Bickeböller, Heike

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Jay"],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P. A."],["dc.contributor.author","Marcus, Michael W."],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Hong, Yun-Chul"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","van der Heijden, Erik H. F. M."],["dc.contributor.author","Kraft, Peter"],["dc.contributor.author","Johansson, Mikael B."],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loïc"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Park, Sungshim L."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Haura, Eric B."],["dc.contributor.author","Scelo, Ghislaine"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Mukeriya, Anush"],["dc.contributor.author","Savić, Milan"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Swiatkowska, Beata"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Holcatova, Ivana"],["dc.contributor.author","Mates, Dana"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Yuan, Jian-Min"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","McKay, James"],["dc.contributor.author","Brennan, Paul"],["dc.date.accessioned","2019-07-09T11:43:32Z"],["dc.date.available","2019-07-09T11:43:32Z"],["dc.date.issued","2017"],["dc.description.abstract","BACKGROUND: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. METHODS AND FINDINGS: We identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls. The MR risk analysis suggested a causal effect of body mass index (BMI) on lung cancer risk for two of the three major histological subtypes, with evidence of a risk increase for squamous cell carcinoma (odds ratio (OR) [95% confidence interval (CI)] = 1.20 [1.01-1.43] and for small cell lung cancer (OR [95%CI] = 1.52 [1.15-2.00]) for each standard deviation (SD) increase in BMI [4.6 kg/m2]), but not for adenocarcinoma (OR [95%CI] = 0.93 [0.79-1.08]) (Pheterogeneity = 4.3x10-3). Additional analysis using a genetic instrument for BMI showed that each SD increase in BMI increased cigarette consumption by 1.27 cigarettes per day (P = 2.1x10-3), providing novel evidence that a genetic susceptibility to obesity influences smoking patterns. There was also evidence that low-density lipoprotein cholesterol was inversely associated with lung cancer overall risk (OR [95%CI] = 0.90 [0.84-0.97] per SD of 38 mg/dl), while fasting insulin was positively associated (OR [95%CI] = 1.63 [1.25-2.13] per SD of 44.4 pmol/l). Sensitivity analyses including a weighted-median approach and MR-Egger test did not detect other pleiotropic effects biasing the main results. CONCLUSIONS: Our results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior."],["dc.identifier.doi","10.1371/journal.pone.0177875"],["dc.identifier.pmid","28594918"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14558"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58904"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.journal","Frontiers of Medicine"],["dc.contributor.author","Qin, Na"],["dc.contributor.author","Li, Yuancheng"],["dc.contributor.author","Wang, Cheng"],["dc.contributor.author","Zhu, Meng"],["dc.contributor.author","Dai, Juncheng"],["dc.contributor.author","Hong, Tongtong"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wichmann, H-Erich"],["dc.contributor.author","Bickeboller, Heike"],["dc.contributor.author","Rennert, Gadi"],["dc.contributor.author","Arnold, Susanne"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Shete, Sanjay"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Brunnstrom, Hans"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Andrew, Angeline"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Zienolddiny, Shan"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Caporaso, Neil"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Stevens, Victoria L."],["dc.contributor.author","Jin, Guangfu"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Hu, Zhibin"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Ma, Hongxia"],["dc.contributor.author","Shen, Hongbing"],["dc.date.accessioned","2021-04-14T08:23:34Z"],["dc.date.available","2021-04-14T08:23:34Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s11684-020-0779-4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80965"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2095-0225"],["dc.relation.issn","2095-0217"],["dc.title","Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","14"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Medical Research"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Muttray, Nils"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Tardón, Guillermo"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P. A."],["dc.contributor.author","Liloglou, Triantafillos"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Wendel, Bernadette"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas R."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Landi, Maria T."],["dc.contributor.author","Shete, Sanjay S."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.authorgroup","The INTEGRAL-ILCCO Consortium"],["dc.date.accessioned","2022-04-01T10:03:08Z"],["dc.date.accessioned","2022-08-18T12:40:47Z"],["dc.date.available","2022-04-01T10:03:08Z"],["dc.date.available","2022-08-18T12:40:47Z"],["dc.date.issued","2022-01-31"],["dc.date.updated","2022-07-29T12:18:28Z"],["dc.description.abstract","Background\r\nAberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility.\r\n\r\nAim\r\nTo assess the association and predictive ability of AhR/Wnt-genes with lung cancer in cases and controls of European descent.\r\n\r\nMethods\r\nOdds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genes DKK2, DKK3, DKK4, FRZB, SFRP4 and Axin2. Logistic regression models with variable selection were trained, validated and tested to predict lung cancer, at which other previously identified SNPs that have been robustly associated with lung cancer risk could also enter the model. Furthermore, decision trees were created to investigate variant × variant interaction. All analyses were performed for overall lung cancer and for subgroups.\r\n\r\nResults\r\nNo genome-wide significant association of AhR/Wnt-genes with overall lung cancer was observed, but within the subgroups of ever smokers (e.g., maker rs2722278 SFRP4; OR  = 1.20; 95% CI 1.13–1.27; p  = 5.6 × 10–10) and never smokers (e.g., maker rs1133683 Axin2; OR  = 1.27; 95% CI 1.19–1.35; p  = 1.0 × 10–12). Although predictability is poor, AhR/Wnt-variants are unexpectedly overrepresented in optimized prediction scores for overall lung cancer and for small cell lung cancer. Remarkably, the score for never-smokers contained solely two AhR/Wnt-variants. The optimal decision tree for never smokers consists of 7 AhR/Wnt-variants and only two lung cancer variants.\r\n\r\nConclusions\r\nThe role of variants belonging to Wnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","European Journal of Medical Research. 2022 Jan 31;27(1):14"],["dc.identifier.doi","10.1186/s40001-022-00638-7"],["dc.identifier.pii","638"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106090"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112985"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.publisher","BioMed Central"],["dc.relation.eissn","2047-783X"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Susceptibility"],["dc.subject","Association"],["dc.subject","Gene–gene integration"],["dc.subject","Prediction"],["dc.subject","Polygenic risk score"],["dc.subject","Decision trees"],["dc.subject","Never smoker"],["dc.subject","Small cell lung cancer"],["dc.title","Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Kachuri, Linda"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Rashkin, Sara R."],["dc.contributor.author","Graff, Rebecca E."],["dc.contributor.author","Bossé, Yohan"],["dc.contributor.author","Manem, Venkata"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Vineis, Paolo"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Scelo, Ghislaine"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Shete, Sanjay S."],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardón, Adonina"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P."],["dc.contributor.author","Dawn Teare, M."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Le Marchand, Loïc"],["dc.contributor.author","Cheng, Iona"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Arnold, Susanne"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Emami, Nima C."],["dc.contributor.author","Warkentin, Matthew T."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Obeidat, Ma’en"],["dc.contributor.author","Martin, Richard M."],["dc.contributor.author","Relton, Caroline"],["dc.contributor.author","Davey Smith, George"],["dc.contributor.author","Haycock, Philip C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Witte, John S."],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2020-12-10T18:09:53Z"],["dc.date.available","2020-12-10T18:09:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41467-019-13855-2"],["dc.identifier.eissn","2041-1723"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73786"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2292"],["dc.bibliographiccitation.lastpage","2292"],["dc.contributor.author","Kachuri, Linda"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Haycock, Phillip"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Tardón, Adonina"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Teare, Dawn"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Marchand, Loic Le"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Gaborieau, Valérie"],["dc.contributor.author","Martin, Richard"],["dc.contributor.author","Relton, Caroline"],["dc.contributor.author","Smith, George Davey"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2022-06-08T07:57:09Z"],["dc.date.available","2022-06-08T07:57:09Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1158/1538-7445.AM2017-2292"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110011"],["dc.notes.intern","DOI-Import GROB-575"],["dc.publisher","American Association for Cancer Research"],["dc.relation.conference","Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC"],["dc.title","Abstract 2292: Lung function and lung cancer risk: a Mendelian randomization study of UK Biobank cohort and the International Lung Cancer Consortium"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]