Weiss, Bernhard Gisbert

[["dc.bibliographiccitation.artnumber","154272"],["dc.bibliographiccitation.journal","BioMed Research International"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Bertlich, Mattis"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Dietzel, Steffen"],["dc.contributor.author","Canis, Martin"],["dc.date.accessioned","2018-11-07T10:03:20Z"],["dc.date.available","2018-11-07T10:03:20Z"],["dc.date.issued","2015"],["dc.description.abstract","Impairment of cochlear blood flow has been discussed as factor in the pathophysiology of various inner ear disorders. However, the microscopic study of cochlear microcirculation is limited due to small scale and anatomical constraints. Here, two-photon fluorescence microscopy is applied to visualize cochlear microvessels. Guinea pigs were injected with Fluorescein isothiocyanateor Texas red-dextrane as plasma marker. Intravital microscopy was performed in four animals and explanted cochleae from four animals were studied. The vascular architecture of the cochlea was visualized up to a depth of 90.0 +/- 22.7 mu m. Imaging yielded a mean contrast-to-noise ratio (CNR) of 3.3 +/- 1.7. Mean diameter in vivo was 16.5 +/- 6.0 mu m for arterioles and 8.0 +/- 2.4 mu m for capillaries. In explanted cochleae, the diameter of radiating arterioles and capillaries was measured with 12.2 +/- 1.6 mu m and 6.6 +/- 1.0 mu m, respectively. The difference between capillaries and arterioles was statistically significant in both experimental setups (P < 0.001 and P = 0.022, two-way ANOVA). Measured vessel diameters in vivo and ex vivo were in agreement with published data. We conclude that two-photon fluorescence microscopy allows the investigation of cochlear microvessels and is potentially a valuable tool for inner ear research."],["dc.description.sponsorship","Open Access Publikationsfonds 2015"],["dc.identifier.doi","10.1155/2015/154272"],["dc.identifier.isi","000353163300001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11857"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38437"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hindawi Publishing Corp"],["dc.relation.issn","2314-6141"],["dc.relation.issn","2314-6133"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Two-Photon Microscopy Allows Imaging and Characterization of Cochlear Microvasculature In Vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","87"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Fledrich, Robert"],["dc.contributor.author","Schlotter-Weigel, Beate"],["dc.contributor.author","Schnizer, Tuuli J."],["dc.contributor.author","Wichert, Sven P."],["dc.contributor.author","Stassart, Ruth Martha"],["dc.contributor.author","Hoerste, Gerd Meyer Zu"],["dc.contributor.author","Klink, Axel"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Haag, Uwe"],["dc.contributor.author","Walter, Maggie C."],["dc.contributor.author","Rautenstrauss, Bernd"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Rossner, Moritz J."],["dc.contributor.author","Sereda, Michael W."],["dc.date.accessioned","2018-11-07T09:15:45Z"],["dc.date.available","2018-11-07T09:15:45Z"],["dc.date.issued","2012"],["dc.description.abstract","Charcot-Marie-Tooth disease is the most common inherited neuropathy and a duplication of the peripheral myelin protein 22 gene causes the most frequent subform Charcot-Marie-Tooth 1A. Patients develop a slowly progressive dysmyelinating and demyelinating peripheral neuropathy and distally pronounced muscle atrophy. The amount of axonal loss determines disease severity. Although patients share an identical monogenetic defect, the disease progression is strikingly variable and the impending disease course can not be predicted in individual patients. Despite promising experimental data, recent therapy trials have failed. Established clinical outcome measures are thought to be too insensitive to detect amelioration within trials. Surrogate biomarkers of disease severity in Charcot-Marie-Tooth 1A are thus urgently needed. Peripheral myelin protein 22 transgenic rats harbouring additional copies of the peripheral myelin protein 22 gene ('Charcot-Marie-Tooth rats'), which were kept on an outbred background mimic disease hallmarks and phenocopy the variable disease severity of patients with Charcot-Marie-Tooth 1A. Hence, we used the Charcot-Marie-Tooth rat to dissect prospective and surrogate markers of disease severity derived from sciatic nerve and skin tissue messenger RNA extracts. Gene set enrichment analysis of sciatic nerve transcriptomes revealed that dysregulation of lipid metabolism associated genes such as peroxisome proliferator-activated receptor gamma constitutes a modifier of present and future disease severity. Importantly, we directly validated disease severity markers from the Charcot-Marie-Tooth rats in 46 patients with Charcot-Marie-Tooth 1A. Our data suggest that the combination of age and cutaneous messenger RNA levels of glutathione S-transferase theta 2 and cathepsin A composes a strong indicator of disease severity in patients with Charcot-Marie-Tooth 1A, as quantified by the Charcot-Marie-Tooth Neuropathy Score. This translational approach, utilizing a transgenic animal model, demonstrates that transcriptional analysis of skin biopsy is suitable to identify biomarkers of Charcot-Marie-Tooth 1A."],["dc.identifier.doi","10.1093/brain/awr322"],["dc.identifier.isi","000300044400016"],["dc.identifier.pmid","22189569"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13524"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27771"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0006-8950"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Jakob, Mark"],["dc.contributor.author","Kruizenga, Marie"],["dc.contributor.author","Freytag, Saskia"],["dc.contributor.author","Bertlich, Mattis"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Haubner, Frank"],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Weiss, Bernhard G."],["dc.date.accessioned","2021-04-14T08:32:11Z"],["dc.date.available","2021-04-14T08:32:11Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00405-020-06389-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83839"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1434-4726"],["dc.relation.issn","0937-4477"],["dc.title","Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","648"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Otology & Neurotology"],["dc.bibliographiccitation.lastpage","654"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Bertlich, Mattis"],["dc.contributor.author","Bettag, Stephan A."],["dc.contributor.author","Desinger, Hendrik"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Canis, Martin"],["dc.date.accessioned","2020-12-10T18:19:57Z"],["dc.date.available","2020-12-10T18:19:57Z"],["dc.date.issued","2017"],["dc.description.abstract","Objective: Disturbance of cochlear microcirculation is considered to be the final common pathway of various inner ear diseases. Hyperfibrinogenemia causing increased plasma viscosity is a known risk factor for sudden sensorineural hearing loss and may lead to a critical reduction of cochlear blood flow. The aim of this study was to evaluate the effect of a substantial reduction of plasma fibrinogen levels by drug-induced defibrinogenation for the treatment of acute hearing loss in vivo. Methods: Acute hearing loss was induced by hyperfibrinogenemia (i.v. injection of 330 mg/kg BW fibrinogen), using a guinea pig animal model. Parameters of cochlear microcirculation and hearing thresholds were quantified by intravital microscopy and evoked response audiometry. After obtaining baseline values, the course of hearing loss and disturbances of microcirculation were investigated under influence of intravenous defibrinogenation therapy (ancrod), corticosteroid, or placebo treatment, using 5 animals/group. Results: Acute hyperfibrinogenemia caused hearing loss from 10 +/- 7 to 26 +/- 10 dB SPL at baseline. Drug-induced reduction of fibrinogen levels showed a significant increase of cochlear microcirculation (1.6-fold) and recovered hearing threshold (11 +/- 6 dB SPL). Placebo or corticosteroid treatment had no effect on hearing loss (35 +/- 7 dB SPL and 32 +/- 18 dB SPL, respectively). Conclusion: Acute hyperfibrinogenemia resulted in hearing loss. Drug-induced reduction of elevated fibrinogen levels caused an increase in cochlear blood flow and a decrease in hearing thresholds. Placebo or corticosteroid treatment had no effect. Reduction of plasma fibrinogen levels could serve as a clinical treatment option for acute hearing loss."],["dc.identifier.doi","10.1097/MAO.0000000000001400"],["dc.identifier.isi","000401025800004"],["dc.identifier.issn","1531-7129"],["dc.identifier.pmid","28369007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75431"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1537-4505"],["dc.relation.issn","1531-7129"],["dc.title","Drug-induced Defibrinogenation as New Treatment Approach of Acute Hearing Loss in an Animal Model for Inner Ear Vascular Impairment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1631"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Head & Neck"],["dc.bibliographiccitation.lastpage","1638"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Wolff, Hendrik A."],["dc.contributor.author","Schneider, Simon"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Steiner, Wolfgang"],["dc.contributor.author","Welz, Christian"],["dc.date.accessioned","2020-12-10T14:06:36Z"],["dc.date.available","2020-12-10T14:06:36Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/hed.v39.8"],["dc.identifier.issn","1043-3074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69956"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Transoral laser microsurgery for treatment for hypopharyngeal cancer in 211 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Modern Pathology"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Chiosea, Simion I."],["dc.contributor.author","Maxwell, Jessica H."],["dc.contributor.author","Shuai, Yongli"],["dc.contributor.author","Brandwein-Gensler, Margaret S."],["dc.contributor.author","Purgina, Bibianna"],["dc.contributor.author","Lai, Chi"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Ferris, Robert L."],["dc.contributor.author","Kim, Seungwon"],["dc.contributor.author","Duvvuri, Uma"],["dc.contributor.author","Johnson, Jonas"],["dc.contributor.author","Seethala, Raja"],["dc.contributor.author","Thompson, Lester D. R."],["dc.date.accessioned","2018-11-07T10:01:24Z"],["dc.date.available","2018-11-07T10:01:24Z"],["dc.date.issued","2015"],["dc.format.extent","322A"],["dc.identifier.isi","000349502201627"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38011"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.conference","104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1530-0285"],["dc.relation.issn","0893-3952"],["dc.title","Early Squamous Cell Carcinoma of the Oral Tongue: Histologic Parameters and Local Control"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","99"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Vascular"],["dc.bibliographiccitation.lastpage","110"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Sohns, Jan M"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Weiss, Bernhard G"],["dc.contributor.author","Kröhn, Hannah"],["dc.contributor.author","Weiberg, Desiree"],["dc.contributor.author","Derlin, Thorsten"],["dc.contributor.author","Schmuck, Sebastian"],["dc.date.accessioned","2020-12-10T18:38:35Z"],["dc.date.available","2020-12-10T18:38:35Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1177/1708538117724628"],["dc.identifier.eissn","1708-539X"],["dc.identifier.issn","1708-5381"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77377"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Screening of extravascular findings in pulmonary embolism computer tomography: 397 patients with 1950 non-pulmonary artery findings"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","246"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal of Otolaryngology"],["dc.bibliographiccitation.lastpage","250"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Canis, Martin"],["dc.date.accessioned","2018-11-07T09:43:07Z"],["dc.date.available","2018-11-07T09:43:07Z"],["dc.date.issued","2014"],["dc.description.abstract","After laryngectomy or lateral pharyngotomy for treatment of laryngeal or hypopharyngeal cancer the occurrence of a pharyngo-cutaneous fistula is a challenging complication. Especially after previous radiotherapy and expanded surgical resections of mucosa the management is demanding. Besides the prolonged hospital stay, increased treatment costs and reduced quality of life, a delayed adjuvant treatment follows the development of a fistula. Treatment strategies range from conservative procedures comprising parenteral nutrition, antibiotics and local wound care to primary surgical closure or reconstructive tissue transfer. We report three cases of using the fibrin/thrombin-coated collagen patch TachoSil (R) as a solitary or adjuvant strategy in surgical treatment. In one patient primary closure of the fistula was achieved by transoral application of the collagen patch. In the other cases a not tension free primary suture was strengthened by the adjuvant use of TachoSil (R). The healing process was rapid and straightforward in all patients. The use of TachoSil (R) may be indicated in between conservative treatment strategies and reconstructive surgery. After occurrence of a fistula the healing process is intended to be accelerated by primary closure with TachoSil (R) or by sealing of a primary suture. (C) 2014 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.amjoto.2013.11.005"],["dc.identifier.isi","000333541800031"],["dc.identifier.pmid","24315631"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34107"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","1532-818X"],["dc.relation.issn","0196-0709"],["dc.title","Coated collagen patches for closure of pharyngo-cutaneous fistulas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1213"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Otology & Neurotology"],["dc.bibliographiccitation.lastpage","1216"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Bertlich, Mattis"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Freytag, Saskia"],["dc.contributor.author","Jakob, Mark"],["dc.contributor.author","Strupp, Michael"],["dc.contributor.author","Pellkofer, Hannah"],["dc.contributor.author","Canis, Martin"],["dc.date.accessioned","2020-12-10T18:19:57Z"],["dc.date.available","2020-12-10T18:19:57Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1097/MAO.0000000000001510"],["dc.identifier.issn","1531-7129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75432"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1104"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","JAMA Otolaryngology—Head & Neck Surgery"],["dc.bibliographiccitation.lastpage","1110"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Maxwell, Jessica H."],["dc.contributor.author","Thompson, Lester D. R."],["dc.contributor.author","Brandwein-Gensler, Margaret S."],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Purgina, Bibianna"],["dc.contributor.author","Prabhu, Arpan V."],["dc.contributor.author","Lai, Chi"],["dc.contributor.author","Shuai, Yongli"],["dc.contributor.author","Carroll, William R."],["dc.contributor.author","Morlandt, Anthony"],["dc.contributor.author","Duvvuri, Umamaheswar"],["dc.contributor.author","Kim, Seungwon"],["dc.contributor.author","Johnson, Jonas T."],["dc.contributor.author","Ferris, Robert L."],["dc.contributor.author","Seethala, Raja"],["dc.contributor.author","Chiosea, Simion I."],["dc.date.accessioned","2018-11-07T09:48:14Z"],["dc.date.available","2018-11-07T09:48:14Z"],["dc.date.issued","2015"],["dc.description.abstract","IMPORTANCE Positive margins are associated with poor prognosis among patients with oral tongue squamous cell carcinoma (SCC). However, wide variation exists in the margin sampling technique. OBJECTIVE To determine the effect of the margin sampling technique on local recurrence (LR) in patients with stage I or II oral tongue SCC. DESIGN, SETTING, AND PARTICIPANTS A retrospective study was conducted from January 1, 1986, to December 31, 2012, in 5 tertiary care centers following tumor resection and elective neck dissection in 280 patients with pathologic (p)T1-2 pNO oral tongue SCC. Analysis was conducted from June 1, 2013, to January 20, 2015. INTERVENTIONS In group 1 (n = 119), tumor bed margins were not sampled. In group 2 (n = 61), margins were examined from the glossectomy specimen, found to be positive or suboptimal, and revised with additional tumor bed margins. In group 3 (n = 100), margins were primarily sampled from the tumor bed without preceding examination of the glossectomy specimen. The margin status (both as a binary [positive vs negative] and continuous [distance to the margin in millimeters] variable) and other clinicopathologic parameters were compared across the 3 groups and correlated with LR. MAIN OUTCOMES AND MEASURES Local recurrence. RESULTS Age, sex, pT stage, lymphovascular or perineural invasion, and adjuvant radiation treatment were similar across the 3 groups. The probability of LR-free survival at 3 years was 0.9 and 0.8 in groups 1 and 3, respectively (P = .03). The frequency of positive glossectomy margins was lowest in group 1 (9 of 117 [7.7%]) compared with groups 2 and 3 (28 of 61 [45.9%] and 23 of 95 [24.2%], respectively) (P < .001). Even after excluding cases with positive margins, the median distance to the closest margin was significantly narrower in group 3 (2 mm) compared with group 1 (3 mm) (P = .008). The status (positive vs negative) of margins obtained from the glossectomy specimen correlated with LR (P = .007), while the status of tumor bed margins did not. The status of the tumor bed margin was 24% sensitive (95% CI, 16%-34%) and 92% specific (95% CI, 85%-97%) for detecting a positive glossectomy margin. CONCLUSIONS AND RELEVANCE The margin sampling technique affects local control in patients with oral tongue SCC. Reliance on margin sampling from the tumor bed is associated with worse local control, most likely owing to narrower margin clearance and greater incidence of positive margins. A resection specimen-based margin assessment is recommended."],["dc.description.sponsorship","[P30CA047904]"],["dc.identifier.doi","10.1001/jamaoto.2015.1351"],["dc.identifier.isi","000367146400012"],["dc.identifier.pmid","26225798"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35263"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Medical Assoc"],["dc.relation.issn","2168-619X"],["dc.relation.issn","2168-6181"],["dc.title","Early Oral Tongue Squamous Cell Carcinoma Sampling of Margins From Tumor Bed and Worse Local Control"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]