Chaieb, Leila

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of the Neurological Sciences"],["dc.bibliographiccitation.lastpage","109"],["dc.bibliographiccitation.volume","354"],["dc.contributor.author","Wickmann, Franziska"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Timaeus, Charles"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.date.accessioned","2018-11-07T09:54:38Z"],["dc.date.available","2018-11-07T09:54:38Z"],["dc.date.issued","2015"],["dc.description.abstract","The present study aimed to investigate the efficacy of repetitive cathodal direct current stimulation (rctDCS) over the visual cortex as a prophylactic treatment in patients with menstrual migraine. 20 female patients were recruited in this double-blind, placebo-controlled study and were assigned to receive either cathodal or sham stimulation. Over 3 menstrual cycles, tDCS with 2 mA intensity and 20 min duration was applied to the visual cortex of the patients, in 5 consecutive sessions 1-5 days prior to the first day of their menstruation. The primary endpoint of the study was the frequency of the migraine attacks at the end of the treatment period, however, additional parameters, such as the number of migraine related days and the intensity of pain were also recorded 3 months before, during and 3 months post-treatment Visual cortex excitability was determined by measuring the phosphene thresholds (PTs) using single pulse transcranial magnetic stimulation (TMS) over the visual cortex. Sixteen patients completed the study. A significant decrease in the number of migraine attacks (p = 0.04) was found in the cathodal group compared to baseline but not compared to sham (p = 0.053). In parallel the PTs increased significantly in this group, compared to the sham group (p < 0.05). Our results indicate that prophylactic treatment with rctDCS over the visual cortex might be able to decrease the number of attacks in patients with menstrual migraine, probably by modifying cortical excitability. (C) 2015 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Migraine Foundation"],["dc.identifier.doi","10.1016/j.jns.2015.05.009"],["dc.identifier.isi","000356978600018"],["dc.identifier.pmid","26003225"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36574"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1878-5883"],["dc.relation.issn","0022-510X"],["dc.title","Prophylactic treatment in menstrual migraine: A proof-of-concept study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","105927"],["dc.bibliographiccitation.journal","Neural Plasticity"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.date.accessioned","2018-11-07T09:01:47Z"],["dc.date.available","2018-11-07T09:01:47Z"],["dc.date.issued","2011"],["dc.description.abstract","A 10-minute application of highfrequency (100-640 Hz) transcranial random noise stimulation (tRNS) over the primary motor cortex (M1) increases baseline levels of cortical excitability, lasting around 1 hr poststimulation Terney et al. (2008). We have extended previous work demonstrating this effect by decreasing the stimulation duration to 4, 5, and 6 minutes to assess whether a shorter duration of tRNS can also induce a change in cortical excitability. Single-pulse monophasic transcranial magnetic stimulation (TMS) was used to measure baseline levels of cortical excitability before and after tRNS. A 5- and 6-minute tRNS application induced a significant facilitation. 4-minute tRNS produced no significant aftereffects on corticospinal excitability. Plastic after effects after tRNS on corticospinal excitability require a minimal stimulation duration of 5 minutes. However, the duration of the aftereffect of 5-min tRNS is very short compared to previous studies using tRNS. Developing different transcranial stimulation techniques may be fundamental in understanding how excitatory and inhibitory networks in the human brain can be modulated and how each technique can be optimised for a controlled and effective application."],["dc.identifier.doi","10.1155/2011/105927"],["dc.identifier.isi","000295634500001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7728"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24517"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hindawi Publishing Corporation"],["dc.relation.issn","0792-8483"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evaluating Aftereffects of Short-Duration Transcranial Random Noise Stimulation on Cortical Excitability"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurogenetics"],["dc.bibliographiccitation.lastpage","11"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T09:43:05Z"],["dc.date.available","2018-11-07T09:43:05Z"],["dc.date.issued","2014"],["dc.description.abstract","Val66Met (rs6265) is a gene variation, a single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene that codes for the protein BDNF. The substitution of Met for Val occurs at position 66 in the pro-region of the BDNF gene and is responsible for altered activity-dependent release and recruitment of BDNF in neurons. This is believed to manifest itself in an altered ability in neuroplasticity induction and an increased predisposition toward a number of neurological disorders. Many studies using neuroplasticity-inducing protocols have investigated the impact of the BDNF polymorphism on cortical modulation and plasticity; however, the results are partly contradictory and dependent on the paradigm used in a given study. The aim of this review is to summarize recent knowledge on the relationship of this BDNF SNP and neuroplasticity."],["dc.identifier.doi","10.1007/s10048-014-0393-1"],["dc.identifier.isi","000333707900001"],["dc.identifier.pmid","24567226"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34100"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1364-6753"],["dc.relation.issn","1364-6745"],["dc.title","Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","67"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Frontiers in Psychiatry"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Antal, A."],["dc.contributor.author","Terney, D."],["dc.contributor.author","Paulus, W."],["dc.date.accessioned","2019-07-09T11:53:38Z"],["dc.date.available","2019-07-09T11:53:38Z"],["dc.date.issued","2012"],["dc.description.abstract","Combined administration of transcranial direct current-stimulation (tDCS) with either pergolide (PER) or D-cycloserine (D-CYC) can prolong the excitability-diminishing effects of cathodal, or the excitability enhancing effect of anodal stimulation for up to 24 h poststimulation. However, it remains unclear whether the potentiation of the observed aftereffects is dominated just by the polarity and duration of the stimulation, or the dual application of combined stimulation and drug administration. The present study looks at whether the aftereffects of oral administration of PER (a D1/D2 agonist) or D-CYC (a partial NMDA receptor agonist), in conjunction with the short-duration antagonistic application of tDCS (either 5 min cathodal followed immediately by 5 min anodal or vice versa), that alone only induces short-lasting aftereffects, can modulate cortical excitability in healthy human subjects, as revealed by a single-pulse MEP (motor-evoked-potential) paradigm. Results indicate that the antagonistic application of tDCS induces short-term neuroplastic aftereffects that are dependent upon the order of the application of short-duration stimulation. The administration of D-CYC resulted in a marked inhibition of cortical excitability under the application of tDCS in both stimulation orders. Intake of PER resulted in an increase in cortical excitability in both stimulation orientations, but was non-significant compared to the placebo condition. These results indicate that the aftereffects of tDCS are dependent upon the order of stimulation applied, and also demonstrate the prolongation of tDCS aftereffects when combined with the administration of CNS active drugs."],["dc.identifier.doi","10.3389/fpsyt.2012.00067"],["dc.identifier.fs","588338"],["dc.identifier.pmid","22783210"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60469"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Research Foundation"],["dc.relation.eissn","1664-0640"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Pharmacological Modulation of the Short-Lasting Effects of Antagonistic Direct Current-Stimulation Over the Human Motor Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","167"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Restorative Neurology and Neuroscience"],["dc.bibliographiccitation.lastpage","175"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T09:02:00Z"],["dc.date.available","2018-11-07T09:02:00Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose: External transcranial electric and magnetic stimulation techniques allow for the fast induction of sustained and measurable changes in cortical excitability. Here we aim to develop a paradigm using transcranial alternating current (tACS) in a frequency range higher than 1 kHz, which potentially interferes with membrane excitation, to shape neuroplastic processes in the human primary motor cortex (M1). Methods: Transcranial alternating current stimulation was applied at 1, 2 and 5 kHz over the left primary motor cortex with a reference electrode over the contralateral orbit in 11 healthy volunteers for a duration of 10 min at an intensity of 1 mA. Monophasic single-pulse transcranial magnetic stimulation (TMS) was used to measure changes in corticospinal excitability, both during and after tACS in the low kHz range, in the right hand muscle. As a control inactive sham stimulation was performed. Results: All frequencies of tACS increased the amplitudes of motor-evoked potentials (MEPs) up to 30-60 min post stimulation, compared to the baseline. Two and 5 kHz stimulations were more efficacious in inducing sustained changes in cortical excitability than 1 kHz stimulation, compared to sham stimulation. Conclusions: Since tACS in the low kHz range appears too fast to interfere with network oscillations, this technique opens a new possibility to directly interfere with cortical excitability, probably via neuronal membrane activation. It may also potentially replace more conventional repetitive transcranial magnetic stimulation (rTMS) techniques for some applications in a clinical setting."],["dc.identifier.doi","10.3233/RNN-2011-0589"],["dc.identifier.isi","000292262500003"],["dc.identifier.pmid","21586823"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24572"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","0922-6028"],["dc.title","Transcranial alternating current stimulation in the low kHz range increases motor cortex excitability"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","642"],["dc.bibliographiccitation.journal","Frontiers in Psychology"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Chaieb, Leila"],["dc.date.accessioned","2018-11-07T09:38:51Z"],["dc.date.available","2018-11-07T09:38:51Z"],["dc.date.issued","2014"],["dc.description.abstract","Stimulation using weak electrical direct currents has shown to be capable of inducing polarity-dependent diminutions or elevations in motor and visual cortical excitability. The aim of the present study was to test if reading during transcranial direct current stimulation (tDCS) is able to modify stimulation-induced plasticity in the visual cortex. Phosphene thresholds (PTs) in 12 healthy subjects were recorded before and after 10 min of anodal, cathodal, and sham tDCS in combination with reading. Reading alone decreased PTs significantly, compared to the sham tDCS condition without reading. Interestingly, after both anodal and cathodal stimulation there was a tendency toward smaller PTs. Our results support the observation that tDCS-induced plasticity is highly dependent on the cognitive state of the subject during stimulation, not only in the case of motor cortex but also in the case of visual cortex stimulation."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.3389/fpsyg.2014.00642"],["dc.identifier.isi","000338686500001"],["dc.identifier.pmid","24999339"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10461"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33151"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-1078"],["dc.relation.issn","1664-1078"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Toward unraveling reading-related modulations of tDCS-induced neuroplasticity in the human visual cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3750"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","3759"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Fischer, Thomas"],["dc.contributor.author","Saiote, Catarina"],["dc.contributor.author","Miller, Robert"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Wang, Danny J. J."],["dc.contributor.author","Plessow, Franziska"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Kirschbaum, Clemens"],["dc.date.accessioned","2018-11-07T09:37:14Z"],["dc.date.available","2018-11-07T09:37:14Z"],["dc.date.issued","2014"],["dc.description.abstract","Stress is a constant characteristic of everyday life in our society, playing a role in triggering several chronic disorders. Therefore, there is an ongoing need to develop new methods in order to manage stress reactions. The regulatory function of right medial-prefrontal cortex (mPFC) is frequently reported by imaging studies during psychosocial stress situations. Here, we examined the effects of inhibitory and excitatory preconditioning stimulation via cathodal and anodal transcranial direct current stimulation (tDCS) on psychosocial stress related behavioral indicators and physiological factors, including the cortisol level in the saliva and changes in brain perfusion. Twenty minutes real or sham tDCS was applied over the right mPFC of healthy subjects before the performance of the Trier Social Stress Test (TSST). Regional cerebral blood flow (rCBF) was measured during stimulation and after TSST, using pseudo-continuous arterial spin labeling (pCASL). Comparing the effect of the different stimulation conditions, during anodal stimulation we found higher rCBF in the right mPFC, compared to the sham and in the right amygdala, superior PFC compared to the cathodal condition. Salivary cortisol levels showed a decrease in the anodal and increase in cathodal groups after completion of the TSST. The behavioral stress indicators indicated the increase of stress level, however, did not show any significant differences among groups. In this study we provide the first insights into the neuronal mechanisms mediating psychosocial stress responses by prefrontal tDCS. (C) 2013 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.22434"],["dc.identifier.isi","000339426700014"],["dc.identifier.pmid","24382804"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32793"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1097-0193"],["dc.relation.issn","1065-9471"],["dc.title","Transcranial Electrical Stimulation Modifies the Neuronal Response to Psychosocial Stress Exposure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","92"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Pisoni, Alberto"],["dc.contributor.author","Saiote, Catarina"],["dc.contributor.author","Opitz, Alexander"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Focke, Niels K."],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T09:46:49Z"],["dc.date.available","2018-11-07T09:46:49Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Sinusoidal transcranial alternating current stimulation (tACS) at 5 kHz applied for 10 min at 1 mA intensity over the hand area of the primary motor cortex (M1) results in sustained changes in cortical excitability as previously demonstrated. Objective: Here we have assessed safety aspects of this stimulation method by measuring neuron-specific enolase (NSE) levels, examining electroencephalogram (EEG) traces and analyzing anatomical data by using magnetic resonance imaging (MRI). Methods: Altogether 18 healthy volunteers participated in the study. tACS was applied at 5 kHz for a duration of 10 min over the left M1 at an intensity of 1 mA. Results: After stimulation no significant changes were detected in NSE levels, no structural alterations were observed in the anatomical scans and no pathological changes were found in the EEG recordings. Conclusions: Our data imply that the application of tACS is safe at least within these parameters and with these applied protocols. (C) 2014 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.brs.2013.08.004"],["dc.identifier.isi","000329947300014"],["dc.identifier.pmid","24064065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34974"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1876-4754"],["dc.relation.issn","1935-861X"],["dc.title","Safety of 5 kHz tACS"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience and Rehabilitation"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Moliadze, Vera"],["dc.contributor.author","Zarrouki, Driss"],["dc.contributor.author","Shoukier, Moneef"],["dc.contributor.author","Paulus, Walter"],["dc.date.accessioned","2016-08-04T08:38:52Z"],["dc.date.accessioned","2021-10-27T13:20:37Z"],["dc.date.available","2016-08-04T08:38:52Z"],["dc.date.available","2021-10-27T13:20:37Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: The brain-derived neurotrophic factor (BDNF) gene is involved in mechanisms of synaptic plasticity in the brain and has been demonstrated to also play a role in influencing brain plasticity induced by transcranial magnetic and electrical stimulation. Objective and methods: This is an update of a previous study from our laboratory. We retrospectively analysed the data of 115 healthy subjects participating in 130 experimental sessions, measuring the amplitude of motor evoked potentials (MEPs) before and after transcranial stimulation of the primary motor cortex (M1). We explored whether BDNF polymorphism shapes the effects of excitatory theta burst stimulation (iTBS, n=23), anodal (n=32) and cathodal (n=19) transcranial direct current (tDCS), random noise (tRNS, n=33) and alternating current (tACS, n=13) stimulation. Results: Although a trend toward altered plasticity was observed in Val- 66Met allele carriers to stimulation with regard to all protocols compared with the response of Val66Val individuals, no significant GENOTYPE x TIME interaction was found. Conclusions: The BDNF polymorphism is suggested to have an impact on transcranial stimulation-induced plasticity in humans, which differs according to the mechanism of plasticity induction. However, according to our data, we suggest that genotyping in general, in transcranial stimulation studies including small number of subjects and at least when the M1 is stimulated, is not necessary. Nevertheless, the impact of BDNF on plasticity inducing protocols might be taken into account for e.g. in cognitive studies, when the prefrontal cortex is stimulated."],["dc.identifier.doi","10.17653/2374-9091.SS0004"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13522"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91970"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2374-9091"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","BDNF Gene Polymorphisms and Motor Cortical Plasticity in Healthy Humans: When Should We Consider It"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","125"],["dc.bibliographiccitation.journal","Frontiers in Neuroscience"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T09:58:35Z"],["dc.date.available","2018-11-07T09:58:35Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Application of transcranial random noise stimulation (tRNS) between 0.1 and 640 Hz of the primary motor cortex (M1) for 10 min induces a persistent excitability increase lasting for at least 60 min. However, the mechanism of tRNS-induced cortical excitability alterations is not yet fully understood. Objective: The main aim of this study was to get first efficacy data with regard to the possible neuronal effect of tRNS. Methods: Single-pulse transcranial magnetic stimulation (TMS) was used to measure levels of cortical excitability before and after combined application of tRNS at an intensity of 1 mA for 10 min stimulation duration and a pharmacological agent (or sham) on eight healthy male participants. Results: The sodium channel blocker carbamazepine showed a tendency toward inhibiting MEPs 5-60 min poststimulation. The GABA(A) agonist lorazepam suppressed tRNS-induced cortical excitability increases at 0-20 and 60 min time points. The partial NMDA receptor agonist D-cycloserine, the NMDA receptor antagonist dextromethorphan and the D-2/D-3 receptor agonist ropinirole had no significant effects on the excitability increases seen with tRNS. Conclusions: In contrast to transcranial direct current stimulation (tDCS), aftereffects of tRNS are seem to be not NMDA receptor dependent and can be suppressed by benzodiazepines suggesting that tDCS and tRNS depend upon different mechanisms."],["dc.description.sponsorship","Open Access Publikationsfonds 2015"],["dc.identifier.doi","10.3389/fnins.2015.00125"],["dc.identifier.isi","000352977200001"],["dc.identifier.pmid","25914617"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11860"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37389"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-453X"],["dc.relation.issn","1662-453X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Transcranial random noise stimulation-induced plasticity is NMDA-receptor independent but sodium-channel blocker and benzodiazepines sensitive"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]