Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy

ISSN
1068-9265
Date Issued
2012-12
Author(s)
Kahlert, Christoph
Gaitzsch, Eva
Steinert, Gunnar
Mogler, Carolin
Herpel, Esther
Hoffmeister, Michael
Jansen, Lina
Benner, Axel
Brenner, Hermann
Chang-Claude, Jenny
Rahbari, Nuh
Schmidt, Thomas
Klupp, Fee
Lahrmann, Bernd
Koch, Moritz
Halama, Niels
Büchler, Markus
Weitz, Juergen
DOI
10.1245/s10434-012-2518-9
Abstract
Aldehyde dehydrogenase 1A1 (ALDH1A1) has been described as a cancer stem cell marker and as a regulator of cellular chemoresistance. Therefore, ALDH1A1 has been suggested as potential biomarker to stratify patients into different risk categories for a "personalized" therapy approach. We have investigated the prognostic role of ALDH1A1 in primary colorectal cancer and its value in predicting response to chemotherapy in metastatic colorectal cancer.