Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines and cytokines

ISSN
1078-0432
Date Issued
2011-02-15
Author(s)
Halama, Niels
Braun, Monika
Kahlert, Christoph
Spille, Anna
Quack, Christian
Rahbari, Nuh
Koch, Moritz
Weitz, Jürgen
Kloor, Matthias
Zoernig, Inka
Schirmacher, Peter
Brand, Karsten
Falk, Christine S.
DOI
10.1158/1078-0432.CCR-10-2173
Abstract
Tumor infiltrating T lymphocytes in colorectal cancer (CRC) have prognostic impact, but the role of natural killer (NK) cells in CRC tissue is unclear. The contribution of intratumoral cytokines and chemokines in shaping the composition of the inflammatory lymphocytic infiltrate is also unclear.