Bickeböller, Heike

[["dc.bibliographiccitation.firstpage","937"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","950"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Haiman, Ch. A."],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Tardón, G."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Kiemeney, B."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Brunnsstöm, Hans"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wichmann, H.-Erich"],["dc.contributor.author","Manz, Judith"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas R."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Pesch, Beate"],["dc.contributor.author","Johnen, Georg"],["dc.contributor.author","Brüning, Thomas"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Gomolka, Maria"],["dc.date.accessioned","2020-12-10T14:10:35Z"],["dc.date.available","2020-12-10T14:10:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00420-018-1334-3"],["dc.identifier.eissn","1432-1246"],["dc.identifier.issn","0340-0131"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70809"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","935"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cancer Epidemiology, Biomarkers & Prevention"],["dc.bibliographiccitation.lastpage","942"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Zhu, Ying"],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Zhang, Ruyang"],["dc.contributor.author","Dong, Xuesi"],["dc.contributor.author","Shen, Sipeng"],["dc.contributor.author","Zhao, Yang"],["dc.contributor.author","Bai, Jianling"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Zhu, Bin"],["dc.contributor.author","Chanock, Stephen J."],["dc.contributor.author","Gu, Fangyi"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Shepherd, Frances A."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Somoano, Ana"],["dc.contributor.author","Fernandez-Tardon, Guillermo"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Barnett, Matthew J."],["dc.contributor.author","Doherty, Jennifer"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Carreras-Torres, Robert"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wichmann, Heunz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Saliba, Walid"],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P.A."],["dc.contributor.author","Marcus, Michael W."],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Ye, Yuanqing"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Wilkens, Lynne R."],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Kachuri, Linda"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","van der Heijden, Erik HFM"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Teare, Dawn M."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Stevens, Victoria L."],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Hu, Zhibin"],["dc.contributor.author","Dai, Juncheng"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Zhu, Dakai"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Chen, Feng"],["dc.contributor.author","Christiani, David C."],["dc.date.accessioned","2020-12-10T18:37:45Z"],["dc.date.available","2020-12-10T18:37:45Z"],["dc.date.issued","2019"],["dc.description.abstract","Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear."],["dc.identifier.doi","10.1158/1055-9965.EPI-18-0356"],["dc.identifier.eissn","1538-7755"],["dc.identifier.issn","1055-9965"],["dc.identifier.pmid","30700444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77082"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1538-7755"],["dc.relation.issn","1055-9965"],["dc.relation.issn","1538-7755"],["dc.title","Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1607"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Cancer Research"],["dc.bibliographiccitation.lastpage","1615"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Warkentin, Matthew T."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Chatterjee, Nilanjan"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Marchand, Loic Le"],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Zienolddiny, Shanbeth"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Amos, Christopher I."],["dc.date.accessioned","2021-04-14T08:28:12Z"],["dc.date.available","2021-04-14T08:28:12Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1158/0008-5472.CAN-20-1237"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82534"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1538-7445"],["dc.relation.issn","0008-5472"],["dc.title","Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1077"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","International Journal of Cancer"],["dc.bibliographiccitation.lastpage","1086"],["dc.bibliographiccitation.volume","148"],["dc.contributor.author","Zhou, Wen"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Haycock, Philip C."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loïc"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Shete, Sanjay S."],["dc.contributor.author","Tardón, Adonina"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Amos, Christopher I."],["dc.date.accessioned","2021-04-14T08:23:41Z"],["dc.date.available","2021-04-14T08:23:41Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1002/ijc.33292"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81011"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1097-0215"],["dc.relation.issn","0020-7136"],["dc.title","Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","219"],["dc.bibliographiccitation.journal","EBioMedicine"],["dc.bibliographiccitation.lastpage","226"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Chen, Li-Shiun"],["dc.contributor.author","Baker, Timothy"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Horton, Amy"],["dc.contributor.author","Culverhouse, Robert"],["dc.contributor.author","Hartz, Sarah"],["dc.contributor.author","Saccone, Nancy"],["dc.contributor.author","Cheng, Iona"],["dc.contributor.author","Deng, Bo"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Hansen, Helen M."],["dc.contributor.author","Horsman, Janet"],["dc.contributor.author","Kim, Claire"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Aben, Katja K."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Chang, Shen-Chih"],["dc.contributor.author","Saum, Kai-Uwe"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Hatsukami, Dorothy K."],["dc.contributor.author","Johnson, Eric O."],["dc.contributor.author","Pande, Mala"],["dc.contributor.author","Wrensch, Margaret R."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","van der Heijden, Erik H."],["dc.contributor.author","Wampfler, Jason"],["dc.contributor.author","Wenzlaff, Angela"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Brenner, Hermann"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Brüske, Irene"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Mayordomo, Jose"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Zhang, Zuo-Feng"],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Bierut, Laura J."],["dc.date.accessioned","2020-12-10T14:23:30Z"],["dc.date.available","2020-12-10T14:23:30Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1016/j.ebiom.2016.08.012"],["dc.identifier.issn","2352-3964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71947"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1709"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Cancer Causes & Control"],["dc.bibliographiccitation.lastpage","1720"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","McCormack, Valerie A."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Muscat, Joshua E."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Tjonneland, Anne"],["dc.contributor.author","Friis, Soren"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Chun, Eun-mi"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Rennert, Hedy S."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Orlow, Irene"],["dc.contributor.author","Park, Bernard J."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Duell, Eric J."],["dc.date.accessioned","2018-11-07T08:49:20Z"],["dc.date.available","2018-11-07T08:49:20Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose To investigate the hypothesis that non-steroidal anti-inflammatory drugs (NSAIDs) lower lung cancer risk. Methods We analysed pooled individual-level data from seven case-control and one cohort study in the International Lung Cancer Consortium (ILCCO). Relative risks for lung cancer associated with self-reported history of aspirin and other NSAID use were estimated within individual studies using logistic regression or proportional hazards models, adjusted for packyears of smoking, age, calendar period, ethnicity and education and were combined using random effects meta-analysis. Results A total of 4,309 lung cancer cases (mean age at diagnosis 65 years, 45% adenocarcinoma and 22% squamous-cell carcinoma) and 58,301 non-cases/controls were included. Amongst controls, 34% had used NSAIDs in the past (81% of them used aspirin). After adjustment for negative confounding by smoking, ever-NSAID use (affirmative answer to the study-specific question on NSAID use) was associated with a 26% reduction (95% confidence interval 8 to 41%) in lung cancer risk in men, but not in women (3% increase (-11% to 30%)). In men, the association was stronger in current and former smokers, and for squamous-cell carcinoma than for adenocarcinomas, but there was no trend with duration of use. No differences were found in the effects on lung cancer risk of aspirin and non-aspirin NSAIDs. Conclusions Evidence from ILCCO suggests that NSAID use in men confers a modest protection for lung cancer, especially amongst ever-smokers. Additional investigation is needed regarding the possible effects of age, duration, dose and type of NSAID and whether effect modification by smoking status or sex exists."],["dc.identifier.doi","10.1007/s10552-011-9847-z"],["dc.identifier.isi","000297799200010"],["dc.identifier.pmid","21987079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21438"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1573-7225"],["dc.relation.issn","0957-5243"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","587"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","597"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","McCormack, Valerie"],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Tjonneland, Anne"],["dc.contributor.author","Friis, Soren"],["dc.contributor.author","Muscat, Joshua E."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Wichmann, H-Erich"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Szeszenia-Dabrowska, Neonila"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Rudnai, Peter"],["dc.contributor.author","Fabianova, Eleonora"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Bencko, Vladimir"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Mates, Dana"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Cote, Michele L."],["dc.contributor.author","Zhang, Z."],["dc.contributor.author","Morgenstern, Hal"],["dc.contributor.author","Oh, Sam S."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Raji, Olaide Y."],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","LeMarchand, Loic"],["dc.contributor.author","Neri, Monica"],["dc.contributor.author","Bonassi, Stefano"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Lan, Qing"],["dc.contributor.author","Hu, Wei"],["dc.contributor.author","Orlow, Irene"],["dc.contributor.author","Park, Bernard J."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T09:13:01Z"],["dc.date.available","2018-11-07T09:13:01Z"],["dc.date.issued","2012"],["dc.description.abstract","Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I-2 = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 95%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 95% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC."],["dc.identifier.doi","10.1093/carcin/bgr307"],["dc.identifier.isi","000300988100014"],["dc.identifier.pmid","22198214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27075"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2180"],["dc.relation.issn","0143-3334"],["dc.title","Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1423"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cancer Epidemiology Biomarkers & Prevention"],["dc.bibliographiccitation.lastpage","1429"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Wang, Yuzhuo"],["dc.contributor.author","Gorlova, Olga Y."],["dc.contributor.author","Gorlov, Ivan P."],["dc.contributor.author","Zhu, Meng"],["dc.contributor.author","Dai, Juncheng"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wichmann, Heunz-Erich"],["dc.contributor.author","Bickeboller, Heike"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Shete, Sanjay"],["dc.contributor.author","Le Marchand, Loïc"],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Brunnstrom, Hans"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Stevens, Victoria L."],["dc.contributor.author","Ma, Hongxia"],["dc.contributor.author","Jin, Guangfu"],["dc.contributor.author","Hu, Zhibin"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Shen, Hongbing"],["dc.date.accessioned","2021-04-14T08:25:18Z"],["dc.date.available","2021-04-14T08:25:18Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1158/1055-9965.EPI-19-1085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81589"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1538-7755"],["dc.relation.issn","1055-9965"],["dc.title","Association Analysis of Driver Gene–Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","14"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Medical Research"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Muttray, Nils"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Tardón, Guillermo"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P. A."],["dc.contributor.author","Liloglou, Triantafillos"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Wendel, Bernadette"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas R."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Landi, Maria T."],["dc.contributor.author","Shete, Sanjay S."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.authorgroup","The INTEGRAL-ILCCO Consortium"],["dc.date.accessioned","2022-04-01T10:03:08Z"],["dc.date.accessioned","2022-08-18T12:40:47Z"],["dc.date.available","2022-04-01T10:03:08Z"],["dc.date.available","2022-08-18T12:40:47Z"],["dc.date.issued","2022-01-31"],["dc.date.updated","2022-07-29T12:18:28Z"],["dc.description.abstract","Background\r\nAberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility.\r\n\r\nAim\r\nTo assess the association and predictive ability of AhR/Wnt-genes with lung cancer in cases and controls of European descent.\r\n\r\nMethods\r\nOdds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genes DKK2, DKK3, DKK4, FRZB, SFRP4 and Axin2. Logistic regression models with variable selection were trained, validated and tested to predict lung cancer, at which other previously identified SNPs that have been robustly associated with lung cancer risk could also enter the model. Furthermore, decision trees were created to investigate variant × variant interaction. All analyses were performed for overall lung cancer and for subgroups.\r\n\r\nResults\r\nNo genome-wide significant association of AhR/Wnt-genes with overall lung cancer was observed, but within the subgroups of ever smokers (e.g., maker rs2722278 SFRP4; OR  = 1.20; 95% CI 1.13–1.27; p  = 5.6 × 10–10) and never smokers (e.g., maker rs1133683 Axin2; OR  = 1.27; 95% CI 1.19–1.35; p  = 1.0 × 10–12). Although predictability is poor, AhR/Wnt-variants are unexpectedly overrepresented in optimized prediction scores for overall lung cancer and for small cell lung cancer. Remarkably, the score for never-smokers contained solely two AhR/Wnt-variants. The optimal decision tree for never smokers consists of 7 AhR/Wnt-variants and only two lung cancer variants.\r\n\r\nConclusions\r\nThe role of variants belonging to Wnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","European Journal of Medical Research. 2022 Jan 31;27(1):14"],["dc.identifier.doi","10.1186/s40001-022-00638-7"],["dc.identifier.pii","638"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106090"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112985"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.publisher","BioMed Central"],["dc.relation.eissn","2047-783X"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Susceptibility"],["dc.subject","Association"],["dc.subject","Gene–gene integration"],["dc.subject","Prediction"],["dc.subject","Polygenic risk score"],["dc.subject","Decision trees"],["dc.subject","Never smoker"],["dc.subject","Small cell lung cancer"],["dc.title","Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1957"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","1968"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Cote, Michele L."],["dc.contributor.author","Liu, Mei"],["dc.contributor.author","Bonassi, Stefano"],["dc.contributor.author","Neri, Monica"],["dc.contributor.author","Schwartz, Ann G."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Muscat, Joshua E."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Aben, Katja K."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Bencko, Vladimir"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Brenner, Hermann"],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Fabianova, Eleonora"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Foretova, Lenka"],["dc.contributor.author","Friis, Soren"],["dc.contributor.author","Harris, Curtis C."],["dc.contributor.author","Holcatova, Ivana"],["dc.contributor.author","Hong, Yun-Chul"],["dc.contributor.author","Isla, Dolores"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Kiyohara, Chikako"],["dc.contributor.author","Lan, Qing"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Mates, Dana"],["dc.contributor.author","Matsuo, Keitaro"],["dc.contributor.author","Mayordomo, Jose I."],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Morgenstern, Hal"],["dc.contributor.author","Mueeller, Heiko"],["dc.contributor.author","Orlow, Irene"],["dc.contributor.author","Park, Bernard J."],["dc.contributor.author","Pinchev, Mila"],["dc.contributor.author","Raji, Olaide Y."],["dc.contributor.author","Rennert, Hedy S."],["dc.contributor.author","Rudnai, Peter"],["dc.contributor.author","Seow, Adeline"],["dc.contributor.author","Stucker, Isabelle"],["dc.contributor.author","Szeszenia-Dabrowska, Neonila"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Tjonnelan, Anne"],["dc.contributor.author","Ugolini, Donatella"],["dc.contributor.author","van der Heijden, Henricus F. M."],["dc.contributor.author","Wichmann, Erich"],["dc.contributor.author","Wiencke, John K."],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Yang, Ping"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Zhang, Z."],["dc.contributor.author","Etzel, Carol J."],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T09:06:38Z"],["dc.date.available","2018-11-07T09:06:38Z"],["dc.date.issued","2012"],["dc.description.abstract","Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group. (c) 2012 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ejca.2012.01.038"],["dc.identifier.isi","000307884500005"],["dc.identifier.pmid","22436981"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25604"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1879-0852"],["dc.relation.issn","0959-8049"],["dc.title","Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]