Bickeböller, Heike

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[["dc.bibliographiccitation.firstpage","1957"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","1968"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Cote, Michele L."],["dc.contributor.author","Liu, Mei"],["dc.contributor.author","Bonassi, Stefano"],["dc.contributor.author","Neri, Monica"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Muscat, Joshua E."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Aben, Katja K."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Bencko, Vladimir"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Brenner, Hermann"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Fabianova, Eleonora"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Foretova, Lenka"],["dc.contributor.author","Friis, Soren"],["dc.contributor.author","Harris, Curtis C."],["dc.contributor.author","Holcatova, Ivana"],["dc.contributor.author","Hong, Yun-Chul"],["dc.contributor.author","Isla, Dolores"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Kiyohara, Chikako"],["dc.contributor.author","Lan, Qing"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Mates, Dana"],["dc.contributor.author","Matsuo, Keitaro"],["dc.contributor.author","Mayordomo, Jose I."],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Morgenstern, Hal"],["dc.contributor.author","Mueeller, Heiko"],["dc.contributor.author","Orlow, Irene"],["dc.contributor.author","Park, Bernard J."],["dc.contributor.author","Pinchev, Mila"],["dc.contributor.author","Raji, Olaide Y."],["dc.contributor.author","Rennert, Hedy S."],["dc.contributor.author","Rudnai, Peter"],["dc.contributor.author","Seow, Adeline"],["dc.contributor.author","Stucker, Isabelle"],["dc.contributor.author","Szeszenia-Dabrowska, Neonila"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Tjonnelan, Anne"],["dc.contributor.author","Ugolini, Donatella"],["dc.contributor.author","van der Heijden, Henricus F. M."],["dc.contributor.author","Wichmann, Erich"],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Zhang, Z."],["dc.contributor.author","Etzel, Carol J."],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T09:06:38Z"],["dc.date.available","2018-11-07T09:06:38Z"],["dc.date.issued","2012"],["dc.description.abstract","Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group. (c) 2012 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2012.01.038"],["dc.identifier.isi","000307884500005"],["dc.identifier.pmid","22436981"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25604"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1879-0852"],["dc.relation.issn","0959-8049"],["dc.title","Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","djv100"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","JNCI Journal of the National Cancer Institute"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Chen, Li-Shiun"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Baker, Timothy"],["dc.contributor.author","Horton, Amy"],["dc.contributor.author","Culverhouse, Rob"],["dc.contributor.author","Saccone, Nancy"],["dc.contributor.author","Cheng, Iona"],["dc.contributor.author","Deng, B. O."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Hansen, Helen M."],["dc.contributor.author","Horsman, Janet"],["dc.contributor.author","Kim, Claire"],["dc.contributor.author","Lutz, Sharon"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Aben, Katja K."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Breslau, Naomi"],["dc.contributor.author","Chang, Shen-Chih"],["dc.contributor.author","Dieffenbach, Aida Karina"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Frederiksen, Brittni"],["dc.contributor.author","Han, Jiali"],["dc.contributor.author","Hatsukami, Dorothy K."],["dc.contributor.author","Johnson, Eric O."],["dc.contributor.author","Pande, Mala"],["dc.contributor.author","Wrensch, Margaret R."],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","van der Heijden, Henricus F. M."],["dc.contributor.author","Wampfler, Jason"],["dc.contributor.author","Wenzlaff, Angela"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Brenner, Hermann"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Hokanson, John E."],["dc.contributor.author","Hunter, David J."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Mayordomo, Jose I."],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Teare, Dawn"],["dc.contributor.author","Wu, X."],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Zhang, Z."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Kraft, Peter"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Bierut, Laura J."],["dc.date.accessioned","2018-11-07T09:57:38Z"],["dc.date.available","2018-11-07T09:57:38Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis. Methods: Meta-analyses examined associations between rs16969968, age of quitting smoking, and age of lung cancer diagnosis in 24 studies of European ancestry (n = 29 072). In each dataset, we used Cox regression models to evaluate the association between rs16969968 and the two primary phenotypes (age of smoking cessation among ever smokers and age of lung cancer diagnosis among lung cancer case patients) and the secondary phenotype of smoking duration. Heterogeneity across studies was assessed with the Cochran Q test. All statistical tests were two-sided. Results: The rs16969968 allele (A) was associated with a lower likelihood of smoking cessation (hazard ratio [HR] = 0.95, 95% confidence interval [CI] = 0.91 to 0.98, P =.0042), and the AA genotype was associated with a four-year delay in median age of quitting compared with the GG genotype. Among smokers with lung cancer diagnoses, the rs16969968 genotype (AA) was associated with a four-year earlier median age of diagnosis compared with the low-risk genotype (GG) (HR = 1.08, 95% CI = 1.04 to 1.12, P = 1.1 10(-5)). Conclusion: These data support the clinical significance of the CHRNA5 variant rs16969968. It predicts delayed smoking cessation and an earlier age of lung cancer diagnosis in this meta-analysis. Given the existing evidence that this CHRNA5 variant predicts favorable response to cessation pharmacotherapy, these findings underscore the potential clinical and public health importance of rs16969968 in CHRNA5 in relation to smoking cessation success and lung cancer risk.d: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis."],["dc.identifier.doi","10.1093/jnci/djv100"],["dc.identifier.isi","000355088600029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37206"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2105"],["dc.relation.issn","0027-8874"],["dc.title","CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis-A Meta-Analysis"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Kachuri, Linda"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Rashkin, Sara R."],["dc.contributor.author","Graff, Rebecca E."],["dc.contributor.author","Bossé, Yohan"],["dc.contributor.author","Manem, Venkata"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Vineis, Paolo"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Scelo, Ghislaine"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Shete, Sanjay S."],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardón, Adonina"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P."],["dc.contributor.author","Dawn Teare, M."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Le Marchand, Loïc"],["dc.contributor.author","Cheng, Iona"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Arnold, Susanne"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Emami, Nima C."],["dc.contributor.author","Warkentin, Matthew T."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Obeidat, Ma’en"],["dc.contributor.author","Martin, Richard M."],["dc.contributor.author","Relton, Caroline"],["dc.contributor.author","Davey Smith, George"],["dc.contributor.author","Haycock, Philip C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Witte, John S."],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2020-12-10T18:09:53Z"],["dc.date.available","2020-12-10T18:09:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41467-019-13855-2"],["dc.identifier.eissn","2041-1723"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73786"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]