Heilbronner, Urs

[["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.contributor.author","Amare, Azmeraw T."],["dc.contributor.author","Schubert, Klaus Oliver"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Clark, Scott R."],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Cearns, Micah"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Tekola-Ayele, Fasil"],["dc.contributor.author","Hsu, Yi-Hsiang"],["dc.contributor.author","Baune, Bernhard T."],["dc.date.accessioned","2020-12-10T18:09:37Z"],["dc.date.available","2020-12-10T18:09:37Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41380-020-0689-5"],["dc.identifier.eissn","1476-5578"],["dc.identifier.issn","1359-4184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73707"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Association of polygenic score for major depression with response to lithium in patients with bipolar disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S968"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Aldinger, Fanny"],["dc.contributor.author","Andlauer, Till F.M."],["dc.contributor.author","Schulze, Thomas"],["dc.date.accessioned","2020-12-10T14:23:55Z"],["dc.date.available","2020-12-10T14:23:55Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2017.08.333"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72075"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","THE IMPACT OF BIPOLAR AND SCHIZOPHRENIA POLYGENIC RISK SCORES ON FAMILIAL FEATURES OF BIPOLAR DISORDER"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S1300"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","S1301"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Comes, Ashley"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Andlauer, Till"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Forstner, Andreas J."],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Kondofersky, Ivan"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Senner, Fanny"],["dc.contributor.author","Sivalingam, Sugirthan"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Schulze, Thomas"],["dc.date.accessioned","2020-12-10T14:23:56Z"],["dc.date.available","2020-12-10T14:23:56Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2018.08.426"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72083"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","SU62THE ROLE OF ENVIRONMENTAL STRESS AND DNA METHYLATION IN THE LONGITUDINAL COURSE OF BIPOLAR DISORDER"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JAMA Psychiatry"],["dc.contributor.author","Amare, Azmeraw T."],["dc.contributor.author","Schubert, Klaus Oliver"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Clark, Scott R."],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Tekola-Ayele, Fasil"],["dc.contributor.author","Hsu, Yi-Hsiang"],["dc.contributor.author","Shekhtman, Tatyana"],["dc.contributor.author","Baune, Bernhard T."],["dc.date.accessioned","2020-12-10T14:05:46Z"],["dc.date.available","2020-12-10T14:05:46Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1001/jamapsychiatry.2017.3433"],["dc.identifier.issn","2168-622X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69650"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder"],["dc.title.alternative","A Genome-Wide Association Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","17823"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Le Clerc, Sigrid"],["dc.contributor.author","Lombardi, Laura"],["dc.contributor.author","Baune, Bernhard T."],["dc.contributor.author","Amare, Azmeraw T."],["dc.contributor.author","Schubert, Klaus Oliver"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Clark, Scott R."],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Cearns, Micah"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Tamouza, Ryad"],["dc.date.accessioned","2021-10-01T09:57:45Z"],["dc.date.available","2021-10-01T09:57:45Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1 11:01 classical allele, associated with a better response to Li ( p  < 1 × 10 −3 ; FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response."],["dc.description.abstract","Abstract Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1 11:01 classical allele, associated with a better response to Li ( p  < 1 × 10 −3 ; FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response."],["dc.identifier.doi","10.1038/s41598-021-97140-7"],["dc.identifier.pii","97140"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89908"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","2045-2322"],["dc.title","HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Psychiatry"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Reinbold, Céline S."],["dc.contributor.author","Forstner, Andreas J."],["dc.contributor.author","Hecker, Julian"],["dc.contributor.author","Fullerton, Janice M."],["dc.contributor.author","Hoffmann, Per"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Adli, Mazda"],["dc.contributor.author","Akiyama, Kazufumi"],["dc.contributor.author","Cichon, Sven"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2020-12-10T18:46:52Z"],["dc.date.available","2020-12-10T18:46:52Z"],["dc.date.issued","2018"],["dc.description.abstract","Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Consortium on Lithium Genetics (ConLiGen). Recently, we performed the first genome-wide analysis of the involvement of miRNAs in BD and identified nine BD-associated miRNAs. However, it is unknown whether these miRNAs are also associated with lithium response in BD. In the present study, we therefore tested whether common variants at these nine candidate miRNAs contribute to the variance in lithium response in BD. Furthermore, we systematically analyzed whether any other miRNA in the genome is implicated in the response to lithium. For this purpose, we performed gene-based tests for all known miRNA coding genes in the ConLiGen GWAS dataset (n = 2,563 patients) using a set-based testing approach adapted from the versatile gene-based test for GWAS (VEGAS2). In the candidate approach, miR-499a showed a nominally significant association with lithium response, providing some evidence for involvement in both development and treatment of BD. In the genome-wide miRNA analysis, 71 miRNAs showed nominally significant associations with the dichotomous phenotype and 106 with the continuous trait for treatment response. A total of 15 miRNAs revealed nominal significance in both phenotypes with miR-633 showing the strongest association with the continuous trait (p = 9.80E-04) and miR-607 with the dichotomous phenotype (p = 5.79E-04). No association between miRNAs and treatment response to lithium in BD in either of the tested conditions withstood multiple testing correction. Given the limited power of our study, the investigation of miRNAs in larger GWAS samples of BD and lithium response is warranted."],["dc.identifier.doi","10.3389/fpsyt.2018.00207"],["dc.identifier.eissn","1664-0640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78571"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-0640"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","548"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychopharmacology"],["dc.bibliographiccitation.lastpage","557"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Czéh, Boldizsár"],["dc.contributor.author","Pudovkina, Olga"],["dc.contributor.author","van der Hart, Marieke G. C."],["dc.contributor.author","Simon, Mária"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2022-10-06T13:27:11Z"],["dc.date.available","2022-10-06T13:27:11Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1007/s00213-005-2184-8"],["dc.identifier.pii","2184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115273"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1432-2072"],["dc.relation.issn","0033-3158"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S1295"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","S1296"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Wendel, Bernadette"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Senner, Fanny"],["dc.contributor.author","Andlauer, Till"],["dc.contributor.author","Comes, Ashley"],["dc.contributor.author","Schulte, Eva"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Schulze, Thomas"],["dc.date.accessioned","2020-12-10T14:23:56Z"],["dc.date.available","2020-12-10T14:23:56Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2018.08.417"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72082"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","SU53A CROSS-DIAGNOSTIC GWAS OF LONGITUDINAL EXECUTIVE FUNCTION PROFILE SCORES"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S951"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Malzahn, Dörthe"],["dc.contributor.author","Sherva, Richard"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Aldinger, Fanny"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Pogarell, Oliver"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gelernter, Joel"],["dc.contributor.author","Schulze, Thomas"],["dc.date.accessioned","2020-12-10T14:23:55Z"],["dc.date.available","2020-12-10T14:23:55Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2017.08.302"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72073"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","POLYGENIC RISK BURDEN AND CANNABIS USE COMORBIDITY IN PATIENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Anderson‐Schmidt, Heike"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Reich‐Erkelenz, Daniela"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Kalman, Janos L."],["dc.contributor.author","Senner, Fanny"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Andlauer, Till F. M."],["dc.contributor.author","Comes, Ashley L."],["dc.contributor.author","Heilbronner, Urs"],["dc.date.accessioned","2021-12-08T12:29:30Z"],["dc.date.available","2021-12-08T12:29:30Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ajmg.b.32717"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/96099"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1552-485X"],["dc.relation.issn","1552-4841"],["dc.title","Cover Image, Volume 180B, Number 2, March 2019"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]