Shirneshan, Katayoon

[["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T09:50:35Z"],["dc.date.available","2018-11-07T09:50:35Z"],["dc.date.issued","2015"],["dc.format.extent","32"],["dc.identifier.isi","000364268800068"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35736"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Evolution of chromosome 7 material loss in myeloid malignancies"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","254"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal Of Haematology"],["dc.bibliographiccitation.lastpage","256"],["dc.bibliographiccitation.volume","95"],["dc.contributor.author","Schanz, Julie"],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Steuernagel, Peter"],["dc.contributor.author","Shirneshan, Katayoo"],["dc.contributor.author","Baesecke, Joerg"],["dc.date.accessioned","2018-11-07T09:52:53Z"],["dc.date.available","2018-11-07T09:52:53Z"],["dc.date.issued","2015"],["dc.description.abstract","A 62-yr-old man with two healthy daughters was diagnosed with osteomyelofibrosis. To our surprise, a female XX-karyotype was observed in bone marrow and confirmed in PHA-stimulated T-lymphocytes from peripheral blood. Further molecular genetic investigation revealed a submicroscopic translocation between the short arm of X and Y, which leads to an XX-male genotype based on an unbalanced translocation X;Y. This rare coincidence was further accentuated as the USP9Y gene, suspected to be to be involved in sperm cell production, was absent, but no azoospermia was present. In general, routine cytogenetics may result in findings that need to be further delineated and, as here, lead to a rare observation."],["dc.identifier.doi","10.1111/ejh.12555"],["dc.identifier.isi","000359600500009"],["dc.identifier.pmid","25808090"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36217"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1600-0609"],["dc.relation.issn","0902-4441"],["dc.title","Primary osteomyelofibrosis and an XX-male genotype"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4348"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Endocrinology"],["dc.bibliographiccitation.lastpage","4357"],["dc.bibliographiccitation.volume","150"],["dc.contributor.author","Burnicka-Turek, Ozanna"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Paprotta, Ilona"],["dc.contributor.author","Grzmil, Pawel"],["dc.contributor.author","Meinhardt, Andreas"],["dc.contributor.author","Engel, Wolfgang"],["dc.contributor.author","Adham, Ibrahim M."],["dc.date.accessioned","2018-11-07T11:24:41Z"],["dc.date.available","2018-11-07T11:24:41Z"],["dc.date.issued","2009"],["dc.description.abstract","Insulin-like factor 6 (INSL6), a member of the insulin-like superfamily, is predominantly expressed in male germ cells. Expression of the Insl6 is first detected in mouse testis at postnatal d 15 when the first wave of spermatogenesis progresses to pachytene spermatocytes. To elucidate the role of INSL6 in germ cell development, we generated Insl6-deficient mice. The majority of the Insl6-deficient males on a hybrid genetic background exhibited impaired fertility, whereas females were fertile. The number of mature sperm and sperm motility were drastically reduced in the epididymis. The reduced sperm count could be due to apoptotic death of a significant number of developing germ cells. Analysis of germ cell development during the juvenile life showed an arrest of the first wave of spermatogenesis in late meiotic prophase. RNA analysis revealed a significant decrease in expression of late meiotic- and postmeiotic-specific marker genes, whereas expression of early meiotic-specific genes remains unaffected in the Insl6(-/-) testes. These results demonstrate that INSL6 is required for the progression of spermatogenesis. (Endocrinology 150: 4348-4357, 2009)"],["dc.identifier.doi","10.1210/en.2009-0201"],["dc.identifier.isi","000269159800041"],["dc.identifier.pmid","19520787"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56461"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Endocrine Soc"],["dc.relation.issn","0013-7227"],["dc.title","Inactivation of Insulin-Like Factor 6 Disrupts the Progression of Spermatogenesis at Late Meiotic Prophase"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","43"],["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Kaempfe, Dietrich"],["dc.contributor.author","Machherndl-Spandl, Sigrid"],["dc.contributor.author","Suessner, Susanne"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schanz, J."],["dc.date.accessioned","2018-11-07T09:34:10Z"],["dc.date.available","2018-11-07T09:34:10Z"],["dc.date.issued","2014"],["dc.identifier.isi","000343816900097"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32120"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Significance of Y-chromosome loss in MDS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Haematologica"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Dierks, Sascha"],["dc.contributor.author","Glass, Bertram"],["dc.contributor.author","Stuhlmann, Reingard"],["dc.contributor.author","Baesecke, Joerg"],["dc.contributor.author","Sievers, B."],["dc.contributor.author","Simon-Becker, S."],["dc.contributor.author","Flach, J."],["dc.contributor.author","Martin, R."],["dc.contributor.author","Bacher, Ulrike"],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T10:13:03Z"],["dc.date.available","2018-11-07T10:13:03Z"],["dc.date.issued","2016"],["dc.format.extent","495"],["dc.identifier.isi","000379484601582"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40359"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ferrata Storti Foundation"],["dc.publisher.place","Pavia"],["dc.relation.conference","21st Congress of the European-Hematology-Association"],["dc.relation.eventlocation","Copenhagen, DENMARK"],["dc.relation.issn","0390-6078"],["dc.title","SPATIAL INTERACTION OF CYTOGENETIC AND MOLECULAR MUTATIONS IN MYELODYSPLASTIC SYNDROMES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","900"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Leukemia Research"],["dc.bibliographiccitation.lastpage","906"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Schanz, Julie"],["dc.contributor.author","Götze, Katharina S."],["dc.contributor.author","Müller-Thomas, Catharina"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Germing, Ulrich"],["dc.contributor.author","Brümmendorf, Tim H."],["dc.contributor.author","Bug, Gesine"],["dc.contributor.author","Ottmann, Oliver G."],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Stadler, Michael"],["dc.contributor.author","Hofmann, Wolf-Karsten"],["dc.contributor.author","Schafhausen, Philippe"],["dc.contributor.author","Lübbert, Michael"],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Blau, Igor W."],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Metz, Michael"],["dc.contributor.author","Detken, Sven"],["dc.contributor.author","Seraphin, Jörg"],["dc.contributor.author","Jentsch-Ullrich, Kathleen"],["dc.contributor.author","Böhme, Angelika"],["dc.contributor.author","Schmidt, Burkhard C."],["dc.contributor.author","Trümper, Lorenz"],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T09:22:10Z"],["dc.date.available","2018-11-07T09:22:10Z"],["dc.date.issued","2013"],["dc.description.abstract","The gold standard of cytogenetic analysis in myelodysplastic syndromes (MDS) is conventional chromosome banding (CCB) analysis of bone marrow (BM) metaphases. Most aberrations can also be detected by fluorescence-in situ-hybridization (FISH). For this prospective multicenter German diagnostic study (www.clinicaltrials.gov: #NCT01355913) 360 patients, as yet, were followed up to 3 years by sequential FISH analyses of immunomagnetically enriched CD34+ peripheral blood (PB) cells using comprehensive FISH probe panels, resulting in a total number of 19,516 FISH analyses. We demonstrate that CD34+ PB FISH correlates significantly with CCB analysis and represents a feasible method for a reliable non-invasive cytogenetic monitoring from PB. (C) 2013 Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","Celgene(R) Germany"],["dc.identifier.doi","10.1016/j.leukres.2013.03.019"],["dc.identifier.isi","000321111900012"],["dc.identifier.pmid","23623559"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29278"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0145-2126"],["dc.title","Molecular cytogenetic monitoring from CD34+peripheral blood cells in myelodysplastic syndromes: First results from a prospective multicenter German diagnostic study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","345"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","MHR Basic science of reproductive medicine"],["dc.bibliographiccitation.lastpage","353"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Zechner, Ulrich"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Wolf, Marieke"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","El Hajj, Nady"],["dc.contributor.author","Weise, Daniela"],["dc.contributor.author","Kaltwasser, Britta"],["dc.contributor.author","Zovoilis, Athanasios"],["dc.contributor.author","Haaf, Thomas"],["dc.contributor.author","Engel, Wolfgang"],["dc.date.accessioned","2018-11-07T08:29:31Z"],["dc.date.available","2018-11-07T08:29:31Z"],["dc.date.issued","2009"],["dc.description.abstract","Recently, several groups described the isolation of mouse spermatogonial stem cells (SSCs) and their potential to develop to embryonic stem cell (ESC)-like cells, so-called multipotent germline stem cells (mGSCs). We were the first to derive such mGSCs from SSCs isolated from adult mouse testis and, therefore, called these mGSCs multipotent adult germline stem cells (maGSCs). Here, we comparatively analyzed gene-specific and global DNA methylation profiles as well as the telomerase biology of several maGSC and male ESC lines. We show that undifferentiated maGSCs are very similar to undifferentiated male ESCs with regard to global DNA methylation, methylation of pluripotency marker gene loci, telomerase activity and telomere length. Imprinted gene methylation levels were generally lower in undifferentiated maGSCs than in undifferentiated male ESCs, but, compared with undifferentiated mGSCs derived by other groups, more similar to those of male ESCs. Differentiation of maGSCs increased the methylation of three of the four analyzed imprinted genes to almost somatic methylation patterns, but dramatically decreased global DNA methylation. Our findings further substantiate the pluripotency of maGSCs and their potential for regenerative medicine."],["dc.identifier.doi","10.1093/molehr/gap023"],["dc.identifier.isi","000265952900003"],["dc.identifier.pmid","19297418"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16675"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1360-9947"],["dc.title","Comparative methylation profiles and telomerase biology of mouse multipotent adult germline stem cells and embryonic stem cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4655"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Endocrinology"],["dc.bibliographiccitation.lastpage","4665"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Burnicka-Turek, Ozanna"],["dc.contributor.author","Mohamed, Belal A."],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Thanasupawat, Thatchawan"],["dc.contributor.author","Hombach-Klonisch, Sabine"],["dc.contributor.author","Klonisch, Thomas"],["dc.contributor.author","Adham, Ibrahim M."],["dc.date.accessioned","2018-11-07T09:05:20Z"],["dc.date.available","2018-11-07T09:05:20Z"],["dc.date.issued","2012"],["dc.description.abstract","Insulin-like factor 5 (INSL5), a member of the insulin superfamily, is expressed in the colorectum and hypothalamus. To facilitate studies into the role of INSL5, we generated Insl5(-/-) mice by gene targeting. Insl5(-/-) mice were born in the expected Mendelian ratio, reached normal body weight, but displayed impaired male and female fertility that are due to marked reduction in sperm motility and irregular length of the estrous cycle. Furthermore, Insl5(-/-) mice showed impairment in glucose homeostasis with characteristic elevation of serum glucose levels at an advanced age. Glucose and insulin tolerance tests revealed that the increased blood glucose in Insl5(-/-) mice was due to glucose intolerance resulting from reduced insulin secretion. Morphometric and immunohistological analyses revealed that the Insl5(-/-) mice had markedly reduced average islets area and beta-cell numbers. Furthermore, immunohistochemistry showed the expression of INSL5 in enteroendocrine cells in the colorectal epithelium and the presence of its putative receptor relaxin family peptide receptor 4 in pancreatic islet cells. These results suggest the potential role of INSL5 signaling in the regulation of insulin secretion and beta-cell homeostasis. (Endocrinology 153: 4655-4665, 2012)"],["dc.identifier.doi","10.1210/en.2012-1161"],["dc.identifier.isi","000309210200008"],["dc.identifier.pmid","22822165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25294"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Endocrine Soc"],["dc.relation.issn","0013-7227"],["dc.title","INSL5-Deficient Mice Display an Alteration in Glucose Homeostasis and an Impaired Fertility"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Germing, U."],["dc.contributor.author","Schuler, E."],["dc.contributor.author","Schulz, Xenia"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Nolte, F."],["dc.contributor.author","Hofmann, W-K"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Bacher, Ulrike"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Ganser, Arnold"],["dc.contributor.author","Letsch, Anne"],["dc.contributor.author","Schafhausen, Philippe"],["dc.contributor.author","Bug, G."],["dc.contributor.author","Bruemmendorf, Tim Hendrik"],["dc.contributor.author","Haas, Rainer"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T10:07:38Z"],["dc.date.available","2018-11-07T10:07:38Z"],["dc.date.issued","2016"],["dc.format.extent","235"],["dc.identifier.isi","000385691300581"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39317"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Cytogenetic monitoring from peripheral blood in patients with myelodysplastic syndrome: First results from the German LEMON-5 trial"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.lastpage","236"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Mueller-Thomas, Catharina"],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Bruemmendorf, Tim Hendrik"],["dc.contributor.author","Nolte, F."],["dc.contributor.author","Hofmann, W-K"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Greenberg, Peter L."],["dc.contributor.author","Bennett, John M."],["dc.contributor.author","Sole, Francesco"],["dc.contributor.author","Mallo, Mar"],["dc.contributor.author","Slovak, Marilyn L."],["dc.contributor.author","Ohyashiki, Kazuma"],["dc.contributor.author","Le Beau, Michelle M."],["dc.contributor.author","Tuechler, Heinz"],["dc.contributor.author","Pfeilstoecker, Michael"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Aul, Carlo"],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Sperr, Wolfgang R."],["dc.contributor.author","Valent, Peter"],["dc.contributor.author","Fonatsch, Christa"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schanz, J."],["dc.date.accessioned","2018-11-07T09:34:15Z"],["dc.date.available","2018-11-07T09:34:15Z"],["dc.date.issued","2014"],["dc.identifier.isi","000343816900574"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32137"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Is IPSS/IPSS-R cytogenetic classification possible from peripheral blood in MDS patients? Comparative results from a prospective German diagnostic study with the data set of an international collaboration"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]