Now showing 1 - 10 of 38
  • 2019Journal Article
    [["dc.bibliographiccitation.firstpage","433"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.lastpage","438"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Büchsel, Rebecca"],["dc.contributor.author","Belz, Michael"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.contributor.author","Kis, Bernhard"],["dc.date.accessioned","2020-12-10T14:08:38Z"],["dc.date.available","2020-12-10T14:08:38Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00115-019-0762-y"],["dc.identifier.eissn","1433-0407"],["dc.identifier.issn","0028-2804"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70503"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","(Teil-)stationäre Therapie von Voll- und Minderjährigen mit einer hyperkinetischen Störung in der deutschen Psychiatrie"],["dc.title.alternative","Day care/inpatient psychiatric treatment of minors and adults with hyperkinetic disorder in German psychiatric hospitals. Basic conditions, diagnoses and comorbidities"],["dc.title.subtitle","Rahmenbedingungen, Diagnosevergabe und Komorbiditäten"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2015Journal Article
    [["dc.bibliographiccitation.firstpage","589"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","600"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Weidinger, Elif"],["dc.contributor.author","Jobst, Andrea"],["dc.contributor.author","Hoell, Imke"],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Yeganeh-Doost, Peyman"],["dc.contributor.author","Strube, Wolfgang"],["dc.contributor.author","Quast, Silke"],["dc.contributor.author","Mueller, Norbert"],["dc.contributor.author","Wobrock, Thomas"],["dc.date.accessioned","2018-11-07T09:51:15Z"],["dc.date.available","2018-11-07T09:51:15Z"],["dc.date.issued","2015"],["dc.description.abstract","Despite many pharmacological and psychosocial treatment options, schizophrenia remains a debilitating disorder. Thus, new treatment strategies rooted in the pathophysiology of the disorder are needed. Recently, vagus nerve stimulation (VNS) has been proposed as a potential treatment option for various neuropsychiatric disorders including schizophrenia. The objective of this study was to investigate for the first time the feasibility, safety and efficacy of transcutaneous VNS in stable schizophrenia. A bicentric randomized, sham-controlled, double-blind trial was conducted from 2010 to 2012. Twenty schizophrenia patients were randomly assigned to one of two treatment groups. The first group (active tVNS) received daily active stimulation of the left auricle for 26 weeks. The second group (sham tVNS) received daily sham stimulation for 12 weeks followed by 14 weeks of active stimulation. Primary outcome was defined as change in the Positive and Negative Symptom Scale total score between baseline and week 12. Various other secondary measures were assessed to investigate safety and efficacy. The intervention was well tolerated with no relevant adverse effects. We could not observe a statistically significant difference in the improvement of schizophrenia psychopathology during the observation period. Neither psychopathological and neurocognitive measures nor safety measures showed significant differences between study groups. Application of tVNS was well tolerated, but did not improve schizophrenia symptoms in our 26-week trial. While unsatisfactory compliance questions the feasibility of patient-controlled neurostimulation in schizophrenia, the overall pattern of symptom change might warrant further investigations in this population."],["dc.description.sponsorship","CerboMed GmbH, Erlangen, Germany"],["dc.identifier.doi","10.1007/s00406-015-0618-9"],["dc.identifier.isi","000361397100006"],["dc.identifier.pmid","26210303"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35876"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1433-8491"],["dc.relation.issn","0940-1334"],["dc.title","Transcutaneous noninvasive vagus nerve stimulation (tVNS) in the treatment of schizophrenia: a bicentric randomized controlled pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
    Details DOI PMID PMC WOS
  • 2017Journal Article
    [["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Bandelow, Borwin"],["dc.contributor.author","Lueken, U."],["dc.contributor.author","Wolff, J."],["dc.contributor.author","Godemann, Frank"],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.contributor.author","Deckert, J."],["dc.contributor.author","Strohle, A."],["dc.contributor.author","Beutel, Manfred E."],["dc.contributor.author","Wiltink, J."],["dc.contributor.author","Domschke, Katharina"],["dc.contributor.author","Berger, M."],["dc.date.accessioned","2018-11-07T10:26:45Z"],["dc.date.available","2018-11-07T10:26:45Z"],["dc.date.issued","2017"],["dc.format.extent","290"],["dc.identifier.doi","10.1007/s00115-017-0291-5"],["dc.identifier.isi","000396329400009"],["dc.identifier.pmid","28188399"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43111"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1433-0407"],["dc.relation.issn","0028-2804"],["dc.title","Guideline-oriented inpatient psychiatric psychotherapeutic/psychosomatic Treatment of Anxiety Disorders. How many Personnel are needed? (vol 87, pg 302, 2016)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
    Details DOI PMID PMC WOS
  • 2018Journal Article
    [["dc.bibliographiccitation.artnumber","e0208458"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Belz, Michael"],["dc.contributor.author","Rehling, Nico"],["dc.contributor.author","Schmidt, Ulrike"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Kis, Bernhard"],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.date.accessioned","2019-07-09T11:49:39Z"],["dc.date.available","2019-07-09T11:49:39Z"],["dc.date.issued","2018"],["dc.description.abstract","The prevalence of infections is supposed to be higher in older patients and to extend the length of hospital stays. This study aimed, first, to test this supposition within a large psychiatric population which we divided into four clusters of psychiatric ICD-10 diagnoses: F00-F03 (dementias), F10 (substance disorders), F20-29 (schizophrenia, schizophreniform and other non-mood psychotic disorders), F32-F33 (major depressive disorders). Second, despite the increasing evidence for the role of infections in psychiatric disorders, it is, to the best of our knowledge, largely unknown whether the rates of infections with pathogens of the four most frequent germ families differ between psychiatric diseases. Thus, in a retrospective study, the results of clinical routine examinations (pap smear, analysis of midstream urine, stool) dependent on symptoms in 8545 patients of a German psychiatric clinic were analyzed in a 12-year dataset. Results show that a longer hospital stay was associated with an increased number of microbiological tests, but led to no significant difference between positive vs. negative findings. Consistent with previous studies, patients with infections were older than patients without infections. For the F10 diagnosis cluster we found a significantly reduced (F10: Staphylococcaceae) and for the F20-29 cluster a heightened risk of infections (Staphylococcaceae, Corynebacteriaceae). Furthermore, patients belonging to the F00-F03 cluster exhibited elevated rates of infections with all four germ families. The latter can be ascribed to patients' age as we found higher age to be associated with these infections, independently of the presence of dementia. Our results suggest that different psychiatric diagnoses are associated with a heightened or lowered risk of bacterial infections and, furthermore, that clinical routine infection-screenings for elderly psychiatric patients seems to be reasonable."],["dc.identifier.doi","10.1371/journal.pone.0208458"],["dc.identifier.pmid","30513128"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15733"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59599"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Bacterial infections among patients with psychiatric disorders: Relation with hospital stay, age, and psychiatric diagnoses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
    Details DOI PMID PMC
  • 2020Journal Article
    [["dc.bibliographiccitation.firstpage","99"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Drug Investigation"],["dc.bibliographiccitation.lastpage","113"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Mahlich, Jörg"],["dc.contributor.author","Olbrich, Kerstin"],["dc.contributor.author","Wilk, Adrian"],["dc.contributor.author","Wimmer, Antonie"],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.date.accessioned","2021-04-14T08:30:25Z"],["dc.date.available","2021-04-14T08:30:25Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s40261-020-00990-8"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83230"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1179-1918"],["dc.relation.issn","1173-2563"],["dc.title","Time to Treatment Discontinuation in German Patients with Schizophrenia: Long-Acting Injectables versus Oral Antipsychotics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2013Journal Article
    [["dc.bibliographiccitation.firstpage","864"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.lastpage","868"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Godemann, Frank"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Hauth, Iris"],["dc.contributor.author","Salize, H.-J."],["dc.contributor.author","Pollmaecher, T."],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.date.accessioned","2018-11-07T09:23:00Z"],["dc.date.available","2018-11-07T09:23:00Z"],["dc.date.issued","2013"],["dc.description.abstract","The new lump sum payment scheme for psychiatric and psychosomatic services is coming into force in 2013. This constitutes another step on the way to performance-based financial compensation of inpatient and day hospital treatment in psychiatric and psychosomatic hospitals in Germany. This fundamental change needs to be accompanied by scientific evaluation with regards to its effects. This article reflects on the legal foundations of such evaluations and the current progress of preparation. Furthermore, own approaches for analysing the effects of the new finance scheme are presented."],["dc.identifier.doi","10.1007/s00115-013-3795-7"],["dc.identifier.isi","000321572900014"],["dc.identifier.pmid","23695005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29478"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0028-2804"],["dc.title","Lump sum payment system in psychiatry and psychosomatics. Concomitant research - quo vadis?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
    Details DOI PMID PMC WOS
  • 2019Journal Article
    [["dc.bibliographiccitation.firstpage","S278"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Wimmer, A."],["dc.contributor.author","Mahlich, J."],["dc.contributor.author","Olbrich, K."],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.date.accessioned","2020-04-02T14:47:27Z"],["dc.date.available","2020-04-02T14:47:27Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2019.09.406"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63563"],["dc.relation.issn","0924-977X"],["dc.title","P.392 Hospitalization rates and therapy costs of German schizophrenia patients who are initiated on long acting injectable medication"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2019Journal Article
    [["dc.bibliographiccitation.firstpage","720"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","739"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Veselinović, Tanja"],["dc.contributor.author","Scharpenberg, Martin"],["dc.contributor.author","Heinze, Martin"],["dc.contributor.author","Cordes, Joachim"],["dc.contributor.author","Mühlbauer, Bernd"],["dc.contributor.author","Juckel, Georg"],["dc.contributor.author","Habel, Ute"],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Timm, Jürgen"],["dc.contributor.author","Gründer, Gerhard"],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Borgmann, Markus"],["dc.contributor.author","Breunig-Lyriti, Vasiliki"],["dc.contributor.author","Schulz, Constanze"],["dc.contributor.author","Brüne, Martin"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Feyerabend, Sandra"],["dc.contributor.author","Figge, Christian"],["dc.contributor.author","Frieling, Helge"],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Handschuh, Dmitri"],["dc.contributor.author","Heller, Jörg"],["dc.contributor.author","Kirchhefer, Rainer"],["dc.contributor.author","Kirner, André"],["dc.contributor.author","Kowalenko, Barbara"],["dc.contributor.author","Lautenschlager, Marion"],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.contributor.author","Naber, Dieter"],["dc.contributor.author","Prumbs, Katharina"],["dc.contributor.author","Wobrock, Thomas"],["dc.date.accessioned","2020-12-10T14:23:57Z"],["dc.date.available","2020-12-10T14:23:57Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2019.03.014"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72086"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Disparate effects of first and second generation antipsychotics on cognition in schizophrenia – Findings from the randomized NeSSy trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2019Journal Article
    [["dc.bibliographiccitation.journal","Frontiers in Pharmacology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Hessmann, Philipp"],["dc.contributor.author","Zeidler, Jan"],["dc.contributor.author","Stahmeyer, Jona"],["dc.contributor.author","Eberhard, Sveja"],["dc.contributor.author","Vogelgsang, Jonathan"],["dc.contributor.author","Abdel-Hamid, Mona"],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Kis, Bernhard"],["dc.date.accessioned","2020-12-10T18:44:36Z"],["dc.date.available","2020-12-10T18:44:36Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3389/fphar.2019.00841"],["dc.identifier.eissn","1663-9812"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78524"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Claims Data Analysis on the Dispensing of Tricyclic Antidepressants Among Patients With Dementia in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
    Details DOI
  • 2022Journal Article
    [["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","07/08"],["dc.bibliographiccitation.journal","Fortschritte der Neurologie · Psychiatrie"],["dc.bibliographiccitation.lastpage","367"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Onur, Oezguer A."],["dc.contributor.author","Wolff-Menzler, Claus"],["dc.contributor.author","von Arnim, Christine A. F."],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Fink, Gereon R."],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Oberstein, Timo"],["dc.contributor.author","Frölich, Lutz"],["dc.date.accessioned","2022-09-01T09:50:17Z"],["dc.date.available","2022-09-01T09:50:17Z"],["dc.date.issued","2022"],["dc.description.abstract","Zusammenfassung\n Demenzen sind teure Erkrankungen: die jährlichen Kosten betragen in\n europäischen Versorgungssystemen etwa 28.000 €/Fall mit\n einer starken Stadien-Abhängigkeit, davon entfallen etwa 19% auf\n die medizinische Versorgung. Die diagnostischen Kosten hingegen verursachen\n davon nur einen geringen Teil. Mit Wandel des konzeptuellen\n Verständnisses von Demenzerkrankungen, der\n Behandlungsmöglichkeiten und der Leitlinien spielen zunehmend auch\n Biomarker-Untersuchungen eine wichtige Rolle. Die ökonomischen\n Auswirkungen der Biomarker-basierten Diagnostik sind derzeit nicht sicher\n abschätzbar. Zur Erhebung der Kosten einer leitlinien-orientierten\n ätiologischen Erst-Diagnostik von kognitiven Störungen wurde\n eine Umfrage im Deutschen Netzwerk Gedächtnisambulanzen (DNG)\n durchgeführt. An 15 Expertenzentren des DNG wurden systematisch die\n Personalbindungszeiten für alle Prozeduren und alle beteiligten\n Berufsgruppen erhoben und die Personalkosten basierend auf den\n tarifvertraglichen Arbeitgeberkosten berechnet. Zusammen mit den Kosten\n für technische Untersuchungen wurden Gesamtkosten der Diagnostik\n für drei Szenarien abgeschätzt: Diagnostik ohne Biomarker\n € 633,97 €, Diagnostik mit Liquoruntersuchungen\n € 1.214,90 und Diagnostik mit FDG- plus Amyloid-PET\n € 4.740,58. Zusätzlich erfolgte eine Analyse der\n derzeitigen realen Kostensituation in Gedächtnisambulanzen, wobei die\n Personalbindungszeiten für einzelne Leistungen und die apparativen\n Kosten ins Verhältnis zur Häufigkeit ihrer Anwendung gesetzt\n wurden. Als Mittelwert aller Zentren ergeben sich dabei Gesamtkosten von\n € 1.394,43/Fall (Mittelwert der Personalkosten\n € 351,72, Mittelwert der Kosten für apparative\n Diagnostik € 1.042,71). Die Ergebnisse zeigen, dass eine\n ätiologische Diagnostik von kognitiven Störungen (Demenzen und\n leichte kognitive Störung) einen Ressourceneinsatz erfordert, welcher\n derzeit weder durch die Vergütungssysteme von Ambulanzen noch durch die\n vertragsärztliche Vergütung kostendeckend erstattet wird. Die\n Biomarker-gestützte Diagnostik dementieller und prädementieller\n Syndrome wird häufiger werden, wenn sie zur Indikationsstellung vor\n einer krankheits-modifizierenden Therapie erforderlich ist. Deshalb\n müssen neue Finanzierungsmodelle entwickelt werden, um die\n gegenwärtige Lücke in der Kostenerstattung für die\n ätiologische Diagnostik kognitiver Störungen zu\n schließen."],["dc.identifier.doi","10.1055/a-1871-9889"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113670"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1439-3522"],["dc.relation.issn","0720-4299"],["dc.title","Kosten der Diagnostik kognitiver Störungen in deutschen\n Gedächtnisambulanzen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
    Details DOI