Off and On Again: De- and Reubiquitination during Membrane Protein Degradation

ISSN
1097-2765
Date Issued
2020
Author(s)
Schmidt, Claudia C.
DOI
10.1016/j.molcel.2020.06.036
Abstract
In this issue of Molecular Cell, Hu et al. (2020) show that the cytosolic E3 ligase RNF126 reubiquitinates membrane proteins after their extraction from the membrane of the endoplasmic reticulum to target them for proteasomal degradation.