Rosenberger, Albert

[["dc.bibliographiccitation.firstpage","937"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","950"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Haiman, Ch. A."],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Tardón, G."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Kiemeney, B."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Brunnsstöm, Hans"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wichmann, H.-Erich"],["dc.contributor.author","Manz, Judith"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas R."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Pesch, Beate"],["dc.contributor.author","Johnen, Georg"],["dc.contributor.author","Brüning, Thomas"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Gomolka, Maria"],["dc.date.accessioned","2020-12-10T14:10:35Z"],["dc.date.available","2020-12-10T14:10:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00420-018-1334-3"],["dc.identifier.eissn","1432-1246"],["dc.identifier.issn","0340-0131"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70809"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","935"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cancer Epidemiology, Biomarkers & Prevention"],["dc.bibliographiccitation.lastpage","942"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Zhu, Ying"],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Zhang, Ruyang"],["dc.contributor.author","Dong, Xuesi"],["dc.contributor.author","Shen, Sipeng"],["dc.contributor.author","Zhao, Yang"],["dc.contributor.author","Bai, Jianling"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Zhu, Bin"],["dc.contributor.author","Chanock, Stephen J."],["dc.contributor.author","Gu, Fangyi"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Shepherd, Frances A."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Somoano, Ana"],["dc.contributor.author","Fernandez-Tardon, Guillermo"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Barnett, Matthew J."],["dc.contributor.author","Doherty, Jennifer"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Carreras-Torres, Robert"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wichmann, Heunz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Saliba, Walid"],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P.A."],["dc.contributor.author","Marcus, Michael W."],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Ye, Yuanqing"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Wilkens, Lynne R."],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Kachuri, Linda"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","van der Heijden, Erik HFM"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Teare, Dawn M."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Stevens, Victoria L."],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Hu, Zhibin"],["dc.contributor.author","Dai, Juncheng"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Zhu, Dakai"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Chen, Feng"],["dc.contributor.author","Christiani, David C."],["dc.date.accessioned","2020-12-10T18:37:45Z"],["dc.date.available","2020-12-10T18:37:45Z"],["dc.date.issued","2019"],["dc.description.abstract","Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear."],["dc.identifier.doi","10.1158/1055-9965.EPI-18-0356"],["dc.identifier.eissn","1538-7755"],["dc.identifier.issn","1055-9965"],["dc.identifier.pmid","30700444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77082"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1538-7755"],["dc.relation.issn","1055-9965"],["dc.relation.issn","1538-7755"],["dc.title","Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1663"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Carcinogenesis"],["dc.bibliographiccitation.lastpage","1672"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Yin, Jieyun"],["dc.contributor.author","Liu, Hongliang"],["dc.contributor.author","Liu, Zhensheng"],["dc.contributor.author","Owzar, Kouros"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Su, L. I."],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Wei, Qingyi"],["dc.date.accessioned","2018-11-07T10:22:59Z"],["dc.date.available","2018-11-07T10:22:59Z"],["dc.date.issued","2017"],["dc.description.abstract","The fatty acids (FAs) metabolism is suggested to play a pivotal role in the development of lung cancer, and we explored that by conducting a pathway-based analysis. We performed a meta-analysis of published datasets of six genome wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium, which included 12 160 cases with lung cancer and 16 838 cancer-free controls. A total of 30 722 single-nucleotide polymorphisms (SNPs) from 317 genes relevant to FA metabolic pathways were identified. An additional dataset fromthe Harvard Lung Cancer Study with 984 cases and 970 healthy controls was also added to the final meta-analysis. In the initial meta-analysis, 26 of 28 SNPs that passed false discovery rate multiple tests were mapped to the CYP4F3 gene. Among the 26 top ranked hits was a proxy SNP, CYP4F3 rs4646904 (P=8.65x10(-6), FDR = 0.018), which is suggested to change splicing pattern/efficiency and to be associated with gene expression levels. However, after adding data of rs4646904 from the Harvard GWAS, the significance in the combined analysis was reduced to P=3.52x10(-3) [odds ratio (OR) = 1.07, 95% confidence interval (95% CI) = 1.03-1.12]. Interestingly, the small Harvard dataset also pointed to the same direction of the association in subgroups of smokers (OR = 1.07) and contributed to a combined OR of 1.13 (95% CI = 1.06-1.20, P=6.70x10(-5)). The results suggest that a potentially functional SNP in CYP4F3 (rs4646904) may contribute to the etiology of lung cancer, especially in smokers. Additional mechanistic studies are warranted to unravel the potential biological significance of the finding."],["dc.identifier.doi","10.1002/mc.22622"],["dc.identifier.isi","000403698200012"],["dc.identifier.pmid","28150878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1098-2744"],["dc.relation.issn","0899-1987"],["dc.title","Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Human Genetics"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Benhamou, Simone"],["dc.contributor.author","Bouchardy, Christine"],["dc.contributor.author","Lewinger, Juan Pablo"],["dc.contributor.author","Witte, John S."],["dc.contributor.author","Chen, Gary"],["dc.contributor.author","Bull, Shelley"],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T10:10:56Z"],["dc.date.available","2018-11-07T10:10:56Z"],["dc.date.issued","2016"],["dc.description.sponsorship","NCI NIH HHS [U19 CA148127]"],["dc.format.extent","963"],["dc.identifier.doi","10.1007/s00439-016-1692-4"],["dc.identifier.isi","000380060700012"],["dc.identifier.pmid","27264937"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39951"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1203"],["dc.relation.issn","0340-6717"],["dc.title","Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls (vol 132, pg 579, 2013)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","219"],["dc.bibliographiccitation.journal","EBioMedicine"],["dc.bibliographiccitation.lastpage","226"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Chen, Li-Shiun"],["dc.contributor.author","Baker, Timothy"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Horton, Amy"],["dc.contributor.author","Culverhouse, Robert"],["dc.contributor.author","Hartz, Sarah"],["dc.contributor.author","Saccone, Nancy"],["dc.contributor.author","Cheng, Iona"],["dc.contributor.author","Deng, Bo"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Hansen, Helen M."],["dc.contributor.author","Horsman, Janet"],["dc.contributor.author","Kim, Claire"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Aben, Katja K."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Chang, Shen-Chih"],["dc.contributor.author","Saum, Kai-Uwe"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Hatsukami, Dorothy K."],["dc.contributor.author","Johnson, Eric O."],["dc.contributor.author","Pande, Mala"],["dc.contributor.author","Wrensch, Margaret R."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","van der Heijden, Erik H."],["dc.contributor.author","Wampfler, Jason"],["dc.contributor.author","Wenzlaff, Angela"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Brenner, Hermann"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Brüske, Irene"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Mayordomo, Jose"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Zhang, Zuo-Feng"],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Bierut, Laura J."],["dc.date.accessioned","2020-12-10T14:23:30Z"],["dc.date.available","2020-12-10T14:23:30Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1016/j.ebiom.2016.08.012"],["dc.identifier.issn","2352-3964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71947"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","679"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The American Journal of Human Genetics"],["dc.bibliographiccitation.lastpage","691"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Chatterjee, Nilanjan"],["dc.contributor.author","Yu, Kai"],["dc.contributor.author","Goldin, Lynn R."],["dc.contributor.author","Goldstein, Alisa M."],["dc.contributor.author","Rotunno, Melissa"],["dc.contributor.author","Mirabello, Lisa"],["dc.contributor.author","Jacobs, Kevin"],["dc.contributor.author","Wheeler, William"],["dc.contributor.author","Yeager, Meredith"],["dc.contributor.author","Bergen, Andrew W."],["dc.contributor.author","Li, Qizhai"],["dc.contributor.author","Consonni, Dario"],["dc.contributor.author","Pesatori, Angela C."],["dc.contributor.author","Wacholder, Sholom"],["dc.contributor.author","Thun, Michael"],["dc.contributor.author","Diver, Ryan"],["dc.contributor.author","Oken, Martin"],["dc.contributor.author","Virtamo, Jarmo"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Wang, Z."],["dc.contributor.author","Burdette, Laurie"],["dc.contributor.author","Doheny, Kimberly F."],["dc.contributor.author","Pugh, Elizabeth W."],["dc.contributor.author","Laurie, Cathy"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Gaborieau, Valerie"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Lathrop, Mark"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Krokan, Hans E."],["dc.contributor.author","Vatten, Lars"],["dc.contributor.author","Skorpen, Frank"],["dc.contributor.author","Arnesen, Egil"],["dc.contributor.author","Benhamou, Simone"],["dc.contributor.author","Bouchard, Christine"],["dc.contributor.author","Metsapalu, Andres"],["dc.contributor.author","Vooder, Tonu"],["dc.contributor.author","Nelis, Mari"],["dc.contributor.author","Vaelk, Kristian"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Sulem, Patrick"],["dc.contributor.author","Thorleifsson, Gudmar"],["dc.contributor.author","Rafnar, Thorunn"],["dc.contributor.author","Eisen, Timothy"],["dc.contributor.author","Sauter, Wiebke"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Stefansson, Kari"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Fraumeni, Joseph F., Jr."],["dc.contributor.author","Savage, Sharon A."],["dc.contributor.author","Bertazzi, Pier Alberto"],["dc.contributor.author","Tucker, Margaret A."],["dc.contributor.author","Chanock, Stephen J."],["dc.contributor.author","Caporaso, Neil E."],["dc.date.accessioned","2018-11-07T11:22:07Z"],["dc.date.available","2018-11-07T11:22:07Z"],["dc.date.issued","2009"],["dc.description.abstract","Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of king cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additional studies, for a total of 13,300 cases and 19,666 controls of European descent. Four Studies also provided histology data for replication, resulting in 3333 adenocarcinomas (AD), 2589 squamous cell carcinomas (SQ), and 1418 small cell carcinomas (SQ. In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.13-1.33, p = 3.02 x 10(-7)), but not with other histologic types (OR = 1.01, p = 0.84 and OR = 1.00, p = 0.93 for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR = 1.24, 95% CI = 1.17-1.31, p = 3.74 x 10(-14) for AD; OR = 0.99, p = 0.69 and OR = 0.97, p = 0.48 for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma."],["dc.identifier.doi","10.1016/j.ajhg.2009.09.012"],["dc.identifier.isi","000271916500014"],["dc.identifier.pmid","19836008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55928"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0002-9297"],["dc.title","A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","djv100"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","JNCI Journal of the National Cancer Institute"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Chen, Li-Shiun"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Baker, Timothy"],["dc.contributor.author","Horton, Amy"],["dc.contributor.author","Culverhouse, Rob"],["dc.contributor.author","Saccone, Nancy"],["dc.contributor.author","Cheng, Iona"],["dc.contributor.author","Deng, B. O."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Hansen, Helen M."],["dc.contributor.author","Horsman, Janet"],["dc.contributor.author","Kim, Claire"],["dc.contributor.author","Lutz, Sharon"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Aben, Katja K."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Breslau, Naomi"],["dc.contributor.author","Chang, Shen-Chih"],["dc.contributor.author","Dieffenbach, Aida Karina"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Frederiksen, Brittni"],["dc.contributor.author","Han, Jiali"],["dc.contributor.author","Hatsukami, Dorothy K."],["dc.contributor.author","Johnson, Eric O."],["dc.contributor.author","Pande, Mala"],["dc.contributor.author","Wrensch, Margaret R."],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","van der Heijden, Henricus F. M."],["dc.contributor.author","Wampfler, Jason"],["dc.contributor.author","Wenzlaff, Angela"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Brenner, Hermann"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Hokanson, John E."],["dc.contributor.author","Hunter, David J."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Mayordomo, Jose I."],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Teare, Dawn"],["dc.contributor.author","Wu, X."],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Zhang, Z."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Kraft, Peter"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Bierut, Laura J."],["dc.date.accessioned","2018-11-07T09:57:38Z"],["dc.date.available","2018-11-07T09:57:38Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis. Methods: Meta-analyses examined associations between rs16969968, age of quitting smoking, and age of lung cancer diagnosis in 24 studies of European ancestry (n = 29 072). In each dataset, we used Cox regression models to evaluate the association between rs16969968 and the two primary phenotypes (age of smoking cessation among ever smokers and age of lung cancer diagnosis among lung cancer case patients) and the secondary phenotype of smoking duration. Heterogeneity across studies was assessed with the Cochran Q test. All statistical tests were two-sided. Results: The rs16969968 allele (A) was associated with a lower likelihood of smoking cessation (hazard ratio [HR] = 0.95, 95% confidence interval [CI] = 0.91 to 0.98, P =.0042), and the AA genotype was associated with a four-year delay in median age of quitting compared with the GG genotype. Among smokers with lung cancer diagnoses, the rs16969968 genotype (AA) was associated with a four-year earlier median age of diagnosis compared with the low-risk genotype (GG) (HR = 1.08, 95% CI = 1.04 to 1.12, P = 1.1 10(-5)). Conclusion: These data support the clinical significance of the CHRNA5 variant rs16969968. It predicts delayed smoking cessation and an earlier age of lung cancer diagnosis in this meta-analysis. Given the existing evidence that this CHRNA5 variant predicts favorable response to cessation pharmacotherapy, these findings underscore the potential clinical and public health importance of rs16969968 in CHRNA5 in relation to smoking cessation success and lung cancer risk.d: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis."],["dc.identifier.doi","10.1093/jnci/djv100"],["dc.identifier.isi","000355088600029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37206"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2105"],["dc.relation.issn","0027-8874"],["dc.title","CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis-A Meta-Analysis"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7406"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Human Molecular Genetics"],["dc.bibliographiccitation.lastpage","7420"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Qian, David C."],["dc.contributor.author","Byun, Jinyoung"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Greene, Casey S."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Mclaughlin, John R."],["dc.contributor.author","Fehringer, Gordon"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Malhotra, Jyoti"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Hunter, David J."],["dc.contributor.author","Henderson, Brian E."],["dc.contributor.author","Haiman, Christopher A."],["dc.contributor.author","Schumacher, Frederick R."],["dc.contributor.author","Eeles, Rosalind A."],["dc.contributor.author","Easton, Douglas F."],["dc.contributor.author","Seminara, Daniela"],["dc.contributor.author","Amos, Christopher I."],["dc.date.accessioned","2018-11-07T09:47:24Z"],["dc.date.available","2018-11-07T09:47:24Z"],["dc.date.issued","2015"],["dc.description.abstract","Results from genome-wide association studies (GWAS) have indicated that strong single-gene effects are the exception, not the rule, for most diseases. We assessed the joint effects of germline genetic variations through a pathway-based approach that considers the tissue-specific contexts of GWAS findings. From GWAS meta-analyses of lung cancer (12 160 cases/16 838 controls), breast cancer (15 748 cases/18 084 controls) and prostate cancer (14 160 cases/12 724 controls) in individuals of European ancestry, we determined the tissue-specific interaction networks of proteins expressed from genes that are likely to be affected by disease-associated variants. Reactome pathways exhibiting enrichment of proteins from each network were compared across the cancers. Our results show that pathways associated with all three cancers tend to be broad cellular processes required for growth and survival. Significant examples include the nerve growth factor (P = 7.86 x 10(-33)), epidermal growth factor (P = 1.18 x 10(-31)) and fibroblast growth factor (P = 2.47 x 10(-31)) signaling pathways. However, within these shared pathways, the genes that influence risk largely differ by cancer. Pathways found to be unique for a single cancer focus on more specific cellular functions, such as interleukin signaling in lung cancer (P = 1.69 x 10(-15)), apoptosis initiation by Bad in breast cancer (P = 3.14 x 10(-9)) and cellular responses to hypoxia in prostate cancer (P = 2.14 x 10(-9)). We present the largest comparative cross-cancer pathway analysis of GWAS to date. Our approach can also be applied to the study of inherited mechanisms underlying risk across multiple diseases in general."],["dc.identifier.doi","10.1093/hmg/ddv440"],["dc.identifier.isi","000368373600020"],["dc.identifier.pmid","26483192"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35107"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2083"],["dc.relation.issn","0964-6906"],["dc.title","Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","280"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","289"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Kang, Xiaozheng"],["dc.contributor.author","Liu, Hongliang"],["dc.contributor.author","Onaitis, Mark W."],["dc.contributor.author","Liu, Zhensheng"],["dc.contributor.author","Owzar, Kouros"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Su, L. I."],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wu, X."],["dc.contributor.author","Ye, Yuanqing"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Wei, Qingyi"],["dc.date.accessioned","2018-11-07T10:17:40Z"],["dc.date.available","2018-11-07T10:17:40Z"],["dc.date.issued","2016"],["dc.description.abstract","After combining the summary results of SNPs in 106 centrosomal genes from eight published lung cancer GWASs, we found that two potential functional SNPs (rs151606 and rs12212247) in FGFR1OP were significantly associated with lung cancer risk.Centrosome abnormalities are often observed in premalignant lesions and in situ tumors and have been associated with aneuploidy and tumor development. We investigated the associations of 9354 single-nucleotide polymorphisms (SNPs) in 106 centrosomal genes with lung cancer risk by first using the summary data from six published genome-wide association studies (GWASs) of the Transdisciplinary Research in Cancer of the Lung (TRICL) (12 160 cases and 16 838 controls) and then conducted in silico replication in two additional independent lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1319 cases and 26 380 controls). A total of 44 significant SNPs with false discovery rate (FDR) a parts per thousand currency sign 0.05 were mapped to one novel gene FGFR1OP and two previously reported genes (TUBB and BRCA2). After combined the results from TRICL with those from Harvard and deCODE, the most significant association (P (combined) = 8.032x10(-6)) was with rs151606 within FGFR1OP. The rs151606 T > G was associated with an increased risk of lung cancer [odds ratio (OR) = 1.10, 95% confidence interval (95% CI) = 1.05-1.14]. Another significant tagSNP rs12212247 T > C (P (combined) = 9.589x10(-6)) was associated with a decreased risk of lung cancer (OR = 0.93, 95% CI = 0.90-0.96). Further in silico functional analyzes revealed that rs151606 might affect transcriptional regulation and result in decreased FGFR1OP expression (P (trend) = 0.022). The findings shed some new light on the role of centrosome abnormalities in the susceptibility to lung carcinogenesis."],["dc.identifier.doi","10.1093/carcin/bgw014"],["dc.identifier.isi","000371696400006"],["dc.identifier.pmid","26905588"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41277"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2180"],["dc.relation.issn","0143-3334"],["dc.title","Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14 463 cases and 44 188 controls"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","197"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.lastpage","206"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Poirier, Julia G."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Tworoger, Shelley"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Brueske, Irene"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Henderson, Brian E."],["dc.contributor.author","Wilkens, Lynne R."],["dc.contributor.author","Zong, Xuchen"],["dc.contributor.author","Li, Yafang"],["dc.contributor.author","Hao, K. E."],["dc.contributor.author","Timens, Wim"],["dc.contributor.author","Bosse, Yohan"],["dc.contributor.author","Sin, Don D."],["dc.contributor.author","Obeidat, Ma'en"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T10:00:15Z"],["dc.date.available","2018-11-07T10:00:15Z"],["dc.date.issued","2015"],["dc.description.abstract","Lung cancer is the leading cause of cancer death worldwide. Although several genetic variants associated with lung cancer have been identified in the past, stringent selection criteria of genome-wide association studies (GWAS) can lead to missed variants. The objective of this study was to uncover missed variants by using the known association between lung cancer and first-degree family history of lung cancer to enrich the variant prioritization for lung cancer susceptibility regions. In this two-stage GWAS study, we first selected a list of variants associated with both lung cancer and family history of lung cancer in four GWAS (3,953 cases, 4,730 controls), then replicated our findings for 30 variants in a meta-analysis of four additional studies (7,510 cases, 7,476 controls). The top ranked genetic variant rs12415204 in chr10q23.33 encoding FFAR4 in the Discovery set was validated in the Replication set with an overall OR of 1.09 (95% CI = 1.04, 1.14, P=1.63x 10(-4)). When combining the two stages of the study, the strongest association was found in rs1158970 at Ch4p15.2 encoding KCNIP4 with an OR of 0.89 (95% CI = 0.85, 0.94, P = 9.64 x 10(-6)). We performed a stratified analysis of rs12415204 and rs1158970 across all eight studies by age, gender, smoking status, and histology, and found consistent results across strata. Four of the 30 replicated variants act as expression quantitative trait loci (eQTL) sites in 1,111 nontumor lung tissues and meet the genome-wide 10% FDR threshold."],["dc.identifier.doi","10.1002/gepi.21882"],["dc.identifier.isi","000351462200007"],["dc.identifier.pmid","25644374"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37765"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1098-2272"],["dc.relation.issn","0741-0395"],["dc.title","Informed Genome-Wide Association Analysis With Family History As a Secondary Phenotype Identifies Novel Loci of Lung Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]