Rosenberger, Albert

[["dc.bibliographiccitation.artnumber","44634"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Pan, Yongchu"],["dc.contributor.author","Liu, Hongliang"],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Kang, Xiaozheng"],["dc.contributor.author","Liu, Zhensheng"],["dc.contributor.author","Owzar, Kouros"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Su, L. I."],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wu, X."],["dc.contributor.author","Ye, Yuanqing"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Wei, Qingyi"],["dc.date.accessioned","2018-11-07T10:26:10Z"],["dc.date.available","2018-11-07T10:26:10Z"],["dc.date.issued","2017"],["dc.description.abstract","mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data from six published genome-wide association studies (GWASs) of Transdisciplinary Research in Cancer of the Lung (TRICL) (12,160 cases and 16,838 controls) and another two lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1,319 cases and 26,380 controls). We found that a total of 12 significant SNPs with false discovery rate (FDR) <= 0.05 were mapped to one novel gene PRPF6 and two previously reported genes (DHX16 and LSM2) that were also confirmed in this study. The six novel SNPs in PRPF6 were in high linkage disequilibrium and associated with PRPF6 mRNA expression in lymphoblastoid cells from 373 Europeans in the 1000 Genomes Project. Taken together, our studies shed new light on the role of mRNA splicing genes in the development of lung cancer."],["dc.identifier.doi","10.1038/srep44634"],["dc.identifier.isi","000397001600001"],["dc.identifier.pmid","28304396"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42982"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","937"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","950"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Haiman, Ch. A."],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Tardón, G."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Kiemeney, B."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Brunnsstöm, Hans"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wichmann, H.-Erich"],["dc.contributor.author","Manz, Judith"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas R."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Pesch, Beate"],["dc.contributor.author","Johnen, Georg"],["dc.contributor.author","Brüning, Thomas"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Gomolka, Maria"],["dc.date.accessioned","2020-12-10T14:10:35Z"],["dc.date.available","2020-12-10T14:10:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00420-018-1334-3"],["dc.identifier.eissn","1432-1246"],["dc.identifier.issn","0340-0131"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70809"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","935"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cancer Epidemiology, Biomarkers & Prevention"],["dc.bibliographiccitation.lastpage","942"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Zhu, Ying"],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Zhang, Ruyang"],["dc.contributor.author","Dong, Xuesi"],["dc.contributor.author","Shen, Sipeng"],["dc.contributor.author","Zhao, Yang"],["dc.contributor.author","Bai, Jianling"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Zhu, Bin"],["dc.contributor.author","Chanock, Stephen J."],["dc.contributor.author","Gu, Fangyi"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Shepherd, Frances A."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Somoano, Ana"],["dc.contributor.author","Fernandez-Tardon, Guillermo"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Barnett, Matthew J."],["dc.contributor.author","Doherty, Jennifer"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Carreras-Torres, Robert"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wichmann, Heunz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Saliba, Walid"],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P.A."],["dc.contributor.author","Marcus, Michael W."],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Ye, Yuanqing"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Wilkens, Lynne R."],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Kachuri, Linda"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","van der Heijden, Erik HFM"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Teare, Dawn M."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Stevens, Victoria L."],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Hu, Zhibin"],["dc.contributor.author","Dai, Juncheng"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Zhu, Dakai"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Chen, Feng"],["dc.contributor.author","Christiani, David C."],["dc.date.accessioned","2020-12-10T18:37:45Z"],["dc.date.available","2020-12-10T18:37:45Z"],["dc.date.issued","2019"],["dc.description.abstract","Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear."],["dc.identifier.doi","10.1158/1055-9965.EPI-18-0356"],["dc.identifier.eissn","1538-7755"],["dc.identifier.issn","1055-9965"],["dc.identifier.pmid","30700444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77082"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1538-7755"],["dc.relation.issn","1055-9965"],["dc.relation.issn","1538-7755"],["dc.title","Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1663"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Carcinogenesis"],["dc.bibliographiccitation.lastpage","1672"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Yin, Jieyun"],["dc.contributor.author","Liu, Hongliang"],["dc.contributor.author","Liu, Zhensheng"],["dc.contributor.author","Owzar, Kouros"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Su, L. I."],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Wei, Qingyi"],["dc.date.accessioned","2018-11-07T10:22:59Z"],["dc.date.available","2018-11-07T10:22:59Z"],["dc.date.issued","2017"],["dc.description.abstract","The fatty acids (FAs) metabolism is suggested to play a pivotal role in the development of lung cancer, and we explored that by conducting a pathway-based analysis. We performed a meta-analysis of published datasets of six genome wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium, which included 12 160 cases with lung cancer and 16 838 cancer-free controls. A total of 30 722 single-nucleotide polymorphisms (SNPs) from 317 genes relevant to FA metabolic pathways were identified. An additional dataset fromthe Harvard Lung Cancer Study with 984 cases and 970 healthy controls was also added to the final meta-analysis. In the initial meta-analysis, 26 of 28 SNPs that passed false discovery rate multiple tests were mapped to the CYP4F3 gene. Among the 26 top ranked hits was a proxy SNP, CYP4F3 rs4646904 (P=8.65x10(-6), FDR = 0.018), which is suggested to change splicing pattern/efficiency and to be associated with gene expression levels. However, after adding data of rs4646904 from the Harvard GWAS, the significance in the combined analysis was reduced to P=3.52x10(-3) [odds ratio (OR) = 1.07, 95% confidence interval (95% CI) = 1.03-1.12]. Interestingly, the small Harvard dataset also pointed to the same direction of the association in subgroups of smokers (OR = 1.07) and contributed to a combined OR of 1.13 (95% CI = 1.06-1.20, P=6.70x10(-5)). The results suggest that a potentially functional SNP in CYP4F3 (rs4646904) may contribute to the etiology of lung cancer, especially in smokers. Additional mechanistic studies are warranted to unravel the potential biological significance of the finding."],["dc.identifier.doi","10.1002/mc.22622"],["dc.identifier.isi","000403698200012"],["dc.identifier.pmid","28150878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1098-2744"],["dc.relation.issn","0899-1987"],["dc.title","Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Human Genetics"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Benhamou, Simone"],["dc.contributor.author","Bouchardy, Christine"],["dc.contributor.author","Lewinger, Juan Pablo"],["dc.contributor.author","Witte, John S."],["dc.contributor.author","Chen, Gary"],["dc.contributor.author","Bull, Shelley"],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T10:10:56Z"],["dc.date.available","2018-11-07T10:10:56Z"],["dc.date.issued","2016"],["dc.description.sponsorship","NCI NIH HHS [U19 CA148127]"],["dc.format.extent","963"],["dc.identifier.doi","10.1007/s00439-016-1692-4"],["dc.identifier.isi","000380060700012"],["dc.identifier.pmid","27264937"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39951"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1203"],["dc.relation.issn","0340-6717"],["dc.title","Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls (vol 132, pg 579, 2013)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","219"],["dc.bibliographiccitation.journal","EBioMedicine"],["dc.bibliographiccitation.lastpage","226"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Chen, Li-Shiun"],["dc.contributor.author","Baker, Timothy"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Horton, Amy"],["dc.contributor.author","Culverhouse, Robert"],["dc.contributor.author","Hartz, Sarah"],["dc.contributor.author","Saccone, Nancy"],["dc.contributor.author","Cheng, Iona"],["dc.contributor.author","Deng, Bo"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Hansen, Helen M."],["dc.contributor.author","Horsman, Janet"],["dc.contributor.author","Kim, Claire"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Aben, Katja K."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Chang, Shen-Chih"],["dc.contributor.author","Saum, Kai-Uwe"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Hatsukami, Dorothy K."],["dc.contributor.author","Johnson, Eric O."],["dc.contributor.author","Pande, Mala"],["dc.contributor.author","Wrensch, Margaret R."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","van der Heijden, Erik H."],["dc.contributor.author","Wampfler, Jason"],["dc.contributor.author","Wenzlaff, Angela"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Brenner, Hermann"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Brüske, Irene"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Mayordomo, Jose"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Zhang, Zuo-Feng"],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Bierut, Laura J."],["dc.date.accessioned","2020-12-10T14:23:30Z"],["dc.date.available","2020-12-10T14:23:30Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1016/j.ebiom.2016.08.012"],["dc.identifier.issn","2352-3964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71947"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1709"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Cancer Causes & Control"],["dc.bibliographiccitation.lastpage","1720"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","McCormack, Valerie A."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Muscat, Joshua E."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Tjonneland, Anne"],["dc.contributor.author","Friis, Soren"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Chun, Eun-mi"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Rennert, Hedy S."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Orlow, Irene"],["dc.contributor.author","Park, Bernard J."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Duell, Eric J."],["dc.date.accessioned","2018-11-07T08:49:20Z"],["dc.date.available","2018-11-07T08:49:20Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose To investigate the hypothesis that non-steroidal anti-inflammatory drugs (NSAIDs) lower lung cancer risk. Methods We analysed pooled individual-level data from seven case-control and one cohort study in the International Lung Cancer Consortium (ILCCO). Relative risks for lung cancer associated with self-reported history of aspirin and other NSAID use were estimated within individual studies using logistic regression or proportional hazards models, adjusted for packyears of smoking, age, calendar period, ethnicity and education and were combined using random effects meta-analysis. Results A total of 4,309 lung cancer cases (mean age at diagnosis 65 years, 45% adenocarcinoma and 22% squamous-cell carcinoma) and 58,301 non-cases/controls were included. Amongst controls, 34% had used NSAIDs in the past (81% of them used aspirin). After adjustment for negative confounding by smoking, ever-NSAID use (affirmative answer to the study-specific question on NSAID use) was associated with a 26% reduction (95% confidence interval 8 to 41%) in lung cancer risk in men, but not in women (3% increase (-11% to 30%)). In men, the association was stronger in current and former smokers, and for squamous-cell carcinoma than for adenocarcinomas, but there was no trend with duration of use. No differences were found in the effects on lung cancer risk of aspirin and non-aspirin NSAIDs. Conclusions Evidence from ILCCO suggests that NSAID use in men confers a modest protection for lung cancer, especially amongst ever-smokers. Additional investigation is needed regarding the possible effects of age, duration, dose and type of NSAID and whether effect modification by smoking status or sex exists."],["dc.identifier.doi","10.1007/s10552-011-9847-z"],["dc.identifier.isi","000297799200010"],["dc.identifier.pmid","21987079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21438"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1573-7225"],["dc.relation.issn","0957-5243"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","587"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","597"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","McCormack, Valerie"],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Tjonneland, Anne"],["dc.contributor.author","Friis, Soren"],["dc.contributor.author","Muscat, Joshua E."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Wichmann, H-Erich"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Szeszenia-Dabrowska, Neonila"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Rudnai, Peter"],["dc.contributor.author","Fabianova, Eleonora"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Bencko, Vladimir"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Mates, Dana"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Cote, Michele L."],["dc.contributor.author","Zhang, Z."],["dc.contributor.author","Morgenstern, Hal"],["dc.contributor.author","Oh, Sam S."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Raji, Olaide Y."],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","LeMarchand, Loic"],["dc.contributor.author","Neri, Monica"],["dc.contributor.author","Bonassi, Stefano"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Lan, Qing"],["dc.contributor.author","Hu, Wei"],["dc.contributor.author","Orlow, Irene"],["dc.contributor.author","Park, Bernard J."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T09:13:01Z"],["dc.date.available","2018-11-07T09:13:01Z"],["dc.date.issued","2012"],["dc.description.abstract","Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I-2 = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 95%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 95% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC."],["dc.identifier.doi","10.1093/carcin/bgr307"],["dc.identifier.isi","000300988100014"],["dc.identifier.pmid","22198214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27075"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2180"],["dc.relation.issn","0143-3334"],["dc.title","Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","679"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The American Journal of Human Genetics"],["dc.bibliographiccitation.lastpage","691"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Chatterjee, Nilanjan"],["dc.contributor.author","Yu, Kai"],["dc.contributor.author","Goldin, Lynn R."],["dc.contributor.author","Goldstein, Alisa M."],["dc.contributor.author","Rotunno, Melissa"],["dc.contributor.author","Mirabello, Lisa"],["dc.contributor.author","Jacobs, Kevin"],["dc.contributor.author","Wheeler, William"],["dc.contributor.author","Yeager, Meredith"],["dc.contributor.author","Bergen, Andrew W."],["dc.contributor.author","Li, Qizhai"],["dc.contributor.author","Consonni, Dario"],["dc.contributor.author","Pesatori, Angela C."],["dc.contributor.author","Wacholder, Sholom"],["dc.contributor.author","Thun, Michael"],["dc.contributor.author","Diver, Ryan"],["dc.contributor.author","Oken, Martin"],["dc.contributor.author","Virtamo, Jarmo"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Wang, Z."],["dc.contributor.author","Burdette, Laurie"],["dc.contributor.author","Doheny, Kimberly F."],["dc.contributor.author","Pugh, Elizabeth W."],["dc.contributor.author","Laurie, Cathy"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Gaborieau, Valerie"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Lathrop, Mark"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Krokan, Hans E."],["dc.contributor.author","Vatten, Lars"],["dc.contributor.author","Skorpen, Frank"],["dc.contributor.author","Arnesen, Egil"],["dc.contributor.author","Benhamou, Simone"],["dc.contributor.author","Bouchard, Christine"],["dc.contributor.author","Metsapalu, Andres"],["dc.contributor.author","Vooder, Tonu"],["dc.contributor.author","Nelis, Mari"],["dc.contributor.author","Vaelk, Kristian"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Sulem, Patrick"],["dc.contributor.author","Thorleifsson, Gudmar"],["dc.contributor.author","Rafnar, Thorunn"],["dc.contributor.author","Eisen, Timothy"],["dc.contributor.author","Sauter, Wiebke"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Stefansson, Kari"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Fraumeni, Joseph F., Jr."],["dc.contributor.author","Savage, Sharon A."],["dc.contributor.author","Bertazzi, Pier Alberto"],["dc.contributor.author","Tucker, Margaret A."],["dc.contributor.author","Chanock, Stephen J."],["dc.contributor.author","Caporaso, Neil E."],["dc.date.accessioned","2018-11-07T11:22:07Z"],["dc.date.available","2018-11-07T11:22:07Z"],["dc.date.issued","2009"],["dc.description.abstract","Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of king cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additional studies, for a total of 13,300 cases and 19,666 controls of European descent. Four Studies also provided histology data for replication, resulting in 3333 adenocarcinomas (AD), 2589 squamous cell carcinomas (SQ), and 1418 small cell carcinomas (SQ. In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.13-1.33, p = 3.02 x 10(-7)), but not with other histologic types (OR = 1.01, p = 0.84 and OR = 1.00, p = 0.93 for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR = 1.24, 95% CI = 1.17-1.31, p = 3.74 x 10(-14) for AD; OR = 0.99, p = 0.69 and OR = 0.97, p = 0.48 for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma."],["dc.identifier.doi","10.1016/j.ajhg.2009.09.012"],["dc.identifier.isi","000271916500014"],["dc.identifier.pmid","19836008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55928"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0002-9297"],["dc.title","A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4826"],["dc.bibliographiccitation.lastpage","4826"],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Muscat, Joshua E."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Wichmann, Erich"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Tjønneland, Anne"],["dc.contributor.author","Friis, Søren"],["dc.contributor.author","LeMarchand, Loic"],["dc.contributor.author","Zhang, Zuo-Feng"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Field, John K."],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Wiencke, John"],["dc.contributor.author","Neri, Monica"],["dc.contributor.author","Lan, Qing"],["dc.contributor.author","Orlow, Irene"],["dc.contributor.author","Park, Bernard J."],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2022-06-08T07:57:08Z"],["dc.date.available","2022-06-08T07:57:08Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1158/1538-7445.AM10-4826"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110006"],["dc.notes.intern","DOI-Import GROB-575"],["dc.publisher","American Association for Cancer Research"],["dc.relation.conference","Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC"],["dc.title","Abstract 4826: International Lung Cancer Consortium: Pooled analysis of previous lung diseases and lung cancer risk"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]