Tumor suppressors: Control of signaling by endocytosis

ISSN
0960-9822
Date Issued
2006
Author(s)
Giebel, B.
DOI
10.1016/j.cub.2006.01.022
Abstract
Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.