Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

ISSN
1741-7015
Date Issued
2016
Author(s)
Jungk, Christine
Mock, Andreas
Exner, Janina
Geisenberger, Christoph
Warta, Rolf
Capper, David
Abdollahi, Amir
Friauf, Sara
Lahrmann, Bernd
Beckhove, Philipp
von Deimling, Andreas
Unterberg, Andreas
Herold-Mende, Christel
DOI
10.1186/s12916-016-0710-7
Abstract
The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers.