Control of p21Cip by BRAP is Critical for Cardiomyocyte Cell Cycle Progression and Survival

ISSN
0008-6363
1755-3245
Date Issued
2019
Author(s)
Volland, Cornelia
Unsöld, Bernhard
Schmidt, Carla
Nickels, Katrin
Knoll, Ralph
Schmidt, Albrecht
DOI
10.1093/cvr/cvz177
Abstract
Identifying the key components in cardiomyocyte cell cycle regulation is of relevance for the understanding of cardiac development and adaptive and maladaptive processes in the adult myocardium. BRCA1-associated protein (BRAP) has been suggested as a cytoplasmic retention factor for several proteins including Cyclin-dependent-kinase inhibitor p21Cip. We observed profound expressional changes of BRAP in early postnatal myocardium and investigated the impact of BRAP on cardiomyocyte cell cycle regulation.