Tölle, Merja H.

[["dc.bibliographiccitation.firstpage","1564"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","1574"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Petry, H"],["dc.contributor.author","Dittmer, U"],["dc.contributor.author","Stahl-Hennig, C"],["dc.contributor.author","Coulibaly, C"],["dc.contributor.author","Makoschey, B"],["dc.contributor.author","Fuchs, D"],["dc.contributor.author","Wachter, H"],["dc.contributor.author","Tolle, T"],["dc.contributor.author","Morys-Wortmann, C"],["dc.contributor.author","Kaup, F J"],["dc.date.accessioned","2022-10-06T13:25:39Z"],["dc.date.available","2022-10-06T13:25:39Z"],["dc.date.issued","1995"],["dc.description.abstract","By superinfection of human immunodeficiency virus type 2 (HIV-2) strain HIV-2ben-infected macaques with simian immunodeficiency virus (SIV) strain SIVmac, we investigated the mutual influences of an apathogenic and a pathogenic virus in vivo. Four rhesus and two cynomolgus monkeys were infected with HIV-2ben in 1988 and 1989, respectively. Virus could be reisolated from five of six animals 6 weeks after infection. The monkeys remained healthy over the next 2 to 3 years. PCR for viral RNA became negative, and virus could no longer be reisolated by coculture. All six macaques were superinfected with the pathogenic SIVmac251/32H. Subsequently, five monkeys became persistently viremic, while one animal was protected against the SIVmac infection. In the peripheral blood mononuclear cells and cocultures of the five viremic animals, DNA from both HIV-2 and SIVmac was present. The plasma contained RNA from both viruses. Thus, superinfection with SIVmac activated HIV-2. A proliferative T-cell response against both HIV-2 and SIVmac was measured in all animals after superinfection. Such a response was regularly seen after infection with the apathogenic HIV-2 but never when the pathogenic SIVmac alone was administered. While naive control monkeys inoculated with SIVmac251/32H regularly develop AIDS-like symptoms soon after infection and have to be killed, none of the preinfected animals has developed AIDS-like symptoms, but two of six animals developed tumors. After the SIVmac challenge, however, apoptotic lymphocytes were detected in the peripheral blood mononuclear cells of all animals. Thus, the presence of an apathogenic viral variant seems to retard the disease occurring after infection with a pathogenic virus rather than to confirm total protection. This partial protection appears to depend on a specific proliferative T-cell response early after infection."],["dc.identifier.doi","10.1128/jvi.69.3.1564-1574.1995"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114887"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Reactivation of human immunodeficiency virus type 2 in macaques after simian immunodeficiency virus SIVmac superinfection"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2765"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","2771"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Tolle, T"],["dc.contributor.author","Petry, H"],["dc.contributor.author","Bachmann, B"],["dc.contributor.author","Hunsmann, G"],["dc.contributor.author","Lüke, W"],["dc.date.accessioned","2022-10-06T13:25:39Z"],["dc.date.available","2022-10-06T13:25:39Z"],["dc.date.issued","1994"],["dc.description.abstract","The sequence variability of distinct regions of the proviral env gene of human immunodeficiency virus type 2 strain ben (HIV-2ben) isolated sequentially over 3 to 4 years from six experimentally infected macaques was studied. The regions investigated were homologous to the V1, V2, V3, V4, V5, and V7 hypervariable regions identified in the env genes of HIV-1 and simian immunodeficiency virus SIVmac, respectively. In contrast to findings with HIV-1 and SIVmac, the V1- and V2-homologous regions were found to be highly conserved during the course of the HIV-2ben infection in macaques. The V3-homologous region showed a degree of variation comparable to that of HIV-1 but not of SIV. In the V4-, V5-, and V7-homologous regions, mutation hot spots were detected in most reisolates of the infected monkeys. Most of these mutations occurred during the first 10 weeks after infection. After 50 weeks, new mutations were rarely detected. At most mutation sites, a dynamic equilibrium between the mutated viral isotype and the infecting predominant wild type was present. This equilibrium might prevent an accumulation of mutations in isolates later in the course of infection."],["dc.identifier.doi","10.1128/jvi.68.4.2765-2771.1994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114886"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Variability of the env gene in cynomolgus macaques persistently infected with human immunodeficiency virus type 2 strain ben"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]