Diederichsen, Ulf

[["dc.bibliographiccitation.firstpage","4793"],["dc.bibliographiccitation.issue","28"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","4800"],["dc.contributor.author","Srivastava, Ratika"],["dc.contributor.author","Ray, Anmol Kumar"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2018-11-07T11:23:34Z"],["dc.date.available","2018-11-07T11:23:34Z"],["dc.date.issued","2009"],["dc.description.abstract","The aggregation and 3D organization of peptide helices are key elements in biology but might also be relevant in nanostructure formation. beta-Peptide helices were used as conformationally stable surrogates of alpha-peptides to be organized by covalently attached nucleobases as recognition units. Because the beta-peptide 14-helix conformation allows addressing individual sides of the helix, the aggregation of helices functionalized on two helix flanks was investigated. Nine helices varying in sequence and nucleobase composition were prepared by solid-phase peptide synthesis and analyzed by temperature-dependent UV and CD spectroscopy and FT-ICR mass spectrometry. Already, sequences of three nucleobases on both sides of the helix provided stable aggregates. Aggregate formation was sequence dependent and led to one complex being stable in water at least up to 80 degrees C. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [GRK 782]"],["dc.identifier.doi","10.1002/ejoc.200900511"],["dc.identifier.isi","000270500300007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56222"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1434-193X"],["dc.title","Higher Aggregation of beta-Peptide Networks Controlled by Nucleobase Pairing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5376"],["dc.bibliographiccitation.issue","32"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","5380"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Stafforst, Thorsten"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2018-11-07T10:29:02Z"],["dc.date.available","2018-11-07T10:29:02Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1002/anie.200600150"],["dc.identifier.isi","000239913400030"],["dc.identifier.pmid","16847855"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43557"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1433-7851"],["dc.title","Thymine oxetanes as charge traps for chemical monitoring of nucleic acid mediated transfer of excess electrons"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2717"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","ChemBioChem"],["dc.bibliographiccitation.lastpage","2719"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2018-11-07T11:21:51Z"],["dc.date.available","2018-11-07T11:21:51Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1002/cbic.200900543"],["dc.identifier.isi","000272391700004"],["dc.identifier.pmid","19830762"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55880"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1439-4227"],["dc.title","Dynamic Sequence Modification: A Design Principle for Synthetic Informational Oligomers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2780"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","2784"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Kleimann, Christoph"],["dc.contributor.author","Sischka, Andy"],["dc.contributor.author","Spiering, Andre"],["dc.contributor.author","Toensing, Katja"],["dc.contributor.author","Sewald, Norbert"],["dc.contributor.author","Diederichsen, Ulf"],["dc.contributor.author","Anselmetti, Dario"],["dc.date.accessioned","2018-11-07T11:21:59Z"],["dc.date.available","2018-11-07T11:21:59Z"],["dc.date.issued","2009"],["dc.description.abstract","The binding kinetics of the intercalative binding of Triostin A to A-DNA was investigated by measuring the force extension response of the DNA-ligand complexes with an optical tweezers system. These force response curves, containing the information about different binding properties, were analyzed based on a recent method (put forth by another research group) for monointercalators that was extended to bisintercalators. Our binding analysis reveals an exponential dependence of the association constant on the applied external force as well as a decreasing binding site size. In general, our results are in agreement with those for the monointercalator ethidium. However, to explain the high-force binding site size, a new model for bisintercalation of Triostin A at high forces is proposed."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB 613]"],["dc.identifier.doi","10.1016/j.bpj.2009.09.001"],["dc.identifier.isi","000271917700016"],["dc.identifier.pmid","19917232"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55903"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0006-3495"],["dc.title","Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2100"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","2106"],["dc.contributor.author","Pitulescu, Marian"],["dc.contributor.author","Grapp, Marcel"],["dc.contributor.author","Kraetzner, Ralph"],["dc.contributor.author","Knepel, Willhart"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2018-11-07T11:16:29Z"],["dc.date.available","2018-11-07T11:16:29Z"],["dc.date.issued","2008"],["dc.description.abstract","Two formacetal-linked dinucleotides TT and TT were synthesized as phosphoramidite building blocks for solid-phase synthesis. Incorporated in a 29-mer DNA, the oligomers P3(TT) and P3(TA) were studied with respect to the binding activity towards the Pax6 homeodomain. Substitution of the negatively charged phosphodiester by a neutral formacetal linker facilitates the bent conformation of double-stranded DNA. The duplex stability was affected more significantly by the TT formacetal modification, whereas destabilization induced by TA was less pronounced. Based on CD spectroscopy, the TA formacetal-modified oligomer P3(TA) A has mainly B-DNA topology, whereas the P3(TT) modified oligomet significantly deviated from B-form DNA. The binding affinity of the P3 oligomer towards Pax6 HD was investigated by in vitro EMSA experiments providing even a small increase in binding affinity for the P3(TA) T oligomer. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)."],["dc.identifier.doi","10.1002/ejoc.200701178"],["dc.identifier.isi","000255508600010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54599"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1434-193X"],["dc.title","Synthesis of formacetal-linked dinucleotides to facilitate dsDNA bending and binding to the homeodomain of Pax6"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1139"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Analytical and Bioanalytical Chemistry"],["dc.bibliographiccitation.lastpage","1147"],["dc.bibliographiccitation.volume","390"],["dc.contributor.author","Fitzner, Ansgar"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Laatsch, Hartmut"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2018-11-07T11:18:24Z"],["dc.date.available","2018-11-07T11:18:24Z"],["dc.date.issued","2008"],["dc.description.abstract","Formation and fragmentation of recognition complexes between trioxacarcin A and various DNA sequences were examined by temperature-dependent UV and CD spectroscopy, HPLC analysis, and ESI mass spectrometry with regard to reaction conditions, intermediates, products, mechanism, and sequence specificity. Cleavage of the trioxacarcin-DNA complexes provided the natural product gutingimycin by guanine abstraction. The resulting DNA with an abasic site was further cleaved into a DNA fragment with a furanyl unit at the 3'-end and an oligonucleotide with a phosphorylated 5'-end."],["dc.identifier.doi","10.1007/s00216-007-1737-6"],["dc.identifier.isi","000252918100017"],["dc.identifier.pmid","18210096"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3482"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55029"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1618-2642"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Formation of gutingimycin: analytical investigation of trioxacarcin A-mediated alkylation of dsDNA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","552"],["dc.bibliographiccitation.issue","7374"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","555"],["dc.bibliographiccitation.volume","479"],["dc.contributor.author","van den Bogaart, Geert"],["dc.contributor.author","Meyenberg, Karsten"],["dc.contributor.author","Risselada, H. Jelger"],["dc.contributor.author","Amin, Hayder"],["dc.contributor.author","Willig, Katrin I."],["dc.contributor.author","Hubrich, Barbara E."],["dc.contributor.author","Dier, Markus"],["dc.contributor.author","Hell, Stefan"],["dc.contributor.author","Grubmüller, Helmut"],["dc.contributor.author","Diederichsen, Ulf"],["dc.contributor.author","Jahn, Reinhard"],["dc.date.accessioned","2017-09-07T11:43:16Z"],["dc.date.available","2017-09-07T11:43:16Z"],["dc.date.issued","2011"],["dc.description.abstract","Neuronal exocytosis is catalysed by the SNAP receptor protein syntaxin-1A(1), which is clustered in the plasma membrane at sites where synaptic vesicles undergo exocytosis(2,3). However, how syntaxin-1A is sequestered is unknown. Here we show that syntaxin clustering is mediated by electrostatic interactions with the strongly anionic lipid phosphatidylinositol-4,5-bisphosphate (PIP2). Using super-resolution stimulated-emission depletion microscopy on the plasma membranes of PC12 cells, we found that PIP2 is the dominant inner-leaflet lipid in microdomains about 73 nanometres in size. This high accumulation of PIP2 was required for syntaxin-1A sequestering, as destruction of PIP2 by the phosphatase synaptojanin-1 reduced syntaxin-1A clustering. Furthermore, coreconstitution of PIP2 and the carboxy-terminal part of syntaxin-1A in artificial giant unilamellar vesicles resulted in segregation of PIP2 and syntaxin-1A into distinct domains even when cholesterol was absent. Our results demonstrate that electrostatic protein-lipid interactions can result in the formation of microdomains independently of cholesterol or lipid phases."],["dc.identifier.doi","10.1038/nature10545"],["dc.identifier.gro","3142626"],["dc.identifier.isi","000297285600056"],["dc.identifier.pmid","22020284"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0028-0836"],["dc.title","Membrane protein sequestering by ionic protein-lipid interactions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13221"],["dc.bibliographiccitation.issue","67"],["dc.bibliographiccitation.journal","Chemical Communications"],["dc.bibliographiccitation.lastpage","13224"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Kabatas, Selda"],["dc.contributor.author","Vreja, Ingrid C."],["dc.contributor.author","Saka, Sinem K."],["dc.contributor.author","Hoeschen, Carmen"],["dc.contributor.author","Kroehnert, Katharina"],["dc.contributor.author","Opazo, Felipe"],["dc.contributor.author","Rizzoli, S. O."],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2017-09-07T11:44:43Z"],["dc.date.available","2017-09-07T11:44:43Z"],["dc.date.issued","2015"],["dc.description.abstract","Imaging techniques should differentiate between specific signals, from the biomolecules of interest, and non-specific signals, from the background. We present a probe containing N-15 and N-14 isotopes in approximately equal proportion, for secondary ion mass spectrometry imaging. This probe designed for a precise biomolecule analysis is insensitive to background signals."],["dc.identifier.doi","10.1039/c5cc03895b"],["dc.identifier.gro","3141979"],["dc.identifier.isi","000359246500017"],["dc.identifier.pmid","26195041"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3201"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1364-548X"],["dc.relation.issn","1359-7345"],["dc.title","A contamination-insensitive probe for imaging specific biomolecules by secondary ion mass spectrometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","245"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Peptide Science"],["dc.bibliographiccitation.lastpage","245"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Moroder, Luis"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2018-08-16T13:05:32Z"],["dc.date.available","2018-08-16T13:05:32Z"],["dc.date.issued","2016"],["dc.description.abstract","With the greatest pleasure, we honor Stephen B. H. Kent on the occasion of his 70th birthday and recognize his pioneering contributions to peptide‐protein chemistry. The chemical ligation method enabled him to realize the dream of synthetic chemists going back to the days of Emil Fischer – the total synthesis of proteins which thus provided almost unlimited possibilities for modulation of their structures in order to understand their function. With his two seminal articles in Science ‘On the backbone‐engineered HIV proteases’ 1 and on the ‘Synthesis of proteins by native chemical ligation’ 2 he introduced the breakthrough approach for the regioselective and chemoselective covalent condensation of unprotected peptide fragments that allowed synthetic access to polypeptide chains of more than 200 amino acids. These robust synthetic methodologies have opened up new opportunities to tackle fundamental biological questions."],["dc.identifier.doi","10.1002/psc.2892"],["dc.identifier.pmid","27160918"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15358"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1099-1387"],["dc.relation.eissn","1075-2617"],["dc.title","Editorial: A Tribute to Stephen B. H. Kent: Towards a new world of proteins enabled by chemical synthesis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1886"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Angewandte Chemie. International Edition"],["dc.bibliographiccitation.lastpage","1889"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2020-11-23T13:55:57Z"],["dc.date.available","2020-11-23T13:55:57Z"],["dc.date.issued","1997"],["dc.identifier.doi","10.1002/anie.199718861"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69034"],["dc.relation.issn","0570-0833"],["dc.relation.issn","1521-3773"],["dc.title","Alaynl PNA: Evidence for Linear Band Structures Based on Guanine-Cytosin Base Pairs"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]