Stein, Alexander J.

[["dc.bibliographiccitation.firstpage","492"],["dc.bibliographiccitation.issue","05"],["dc.bibliographiccitation.journal","Public Health Nutrition"],["dc.bibliographiccitation.lastpage","501"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Stein, Alexander J."],["dc.contributor.author","Nestel, Penelope"],["dc.contributor.author","Meenakshi, J. V."],["dc.contributor.author","Qaim, Matin"],["dc.contributor.author","Sachdev, H. P. S."],["dc.contributor.author","Bhutta, Zulfiqar A."],["dc.date.accessioned","2017-09-07T11:44:30Z"],["dc.date.available","2017-09-07T11:44:30Z"],["dc.date.issued","2007"],["dc.description.abstract","To estimate the potential impact of zinc biofortification of rice and wheat on public health in India and to evaluate its cost-effectiveness compared with alternative interventions and international standards.The burden of zinc deficiency (ZnD) in India was expressed in disability-adjusted life years (DALYs) lost. Current zinc intakes were derived from a nationally representative household food consumption survey (30-day recall) and attributed to household members based on adult equivalent weights. Using a dose–response function, projected increased zinc intakes from biofortified rice and wheat were translated into potential health improvements for pessimistic and optimistic scenarios. After estimating the costs of developing and disseminating the new varieties, the cost-effectiveness of zinc biofortification was calculated for both scenarios and compared with alternative micronutrient interventions and international reference standards.India.Representative household survey (n = 119 554).The calculated annual burden of ZnD in India is 2.8 million DALYs lost. Zinc biofortification of rice and wheat may reduce this burden by 20–51% and save 0.6–1.4 million DALYs each year, depending on the scenario. The cost for saving one DALY amounts to 0.73–7.31, which is very cost-effective by standards of the World Bank and the World Health Organization, and is lower than that of most other micronutrient interventions.Not only may zinc biofortification save lives and prevent morbidity among millions of people, it may also help accommodate the need to economise and to allocate resources more efficiently. Further research is needed to corroborate these findings."],["dc.identifier.doi","10.1017/s1368980007223857"],["dc.identifier.gro","3150270"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7016"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1368-9800"],["dc.title","Plant breeding to control zinc deficiency in India: how cost-effective is biofortification?"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2858"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","2863"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Schuette, C. G."],["dc.contributor.author","Hatsuzawa, K."],["dc.contributor.author","Margittai, M."],["dc.contributor.author","Stein, A."],["dc.contributor.author","Riedel, D."],["dc.contributor.author","Kuster, P."],["dc.contributor.author","Konig, M."],["dc.contributor.author","Seidel, C."],["dc.contributor.author","Jahn, R."],["dc.date.accessioned","2021-06-01T10:51:03Z"],["dc.date.available","2021-06-01T10:51:03Z"],["dc.date.issued","2004"],["dc.identifier.doi","10.1073/pnas.0400044101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86875"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1091-6490"],["dc.relation.issn","0027-8424"],["dc.title","Determinants of liposome fusion mediated by synaptic SNARE proteins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1200"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Nature Biotechnology"],["dc.bibliographiccitation.lastpage","1201"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Stein, Alexander J."],["dc.contributor.author","Sachdev, H. P. S."],["dc.contributor.author","Qaim, Matin"],["dc.date.accessioned","2017-09-07T11:44:47Z"],["dc.date.available","2017-09-07T11:44:47Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1038/nbt1006-1200b"],["dc.identifier.gro","3150323"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7074"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1087-0156"],["dc.title","Potential impact and cost-effectiveness of Golden Rice"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","203"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Molecular Cell"],["dc.bibliographiccitation.lastpage","204"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Schmidt, Claudia C."],["dc.contributor.author","Stein, Alexander"],["dc.date.accessioned","2022-07-11T12:22:06Z"],["dc.date.available","2022-07-11T12:22:06Z"],["dc.date.issued","2020"],["dc.description.abstract","In this issue of Molecular Cell, Hu et al. (2020) show that the cytosolic E3 ligase RNF126 reubiquitinates membrane proteins after their extraction from the membrane of the endoplasmic reticulum to target them for proteasomal degradation."],["dc.identifier.doi","10.1016/j.molcel.2020.06.036"],["dc.identifier.pmid","32679074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112456"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/120"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P15: Mechanismen der Substraterkennung bei dem ER-assozierten Proteinabbau"],["dc.relation.eissn","1097-4164"],["dc.relation.issn","1097-2765"],["dc.relation.workinggroup","RG Stein (Membrane Protein Biochemistry)"],["dc.title","Off and On Again: De- and Reubiquitination during Membrane Protein Degradation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1797"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Social Science & Medicine"],["dc.bibliographiccitation.lastpage","1808"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Stein, Alexander J."],["dc.contributor.author","Meenakshi, J. V."],["dc.contributor.author","Qaim, Matin"],["dc.contributor.author","Nestel, Penelope"],["dc.contributor.author","Sachdev, H. P. S."],["dc.contributor.author","Bhutta, Zulfiqar A."],["dc.date.accessioned","2017-09-07T11:44:30Z"],["dc.date.available","2017-09-07T11:44:30Z"],["dc.date.issued","2008"],["dc.description.abstract","Iron deficiency is a widespread nutrition and health problem in developing countries, causing impairments in physical activity and cognitive development, as well as maternal mortality. Although food fortification and supplementation programmes have been effective in some countries, their overall success remains limited. Biofortification, that is, breeding food crops for higher micronutrient content, is a relatively new approach, which has been gaining international attention recently. We propose a methodology for ex ante impact assessment of iron biofortification, building on a disability-adjusted life years (DALYs) framework. This methodology is applied in an Indian context. Using a large and representative data set of household food consumption, the likely effects of iron-rich rice and wheat varieties are simulated for different target groups and regions. These varieties, which are being developed by an international public research consortium, based on conventional breeding techniques, might be ready for local distribution within the next couple of years. The results indicate sizeable potential health benefits. Depending on the underlying assumptions, the disease burden associated with iron deficiency could be reduced by 19–58%. Due to the relatively low institutional cost to reach the target population, the expected cost-effectiveness of iron biofortification compares favourably with other micronutrient interventions. Nonetheless, biofortification should not be seen as a substitute for other interventions. Each approach has its particular strengths, so they complement one another."],["dc.identifier.doi","10.1016/j.socscimed.2008.01.006"],["dc.identifier.gro","3150268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7014"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0277-9536"],["dc.relation.orgunit","Department für Agrarökonomie und Rurale Entwicklung"],["dc.subject","Iron deficiency; Biofortification; DALYs; Impact assessment; India; Cost-effectiveness analysis"],["dc.title","Potential impacts of iron biofortification in India"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","21"],["dc.bibliographiccitation.journal","Global food security"],["dc.bibliographiccitation.lastpage","29"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Gödecke, Theda"],["dc.contributor.author","Stein, Alexander J."],["dc.contributor.author","Qaim, Matin"],["dc.date.accessioned","2020-12-10T14:24:22Z"],["dc.date.available","2020-12-10T14:24:22Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.gfs.2018.03.004"],["dc.identifier.issn","2211-9124"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72227"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.haserratum","/handle/2/72229"],["dc.relation.orgunit","Department für Agrarökonomie und Rurale Entwicklung"],["dc.title","The global burden of chronic and hidden hunger: Trends and determinants"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","274"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Nature Cell Biology"],["dc.bibliographiccitation.lastpage","281"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Vasic, Vedran"],["dc.contributor.author","Denkert, Niels"],["dc.contributor.author","Schmidt, Claudia C."],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Stein, Alexander"],["dc.contributor.author","Meinecke, Michael"],["dc.date.accessioned","2021-04-14T08:27:11Z"],["dc.date.available","2021-04-14T08:27:11Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41556-020-0473-4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82199"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1476-4679"],["dc.relation.issn","1465-7392"],["dc.relation.orgunit","Institut für Zellbiochemie"],["dc.title","Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","115"],["dc.bibliographiccitation.issue","3_suppl"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.lastpage","115"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Seufferlein, Thomas"],["dc.contributor.author","Ettrich, Thomas Jens"],["dc.contributor.author","Stein, Alexander"],["dc.contributor.author","Arnold, Dirk"],["dc.contributor.author","Prager, Gerald W."],["dc.contributor.author","Kasper, Stefan"],["dc.contributor.author","Niedermeier, Michael"],["dc.contributor.author","Müller, Lothar"],["dc.contributor.author","Kubicka, Stefan"],["dc.contributor.author","Kestler, Hans A."],["dc.date.accessioned","2021-06-01T09:42:16Z"],["dc.date.available","2021-06-01T09:42:16Z"],["dc.date.issued","2021"],["dc.description.abstract","115 Background: Antiangiogenic agents, in particular monoclonal antibodies (mAbs) against VEGF, a major driver of tumor angiogenesis, are widely used in cancer therapy including metastatic colorectal cancer (mCRC). However, some patients do not profit from antiangiogenic treatments (AT), other patients benefit initially, but subsequently develop resistance not only to chemotherapy but also to AT. So far, no biomarkers are available to predict resistance to AT. Having an accurate assessment of imminent resistance to an AT may e.g. enable to respond by treating the patient with a more broadly acting antiangiogenic agent and thereby further delay resistance to the treatment and at the same time avoid employing a not anymore efficacious treatment. We hypothesized that repeated analysis of multiple cytokines related to angiogenesis together with machine learning approaches may enable an accurate prediction of anti-VEGF resistance during first-line treatment of mCRC patients with FOLFOX plus bevacizumab. The PERMAD trial aimed at establishing a CAF marker combination that enables the prediction of treatment resistance of patients with mCRC receiving Bevacizumab plus mFOLFOX6 in a palliative first-line setting about three months prior to radiological progress using an omics approach and bioinformatics. Methods: A phase I/II biomarker trial was conducted, including 15 centers in Germany and Austria. All mCRC patients included were treatment naïve and received FOLFOX plus Bevacizumab treatment. 102 different, preselected CAFs were prospectively collected and centrally analyzed in plasma samples (n = 647) obtained prior to treatment and biweekly until radiological progress determined by CT scan every 2 months. The values of CAFs affected in a similar fashion by both chemotherapy and disease progress were excluded. Using the remaining CAFs we employed a random forest predictor to define a combination of 5 CAF (CAF marker combination) whose change in values/pattern correlated with subsequent progress 3 months prior to radiological progress according to RECIST 1.1. Results: Using the samples described above and a random forest predictor we established a CAF marker combination comprising 5 CAF whose specific change in value/pattern over time indicated treatment resistance 3 months prior to radiological progress. The model allowed to differentiate timepoints without progress from timepoints predicting progress 100 days before radiological progress with an accuracy of 83%, a sensitivity of 76% and specificity of 88%. Conclusions: Using advanced bioinformatics, we identified a CAF marker combination that points out treatment resistance to FOLFOX plus Bevacizumab in patients with mCRC 3 months prior to radiological progress. Clinical trial information: NCT02331927."],["dc.identifier.doi","10.1200/JCO.2021.39.3_suppl.115"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85199"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1527-7755"],["dc.relation.issn","0732-183X"],["dc.title","Predicting resistance to first-line FOLFOX plus bevacizumab in metastatic colorectal cancer: Final results of the multicenter, international PERMAD trial."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","274"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Ernährungs-Umschau"],["dc.bibliographiccitation.lastpage","280"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Qaim, Matin"],["dc.contributor.author","Stein, Alexander J."],["dc.date.accessioned","2018-11-07T08:30:14Z"],["dc.date.available","2018-11-07T08:30:14Z"],["dc.date.issued","2009"],["dc.description.abstract","Biofortification of staple crops is a new approach to control micronutrient malnutrition. These crops are bred for higher concentrations of micronutrients in their edible parts. Especially in developing countries, the objective is to reach target populations that live in remote rural areas, where they are hardly covered by other micronutrient programmes. Initial studies indicate that it is possible to achieve acceptance of these crops among target groups. Analyses further show that these crops are economically efficient and can considerably reduce the burden of disease of micronutrient malnutrition, if the general conditions are favourable. In some cases, biofortified crops could also be an interesting alternative in industrialised countries."],["dc.identifier.isi","000266331900004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16842"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0174-0008"],["dc.relation.orgunit","Department für Agrarökonomie und Rurale Entwicklung"],["dc.title","Biofortification of Staple Crops How well does it work and what does it cost?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","46"],["dc.bibliographiccitation.journal","Global food security"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Gödecke, Theda"],["dc.contributor.author","Stein, Alexander J."],["dc.contributor.author","Qaim, Matin"],["dc.date.accessioned","2020-12-10T14:24:22Z"],["dc.date.available","2020-12-10T14:24:22Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.gfs.2019.09.001"],["dc.identifier.issn","2211-9124"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72229"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.iserratumof","/handle/2/72227"],["dc.relation.orgunit","Department für Agrarökonomie und Rurale Entwicklung"],["dc.title","Corrigendum to ‘The global burden of chronic and hidden hunger: Trends and determinants’"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]