Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients

ISSN
1476-4598
Date Issued
2015-05-20
Author(s)
Schrader, Carola H
Kolb, Markus
Zaoui, Karim
Flechtenmacher, Christa
Weber, Klaus-Josef
Hielscher, Thomas
Plinkert, Peter K.
Hess, Jochen
DOI
10.1186/s12943-015-0381-6
Abstract
Dysregulated expression of Kallikrein-related peptidase 6 (KLK6) is a common feature for many human malignancies and numerous studies evaluated KLK6 as a promising biomarker for early diagnosis or unfavorable prognosis. However, the expression of KLK6 in carcinomas derived from mucosal epithelia, including head and neck squamous cell carcinoma (HNSCC), and its mode of action has not been addressed so far.