Thyroid Hormones and Vitamin D in Patients with Breast Cancer with Mutations in BRCA1 or BRCA2 Genes

Date Issued
2016-06
Author(s)
Kolben, Thomas
Hary, Thomas
Holdt, Lesca M
Schwarz, Theresa M
Goess, Christine
Wuerstlein, Rachel
Toth, Bettina
Weissenbacher, Tobias
Jeschke, Udo
Harbeck, Nadia
Ditsch, Nina
Abstract
The thyroid hormones free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH) and vitamin D seem to be involved in the process of differentiation and proliferation of breast tissue. Little is known about these factors in breast cancer 1 and 2 (BRCA1/BRCA2)-mutation carriers with breast cancer (BC). The purpose of this investigation was to evaluate the association of thyroid gland function and vitamin D with BC in patients with BRCA mutations.