Menzel, Julia

[["dc.bibliographiccitation.firstpage","eaaz1436"],["dc.bibliographiccitation.issue","647"],["dc.bibliographiccitation.journal","Science Signaling"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Kownatzki-Danger, Daniel"],["dc.contributor.author","Tokar, Sergiy"],["dc.contributor.author","Ballone, Alice"],["dc.contributor.author","Unthan-Fechner, Kirsten"],["dc.contributor.author","Kilisch, Markus"],["dc.contributor.author","Lenz, Christof"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Mori, Mattia"],["dc.contributor.author","Ottmann, Christian"],["dc.contributor.author","Shattock, Michael J."],["dc.contributor.author","Lehnart, Stephan E."],["dc.contributor.author","Schwappach, Blanche"],["dc.date.accessioned","2021-04-14T08:32:51Z"],["dc.date.available","2021-04-14T08:32:51Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1126/scisignal.aaz1436"],["dc.identifier.pmid","32873725"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84038"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/68"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/368"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/126"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A07: Rolle der TRC40-Maschinerie im Proteostase-Netzwerk von Kardiomyozyten"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation.eissn","1937-9145"],["dc.relation.issn","1945-0877"],["dc.relation.workinggroup","RG Lehnart"],["dc.relation.workinggroup","RG Schwappach (Membrane Protein Biogenesis)"],["dc.relation.workinggroup","RG Lenz"],["dc.relation.workinggroup","RG Urlaub (Bioanalytische Massenspektrometrie)"],["dc.title","14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1790"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.lastpage","1801"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Fakuade, Funsho E"],["dc.contributor.author","Steckmeister, Vanessa"],["dc.contributor.author","Seibertz, Fitzwilliam"],["dc.contributor.author","Gronwald, Judith"],["dc.contributor.author","Kestel, Stefanie"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Pronto, Julius Ryan D"],["dc.contributor.author","Taha, Karim"],["dc.contributor.author","Haghighi, Fereshteh"],["dc.contributor.author","Voigt, Niels"],["dc.date.accessioned","2021-08-12T07:45:13Z"],["dc.date.available","2021-08-12T07:45:13Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract Aims  Atrial fibrillation (AF) is a commonly occurring arrhythmia after cardiac surgery (postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced atrial contractile function is a predictor of poAF and that Ca2+ plays an important role in both excitation–contraction coupling and atrial arrhythmogenesis, this study aims to test whether alterations of intracellular Ca2+ handling contribute to impaired atrial contractility and to the arrhythmogenic substrate predisposing patients to poAF. Methods and results  Right atrial appendages were obtained from patients in sinus rhythm undergoing open-heart surgery. Cardiomyocytes were investigated by simultaneous measurement of [Ca2+]i and action potentials (APs, patch-clamp). Patients were followed-up for 6 days to identify those with and without poAF. Speckle-tracking analysis of preoperative echocardiography revealed reduced left atrial contraction strain in poAF patients. At the time of surgery, cellular Ca2+ transients (CaTs) and the sarcoplasmic reticulum (SR) Ca2+ content were smaller in the poAF group. CaT decay was slower in poAF, but the decay of caffeine-induced Ca2+ transients was unaltered, suggesting preserved sodium-calcium exchanger function. In agreement, western blots revealed reduced SERCA2a expression in poAF patients but unaltered phospholamban expression/phosphorylation. Computational modelling indicated that reduced SERCA activity promotes occurrence of CaT and AP alternans. Indeed, alternans of CaT and AP occurred more often and at lower stimulation frequencies in atrial myocytes from poAF patients. Resting membrane potential and AP duration were comparable between both groups at various pacing frequencies (0.25–8 Hz). Conclusions  Biochemical, functional, and modelling data implicate reduced SERCA-mediated Ca2+ reuptake into the SR as a major contributor to impaired preoperative atrial contractile function and to the pre-existing arrhythmogenic substrate in patients developing poAF."],["dc.description.abstract","Abstract Aims  Atrial fibrillation (AF) is a commonly occurring arrhythmia after cardiac surgery (postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced atrial contractile function is a predictor of poAF and that Ca2+ plays an important role in both excitation–contraction coupling and atrial arrhythmogenesis, this study aims to test whether alterations of intracellular Ca2+ handling contribute to impaired atrial contractility and to the arrhythmogenic substrate predisposing patients to poAF. Methods and results  Right atrial appendages were obtained from patients in sinus rhythm undergoing open-heart surgery. Cardiomyocytes were investigated by simultaneous measurement of [Ca2+]i and action potentials (APs, patch-clamp). Patients were followed-up for 6 days to identify those with and without poAF. Speckle-tracking analysis of preoperative echocardiography revealed reduced left atrial contraction strain in poAF patients. At the time of surgery, cellular Ca2+ transients (CaTs) and the sarcoplasmic reticulum (SR) Ca2+ content were smaller in the poAF group. CaT decay was slower in poAF, but the decay of caffeine-induced Ca2+ transients was unaltered, suggesting preserved sodium-calcium exchanger function. In agreement, western blots revealed reduced SERCA2a expression in poAF patients but unaltered phospholamban expression/phosphorylation. Computational modelling indicated that reduced SERCA activity promotes occurrence of CaT and AP alternans. Indeed, alternans of CaT and AP occurred more often and at lower stimulation frequencies in atrial myocytes from poAF patients. Resting membrane potential and AP duration were comparable between both groups at various pacing frequencies (0.25–8 Hz). Conclusions  Biochemical, functional, and modelling data implicate reduced SERCA-mediated Ca2+ reuptake into the SR as a major contributor to impaired preoperative atrial contractile function and to the pre-existing arrhythmogenic substrate in patients developing poAF."],["dc.identifier.doi","10.1093/cvr/cvaa162"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88398"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1755-3245"],["dc.relation.issn","0008-6363"],["dc.title","Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","523"],["dc.bibliographiccitation.lastpage","587"],["dc.contributor.author","Ho Yoon, Jung"],["dc.contributor.author","Jung, Hyung-Suk"],["dc.contributor.author","Hwan Lee, Min"],["dc.contributor.author","Hwan Kim, Gun"],["dc.contributor.author","Ji Song, Seul"],["dc.contributor.author","Yeong Seok, Jun"],["dc.contributor.author","Jean Yoon, Kyung"],["dc.contributor.author","Seong Hwang, Cheol"],["dc.contributor.author","Besland, M.-P."],["dc.contributor.author","Tranchant, J."],["dc.contributor.author","Souchier, E."],["dc.contributor.author","Moreau, P."],["dc.contributor.author","Salmon, S."],["dc.contributor.author","Corraze, B."],["dc.contributor.author","Janod, E."],["dc.contributor.author","Cario, L."],["dc.contributor.author","Zazpe, Raúl"],["dc.contributor.author","Ungureanu, Mariana"],["dc.contributor.author","Llopis, Roger"],["dc.contributor.author","Golmar, Federico"],["dc.contributor.author","Stoliar, Pablo"],["dc.contributor.author","Casanova, Félix"],["dc.contributor.author","Eduardo Hueso, Luis"],["dc.contributor.author","Hermes, C."],["dc.contributor.author","Wimmer, M."],["dc.contributor.author","Menzel, S."],["dc.contributor.author","Fleck, K."],["dc.contributor.author","Rana, V."],["dc.contributor.author","Salinga, M."],["dc.contributor.author","Böttger, U."],["dc.contributor.author","Bruchhaus, R."],["dc.contributor.author","Wuttig, M."],["dc.contributor.author","Waser, R."],["dc.contributor.author","Lentz, F."],["dc.contributor.author","Hermes, C."],["dc.contributor.author","Rösgen, B."],["dc.contributor.author","Selle, T."],["dc.contributor.author","Bruchhaus, R."],["dc.contributor.author","Rana, V."],["dc.contributor.author","Waser, R."],["dc.contributor.author","Marchewka, Astrid"],["dc.contributor.author","Menzel, Stephan"],["dc.contributor.author","Böttger, Ulrich"],["dc.contributor.author","Waser, Rainer"],["dc.contributor.author","Hoskins, Brian"],["dc.contributor.author","Alibart, Fabien"],["dc.contributor.author","Strukov, Dmitri"],["dc.contributor.author","Pellegrino, Luca"],["dc.contributor.author","Manca, Nicola"],["dc.contributor.author","Kanki, Teruo"],["dc.contributor.author","Tanaka, Hidekazu"],["dc.contributor.author","Biasotti, Michele"],["dc.contributor.author","Bellingeri, Emilio"],["dc.contributor.author","Sergio Siri, Antonio"],["dc.contributor.author","Marré, Daniele"],["dc.contributor.author","M. Padilha, Antonio Claudio"],["dc.contributor.author","Martini Dalpian, Gustavo"],["dc.contributor.author","Reily Rocha, Alexandre"],["dc.contributor.author","Prodromakis, Themistoklis"],["dc.contributor.author","Salaoru, Iulia"],["dc.contributor.author","Khiat, Ali"],["dc.contributor.author","Toumazou, Christopher"],["dc.contributor.author","Gale, Ella M."],["dc.contributor.author","Madhavan, A."],["dc.contributor.author","Adam, G."],["dc.contributor.author","Alibart, F."],["dc.contributor.author","Gao, L."],["dc.contributor.author","Strukov, D. B."],["dc.contributor.author","Wamwangi, D."],["dc.contributor.author","Welnic, W."],["dc.contributor.author","Wuttig, M."],["dc.contributor.author","Gholipour, Behrad"],["dc.contributor.author","Huang, Chung-Che"],["dc.contributor.author","Anastasopoulos, Alexandros"],["dc.contributor.author","Al-Saab, Feras"],["dc.contributor.author","Hayden, Brian E."],["dc.contributor.author","Hewak, Daniel W."],["dc.contributor.author","Lan, Rui"],["dc.contributor.author","Endo, Rie"],["dc.contributor.author","Kuwahara, Masashi"],["dc.contributor.author","Kobayashi, Yoshinao"],["dc.contributor.author","Susa, Masahiro"],["dc.contributor.author","Baumeister, Paul"],["dc.contributor.author","Wortmann, Daniel"],["dc.contributor.author","Blügel, Stefan"],["dc.contributor.author","Mazzarello, Riccardo"],["dc.contributor.author","Li, Yan"],["dc.contributor.author","Zhang, Wei"],["dc.contributor.author","Ronneberger, Ider"],["dc.contributor.author","Simon, Ronnie"],["dc.contributor.author","Gallus, Jens"],["dc.contributor.author","Bessas, Dimitrios"],["dc.contributor.author","Sergueev, Ilya"],["dc.contributor.author","Wille, Hans-Christian"],["dc.contributor.author","Pierre Hermann, Raphaël"],["dc.contributor.author","Luckas, Jennifer"],["dc.contributor.author","Rausch, Pascal"],["dc.contributor.author","Krebs, Daniel"],["dc.contributor.author","Zalden, Peter"],["dc.contributor.author","Boltz, Janika"],["dc.contributor.author","Raty, Jean-Yves"],["dc.contributor.author","Salinga, Martin"],["dc.contributor.author","Longeaud, Christophe"],["dc.contributor.author","Wuttig, Matthias"],["dc.contributor.author","Kim, Haeri"],["dc.contributor.author","Kim, Dong-Wook"],["dc.contributor.author","Phark, Soo-Hyon"],["dc.contributor.author","Hong, Seungbum"],["dc.contributor.author","Park, C."],["dc.contributor.author","Herpers, A."],["dc.contributor.author","Bruchhaus, R."],["dc.contributor.author","Verbeeck, J."],["dc.contributor.author","Egoavil, R."],["dc.contributor.author","Borgatti, F."],["dc.contributor.author","Panaccione, G."],["dc.contributor.author","Offi, F."],["dc.contributor.author","Dittmann, R."],["dc.contributor.author","Clima, Sergiu"],["dc.contributor.author","Sankaran, Kiroubanand"],["dc.contributor.author","Mees, Maarten"],["dc.contributor.author","Yin Chen, Yang"],["dc.contributor.author","Goux, Ludovic"],["dc.contributor.author","Govoreanu, Bogdan"],["dc.contributor.author","Wouters, Dirk J."],["dc.contributor.author","Kittl, Jorge"],["dc.contributor.author","Jurczak, Malgorzata"],["dc.contributor.author","Pourtois, Geoffrey"],["dc.contributor.author","Calka, P."],["dc.contributor.author","Martinez, E."],["dc.contributor.author","Delaye, V."],["dc.contributor.author","Lafond, D."],["dc.contributor.author","Audoit, G."],["dc.contributor.author","Mariolle, D."],["dc.contributor.author","Chevalier, N."],["dc.contributor.author","Grampeix, H."],["dc.contributor.author","Cagli, C."],["dc.contributor.author","Jousseaume, V."],["dc.contributor.author","Guedj, C."],["dc.contributor.author","Shrestha, Pragya"],["dc.contributor.author","Ochia, Adaku"],["dc.contributor.author","Cheung, Kin. P."],["dc.contributor.author","Campbell, Jason"],["dc.contributor.author","Baumgart, Helmut"],["dc.contributor.author","Harris, Gary"],["dc.contributor.author","Scherff, Malte"],["dc.contributor.author","Meyer, Bjoern"],["dc.contributor.author","Scholz, Julius"],["dc.contributor.author","Hoffmann, Joerg"],["dc.contributor.author","Jooss, Christian"],["dc.contributor.author","Xiao, Bo"],["dc.contributor.author","Tada, Tomofumi"],["dc.contributor.author","Gu, Tingkun"],["dc.contributor.author","Tawara, Arihiro"],["dc.contributor.author","Watanabe, Satoshi"],["dc.contributor.author","Young, Tai-Fa"],["dc.contributor.author","Yang, Ya-Liang"],["dc.contributor.author","Chang, Ting-Chang"],["dc.contributor.author","Hsu, Kuang-Ting"],["dc.contributor.author","Chen, Chao-Yu"],["dc.contributor.author","Burkert, A"],["dc.contributor.author","Valov, I."],["dc.contributor.author","Staikov, G."],["dc.contributor.author","Waser, R."],["dc.contributor.author","van den Hurk, Jan"],["dc.contributor.author","Valov, Ilia"],["dc.contributor.author","Waser, Rainer"],["dc.contributor.author","Valov, Ilia"],["dc.contributor.author","Tappertzhofen, Stefan"],["dc.contributor.author","van der Hurk, Jan"],["dc.contributor.author","Waser, Rainer"],["dc.contributor.author","Adam, G."],["dc.contributor.author","Alibart, F."],["dc.contributor.author","Gao, L."],["dc.contributor.author","Hoskins, B."],["dc.contributor.author","Strukov, D. B."],["dc.contributor.author","Jean Yoon, Kyung"],["dc.contributor.author","Ji Song, Seul"],["dc.contributor.author","Kim, Gun Hwan"],["dc.contributor.author","Seok, Jun Yeong"],["dc.contributor.author","Ho Yoon, Jeong"],["dc.contributor.author","Seong Hwang, Cheol"],["dc.contributor.author","Yoon, Jung Ho"],["dc.contributor.author","Yoon, Kyung Jin"],["dc.contributor.author","Shuai, Yao"],["dc.contributor.author","Wu, Chuangui"],["dc.contributor.author","Zhang, Wanli"],["dc.contributor.author","Zhou, Shengqiang"],["dc.contributor.author","Bürger, Danilo"],["dc.contributor.author","Slesazeck, Stefan"],["dc.contributor.author","Mikolajick, Thomas"],["dc.contributor.author","Helm, Manfred"],["dc.contributor.author","Schmidt, Heidemarie"],["dc.contributor.author","Gale, Ella"],["dc.contributor.author","Pearson, David"],["dc.contributor.author","Kitson, Stephen"],["dc.contributor.author","Adamatzky, Andrew"],["dc.contributor.author","Costello, Ben de Lacy"],["dc.contributor.author","Lehtonen, Eero"],["dc.contributor.author","Poikonen, Jussi"],["dc.contributor.author","Laiho, Mika"],["dc.contributor.author","Kanerva, Pentti"],["dc.contributor.author","Lim, Hyungkwang"],["dc.contributor.author","Jang, Ho-won"],["dc.contributor.author","Jeong, Doo Seok"],["dc.contributor.author","Cao, Xun"],["dc.contributor.author","Jiang, Meng"],["dc.contributor.author","Zhang, Feng"],["dc.contributor.author","Liu, Xinjun"],["dc.contributor.author","Jin, Ping"],["dc.contributor.author","Zhang, Kai"],["dc.contributor.author","Tangirala, Madhavi"],["dc.contributor.author","Shrestha, Pragya"],["dc.contributor.author","Baumgart, Helmut"],["dc.contributor.author","Kittiwatanakul, Salinporn"],["dc.contributor.author","Lu, Jiwei"],["dc.contributor.author","Wolf, Stuart"],["dc.contributor.author","Pallem, Venkateswara"],["dc.contributor.author","Dussarrat, Christian"],["dc.contributor.author","Pinto, S."],["dc.contributor.author","Krishna, R."],["dc.contributor.author","Dias, C."],["dc.contributor.author","Pimentel, G."],["dc.contributor.author","Oliveira, G. N. P."],["dc.contributor.author","Teixeira, J. M."],["dc.contributor.author","Aguiar, P."],["dc.contributor.author","Titus, E."],["dc.contributor.author","Gracio, J."],["dc.contributor.author","Ventura, J."],["dc.contributor.author","Araujo, J. P."],["dc.contributor.editor","Heber, Jörg"],["dc.contributor.editor","Schlom, Darrell"],["dc.contributor.editor","Tokura, Yoshinori"],["dc.contributor.editor","Waser, Rainer"],["dc.contributor.editor","Wuttig, Matthias"],["dc.date.accessioned","2021-12-08T12:29:05Z"],["dc.date.available","2021-12-08T12:29:05Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1002/9783527667703.ch67"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95954"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.publisher","Wiley-VCH Verlag GmbH & Co. KGaA"],["dc.publisher.place","Weinheim, Germany"],["dc.relation.eisbn","9783527667703"],["dc.relation.isbn","9783527411917"],["dc.relation.ispartof","Frontiers in Electronic Materials : \n A Collection of Extended Abstracts of the Nature Conference Frontiers in Electronic Materials, June 17\n th\n to 20\n th\n 2012, Aachen, Germany"],["dc.title","Poster: Memristive Systems"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","200"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Medical Genetics"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Witsch-Baumgartner, M."],["dc.contributor.author","Schwentner, I."],["dc.contributor.author","Gruber, M."],["dc.contributor.author","Benlian, P."],["dc.contributor.author","Bertranpetit, J."],["dc.contributor.author","Bieth, E."],["dc.contributor.author","Chevy, F."],["dc.contributor.author","Clusellas, N."],["dc.contributor.author","Estivill, X."],["dc.contributor.author","Gasparini, G."],["dc.contributor.author","Giros, M."],["dc.contributor.author","Kelley, R. I."],["dc.contributor.author","Krajewska-Walasek, M."],["dc.contributor.author","Menzel, J."],["dc.contributor.author","Miettinen, T."],["dc.contributor.author","Ogorelkova, M."],["dc.contributor.author","Rossi, M."],["dc.contributor.author","Scala, I."],["dc.contributor.author","Schinzel, A."],["dc.contributor.author","Schmidt, K."],["dc.contributor.author","Schoenitzer, D."],["dc.contributor.author","Seemanova, E."],["dc.contributor.author","Sperling, K."],["dc.contributor.author","Syrrou, M."],["dc.contributor.author","Talmud, P. J."],["dc.contributor.author","Wollnik, Bernd"],["dc.contributor.author","Krawczak, M."],["dc.contributor.author","Labuda, D."],["dc.contributor.author","Utermann, G."],["dc.date.accessioned","2017-09-07T11:48:45Z"],["dc.date.available","2017-09-07T11:48:45Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Smith-Lemli-Opitz syndrome (SLOS) (MIM 270 400) is an autosomal recessive multiple congenital anomalies/mental retardation syndrome caused by mutations in the Delta 7-sterol reductase (DHCR7, E.C.1.3.1.21) gene. The prevalence of SLOS has been estimated to range between 1: 15000 and 1: 60000 in populations of European origin. Methods and results: We have analysed the frequency, origin, and age of DHCR7 mutations in European populations. In 263 SLOS patients 10 common alleles (c.964-1G>C, p.Trp151X, p.Thr93Met, p.Val326Leu, p.Arg352Trp, p.Arg404Cys, p.Phe302Leu, p.Leu157Pro, p.Gly410Ser, p.Arg445Gln) were found to constitute approximately 80% of disease-causing mutations. As reported before, the mutational spectra differed significantly between populations, and frequency peaks of common mutations were observed in North-West (c.9641G>C), North-East (p.Trp151X, p.Val326Leu) and Southern Europe (p.Thr93Met). SLOS was virtually absent from Finland. The analysis of nearly 8000 alleles from 10 different European populations confirmed a geographical distribution of DHCR7 mutations as reported in previous studies. The common Null mutations in Northern Europe (combined ca. 1: 70) occurred at a much higher frequency than expected from the reported prevalence of SLOS. In contrast the most common mutation in Mediterranean SLOS patients (p.Thr93Met) had a low population frequency. Haplotypes were constructed for SLOS chromosomes, and for wild-type chromosomes of African and European origins using eight cSNPs in the DHCR7 gene. The DHCR7 orthologue was sequenced in eight chimpanzees (Pan troglodytes) and three microsatellites were analysed in 50 of the SLOS families in order to estimate the age of the three major SLOS-causing mutations. Conclusions: The results indicate a time of first appearance of c.964-1G>C and p.Trp151X some 3000 years ago in North-West and North-East Europe, respectively. The p.Thr93Met mutations on the J haplotype has probably first arisen approximately 6000 years ago in the Eastern Mediterranean. Together, it appears that a combination of founder effects, recurrent mutations, and drift have shaped the present frequency distribution of DHCR7 mutations in Europe."],["dc.identifier.doi","10.1136/jmg.2007.053520"],["dc.identifier.gro","3143326"],["dc.identifier.isi","000254562600002"],["dc.identifier.pmid","17965227"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/828"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0022-2593"],["dc.title","Age and origin of major Smith-Lemli-Opitz syndrome (SLOS) mutations in European populations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","914286"],["dc.bibliographiccitation.journal","Frontiers in Cell and Developmental Biology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Stiekema, Merel"],["dc.contributor.author","Houben, Frederik"],["dc.contributor.author","Verheyen, Fons"],["dc.contributor.author","Borgers, Marcel"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Meschkat, Martin"],["dc.contributor.author","van Zandvoort, Marc A. M. J."],["dc.contributor.author","Ramaekers, Frans C. S."],["dc.contributor.author","Broers, Jos L. V."],["dc.date.accessioned","2022-09-01T09:51:06Z"],["dc.date.available","2022-09-01T09:51:06Z"],["dc.date.issued","2022"],["dc.description.abstract","Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds. We define the NR as tubular invaginations consisting of either both the inner and outer nuclear membrane, or only the inner nuclear membrane. Specifically, invaginations of both the inner and outer nuclear membrane are also called type II NR, while those of only the inner nuclear membrane are defined as type I NR. The formation and structure of the NR is determined by proteins associated to the nuclear membrane, which induce a high membrane curvature leading to tubular invaginations. Here we review and discuss the current knowledge of nuclear invaginations and the NR in particular. An increase in tubular invaginations of the nuclear envelope is associated with several pathologies, such as laminopathies, cancer, (reversible) heart failure, and Alzheimer’s disease. Furthermore, viruses can induce both type I and II NR. In laminopathies, the amount of A-type lamins throughout the nucleus is generally decreased or the organization of lamins or lamin-associated proteins is disturbed. Also, lamin overexpression or modulation of lamin farnesylation status impacts NR formation, confirming the importance of lamin processing in NR formation. Virus infections reorganize the nuclear lamina\n via\n (de)phosphorylation of lamins, leading to an uneven thickness of the nuclear lamina and in turn lobulation of the nuclear membrane and the formation of invaginations of the inner nuclear membrane. Since most studies on the NR have been performed with cell cultures, we present additional proof for the existence of these structures\n in vivo\n , focusing on a variety of differentiated cardiovascular and hematopoietic cells. Furthermore, we substantiate the knowledge of the lamin composition of the NR by super-resolution images of the lamin A/C and B1 organization. Finally, we further highlight the essential role of lamins in NR formation by demonstrating that (over)expression of lamins can induce aberrant NR structures."],["dc.identifier.doi","10.3389/fcell.2022.914286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113882"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2296-634X"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","GMS Medizinische Informatik, Biometrie und Epidemiologie"],["dc.bibliographiccitation.lastpage","10"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Weil, Philipp"],["dc.contributor.author","Nussbeck, Sara Y."],["dc.date.accessioned","2019-01-17T16:26:02Z"],["dc.date.available","2019-01-17T16:26:02Z"],["dc.date.issued","2015"],["dc.description.abstract","In the last few years electronic laboratory notebooks (ELNs) have become popular. ELNs offer the great possibility to capture metadata automatically. Due to the high documentation effort metadata documentation is neglected in science. To close the gap between good data documentation and high documentation effort for the scientists a first user-friendly solution to capture metadata in an easy way was developed. At first, different protocols for the Western Blot were collected within the Collaborative Research Center 1002 and analyzed. Together with existing metadata standards identified in a literature search a first version of the metadata scheme was developed. Secondly, the metadata scheme was customized for future users including the implementation of default values for automated metadata documentation. Twelve protocols for the Western Blot were used to construct one standard protocol with ten different experimental steps. Three already existing metadata standards were used as models to construct the first version of the metadata scheme consisting of 133 data fields in ten experimental steps. Through a revision with future users the final metadata scheme was shortened to 90 items in three experimental steps. Using individualized default values 51.1% of the metadata can be captured with present values in the ELN. This lowers the data documentation effort. At the same time, researcher could benefit by providing standardized metadata for data sharing and re-use."],["dc.description.abstract","In den letzten Jahren sind elektronische Laborbücher (ELNs) immer populärer geworden. ELNs bieten die Möglichkeit Metadaten automatisch zu erfassen. Durch den hohen Dokumentationsaufwand wird die Erfassung von Metadaten in den Naturwissenschaften oft vernachlässigt. Um die Lücke zwischen guter Datendokumentation und einem hohen Dokumentationsaufwand zu schließen, wurde ein nutzerfreundliches System in einem ELN entwickelt, um Metadaten vereinfacht zu erfassen. Zuerst wurden Western Blot Protokolle im Sonderforschungsbereich 1002 gesammelt und analysiert. Zusammen mit in einer Literaturrecherche identifizierten existierenden Metadatenstandards wurde eine erste Version des Metadatenschemas entwickelt. Im zweiten Schritt wurde das Metadatenschema durch die Umsetzung von individualisierten Default-Werten an die zukünftigen Nutzer angepasst. Zwölf Protokolle des Western Blot wurden auf ein Standardprotokoll aus zehn unterschiedlichen experimentellen Schritten reduziert. Drei bereits existierende Metadatenstandards wurden als Vorlage verwendet, um die erste Version des Metadatenschemas zu erstellen. Dieses bestand aus 133 Datenfeldern in zehn experimentellen Schritten. Während der gemeinsamen Überarbeitung mit den zukünftigen Nutzern wurde die finale Version des Metadatenschemas auf 90 Datenfelder in drei experimentellen Schritten gekürzt. Durch die Integration von Default-Werten können 51,1% der Metadaten vereinfacht erfasst werden. Dadurch wird der Dokumentationsaufwand verringert und gleichzeitig können Wissenschaftler durch die Bereitstellung von standardisierten Metadaten bei Datenaustausch oder der Datennachnutzung profitieren."],["dc.identifier.doi","10.3205/mibe000162"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57351"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/91"],["dc.language.iso","en"],["dc.notes.status","fcwi"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | INF: Unterstützung der SFB 1002 Forschungsdatenintegration, -visualisierung und -nachnutzung"],["dc.relation.issn","1860-9171"],["dc.relation.workinggroup","RG Nußbeck"],["dc.title","Metadata capture in an electronic notebook: How to make it as simple as possible?"],["dc.title.subtitle","Metadatenerfassung in einem elektronischen Laborbuch: Wie macht man es so einfach wie möglich?"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","631"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","EMBO reports"],["dc.bibliographiccitation.lastpage","634"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Nussbeck, Sara Y."],["dc.contributor.author","Weil, Philipp"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Marzec, Bartlomiej"],["dc.contributor.author","Lorberg, Kai"],["dc.contributor.author","Schwappach, Blanche"],["dc.date.accessioned","2017-09-07T11:46:13Z"],["dc.date.available","2017-09-07T11:46:13Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.15252/embr.201338358"],["dc.identifier.gro","3142110"],["dc.identifier.isi","000337360300005"],["dc.identifier.pmid","24833749"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4655"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/43"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | INF: Unterstützung der SFB 1002 Forschungsdatenintegration, -visualisierung und -nachnutzung"],["dc.relation.eissn","1469-3178"],["dc.relation.issn","1469-221X"],["dc.relation.workinggroup","RG Nußbeck"],["dc.relation.workinggroup","RG Schwappach (Membrane Protein Biogenesis)"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","The laboratory notebook in the 21st century The electronic laboratory notebook would enhance good scientific practice and increase research productivity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","380"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nanoscale"],["dc.bibliographiccitation.lastpage","387"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Kraxner, Julia"],["dc.contributor.author","Lorenz, Charlotta"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Parfentev, Iwan"],["dc.contributor.author","Silbern, Ivan"],["dc.contributor.author","Denz, Manuela"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Schwappach, Blanche"],["dc.contributor.author","Köster, Sarah"],["dc.date.accessioned","2021-09-01T06:42:51Z"],["dc.date.available","2021-09-01T06:42:51Z"],["dc.date.issued","2021"],["dc.description.abstract","The mechanical properties of biological cells are determined by the cytoskeleton, a composite biopolymer network consisting of microtubules, actin filaments and intermediate filaments (IFs). By differential expression of cytoskeletal proteins, modulation of the network architecture and interactions between the filaments, cell mechanics may be adapted to varying requirements on the cell. Here, we focus on the intermediate filament protein vimentin and introduce post-translational modifications as an additional, much faster mechanism for mechanical modulation. We study the impact of phosphorylation on filament mechanics by recording force-strain curves using optical traps. Partial phosphorylation softens the filaments. We show that binding of the protein 14-3-3 to phosphorylated vimentin IFs further enhances this effect and speculate that in the cell 14-3-3 may serve to preserve the softening and thereby the altered cell mechanics. We explain our observation by the additional charges introduced during phosphorylation."],["dc.identifier.doi","10.1039/D0NR07322A"],["dc.identifier.pmid","33351020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89158"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/132"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/91"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | A08: Die Rolle post-translational modifizierter Proteine in der synaptischen Übertragung"],["dc.relation.eissn","2040-3372"],["dc.relation.issn","2040-3364"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Köster (Cellular Biophysics)"],["dc.relation.workinggroup","RG Schwappach (Membrane Protein Biogenesis)"],["dc.relation.workinggroup","RG Urlaub (Bioanalytische Massenspektrometrie)"],["dc.rights","CC BY 3.0"],["dc.subject.gro","cytoskeleton"],["dc.subject.gro","cellular biophysics"],["dc.title","Post-translational modifications soften vimentin intermediate filaments"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Kraxner, Julia"],["dc.contributor.author","Lorenz, Charlotta"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Parfentev, Iwan"],["dc.contributor.author","Silbern, Ivan"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Schwappach, Blanche"],["dc.contributor.author","Köster, Sarah"],["dc.date.accessioned","2020-06-29T07:24:15Z"],["dc.date.available","2020-06-29T07:24:15Z"],["dc.date.issued","2020"],["dc.description.abstract","The mechanical properties of biological cells are determined by the cytoskeleton, a composite biopolymer network consisting of microtubules, actin filaments and intermediate filaments (IFs). By differential expression of the cytoskeletal proteins, modulation of the network architecture and the interactions between the filaments, cell mechanics may be adapted to varying requirements on the cell. Here, we focus on the intermediate filament protein vimentin and introduce post-translational modifications as an additional, much faster mechanism for mechanical modulation. We study the impact of phosphorylation on filament mechanics by recording precise force-strain curves using optical traps. Whereas full phosphorylation leads to disassembly of IFs, partial phosphorylation results in softening of the filaments. We show that binding of the protein 14–3–3 to phosphorylated vimentin IFs further enhances this effect and speculate that in the cell 14–3–3 may serve to preserve the softening and thereby the altered cell mechanics. By employing phosphomimetic mutants and complementary Monte Carlo simulations, we explain our observation through the additional charges introduced during."],["dc.identifier.doi","10.1101/2020.06.05.135780"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66763"],["dc.language.iso","en"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.subject.gro","cellular biophysics"],["dc.title","Post-Translational Modifications Soften Intermediate Filaments"],["dc.type","preprint"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1108"],["dc.bibliographiccitation.lastpage","1108"],["dc.contributor.author","Menzel, Julia"],["dc.contributor.author","Weil, Philipp"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Mathieu, Nadine"],["dc.contributor.author","Demiroglu, Sara Y."],["dc.date.accessioned","2019-01-14T14:59:13Z"],["dc.date.available","2019-01-14T14:59:13Z"],["dc.date.issued","2013"],["dc.description.abstract","Sustainable data management in biomedical research requires documentation of metadata for all experiments and results. Scientists usually document research data and metadata in laboratory paper notebooks. An electronic laboratory notebook (ELN) can keep metadata linked to research data resulting in a better understanding of the research results, meaning a scientific benefit [1]. Besides other challenges [2], the biggest hurdles for introducing an ELN seem to be usability, file formats, and data entry mechanisms [3] and that many ELNs are assigned to specific research fields such as biology, chemistry, or physics [4]. We aimed to identify requirements for the introduction of ELN software in a biomedical collaborative research center [5] consisting of different scientific fields and to find software fulfilling most of these requirements."],["dc.identifier.doi","10.3233/978-1-61499-289-9-1108"],["dc.identifier.pmid","23920882"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57309"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/38"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | INF: Unterstützung der SFB 1002 Forschungsdatenintegration, -visualisierung und -nachnutzung"],["dc.relation.eisbn","978-1-61499-289-9"],["dc.relation.isbn","978-1-61499-288-2"],["dc.relation.ispartof","MEDINFO 2013"],["dc.relation.ispartofseries","Studies in Health Technology and Informatics; 192"],["dc.relation.workinggroup","RG Nußbeck"],["dc.title","Requirement Analysis for an Electronic Laboratory Notebook for Sustainable Data Management in Biomedical Research"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]