Now showing 1 - 8 of 8
  • 2009Journal Article
    [["dc.bibliographiccitation.firstpage","3343"],["dc.bibliographiccitation.issue","9b"],["dc.bibliographiccitation.journal","Journal of Cellular and Molecular Medicine"],["dc.bibliographiccitation.lastpage","3357"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Probst-Kepper, M."],["dc.contributor.author","Geffers, R."],["dc.contributor.author","Kröger, A."],["dc.contributor.author","Viegas, N."],["dc.contributor.author","Erck, C."],["dc.contributor.author","Hecht, H.-J."],["dc.contributor.author","Lünsdorf, H."],["dc.contributor.author","Roubin, R."],["dc.contributor.author","Moharregh-Khiabani, D."],["dc.contributor.author","Wagner, K."],["dc.contributor.author","Weiss, S."],["dc.date.accessioned","2021-12-08T12:27:54Z"],["dc.date.available","2021-12-08T12:27:54Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1111/j.1582-4934.2009.00782.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95489"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.issn","1582-1838"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","GARP: a key receptor controlling FOXP3 in human regulatory T cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2017-12-04Journal Article Research Paper
    [["dc.bibliographiccitation.artnumber","76"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Pharmacology & Toxicology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Arnold, Inken"],["dc.contributor.author","Straube, Kati"],["dc.contributor.author","Himmel, Wolfgang"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Weiß, Vivien"],["dc.contributor.author","Heyden, Laura Miriam"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-04-18T14:43:20Z"],["dc.date.accessioned","2021-10-27T13:21:05Z"],["dc.date.available","2018-04-18T14:43:20Z"],["dc.date.available","2021-10-27T13:21:05Z"],["dc.date.issued","2017-12-04"],["dc.date.updated","2018-04-18T14:43:20Z"],["dc.description.abstract","Background Many elderly patients receive psychotropic drugs. Treatment with psychotropic agents is associated with serious side effects including an increased risk of falls and fractures. Several psychotropic drugs are considered potentially inappropriate for treatment of the elderly. Methods A retrospective chart review was conducted covering all patients aged ≥ 65 years who were admitted to Evangelisches Krankenhaus Göttingen-Weende between 01/01/2013 and 03/31/2013. Psychotropic drugs reviewed for included benzodiazepines, Z-drugs, antidepressants and neuroleptics, but not drugs for sedation during artificial ventilation or pre-medication before surgery. Potentially inappropriate drugs were identified according to the PRISCUS list. To assess which factors were associated with the administration of psychotropic drugs, univariate and multivariable logistic regression analyses were performed. Results The charts of 2130 patients (1231 women) were analyzed. 53.9% of all patients received at least one psychotropic medication (29.5% benzodiazepines, 12.6% Z-drugs, 22.2% antidepressants, 11.9% neuroleptics). The mean number of psychotropic drugs prescribed per patient with at least one prescription was 1.6. Patients treated in the geriatric department most often received antidepressants (45.0%), neuroleptics (20.6%) and Z-drugs (27.5%). Benzodiazepines and Z-drugs were prescribed mostly as medication on demand (77.7% of benzodiazepines, 73.9% of Z-drugs). Surgical patients most frequently received benzodiazepines (37.1%). Nearly one-third of all patients ≥ 65 years was treated with at least one potentially inappropriate psychotropic medication. The mean number of potentially inappropriate psychotropic medications per patient with at least one psychotropic prescription was 0.69. The percentage of patients with potentially inappropriate psychotropic medication was highest in the surgical departments (74.1%). Female gender (adjusted OR 1.36; 95% CI 1.14 to 1.63), stay in the Department of Geriatrics (2.69; 2.01 to 3.60) or the interdisciplinary intensive care unit (1.87; 1.33 to 2.64) and age ≥ 85 years (1.33; 1.10 to 1.60) were associated with psychotropic drug treatment. Conclusions A high percentage of patients aged ≥ 65 years received psychotropic drugs. The chance that a potentially inappropriate psychotropic drug would be administered was highest in the surgical departments. Antidepressants, neuroleptics and Z-drugs were used surprisingly often in geriatric medicine. Educational strategies could reduce the use of psychotropic drugs and the prescription of potentially inappropriate medications."],["dc.identifier.doi","10.1186/s40360-017-0183-0"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91993"],["dc.language.rfc3066","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.euproject","The study was funded by the German Federal Ministry of Health, the research grant was awarded in a competitive, peer-reviewed procedure (grant number: FKZ-IIA5-2513DSM228)"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","High prevalence of prescription of psychotropic drugs for older patients in a general hospital"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2016Conference Abstract
    [["dc.bibliographiccitation.journal","European Journal of Public Health"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Weiss, Vivien"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Nau, R."],["dc.contributor.author","Himmel, Wolfgang"],["dc.date.accessioned","2018-11-07T10:05:55Z"],["dc.date.available","2018-11-07T10:05:55Z"],["dc.date.issued","2016"],["dc.format.extent","198"],["dc.identifier.isi","000398600402055"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38999"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","1464-360X"],["dc.relation.issn","1101-1262"],["dc.title","Prescribing of hypnotics and sedatives between secondary and primary care"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article Research Paper
    [["dc.bibliographiccitation.firstpage","87"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Clinical Pharmacology"],["dc.bibliographiccitation.lastpage","97"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Weiß, Vivien"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Glaeske, Gerd"],["dc.contributor.author","Hummers, Eva"],["dc.contributor.author","Himmel, Wolfgang"],["dc.date.accessioned","2021-06-01T10:49:07Z"],["dc.date.available","2021-06-01T10:49:07Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00228-018-2555-9"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15543"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86173"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1432-1041"],["dc.relation.issn","0031-6970"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The interplay of context factors in hypnotic and sedative prescription in primary and secondary care — a qualitative study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2021Journal Article Research Paper
    [["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Pflege"],["dc.bibliographiccitation.lastpage","103"],["dc.bibliographiccitation.volume","35"],["dc.contributor.affiliation",", ;"],["dc.contributor.affiliation",", ;"],["dc.contributor.affiliation",", ;"],["dc.contributor.affiliation",", ;"],["dc.contributor.affiliation",", ;"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Kasper-Deußen, Anne-Kathrin"],["dc.contributor.author","Weiß, Vivien"],["dc.contributor.author","Marx, Gabriella"],["dc.contributor.author","Himmel, Wolfgang"],["dc.creator.author","Heinemann S"],["dc.creator.author","Kasper-Deußen AK"],["dc.creator.author","Weiß V"],["dc.creator.author","Marx G"],["dc.creator.author","Himmel W"],["dc.date.accessioned","2021-12-20T07:29:18Z"],["dc.date.available","2021-12-20T07:29:18Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-25T21:45:34Z"],["dc.description.abstract","Zusammenfassung. Hintergrund und Zielsetzung: Die Linderung von Ein- und Durchschlafproblemen ist eine häufige Herausforderung im Krankenhaus. Ziel dieser Studie war es herauszuarbeiten, wie Auszubildende in der Gesundheits- und Krankenpflege Schlafprobleme von Patientinnen und Patienten und den Einsatz von Schlafmitteln, insbesondere von Benzodiazepinen und Z-Substanzen, erleben. Methoden: In vier Gruppendiskussionen wurden die Erfahrungen von Auszubildenden erhoben. Die Transkripte der Diskussionen wurden mittels dokumentarischer Methode ausgewertet und nach abschließender inhaltsanalytischer Verdichtung zu Hauptkategorien zusammengefasst. Ergebnisse: Die Auszubildenden erleben eine großzügige Gabe von Schlafmitteln, die – trotz geringer Evidenz – seitens der Pflege als bestmögliche Lösung von Schlafproblemen angesehen wird. Nicht-medikamentöse Alternativen werden selten gelehrt, sind oft nicht vorrätig und ihr Einsatz wird kaum trainiert. Das pharmakologische Wissen der Auszubildenden ist teilweise gering bzw. gelingt die Umsetzung in die Praxis nur bedingt. Schlaf und Schlafprobleme sind, z. B. im Vergleich zur Schmerzbehandlung, keine prioritären Themen im Krankenhaus. Schlussfolgerungen: Mehr Wissen und größere Sensibilität gegenüber Schlafproblemen sind erforderlich. Beispielhaft sollte in der Ausbildung gezeigt werden, wie das Wissen über Medikamente und Alternativen sinnvoll in Problemsituationen angewandt werden können – hier sind gute Vorbilder auf ärztlicher und / oder pflegerischer Seite gefragt."],["dc.identifier.doi","10.1024/1012-5302/a000853"],["dc.identifier.pmid","34854326"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97050"],["dc.language.iso","de"],["dc.notes.intern","DeepGreen Import"],["dc.relation.eissn","1664-283X"],["dc.relation.issn","1012-5302"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 4.0"],["dc.title","Erfahrungen im Umgang mit Schlafmitteln: Gruppendiskussionen mit Auszubildenden in der Pflege über Benzodiazepine und Z-Substanzen"],["dc.title.alternative","Experiences when handling sleep medicines: Group discussions with nursing students about benzodiazepines and Z-drugs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2016Journal Article Research Paper
    [["dc.bibliographiccitation.artnumber","e011908"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","BMJ Open"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Weiss, Vivien"],["dc.contributor.author","Straube, Kati"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Grimmsmann, Thomas"],["dc.contributor.author","Himmel, Wolfgang"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.date.accessioned","2018-11-07T10:20:03Z"],["dc.date.available","2018-11-07T10:20:03Z"],["dc.date.issued","2016"],["dc.description.abstract","Introduction: Hypnotics and sedatives, especially benzodiazepines and Z-drugs, are frequently prescribed for longer periods than recommended-in spite of potential risks for patients. Any intervention to improve this situation has to take into account the interplay between different actors, interests and needs. The ultimate goal of this study is to develop-together with the professionals involved-ideas for reducing the use of hypnotics and sedatives and then to implement and evaluate adequate interventions in the hospital and at the primary and secondary care interface. Methods and analysis: The study will take place in a regional hospital in northern Germany and in some general practices in this region. We will collect data from doctors, nurses, patients and a major social health insurer to define the problem from multiple perspectives. These data will be explored and discussed with relevant stakeholders to develop interventions. The interventions will be implemented and, in a final step, evaluated. Both quantitative and qualitative data, including surveys, interviews, chart reviews and secondary analysis of social health insurance data, will be collected to obtain a full understanding of the frequency and the reasons for using hypnotics and sedatives. Ethics and dissemination: Approval has been granted from the ethics review committee of the University Medical Center Gottingen, Germany. Results will be disseminated to researchers, clinicians and policy makers in peer-reviewed journal articles and conference publications. One or more dissemination events will be held locally during continuous professional development events for local professionals, including (but not confined to) the study participants."],["dc.description.sponsorship","German Federal Ministry of Health; [FKZ-IIA5-2513DSM228]"],["dc.identifier.doi","10.1136/bmjopen-2016-011908"],["dc.identifier.isi","000382336700064"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13757"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41801"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","2044-6055"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Understanding and reducing the prescription of hypnotics and sedatives at the interface of hospital care and general practice: a protocol for a mixed-methods study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2015Conference Abstract
    [["dc.bibliographiccitation.journal","Zeitschrift für Gerontologie und Geriatrie"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Straube, Kati"],["dc.contributor.author","Arnold, Inka"],["dc.contributor.author","Himmel, Wolfgang"],["dc.contributor.author","Weiss, Vivien"],["dc.contributor.author","Karaus, Michael"],["dc.contributor.author","Hummers-Pradier, Eva"],["dc.contributor.author","Nau, R."],["dc.date.accessioned","2018-11-07T09:52:35Z"],["dc.date.available","2018-11-07T09:52:35Z"],["dc.date.issued","2015"],["dc.format.extent","47"],["dc.identifier.isi","000360847800148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36159"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1435-1269"],["dc.relation.issn","0948-6704"],["dc.title","Prescription of Psychotropic Drugs for over-65 Years in a Hospital of Basic and Standard Care with particular Consideration to the geriatric Clinic"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2018Journal Article Research Paper
    [["dc.bibliographiccitation.firstpage","291"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pflege"],["dc.bibliographiccitation.lastpage","300"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Kauffmann, Lea"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Himmel, Wolfgang"],["dc.contributor.author","Hußmann, Olaf"],["dc.contributor.author","Schlott, Thilo"],["dc.contributor.author","Weiß, Vivien"],["dc.date.accessioned","2020-12-10T18:09:20Z"],["dc.date.available","2020-12-10T18:09:20Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1024/1012-5302/a000639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73617"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1664-283X"],["dc.relation.issn","1012-5302"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 4.0"],["dc.title","Nicht-medikamentöse Maßnahmen bei Ein- und Durchschlafproblemen von älteren Patienten im Krankenhaus – Qualitative Interviews mit Pflegenden"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]
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