Chapuy, Björn

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Cancer Research"],["dc.bibliographiccitation.lastpage","404"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Koch, Raphael"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Vogel, Daniel"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Wenzel, Dirk"],["dc.contributor.author","Becker, Sabrina"],["dc.contributor.author","Sinzig, Ursula"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","von Mach, Tobias"],["dc.contributor.author","Jacob, Ralf"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T10:19:22Z"],["dc.date.available","2018-11-07T10:19:22Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose: Although R-CHOP-based immunochemotherapy cures significant proportions of patients with aggressive B-cell lymphoma, tumor cell susceptibility to chemotherapy varies, with mostly fatal outcome in cases of resistant disease. We and others have shown before that export of cytostatic drugs contributes to drug resistance. Now we provide a novel approach to overcome exosome-mediated drug resistance in aggressive B-cell lymphomas. Experimental Design: We used well-established centrifugation protocols to purify exosomes from DLBCL cell lines and detected anthracyclines using FACS and HPLC. We used shRNA knockdown of ABCA3 to determine ABCA3 dependence of chemotherapy susceptibility and monitored ABCA3 expression after indomethacin treatment using qPCR. Finally, we established an in vivo assay using a chorioallantoic membrane (CAM) assay to determine the synergy of anthracycline and indomethacin treatment. Results: We show increased efficacy of the anthracycline doxorubicin and the anthracenedione pixantrone by suppression of exosomal drug resistance with indomethacin. B-cell lymphoma cells in vitro efficiently extruded doxorubicin and pixantrone, in part compacted in exosomes. Exosomal biogenesis was critically dependent on the expression of the ATP-transporter A3 (ABCA3). Genetic or chemical depletion of ABCA3 augmented intracellular retention of both drugs and shifted the subcellular drug accumulation to prolonged nuclear retention. Indomethacin increased the cytostatic efficacy of both drugs against DLBCL cell lines in vitro and in vivo in a CAM assay. Conclusions: We propose pretreatment with indomethacin toward enhanced antitumor efficacy of anthracyclines and anthracenediones. (C) 2015 AACR."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft; University Medicine Goettingen"],["dc.identifier.doi","10.1158/1078-0432.CCR-15-0577"],["dc.identifier.isi","000369076500016"],["dc.identifier.pmid","26369630"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41643"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1557-3265"],["dc.relation.issn","1078-0432"],["dc.title","Nuclear Trapping through Inhibition of Exosomal Export by Indomethacin Increases Cytostatic Efficacy of Doxorubicin and Pixantrone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1361"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Haematologica"],["dc.bibliographiccitation.lastpage","1368"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Chen, Linfeng"],["dc.contributor.author","Ouyang, Jing"],["dc.contributor.author","Wienand, Kirsty"],["dc.contributor.author","Bojarczuk, Kamil"],["dc.contributor.author","Hao, Yansheng"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Neuberg, Donna"],["dc.contributor.author","Juszczynski, Przemyslaw"],["dc.contributor.author","Lawton, Lee N."],["dc.contributor.author","Rodig, Scott J."],["dc.contributor.author","Monti, Stefano"],["dc.contributor.author","Shipp, Margaret A."],["dc.date.accessioned","2020-12-10T18:44:18Z"],["dc.date.available","2020-12-10T18:44:18Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3324/haematol.2019.216218"],["dc.identifier.eissn","1592-8721"],["dc.identifier.issn","0390-6078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78403"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.orgunit","Klinik für Hämatologie und Medizinische Onkologie"],["dc.title","CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","362"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Oncology"],["dc.bibliographiccitation.lastpage","370"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Overbeck, Tobias R."],["dc.contributor.author","Hupfeld, Timo"],["dc.contributor.author","Krause, Doris"],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Guedenzoph, Bjoern"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Inagaki, Nobuya"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T09:29:56Z"],["dc.date.available","2018-11-07T09:29:56Z"],["dc.date.issued","2013"],["dc.description.abstract","Patients with advanced-stage bronchial cancer benefit from systemic cytostatic therapy, in particular from regimens integrating cisplatin and taxanes. However, eventual disease progression leads to a fatal outcome in most cases, originating from tumor cells resisting chemotherapy. We here show that the intracellular ATP-binding cassette transporter A3 (ABCA3), previously recognized as critical for the secretion of surfactant components from type 2 pneumocytes, is expressed in non-small-cell lung cancer (NSCLC) cells. With some heterogeneity in a given specimen, expression levels detected immunohistochemically in primary cancer tissue were highest in adenocarcinomas and lowest in small cell lung cancers. Genetic silencing of ABCA3 in the NSCLC cell line models A549, NCI-H1650 and NCI-H1975 significantly increased tumor cell susceptibility to the cytostatic effects of both cisplatin (in all cell lines) and paclitaxel (in two of three cell lines). Taken together, ABCA3 emerges as a modulator of NSCLC cell susceptibility to cytostatic therapy. Copyright (c) 2013 S. Karger AG, Basel"],["dc.description.sponsorship","Faculty of Medicine, Georg August University Gottingen, Germany"],["dc.identifier.doi","10.1159/000348884"],["dc.identifier.isi","000320219100007"],["dc.identifier.pmid","23689165"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10826"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31175"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0030-2414"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Intracellular ATP-Binding Cassette Transporter A3 is Expressed in Lung Cancer Cells and Modulates Susceptibility to Cisplatin and Paclitaxel"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Bone Marrow Transplantation"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Hasenkamp, J."],["dc.contributor.author","Missal, Inga"],["dc.contributor.author","Borgerding, Andrea"],["dc.contributor.author","Falk, C. S."],["dc.contributor.author","Wommelsdorf, T."],["dc.contributor.author","Dingeldein, S."],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Jung, Werner"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Glass, Bertram"],["dc.date.accessioned","2018-11-07T11:03:23Z"],["dc.date.available","2018-11-07T11:03:23Z"],["dc.date.issued","2007"],["dc.format.extent","S139"],["dc.identifier.isi","000245207400373"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51607"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","London"],["dc.relation.conference","33rd Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation"],["dc.relation.eventlocation","Lyon, FRANCE"],["dc.relation.issn","0268-3369"],["dc.title","Incidence of allo-reactive NK cells after allogeneic haematopoietic stem cell transplantation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2704"],["dc.bibliographiccitation.issue","26"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.lastpage","2706"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Chapuy, Björn"],["dc.date.accessioned","2020-12-10T18:38:42Z"],["dc.date.available","2020-12-10T18:38:42Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1182/blood-2018-10-878629"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77415"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.orgunit","Klinik für Hämatologie und Medizinische Onkologie"],["dc.title","Tropism of PCNSL: is it all about autoantigens?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","220"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.lastpage","221"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Kaune, Kjell Matthias"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Steidl, Christian"],["dc.contributor.author","Ressel, A."],["dc.contributor.author","Baesecke, Joerg"],["dc.contributor.author","Glass, Bertram"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:12:10Z"],["dc.date.available","2018-11-07T10:12:10Z"],["dc.date.issued","2006"],["dc.identifier.isi","000235370600115"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40180"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","33rd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Aachen, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","Sweet-like bullous skin infiltrations in a chronic myeloic leucemia patient treated with tyrosine kinase inhibitors"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.volume","108"],["dc.contributor.author","Schreiter, Jessica"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Nayemia, Karim"],["dc.contributor.author","Chapuy, Bjoem"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Engel, Wolfgang"],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T08:57:49Z"],["dc.date.available","2018-11-07T08:57:49Z"],["dc.date.issued","2006"],["dc.format.extent","480A"],["dc.identifier.isi","000242440002204"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23491"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.publisher.place","Washington"],["dc.relation.eventlocation","Orlando, FL"],["dc.relation.issn","0006-4971"],["dc.title","Hematopoietic and endothelial progenitor cells from mouse adult testis derived stem cell lines."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Diering, Nina"],["dc.contributor.author","Aung, T."],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Koch, R."],["dc.contributor.author","Becker, S."],["dc.contributor.author","Krause, D."],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T08:38:49Z"],["dc.date.available","2018-11-07T08:38:49Z"],["dc.date.issued","2010"],["dc.format.extent","188"],["dc.identifier.isi","000282988401085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18846"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Putative tumor stem cells of SP phenotype in aggressive B-cell lymphoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","218"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Scandinavian Journal of Immunology"],["dc.bibliographiccitation.lastpage","229"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Hasenkamp, J."],["dc.contributor.author","Borgerding, A."],["dc.contributor.author","Uhrberg, M."],["dc.contributor.author","Falk, C."],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Wulf, G."],["dc.contributor.author","Jung, W."],["dc.contributor.author","Trümper, L."],["dc.contributor.author","Glass, B."],["dc.date.accessioned","2021-06-01T10:47:17Z"],["dc.date.available","2021-06-01T10:47:17Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1111/j.1365-3083.2007.02058.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85548"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1365-3083"],["dc.relation.issn","0300-9475"],["dc.title","Self-tolerance of Human Natural Killer Cells Lacking Self-HLA-specific Inhibitory Receptors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","24"],["dc.bibliographiccitation.issue","S1"],["dc.bibliographiccitation.journal","Hematological Oncology"],["dc.bibliographiccitation.lastpage","30"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Wienand, Kirsty"],["dc.contributor.author","Chapuy, Björn"],["dc.date.accessioned","2021-07-05T14:57:25Z"],["dc.date.available","2021-07-05T14:57:25Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1002/hon.2847"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87641"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-441"],["dc.relation.eissn","1099-1069"],["dc.relation.issn","0278-0232"],["dc.relation.orgunit","Klinik für Hämatologie und Medizinische Onkologie"],["dc.title","Molecular classification of aggressive lymphomas—past, present, future"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]