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Bickeböller, Heike
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Bickeböller, Heike
Official Name
Bickeböller, Heike
Alternative Name
Bickeboeller, H.
Bickeboller, Heike
Bickeböller, H.
Bickeboeller, Heike
Bickeboller, H.
Main Affiliation
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2015Conference Abstract [["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Friedrichs, Stefanie"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Christiani, David"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Brueske, Irene"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Rafnar, Thorunn"],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T09:49:47Z"],["dc.date.available","2018-11-07T09:49:47Z"],["dc.date.issued","2015"],["dc.format.extent","549"],["dc.identifier.isi","000363340500056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35571"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","Annual Meeting of the International-Genetic-Epidemiology-Society (IGES)"],["dc.relation.eventlocation","Baltimore, MD"],["dc.relation.issn","1098-2272"],["dc.relation.issn","0741-0395"],["dc.title","Kernel-based Pathway Meta-Analysis in ILCCO / TRICL Genome-wide Association Studies"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2012Conference Abstract [["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Sohns, Melanie"],["dc.contributor.author","Viktorova, Elena"],["dc.contributor.author","Fehringer, Gord"],["dc.contributor.author","Gaborieau, Valerie"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T09:04:08Z"],["dc.date.available","2018-11-07T09:04:08Z"],["dc.date.issued","2012"],["dc.format.extent","756"],["dc.identifier.isi","000309913200133"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25044"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","Annual Meeting of the International-Genetic-Epidemiology-Society (IGES)"],["dc.relation.eventlocation","Stevenson, WA"],["dc.relation.issn","0741-0395"],["dc.title","Application of the Empirical Hierarchical Bayes Approach for Gene-Environment Interaction to TRICL Lung Cancer GWAS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2018Journal Article [["dc.bibliographiccitation.firstpage","937"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","950"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Haiman, Ch. A."],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Tardón, G."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Kiemeney, B."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Brunnsstöm, Hans"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Wichmann, H.-Erich"],["dc.contributor.author","Manz, Judith"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas R."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Pesch, Beate"],["dc.contributor.author","Johnen, Georg"],["dc.contributor.author","Brüning, Thomas"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Gomolka, Maria"],["dc.date.accessioned","2020-12-10T14:10:35Z"],["dc.date.available","2020-12-10T14:10:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00420-018-1334-3"],["dc.identifier.eissn","1432-1246"],["dc.identifier.issn","0340-0131"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70809"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]Details DOI2019Journal Article [["dc.bibliographiccitation.firstpage","935"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cancer Epidemiology, Biomarkers & Prevention"],["dc.bibliographiccitation.lastpage","942"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Zhu, Ying"],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Zhang, Ruyang"],["dc.contributor.author","Dong, Xuesi"],["dc.contributor.author","Shen, Sipeng"],["dc.contributor.author","Zhao, Yang"],["dc.contributor.author","Bai, Jianling"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Zhu, Bin"],["dc.contributor.author","Chanock, Stephen J."],["dc.contributor.author","Gu, Fangyi"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Shepherd, Frances A."],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Fernández-Somoano, Ana"],["dc.contributor.author","Fernandez-Tardon, Guillermo"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Barnett, Matthew J."],["dc.contributor.author","Doherty, Jennifer"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Carreras-Torres, Robert"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Wichmann, Heunz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Saliba, Walid"],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P.A."],["dc.contributor.author","Marcus, Michael W."],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Ye, Yuanqing"],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Wilkens, Lynne R."],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Kachuri, Linda"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","van der Heijden, Erik HFM"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Woll, Penella J."],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Teare, Dawn M."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Stevens, Victoria L."],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Hu, Zhibin"],["dc.contributor.author","Dai, Juncheng"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Zhu, Dakai"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Chen, Feng"],["dc.contributor.author","Christiani, David C."],["dc.date.accessioned","2020-12-10T18:37:45Z"],["dc.date.available","2020-12-10T18:37:45Z"],["dc.date.issued","2019"],["dc.description.abstract","Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear."],["dc.identifier.doi","10.1158/1055-9965.EPI-18-0356"],["dc.identifier.eissn","1538-7755"],["dc.identifier.issn","1055-9965"],["dc.identifier.pmid","30700444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77082"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1538-7755"],["dc.relation.issn","1055-9965"],["dc.relation.issn","1538-7755"],["dc.title","Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]Details DOI PMID PMC2017Journal Article [["dc.bibliographiccitation.firstpage","1663"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Carcinogenesis"],["dc.bibliographiccitation.lastpage","1672"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Yin, Jieyun"],["dc.contributor.author","Liu, Hongliang"],["dc.contributor.author","Liu, Zhensheng"],["dc.contributor.author","Owzar, Kouros"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Su, L. I."],["dc.contributor.author","Wei, Yongyue"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Wei, Qingyi"],["dc.date.accessioned","2018-11-07T10:22:59Z"],["dc.date.available","2018-11-07T10:22:59Z"],["dc.date.issued","2017"],["dc.description.abstract","The fatty acids (FAs) metabolism is suggested to play a pivotal role in the development of lung cancer, and we explored that by conducting a pathway-based analysis. We performed a meta-analysis of published datasets of six genome wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium, which included 12 160 cases with lung cancer and 16 838 cancer-free controls. A total of 30 722 single-nucleotide polymorphisms (SNPs) from 317 genes relevant to FA metabolic pathways were identified. An additional dataset fromthe Harvard Lung Cancer Study with 984 cases and 970 healthy controls was also added to the final meta-analysis. In the initial meta-analysis, 26 of 28 SNPs that passed false discovery rate multiple tests were mapped to the CYP4F3 gene. Among the 26 top ranked hits was a proxy SNP, CYP4F3 rs4646904 (P=8.65x10(-6), FDR = 0.018), which is suggested to change splicing pattern/efficiency and to be associated with gene expression levels. However, after adding data of rs4646904 from the Harvard GWAS, the significance in the combined analysis was reduced to P=3.52x10(-3) [odds ratio (OR) = 1.07, 95% confidence interval (95% CI) = 1.03-1.12]. Interestingly, the small Harvard dataset also pointed to the same direction of the association in subgroups of smokers (OR = 1.07) and contributed to a combined OR of 1.13 (95% CI = 1.06-1.20, P=6.70x10(-5)). The results suggest that a potentially functional SNP in CYP4F3 (rs4646904) may contribute to the etiology of lung cancer, especially in smokers. Additional mechanistic studies are warranted to unravel the potential biological significance of the finding."],["dc.identifier.doi","10.1002/mc.22622"],["dc.identifier.isi","000403698200012"],["dc.identifier.pmid","28150878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1098-2744"],["dc.relation.issn","0899-1987"],["dc.title","Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2021Journal Article [["dc.bibliographiccitation.firstpage","1607"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Cancer Research"],["dc.bibliographiccitation.lastpage","1615"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Warkentin, Matthew T."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","Chatterjee, Nilanjan"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Marchand, Loic Le"],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Zienolddiny, Shanbeth"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Amos, Christopher I."],["dc.date.accessioned","2021-04-14T08:28:12Z"],["dc.date.available","2021-04-14T08:28:12Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1158/0008-5472.CAN-20-1237"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82534"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1538-7445"],["dc.relation.issn","0008-5472"],["dc.title","Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]Details DOI2020Journal Article [["dc.bibliographiccitation.firstpage","1077"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","International Journal of Cancer"],["dc.bibliographiccitation.lastpage","1086"],["dc.bibliographiccitation.volume","148"],["dc.contributor.author","Zhou, Wen"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Haycock, Philip C."],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Andrew, Angeline S."],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Field, John K."],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loïc"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Shete, Sanjay S."],["dc.contributor.author","Tardón, Adonina"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Amos, Christopher I."],["dc.date.accessioned","2021-04-14T08:23:41Z"],["dc.date.available","2021-04-14T08:23:41Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1002/ijc.33292"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81011"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1097-0215"],["dc.relation.issn","0020-7136"],["dc.title","Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]Details DOI2016Journal Article [["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Human Genetics"],["dc.bibliographiccitation.volume","135"],["dc.contributor.author","Brenner, Darren R."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Boffetta, Paolo"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Benhamou, Simone"],["dc.contributor.author","Bouchardy, Christine"],["dc.contributor.author","Lewinger, Juan Pablo"],["dc.contributor.author","Witte, John S."],["dc.contributor.author","Chen, Gary"],["dc.contributor.author","Bull, Shelley"],["dc.contributor.author","Hung, Rayjean J."],["dc.date.accessioned","2018-11-07T10:10:56Z"],["dc.date.available","2018-11-07T10:10:56Z"],["dc.date.issued","2016"],["dc.description.sponsorship","NCI NIH HHS [U19 CA148127]"],["dc.format.extent","963"],["dc.identifier.doi","10.1007/s00439-016-1692-4"],["dc.identifier.isi","000380060700012"],["dc.identifier.pmid","27264937"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39951"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1203"],["dc.relation.issn","0340-6717"],["dc.title","Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls (vol 132, pg 579, 2013)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2009Journal Article [["dc.bibliographiccitation.firstpage","500"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Biochemistry"],["dc.bibliographiccitation.lastpage","509"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Timofeeva, Maria N."],["dc.contributor.author","Jaeger, Birgit"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Sauter, Wiebke"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.date.accessioned","2018-11-07T08:30:58Z"],["dc.date.available","2018-11-07T08:30:58Z"],["dc.date.issued","2009"],["dc.description.abstract","Objectives: Deletion polymorphisms of Glutathione-S-transferase (GST) M I and T I are considered risk factors for various diseases. However, most previous studies only distinguished \"null\" and \"non-null\" genotypes. Our aim was to develop a reliable. high-throughput GSTM1/T1 genotyping method able to determine allele copy numbers. Design and methods: We developed a multiplex real time PCR method to distinguish between heterozygous (1/0) and homozygous (1/1) GSTM1 and GSTT1 genotypes. The principle of relative quantification was applied and an expectation-maximisation (EM) algorithm was developed to assign one of 3 possible genotypes: 1/1, 1/0 or 0/0 for each of the two genes. Results: 1320 Caucasians were genotyped using the newly developed method. The observed genotype distributions did not deviate from the expected and were in Hardly-Weinberg equilibrium. GSTM1 duplication was detected in one sample. Conclusion: This new semiquantitative genotyping method is a sensitive and promising tool for large-scale molecular epidemiological and clinical studies. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.clinbiochem.2008.12.011"],["dc.identifier.isi","000264538300010"],["dc.identifier.pmid","19161997"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17014"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0009-9120"],["dc.title","A multiplex real-time PCR method for detection of GSTM1 and GSTT1 copy numbers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2017Journal Article [["dc.bibliographiccitation.firstpage","336"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","346"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Li, Yafang"],["dc.contributor.author","Xiao, Xiangjun"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Gorlova, Olga"],["dc.contributor.author","Qian, David"],["dc.contributor.author","Leighl, Natasha"],["dc.contributor.author","Johansen, Jakob S"],["dc.contributor.author","Barnett, Matt"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Cox, Angela"],["dc.contributor.author","Taylor, Fiona"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Wichmann, H -Erich"],["dc.contributor.author","Manz, Judith"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Arnold, Susanne M"],["dc.contributor.author","Haura, Eric B"],["dc.contributor.author","Bolca, Ciprian"],["dc.contributor.author","Holcatova, Ivana"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Kontic, Milica"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Mukeria, Anush"],["dc.contributor.author","Ognjanovic, Simona"],["dc.contributor.author","Orlowski, Tadeusz M"],["dc.contributor.author","Scelo, Ghislaine"],["dc.contributor.author","Swiatkowska, Beata"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Bakke, Per"],["dc.contributor.author","Skaug, Vidar"],["dc.contributor.author","Zienolddiny, Shanbeh"],["dc.contributor.author","Duell, Eric J"],["dc.contributor.author","Butler, Lesley M"],["dc.contributor.author","Houlston, Richard"],["dc.contributor.author","Soler Artigas, María"],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Johansson, Mikael"],["dc.contributor.author","Shepherd, Frances A"],["dc.contributor.author","Marcus, Michael W"],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Muller, David C"],["dc.contributor.author","Overvad, Kim"],["dc.contributor.author","Trichopoulou, Antonia"],["dc.contributor.author","Tumino, Rosario"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Bojesen, Stig E"],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Marchand, Loic Le"],["dc.contributor.author","Albanes, Demetrios"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Aldrich, Melinda C"],["dc.contributor.author","Bush, William S"],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Teare, M Dawn"],["dc.contributor.author","Field, John K"],["dc.contributor.author","Kiemeney, Lambertus A"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Schabath, Matthew B"],["dc.contributor.author","Andrew, Angeline S"],["dc.contributor.author","Bertazzi, Pier Alberto"],["dc.contributor.author","Pesatori, Angela C"],["dc.contributor.author","Christiani, David C"],["dc.contributor.author","Caporaso, Neil"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","McKay, James D"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Hung, Rayjean J"],["dc.contributor.author","Amos, Christopher I"],["dc.date.accessioned","2020-12-10T18:18:27Z"],["dc.date.available","2020-12-10T18:18:27Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1093/carcin/bgx113"],["dc.identifier.eissn","1460-2180"],["dc.identifier.issn","0143-3334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75087"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]Details DOI