Bemme, Sebastian

[["dc.bibliographiccitation.firstpage","4754"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Investigative ophthalmology & visual science"],["dc.bibliographiccitation.lastpage","4767"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Weick, Michael"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2019-07-09T11:44:50Z"],["dc.date.available","2019-07-09T11:44:50Z"],["dc.date.issued","2017-09-01"],["dc.description.abstract","Purpose: Phosphene perception is a characteristic side effect of heart rate-reducing medication that acts on hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels. It is hypothesized that these phosphenes are caused by blocking HCN channels in photoreceptors and neurons of the retina, yet the underlying changes in visual signal processing in the retina caused by the HCN channel block are still unknown. Methods: We examined the effects of pharmacologic HCN channel block on the encoding of visual signals in retinal ganglion cells by recording ganglion cell spiking activity from isolated mouse retinas mounted on multielectrode arrays. Spontaneous activity and responses to various visual stimuli were measured before, during, and after administration of 3 μM ivabradine. Results: Retinal ganglion cells generally showed slower response kinetics and reduced sensitivity to high temporal frequencies under ivabradine. Moreover, ivabradine differentially affected the sensitivity of On and Off ganglion cells. On cells showed reduced response gain, whereas Off cells experienced an increase in response threshold. In line with these differential effects, Off cells, in contrast to On cells, also showed reduced baseline activity during visual stimulation and reduced spontaneous activity. Furthermore, Off cells, but not On cells, showed increased burst-like spiking activity in the presence of ivabradine. Conclusions: Our data suggest that pharmacologic HCN channel block in the retina leads to a shift in the relative activity of the On and Off pathways of the retina. We hypothesize that this imbalance may underlie the medication-induced perception of phosphenes."],["dc.identifier.doi","10.1167/iovs.17-21572"],["dc.identifier.pmid","28973319"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14921"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59108"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/724822/EU//CODE4Vision"],["dc.relation.issn","1552-5783"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","006"],["dc.subject.ddc","573"],["dc.subject.ddc","612"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Benzazepines"],["dc.subject.mesh","Cardiovascular Agents"],["dc.subject.mesh","Cells, Cultured"],["dc.subject.mesh","Disease Models, Animal"],["dc.subject.mesh","Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Inbred C57BL"],["dc.subject.mesh","Phosphenes"],["dc.subject.mesh","Potassium Channel Blockers"],["dc.subject.mesh","Retina"],["dc.subject.mesh","Retinal Ganglion Cells"],["dc.title","Differential Effects of HCN Channel Block on On and Off Pathways in the Retina as a Potential Cause for Medication-Induced Phosphene Perception."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","499"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","504"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Storch, M."],["dc.contributor.author","Bemme, S."],["dc.contributor.author","Rehak, M."],["dc.contributor.author","Hoerauf, H."],["dc.contributor.author","Feltgen, N."],["dc.date.accessioned","2020-12-10T14:10:15Z"],["dc.date.available","2020-12-10T14:10:15Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00347-017-0513-z"],["dc.identifier.eissn","1433-0423"],["dc.identifier.issn","0941-293X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70696"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Ultraweitwinkelangiographie beim retinalen Venenverschluss"],["dc.title.alternative","Ultra-widefield angiography for retinal vein occlusion. How large is large enough?"],["dc.title.subtitle","Wie groß ist groß genug?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Investigative Ophthalmology & Visual Science"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Walz, Johanna Madeleine"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Boehringer, Daniel"],["dc.contributor.author","Pielen, Amelie"],["dc.contributor.author","Aisenbrey, Sabine"],["dc.contributor.author","Breuss, Helge"],["dc.contributor.author","Alex, Anne F."],["dc.contributor.author","Wagenfeld, Lars"],["dc.contributor.author","Schiedel, Susanne"],["dc.contributor.author","Krohne, Tim U."],["dc.contributor.author","Stahl, Andreas"],["dc.date.accessioned","2018-11-07T10:08:44Z"],["dc.date.available","2018-11-07T10:08:44Z"],["dc.date.issued","2016"],["dc.identifier.isi","000394210603012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39526"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Assoc Research Vision Ophthalmology Inc"],["dc.publisher.place","Rockville"],["dc.relation.conference","Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO)"],["dc.relation.eventlocation","Seattle, WA"],["dc.relation.issn","1552-5783"],["dc.relation.issn","0146-0404"],["dc.title","The German ROP Registry: Association of demographic factors and the requirement for re-treatments of retinopathy of prematurity"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","100031"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Ophthalmology Science"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Heins, Amelie"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Storch, Marcus Werner"],["dc.contributor.author","Khattab, Mohammed Haitham"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","van Oterendorp, Christian"],["dc.date.accessioned","2022-05-13T06:27:45Z"],["dc.date.available","2022-05-13T06:27:45Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1016/j.xops.2021.100031"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107850"],["dc.language.iso","en"],["dc.relation.issn","2666-9145"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Reliability of Subjective Assessment of Spectral-Domain OCT Pathologic Features by Multiple Raters in Retinal Vein Occlusion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","338"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Fischer-Wedi, Charlotte V."],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Kortleben, Mai-Linh"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2021-04-14T08:29:40Z"],["dc.date.available","2021-04-14T08:29:40Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3390/jcm10020338"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82962"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2077-0383"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","The Retrobulbar Spot Sign and Prominent Middle Limiting Membrane as Prognostic Markers in Non-Arteritic Retinal Artery Occlusion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","aos.14940"],["dc.bibliographiccitation.firstpage","295"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Ophthalmologica"],["dc.bibliographiccitation.lastpage","301"],["dc.bibliographiccitation.volume","100"],["dc.contributor.affiliation","Gebler, Marie; 1\r\nDepartment of Ophthalmology University Medical Center Goettingen Goettingen Germany"],["dc.contributor.affiliation","Pfeiffer, Sebastian; 2\r\nDepartment of Research, Teaching and Clinical Science University Medical Center Goettingen Goettingen Germany"],["dc.contributor.affiliation","Callizo, Josep; 1\r\nDepartment of Ophthalmology University Medical Center Goettingen Goettingen Germany"],["dc.contributor.affiliation","Hoerauf, Hans; 1\r\nDepartment of Ophthalmology University Medical Center Goettingen Goettingen Germany"],["dc.contributor.affiliation","Feltgen, Nicolas; 1\r\nDepartment of Ophthalmology University Medical Center Goettingen Goettingen Germany"],["dc.contributor.author","Gebler, Marie"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Callizo, Josep"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Bemme, Sebastian"],["dc.date.accessioned","2021-07-05T14:57:41Z"],["dc.date.available","2021-07-05T14:57:41Z"],["dc.date.issued","2021"],["dc.date.updated","2022-06-14T21:23:28Z"],["dc.description.abstract","Abstract Purpose To assess the incidence of cystoid macular oedema (CME) diagnosed by spectral domain optical coherence tomography (SD‐OCT) after primary rhegmatogenous retinal detachment (RRD) surgery. Methods From April 2016 to October 2017, 150 eyes of 150 patients presenting with primary RRD were included consecutively in this prospective single‐centre study. Patients with the following characteristics were excluded: previous vitreoretinal surgery, combined cataract surgery, preoperatively presentation with any intraocular or systemic inflammatory condition, visible macular oedema or epiretinal membrane (ERM) on funduscopy. SD‐OCT (Spectralis, Heidelberg Engineering) was conducted 3 and 6 weeks after surgery. Results One hundred and twenty‐eight of the 150 patients completed the study, of whom 107 (age: 61.7 ± 11.5 years, mean ± SD) showed successful retinal attachment during follow‐up visits. The most frequent operation method was scleral buckling (54.2%), followed by vitrectomy (25.2%) and the combination of both techniques (20.6%). Postoperative SD‐OCT revealed CME, neurosensory detachment and ERM in 18.7, 31.8 and 32.7% of all cases, respectively. The risk of postoperative CME was significantly elevated in patients with ERM (42.9 versus 6.9%, p < 0.001). In addition, patients with initial detachment of the macula had more postoperative CME (26.5 versus 11.1%, p = 0.044). BCVA improvement was significantly lower in patients with CME compared to patients without 6 weeks after surgery for macula‐on RRD. Conclusions This prospective study confirmed that postoperative CME is a frequent complication after RRD surgery; we identified ERM and macula‐off RRD as potential risk factors. As CME potentially delays visual recovery, postoperative follow‐ups should include SD‐OCT."],["dc.identifier.doi","10.1111/aos.14940"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87706"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-441"],["dc.relation.eissn","1755-3768"],["dc.relation.issn","1755-375X"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.title","Incidence and risk factors for macular oedema after primary rhegmatogenous retinal detachment surgery: a prospective single‐centre study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.contributor.author","Take, Patricia"],["dc.contributor.author","Dittmann, Carolin Alisa"],["dc.contributor.author","Mackerodt, Laura"],["dc.contributor.author","Callizo, Josep"],["dc.contributor.author","Striebe, Nina-Antonia"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Bemme, Sebastian"],["dc.date.accessioned","2021-04-14T08:23:36Z"],["dc.date.available","2021-04-14T08:23:36Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00347-020-01218-y"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80983"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1433-0423"],["dc.relation.issn","0941-293X"],["dc.title","Das modifizierte Treat-and-Extend-Schema mit Injektionsblöcken in der IVOM-Therapie"],["dc.title.alternative","Retrospektive Analyse aus der täglichen klinischen Anwendung"],["dc.title.translated","The modified treat and extend scheme with injection blocks in intravitreal injection treatment: Retrospective analysis from the routine clinical application"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","856"],["dc.bibliographiccitation.volume","116"],["dc.contributor.author","Striebe, N.-A."],["dc.contributor.author","Feltgen, N."],["dc.contributor.author","Khattab, M. H."],["dc.contributor.author","Spier, L."],["dc.contributor.author","Callizo, J."],["dc.contributor.author","Bemme, S."],["dc.contributor.author","Hoerauf, H."],["dc.contributor.author","van Oterendorp, C."],["dc.date.accessioned","2020-12-10T14:10:17Z"],["dc.date.available","2020-12-10T14:10:17Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00347-018-0839-1"],["dc.identifier.eissn","1433-0423"],["dc.identifier.issn","0941-293X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70710"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Hat der Mikropulslaser bei chronischer CCS einen Effekt?"],["dc.title.alternative","Does the micropulse laser have an effect on chronic CSC?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","399"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Der Ophthalmologe"],["dc.bibliographiccitation.lastpage","403"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Nguyen-Höhl, Anna"],["dc.contributor.author","Khattab, Mohammed H."],["dc.contributor.author","Henneke, Marco"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Bemme, Sebastian"],["dc.date.accessioned","2021-04-14T08:26:11Z"],["dc.date.available","2021-04-14T08:26:11Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00347-020-01147-w"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81858"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1433-0423"],["dc.relation.issn","0941-293X"],["dc.title","Einseitige Optikusatrophie bei einem 9-jährigen Patienten"],["dc.title.translated","Unilateral optic atrophy in a 9-year-old patient"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0241005"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Gebest, Julia"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","van Oterendorp, Christian"],["dc.contributor.editor","Grzybowski, Andrzej"],["dc.date.accessioned","2021-04-14T08:31:16Z"],["dc.date.available","2021-04-14T08:31:16Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0241005"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17683"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83535"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Influence of pars plana vitrectomy for macular surgery on the medium term intraocular pressure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]