Rosenberger, Albert

[["dc.bibliographiccitation.firstpage","937"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","950"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Haiman, Ch. A."],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Tardón, G."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Kiemeney, B."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Brunnsstöm, Hans"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wichmann, H.-Erich"],["dc.contributor.author","Manz, Judith"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas R."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Pesch, Beate"],["dc.contributor.author","Johnen, Georg"],["dc.contributor.author","Brüning, Thomas"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Gomolka, Maria"],["dc.date.accessioned","2020-12-10T14:10:35Z"],["dc.date.available","2020-12-10T14:10:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00420-018-1334-3"],["dc.identifier.eissn","1432-1246"],["dc.identifier.issn","0340-0131"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70809"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","935"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cancer Epidemiology, Biomarkers & Prevention"],["dc.bibliographiccitation.lastpage","942"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Zhu, Ying"],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Zhang, Ruyang"],["dc.contributor.author","Dong, Xuesi"],["dc.contributor.author","Shen, Sipeng"],["dc.contributor.author","Zhao, Yang"],["dc.contributor.author","Bai, Jianling"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Zhu, Bin"],["dc.contributor.author","Chanock, Stephen J."],["dc.contributor.author","Gu, Fangyi"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Shepherd, Frances A."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Somoano, Ana"],["dc.contributor.author","Fernandez-Tardon, Guillermo"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Barnett, Matthew J."],["dc.contributor.author","Doherty, Jennifer"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Carreras-Torres, Robert"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wichmann, Heunz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Saliba, Walid"],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P.A."],["dc.contributor.author","Marcus, Michael W."],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Ye, Yuanqing"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Wilkens, Lynne R."],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Kachuri, Linda"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","van der Heijden, Erik HFM"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Teare, Dawn M."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Stevens, Victoria L."],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Hu, Zhibin"],["dc.contributor.author","Dai, Juncheng"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Zhu, Dakai"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Chen, Feng"],["dc.contributor.author","Christiani, David C."],["dc.date.accessioned","2020-12-10T18:37:45Z"],["dc.date.available","2020-12-10T18:37:45Z"],["dc.date.issued","2019"],["dc.description.abstract","Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear."],["dc.identifier.doi","10.1158/1055-9965.EPI-18-0356"],["dc.identifier.eissn","1538-7755"],["dc.identifier.issn","1055-9965"],["dc.identifier.pmid","30700444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77082"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1538-7755"],["dc.relation.issn","1055-9965"],["dc.relation.issn","1538-7755"],["dc.title","Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1663"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Carcinogenesis"],["dc.bibliographiccitation.lastpage","1672"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Yin, Jieyun"],["dc.contributor.author","Liu, Hongliang"],["dc.contributor.author","Liu, Zhensheng"],["dc.contributor.author","Owzar, Kouros"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Su, L. I."],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Wei, Qingyi"],["dc.date.accessioned","2018-11-07T10:22:59Z"],["dc.date.available","2018-11-07T10:22:59Z"],["dc.date.issued","2017"],["dc.description.abstract","The fatty acids (FAs) metabolism is suggested to play a pivotal role in the development of lung cancer, and we explored that by conducting a pathway-based analysis. We performed a meta-analysis of published datasets of six genome wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium, which included 12 160 cases with lung cancer and 16 838 cancer-free controls. A total of 30 722 single-nucleotide polymorphisms (SNPs) from 317 genes relevant to FA metabolic pathways were identified. An additional dataset fromthe Harvard Lung Cancer Study with 984 cases and 970 healthy controls was also added to the final meta-analysis. In the initial meta-analysis, 26 of 28 SNPs that passed false discovery rate multiple tests were mapped to the CYP4F3 gene. Among the 26 top ranked hits was a proxy SNP, CYP4F3 rs4646904 (P=8.65x10(-6), FDR = 0.018), which is suggested to change splicing pattern/efficiency and to be associated with gene expression levels. However, after adding data of rs4646904 from the Harvard GWAS, the significance in the combined analysis was reduced to P=3.52x10(-3) [odds ratio (OR) = 1.07, 95% confidence interval (95% CI) = 1.03-1.12]. Interestingly, the small Harvard dataset also pointed to the same direction of the association in subgroups of smokers (OR = 1.07) and contributed to a combined OR of 1.13 (95% CI = 1.06-1.20, P=6.70x10(-5)). The results suggest that a potentially functional SNP in CYP4F3 (rs4646904) may contribute to the etiology of lung cancer, especially in smokers. Additional mechanistic studies are warranted to unravel the potential biological significance of the finding."],["dc.identifier.doi","10.1002/mc.22622"],["dc.identifier.isi","000403698200012"],["dc.identifier.pmid","28150878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1098-2744"],["dc.relation.issn","0899-1987"],["dc.title","Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Human Genetics"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Benhamou, Simone"],["dc.contributor.author","Bouchardy, Christine"],["dc.contributor.author","Lewinger, Juan Pablo"],["dc.contributor.author","Witte, John S."],["dc.contributor.author","Chen, Gary"],["dc.contributor.author","Bull, Shelley"],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T10:10:56Z"],["dc.date.available","2018-11-07T10:10:56Z"],["dc.date.issued","2016"],["dc.description.sponsorship","NCI NIH HHS [U19 CA148127]"],["dc.format.extent","963"],["dc.identifier.doi","10.1007/s00439-016-1692-4"],["dc.identifier.isi","000380060700012"],["dc.identifier.pmid","27264937"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39951"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1203"],["dc.relation.issn","0340-6717"],["dc.title","Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls (vol 132, pg 579, 2013)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","500"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Biochemistry"],["dc.bibliographiccitation.lastpage","509"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Timofeeva, Maria N."],["dc.contributor.author","Jaeger, Birgit"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Sauter, Wiebke"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.date.accessioned","2018-11-07T08:30:58Z"],["dc.date.available","2018-11-07T08:30:58Z"],["dc.date.issued","2009"],["dc.description.abstract","Objectives: Deletion polymorphisms of Glutathione-S-transferase (GST) M I and T I are considered risk factors for various diseases. However, most previous studies only distinguished \"null\" and \"non-null\" genotypes. Our aim was to develop a reliable. high-throughput GSTM1/T1 genotyping method able to determine allele copy numbers. Design and methods: We developed a multiplex real time PCR method to distinguish between heterozygous (1/0) and homozygous (1/1) GSTM1 and GSTT1 genotypes. The principle of relative quantification was applied and an expectation-maximisation (EM) algorithm was developed to assign one of 3 possible genotypes: 1/1, 1/0 or 0/0 for each of the two genes. Results: 1320 Caucasians were genotyped using the newly developed method. The observed genotype distributions did not deviate from the expected and were in Hardly-Weinberg equilibrium. GSTM1 duplication was detected in one sample. Conclusion: This new semiquantitative genotyping method is a sensitive and promising tool for large-scale molecular epidemiological and clinical studies. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.clinbiochem.2008.12.011"],["dc.identifier.isi","000264538300010"],["dc.identifier.pmid","19161997"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17014"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0009-9120"],["dc.title","A multiplex real-time PCR method for detection of GSTM1 and GSTT1 copy numbers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","336"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","346"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Li, Yafang"],["dc.contributor.author","Xiao, Xiangjun"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Gorlova, Olga"],["dc.contributor.author","Qian, David"],["dc.contributor.author","Leighl, Natasha"],["dc.contributor.author","Johansen, Jakob S"],["dc.contributor.author","Barnett, Matt"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Wichmann, H -Erich"],["dc.contributor.author","Manz, Judith"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Arnold, Susanne M"],["dc.contributor.author","Haura, Eric B"],["dc.contributor.author","Bolca, Ciprian"],["dc.contributor.author","Holcatova, Ivana"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Kontic, Milica"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Mukeria, Anush"],["dc.contributor.author","Ognjanovic, Simona"],["dc.contributor.author","Orlowski, Tadeusz M"],["dc.contributor.author","Scelo, Ghislaine"],["dc.contributor.author","Swiatkowska, Beata"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Bakke, Per"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Duell, Eric J"],["dc.contributor.author","Butler, Lesley M"],["dc.contributor.author","Houlston, Richard"],["dc.contributor.author","Soler Artigas, María"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Shepherd, Frances A"],["dc.contributor.author","Marcus, Michael W"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Muller, David C"],["dc.contributor.author","Overvad, Kim"],["dc.contributor.author","Trichopoulou, Antonia"],["dc.contributor.author","Tumino, Rosario"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E"],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Marchand, Loic Le"],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Aldrich, Melinda C"],["dc.contributor.author","Bush, William S"],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Teare, M Dawn"],["dc.contributor.author","Field, John K"],["dc.contributor.author","Kiemeney, Lambertus A"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B"],["dc.contributor.author","Andrew, Angeline S"],["dc.contributor.author","Bertazzi, Pier Alberto"],["dc.contributor.author","Pesatori, Angela C"],["dc.contributor.author","Christiani, David C"],["dc.contributor.author","Caporaso, Neil"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","McKay, James D"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Hung, Rayjean J"],["dc.contributor.author","Amos, Christopher I"],["dc.date.accessioned","2020-12-10T18:18:27Z"],["dc.date.available","2020-12-10T18:18:27Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1093/carcin/bgx113"],["dc.identifier.eissn","1460-2180"],["dc.identifier.issn","0143-3334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75087"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","219"],["dc.bibliographiccitation.journal","EBioMedicine"],["dc.bibliographiccitation.lastpage","226"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Chen, Li-Shiun"],["dc.contributor.author","Baker, Timothy"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Horton, Amy"],["dc.contributor.author","Culverhouse, Robert"],["dc.contributor.author","Hartz, Sarah"],["dc.contributor.author","Saccone, Nancy"],["dc.contributor.author","Cheng, Iona"],["dc.contributor.author","Deng, Bo"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Hansen, Helen M."],["dc.contributor.author","Horsman, Janet"],["dc.contributor.author","Kim, Claire"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Aben, Katja K."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Chang, Shen-Chih"],["dc.contributor.author","Saum, Kai-Uwe"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Hatsukami, Dorothy K."],["dc.contributor.author","Johnson, Eric O."],["dc.contributor.author","Pande, Mala"],["dc.contributor.author","Wrensch, Margaret R."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","van der Heijden, Erik H."],["dc.contributor.author","Wampfler, Jason"],["dc.contributor.author","Wenzlaff, Angela"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Brenner, Hermann"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Brüske, Irene"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Mayordomo, Jose"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Zhang, Zuo-Feng"],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Bierut, Laura J."],["dc.date.accessioned","2020-12-10T14:23:30Z"],["dc.date.available","2020-12-10T14:23:30Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1016/j.ebiom.2016.08.012"],["dc.identifier.issn","2352-3964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71947"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1547"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","International Journal of Cancer"],["dc.bibliographiccitation.lastpage","1561"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Timofeeva, Maria N."],["dc.contributor.author","Kropp, Silke"],["dc.contributor.author","Sauter, Wiebke"],["dc.contributor.author","Beckmann, Lars"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Illig, Thomas"],["dc.contributor.author","Jaeger, Birgit"],["dc.contributor.author","Mittelstrass, Kirstin"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Bartsch, Helmut"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.date.accessioned","2018-11-07T08:38:31Z"],["dc.date.available","2018-11-07T08:38:31Z"],["dc.date.issued","2010"],["dc.description.abstract","Early-onset lung cancer diagnosed up to the age of 50 is a very rare disease, with an increasing incidence rate. Differences in aetiology, characteristics and epidemiology of early and older onset lung cancer have been described previously, suggesting the importance of genetic factors in early-onset lung cancer aetiology. A case-control study was conducted to investigate the effects of genetic polymorphisms in the MPO, EPHX1, GSTT1, GSTM1, GSTP1 and NQO1 genes on the risk of early-onset lung cancer development. Six hundred thirty-eight Caucasian patients under the age of 51 with confirmed primary lung cancer and 1,300 cancer free control individuals, matched by age and sex, were included in this analysis. Seventeen single nucleotide polymorphisms and two deletion polymorphisms were genotyped. No significant association was found for any of the analyzed polymorphisms and overall lung cancer risk. Nonsignificantly decreased risk of lung cancer was observed for carriers of 1 or 2 copies of GSTM1. Subgroup analysis revealed gender- and/or smoking-specific effects of EPHX1 rs2854455 (IV-1464C > T) and rs2234922 (His139Arg), GSTT1 deletion, GSTP1 rs1695 (Ile105Val), rs947895 (+991C > A) and rs4891 (Ser185Ser) and NQO1 rs1800566 (Pro187Ser) polymorphisms. However, none of the observed effects were confirmed by interaction tests nor were they significant after Bonferroni correction for multiple testing. In summary, our study suggested a modifying effect of polymorphisms in EPHX1, GSTP1, GSTT1, GSTM1 and NQO1 genes on the risk of early-onset lung cancer. To confirm these observations and to eliminate possible bias in our analyses, larger studies are warranted."],["dc.identifier.doi","10.1002/ijc.25175"],["dc.identifier.isi","000281340200006"],["dc.identifier.pmid","20091863"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18782"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Inc"],["dc.relation.issn","0020-7136"],["dc.title","Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","679"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The American Journal of Human Genetics"],["dc.bibliographiccitation.lastpage","691"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Chatterjee, Nilanjan"],["dc.contributor.author","Yu, Kai"],["dc.contributor.author","Goldin, Lynn R."],["dc.contributor.author","Goldstein, Alisa M."],["dc.contributor.author","Rotunno, Melissa"],["dc.contributor.author","Mirabello, Lisa"],["dc.contributor.author","Jacobs, Kevin"],["dc.contributor.author","Wheeler, William"],["dc.contributor.author","Yeager, Meredith"],["dc.contributor.author","Bergen, Andrew W."],["dc.contributor.author","Li, Qizhai"],["dc.contributor.author","Consonni, Dario"],["dc.contributor.author","Pesatori, Angela C."],["dc.contributor.author","Wacholder, Sholom"],["dc.contributor.author","Thun, Michael"],["dc.contributor.author","Diver, Ryan"],["dc.contributor.author","Oken, Martin"],["dc.contributor.author","Virtamo, Jarmo"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Wang, Z."],["dc.contributor.author","Burdette, Laurie"],["dc.contributor.author","Doheny, Kimberly F."],["dc.contributor.author","Pugh, Elizabeth W."],["dc.contributor.author","Laurie, Cathy"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Gaborieau, Valerie"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Lathrop, Mark"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Krokan, Hans E."],["dc.contributor.author","Vatten, Lars"],["dc.contributor.author","Skorpen, Frank"],["dc.contributor.author","Arnesen, Egil"],["dc.contributor.author","Benhamou, Simone"],["dc.contributor.author","Bouchard, Christine"],["dc.contributor.author","Metsapalu, Andres"],["dc.contributor.author","Vooder, Tonu"],["dc.contributor.author","Nelis, Mari"],["dc.contributor.author","Vaelk, Kristian"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Sulem, Patrick"],["dc.contributor.author","Thorleifsson, Gudmar"],["dc.contributor.author","Rafnar, Thorunn"],["dc.contributor.author","Eisen, Timothy"],["dc.contributor.author","Sauter, Wiebke"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Stefansson, Kari"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Fraumeni, Joseph F., Jr."],["dc.contributor.author","Savage, Sharon A."],["dc.contributor.author","Bertazzi, Pier Alberto"],["dc.contributor.author","Tucker, Margaret A."],["dc.contributor.author","Chanock, Stephen J."],["dc.contributor.author","Caporaso, Neil E."],["dc.date.accessioned","2018-11-07T11:22:07Z"],["dc.date.available","2018-11-07T11:22:07Z"],["dc.date.issued","2009"],["dc.description.abstract","Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of king cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additional studies, for a total of 13,300 cases and 19,666 controls of European descent. Four Studies also provided histology data for replication, resulting in 3333 adenocarcinomas (AD), 2589 squamous cell carcinomas (SQ), and 1418 small cell carcinomas (SQ. In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.13-1.33, p = 3.02 x 10(-7)), but not with other histologic types (OR = 1.01, p = 0.84 and OR = 1.00, p = 0.93 for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR = 1.24, 95% CI = 1.17-1.31, p = 3.74 x 10(-14) for AD; OR = 0.99, p = 0.69 and OR = 0.97, p = 0.48 for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma."],["dc.identifier.doi","10.1016/j.ajhg.2009.09.012"],["dc.identifier.isi","000271916500014"],["dc.identifier.pmid","19836008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55928"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0002-9297"],["dc.title","A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1127"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cancer Epidemiology Biomarkers & Prevention"],["dc.bibliographiccitation.lastpage","1135"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Sauter, Wiebke"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Beckmann, Lars"],["dc.contributor.author","Kropp, Silke"],["dc.contributor.author","Mittelstrass, Kirstin"],["dc.contributor.author","Timofeeva, Maria N."],["dc.contributor.author","Woelke, Gabi"],["dc.contributor.author","Steinwachs, Angelika"],["dc.contributor.author","Scheiner, Daniela"],["dc.contributor.author","Meese, Eckart"],["dc.contributor.author","Sybrecht, Gerhard"],["dc.contributor.author","Kronenberg, Florian"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Illig, Thomas"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.date.accessioned","2018-11-07T11:15:22Z"],["dc.date.available","2018-11-07T11:15:22Z"],["dc.date.issued","2008"],["dc.description.abstract","Matrix metalloproteinases (MMP) play a key role in the breakdown of extracellular matrix and in inflammatory processes. MMP1 is the most highly expressed interstitial collagenase degrading fibrillar collagens. Overexpression of MMP1 has been shown in tumor tissues and has been suggested to be associated with tumor invasion and metastasis. Nine haplotype tagging and additional two intronic single nucleotide polymorphisms (SNP) of MMPI were genotyped in a case control sample, consisting of 635 lung cancer cases with onset of disease below 51 years of age and 1,300 age- and sex-matched cancer-free controls. Two regions of linkage disequilibrium (LD) of MMP1 could be observed: a region of low LD comprising the 5' region including the promoter and a region of high LD starting from exon 1 to the end of the gene and including the 3' flanking region. Several SNPs were identified to be individually significantly associated with risk of early-onset lung cancer. The most significant effect was seen for rs1938901 (P = 0.0089), rs193008 (P = 0.0108), and rs996999 (P = 0.0459). For rs996999, significance vanished after correction for multiple testing. For each of these SNPs, the major allele was associated with an increase in risk with an odds ratio between 1.2 and 1.3 (95% confidence interval, 1.0-1.5). The haplotype analysis supported these findings, especially for subgroups with high smoking intensity. In summary, we identified MMPI to be associated with an increased risk for lung cancer, which was modified by smoking."],["dc.identifier.doi","10.1158/1055-9965.EPI-07-2840"],["dc.identifier.isi","000256012800017"],["dc.identifier.pmid","18483334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54351"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Cancer Research"],["dc.relation.issn","1055-9965"],["dc.title","Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]