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pH-Dependent fluorescence of [La(OH) 2 ] + [ARS] − hybrid nanoparticles for intracellular pH-sensing
ISSN
1359-7345
Date Issued
2022
Author(s)
DOI
10.1039/D2CC01507B
Abstract
[La(OH)
2
]
+
[ARS]
−
inorganic–organic hybrid nanoparticles (ARS: alizarin red S) exhibit pH-dependent absorption and pH-dependent emission, allowing to monitor nanoparticle internalization in cells and the intracellular pH.
2
]
+
[ARS]
−
inorganic–organic hybrid nanoparticles (ARS: alizarin red S) exhibit pH-dependent absorption and pH-dependent emission, allowing to monitor nanoparticle internalization in cells and the intracellular pH.
Saline inorganic–organic hybrid nanoparticles (IOH-NPs) [La(OH)
2
]
+
[ARS]
−
(ARS: alizarin red S) are prepared in water as a new compound (particle size: 47 ± 7 nm, ARS load: 65 wt%). The IOH-NPs not only show a pH-dependent absorption colour but also a pH-dependent fluorescence with green emission at pH 5.0–9.0 and red emission at pH < 4.5. According to first
in vitro
studies, the pH-dependend fluorescence can be used to monitor nanoparticle internalization in cells as well as the respective intracellular pH.
2
]
+
[ARS]
−
(ARS: alizarin red S) are prepared in water as a new compound (particle size: 47 ± 7 nm, ARS load: 65 wt%). The IOH-NPs not only show a pH-dependent absorption colour but also a pH-dependent fluorescence with green emission at pH 5.0–9.0 and red emission at pH < 4.5. According to first
in vitro
studies, the pH-dependend fluorescence can be used to monitor nanoparticle internalization in cells as well as the respective intracellular pH.
