Purinergic activation of dorsal root ganglion neurones in vivo

ISSN
0304-3940
Date Issued
2011
Author(s)
Nadrigny, Fabien
DOI
10.1016/j.neulet.2010.10.005
Abstract
Functional relevance of non-synaptic purinergic receptors on dorsal root ganglion cells was tested in vivo by the influence of ATP using 2P-LSM and Ca imaging. Within a few seconds after local application of ATP, neurones in dorsal root ganglion were activated indicated by an increase of their calcium signal. The signal reached its maximum within a few seconds and declined to control values after about 30s. Purinergic action seems to include non-synaptic cell-to-cell communication within dorsal root ganglia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.