Julichrome Q(6) glucuronide, a monomeric subunit of the julimycin B-1 complex from a terrestrial treptomyces sp.

The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q(6) glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q(1 center dot 2) (7a), Q(1 center dot 5) (7b), and Q(3 center dot 5) (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-beta-naphthylamine (10). The isomeric N-phertyl-alpha-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.