to evidence level and expert opinion. Objectives: To examine the clinical features of patients with necrobiosis lipoidica and to give recommendations for topical and systemic treatment. Materials & Methods: This multicentre retrospective study covers data from 100 patients with the diagnosis of NL of the lower leg, treated during the period between 01/2006 and 06/2014. Data from 5 German dermatological centres with 23 men and 77 women with a median age of 52 years were evaluated. We also asked 15 dermatological experts for their opinions about ulceration, associated diseases and their preferences for treatment modalities of NL. Results: Patients' ages ranged from 15 to 95 years (median age 52 years, mean age 49.8 years). NL was significantly more common in women (77%). Ulceration of the NL was observed in 33% of cases, in particular in male patients and in patients with concomitant diabetes mellitus. Thyroidal disorders were found in 15% of all cases. Conclusion: Our data confirm that female sex, middle age and endocrine disorders like diabetes mellitus or thyroid dysfunction are characteristics of patients suffering from NL. Existing therapeutic options were very variable and - according to the opinion of our experts - only a few highly effective."],["dc.identifier.doi","10.1684/ejd.2015.2636"],["dc.identifier.isi","000370143500010"],["dc.identifier.pmid","26575980"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35447"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Libbey Eurotext Ltd"],["dc.relation.issn","1952-4013"],["dc.relation.issn","1167-1122"],["dc.title","Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Baltzer, Anne"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T09:53:40Z"],["dc.date.available","2018-11-07T09:53:40Z"],["dc.date.issued","2015"],["dc.format.extent","41"],["dc.identifier.isi","000360219800091"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Complete Remission of cutaneous Melanoma Metastases with Combination Therapy of Ipilimumab and Diphenylcyclopropenone (DPCP)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","158"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","164"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Gutzmer, Ralf"],["dc.contributor.author","Satzger, Imke"],["dc.contributor.author","Starz, Hans"],["dc.contributor.author","Bader, Christina"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Kapp, Alexander"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T09:42:15Z"],["dc.date.available","2018-11-07T09:42:15Z"],["dc.date.issued","2014"],["dc.description.abstract","Head or neck location of primary cutaneous melanomas has been described as an adverse prognostic factor, but this has to be reassessed after the introduction of sentinel lymph node (SLN) excision (SLNE). Descriptive statistics, Kaplan-Meier estimates and Cox proportional hazard models were used to study retrospectively a population of 2302 consecutive melanoma patients from three German melanoma centres undergoing SLNE. Approximately 10% of the patients (N=237) had a primary melanoma located at the head or neck (HNM). In both the SLN-positive and SLN-negative subpopulation, patients with HNM were significantly older, more frequently men and had thicker primaries compared with patients with tumours in other locations. The proportion of positive SLNs was lower in HNM compared with other locations of the primary (20 vs. 26%, P=0.048). The false-negative rate was higher in HNM (17.5 vs. 8.4%, P=0.05). In patients with HNM, the SLN status was a significant factor for recurrence-free survival but not for overall survival. SLN-negative HNM patients had a significantly worse overall survival than the SLN negatives with primaries at other sites, whereas the prognosis of the SLN-positive patients was similar in both groups. The prevalence of lymph node metastases after SLNE is lower in patients with HNM compared with other melanoma locations. As a result, the prognostic information provided by the SLN for HNM seems less important. Decision making for SLNE in HNM should be carefully balanced considering the potential morbidity of the procedure."],["dc.identifier.doi","10.1097/CMR.0000000000000042"],["dc.identifier.isi","000332601400009"],["dc.identifier.pmid","24346168"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33915"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1473-5636"],["dc.relation.issn","0960-8931"],["dc.title","Lower prevalence of lymphatic metastasis and poorer survival of the sentinel node-negative patients limit the prognostic value of sentinel node biopsy for head or neck melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1137"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Onkologe"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T09:48:32Z"],["dc.date.available","2018-11-07T09:48:32Z"],["dc.date.issued","2015"],["dc.description.abstract","Despite the rarity of extracutaneous melanomas they represent a tumor entity with a very high mortality due to delayed diagnosis. This review article presents the various biological and diagnostic characteristics of extracutaneous melanomas with special emphasis on mucosal melanoma and provides an overview of new pharmacological approaches urgently needed due to the lack of efficacious standard therapies. A systematic literature search was conducted by using the English terms extracutaneous melanoma, mucosal melanoma, uveal melanoma, leptomeningeal melanoma and c-KIT in the Medline database between 1982 and 2014. Extracutaneous melanomas comprise approximately 1.4-5 % of all melanomas and are a rare tumor entity. They develop from de-differentiated dendritic melanocytes in the mucus membranes of the gastrointestinal tract, genitourinary tract and respiratory system, in the back of the eyes or the meninges. As they are difficult to detect, extracutaneous melanomas are often already associated with an advanced disease progression at the time of first diagnosis. The class of c-KIT inhibitors has proven to be a new effective targeted therapy for extracutaneous melanomas harboring the appropriate mutational status. Because of the rarity of this tumor entity prospective, randomized control trials are lacking. Therapeutic approaches should, therefore, always be individualized taking into account the special requirements in each case."],["dc.identifier.doi","10.1007/s00761-014-2884-y"],["dc.identifier.isi","000365723700004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35328"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1433-0415"],["dc.relation.issn","0947-8965"],["dc.title","Extracutaneous melanoma with special emphasis on mucosal melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Baltzer, Anne"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Thoms, Kai Martin"],["dc.date.accessioned","2018-11-07T09:53:40Z"],["dc.date.available","2018-11-07T09:53:40Z"],["dc.date.issued","2015"],["dc.format.extent","13"],["dc.identifier.isi","000360219800034"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36372"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Factors with Influence on the Amount of Fuid Drainage after radical Lymphadenectomy in Melanoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","120"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Lymphology"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Kretschmer, L."],["dc.contributor.author","Hellriegel, S."],["dc.contributor.author","Thoms, K. M."],["dc.contributor.author","Schon, M. P."],["dc.contributor.author","Al Ghazal, P."],["dc.contributor.author","Zapf, A."],["dc.date.accessioned","2019-01-29T10:49:53Z"],["dc.date.available","2019-01-29T10:49:53Z"],["dc.date.issued","2017"],["dc.description.abstract","Lymphedema (LE) following lymph node dissection is a major problem for cancer patients, and radiation therapy, extended surgery, groin dissection, obesity, and older age are well-established risk factors of LE. We studied whether these risk factors are further associated with high volumes of postoperative drainage fluid after complete lymph node dissection (CLND) for melanoma metastases. Moreover, we examined whether a high amount of drainage fluid after sentinel lymph node biopsy (SLNB) can predict a high amount of drainage fluid after subsequent CLND. Using descriptive statistics and regression analyses, we analyzed the cumulative volumes of postoperative drainage fluid for 836 melanoma patients with lymph node excision in the axilla or groin. In multiple regression analyses, the well-established risk factors of LE, i.e., increased body mass index, older age, and ilioinguinal versus inguinal versus axillary dissection predicted a high drainage volume after CLND. Of note, a high drainage fluid volume after SLNB also predicted a high drainage volume after subsequent CLND. In patients with groin dissections, who are particularly susceptible to swelling, extended iliac dissection, age above 60, and a cumulative drainage volume of more than 100 ml in the preceding SLNB were predictors of the cumulative drainage volume. We find that common risk factors predict the volume of postoperative drainage fluid after CLND and postoperative LE. Further, high postoperative drainage volume may therefore function as a potential early predictor of LE following CLND."],["dc.identifier.pmid","30234248"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57419"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","2522-7963"],["dc.title","The volume of postoperative drainage fluid as a potential early predictor of lymphedema after lymph node excision for metastatic melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Bremmer, S."],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Olbricht, N."],["dc.contributor.author","Schon, M."],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Thoms, Kai Martin"],["dc.date.accessioned","2018-11-07T10:08:54Z"],["dc.date.available","2018-11-07T10:08:54Z"],["dc.date.issued","2016"],["dc.format.extent","40"],["dc.identifier.isi","000383669600091"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39560"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Remission of metastatic Melanomas under Checkpoint Inhibition does not protect against the bright Skin Cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1129"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","1131"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Klode, Joachim"],["dc.contributor.author","Dissemond, Joachim"],["dc.date.accessioned","2018-11-07T09:32:03Z"],["dc.date.available","2018-11-07T09:32:03Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1111/ddg.14570"],["dc.identifier.isi","000346053400065"],["dc.identifier.pmid","25482699"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31660"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Diagnostic criteria for pyoderma gangrenosum: results of a survey among dermatologic wound experts in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","313"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","327"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Grönemeyer, Lisa-Lena"],["dc.contributor.author","Schön, Michael P."],["dc.date.accessioned","2020-12-10T18:27:17Z"],["dc.date.available","2020-12-10T18:27:17Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1111/ddg.13460_g"],["dc.identifier.issn","1610-0379"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76299"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Lipomatoses"],["dc.title.alternative","CME Article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1023"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","1030"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Jockenhoefer, Finja"],["dc.contributor.author","Herberger, Katharina"],["dc.contributor.author","Schaller, Joerg"],["dc.contributor.author","Hohaus, Katja Christina"],["dc.contributor.author","Stoffels-Weindorf, Maren"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Augustin, Matthias"],["dc.contributor.author","Dissemond, Joachim"],["dc.date.accessioned","2018-11-07T10:07:26Z"],["dc.date.available","2018-11-07T10:07:26Z"],["dc.date.issued","2016"],["dc.description.abstract","Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic, ulcerative skin disease of largely unknown pathophysiology. Material and methods : In this study, potentially relevant cofactors and comorbidities in patients with PG from three dermatological wound care centers in Germany were evaluated. Results: Of the 121 patients assessed, women (66.9 %) were more frequently affected than men. Patient age ranged from 18 to 96 years (mean 59.8). Wound size varied from 1-600 cm(2) (mean 65.6 cm(2)), and the pain intensity was predominantly very high (VAS 1-10, mean 7). The lower legs were most commonly (71.9 %) affected. Overall, 12 (9.9 %) patients had inflammatory bowel disease (ulcerative colitis, 5.8 %; Crohn's disease, 4.1 %), 14.1 % exhibited rheumatic comorbidities. Neoplasms were found in 20.6 % of patients, with 6.6 % classified as hematological and 14.0 % as solid neoplasms. With respect to criteria for the metabolic syndrome, obesity was found in 69.4 %, arterial hypertension in 57.9 %, and diabetes mellitus in 33.9 % of patients. Conclusions: The present data analysis confirms the association of PG with metabolic syndrome and neoplasms. In the future, these aspects should be included in the targeted diagnostic workup of patients with PG and subsequently treated in a timely fashion."],["dc.identifier.doi","10.1111/ddg.12791"],["dc.identifier.isi","000388277100007"],["dc.identifier.pmid","27767262"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39279"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Tricenter analysis of cofactors and comorbidity in patients with pyoderma gangrenosum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]