Lehmann, Wolfgang

[["dc.bibliographiccitation.firstpage","1005"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","1014"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Peters, Michael"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Takahira, Sayuri"],["dc.contributor.author","Takeuchi, Yoshiaki"],["dc.contributor.author","Jordan, Kirsten"],["dc.date.accessioned","2018-11-07T09:09:30Z"],["dc.date.available","2018-11-07T09:09:30Z"],["dc.date.issued","2006"],["dc.description.abstract","Two meta-analyses (Linn and Petersen, 1985; Voyer et al., 1995) discuss variables that affect mental rotation performance but they do not mention a potentially important variable, the Academic Program in which students are enrolled. Sex differences in brain size have been related to sex differences in spatial performance (e.g., Falk et al., 1999) and thus it is important to know whether mental rotation performance shows a significant interaction between Sex and Academic Program. To put our understanding of the Academic Program effect on a firmer empirical footing, we conducted a large scale multicultural study, with samples from Canada, Germany and Japan, using identical test procedures in all studies. Significant main effects for Sex and Academic Program were found in all four studies, with large effect sizes for Sex and medium to large effect sizes for Academic Program (based on Cohen's d). No significant interactions between these variables were found in the four samples. Our demonstration of a reliable Academic Program effect has clear and important pragmatic implications for a broad range of work on spatial ability and its interpretation."],["dc.identifier.doi","10.1016/S0010-9452(08)70206-5"],["dc.identifier.isi","000242843400005"],["dc.identifier.pmid","17172180"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26280"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Masson Divisione Periodici"],["dc.relation.issn","0010-9452"],["dc.title","Mental rotation test performance in four cross-cultural samples (N=3367): Overall sex differences and the role of academic program in performance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","277"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Bone and Mineral Research"],["dc.bibliographiccitation.lastpage","284"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Rolvien, Tim"],["dc.contributor.author","Koehne, Till"],["dc.contributor.author","Kornak, Uwe"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Amling, Michael"],["dc.contributor.author","Schinke, Thorsten"],["dc.contributor.author","Oheim, Ralf"],["dc.date.accessioned","2018-11-07T10:27:44Z"],["dc.date.available","2018-11-07T10:27:44Z"],["dc.date.issued","2017"],["dc.description.abstract","Gnathodiaphyseal dysplasia (GDD) is a rare skeletal syndrome that involves an osteopetrosis-like sclerosis of the long bones and fibrous dysplasia-like cemento-osseous lesions of the jawbone. Although the genetic analysis of the respective patients has revealed mutations in the ANO5 gene as an underlying cause, there is still no established consensus regarding the bone status of GDD patients. We report a new case of GDD in a 13-year-old boy with recurrent diaphyseal fractures of the femur, in whom we identified a novel de novo missense mutation in the ANO5 gene, causing a p.Ser500Phe substitution at the protein level. After confirming the presence of GDD-characteristic abnormalities within the jaw bones, we focused on a full osteologic assessment using dual-energy X-ray absorptiometry (DXA), high-resolution peripheral quantitative computed tomography (HR-pQCT), and serum analyses. We thereby identified increased trabecular bone mass accompanied by elevated serum markers of bone formation and bone resorption. The high turnover bone pathology was further confirmed through the analysis of an iliac crest biopsy, where osteoblast and osteoclast indices were remarkably increased. Taken together, our findings provide evidence for a critical and generalized role of anoctamin-5 (the protein encoded by the ANO5 gene) in skeletal biology. As it is reasonable to speculate that modifying the function of anoctamin-5 might be useful for therapeutically activating bone remodeling, it is now required to analyze its function at a molecular level, for instance in mouse models. (C) 2016 American Society for Bone and Mineral Research."],["dc.identifier.doi","10.1002/jbmr.2980"],["dc.identifier.isi","000396935300011"],["dc.identifier.pmid","27541832"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43288"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1523-4681"],["dc.relation.issn","0884-0431"],["dc.title","A Novel ANO5 Mutation Causing Gnathodiaphyseal Dysplasia With High Bone Turnover Osteosclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1422"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Personalized Medicine"],["dc.bibliographiccitation.volume","12"],["dc.contributor.affiliation","Fieseler, George; 1Clinic for Orthopedic and Trauma Surgery, Sports Medicine, Clinic Hannoversch Münden, 34346 Hannoversch Münden, Germany"],["dc.contributor.affiliation","Schwesig, René; 2Department of Orthopedic and Trauma Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany"],["dc.contributor.affiliation","Sendler, Julia; 1Clinic for Orthopedic and Trauma Surgery, Sports Medicine, Clinic Hannoversch Münden, 34346 Hannoversch Münden, Germany"],["dc.contributor.affiliation","Cornelius, Jakob; 2Department of Orthopedic and Trauma Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany"],["dc.contributor.affiliation","Schulze, Stephan; 2Department of Orthopedic and Trauma Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany"],["dc.contributor.affiliation","Lehmann, Wolfgang; 3Clinic for Orthopedic, Trauma and Reconstructive Surgery, Georg August University Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Hermassi, Souhail; 4Physical Education Department, College of Education, Qatar University, Doha 2713, Qatar"],["dc.contributor.affiliation","Delank, Karl-Stefan; 2Department of Orthopedic and Trauma Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany"],["dc.contributor.affiliation","Laudner, Kevin; 5Department of Health Sciences, University of Colorado Colorado Springs, Colorado Springs, CO 80918, USA"],["dc.contributor.author","Fieseler, George"],["dc.contributor.author","Schwesig, René"],["dc.contributor.author","Sendler, Julia"],["dc.contributor.author","Cornelius, Jakob"],["dc.contributor.author","Schulze, Stephan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hermassi, Souhail"],["dc.contributor.author","Delank, Karl-Stefan"],["dc.contributor.author","Laudner, Kevin"],["dc.contributor.editor","Gesslein, Markus"],["dc.contributor.editor","Kurz, Eduard"],["dc.date.accessioned","2022-10-04T10:21:08Z"],["dc.date.available","2022-10-04T10:21:08Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:14:45Z"],["dc.description.abstract","To determine how the internal rotation and shift (IRO/shift) test compares to the gold standard of clinical tests (Jobe test) for diagnosing supraspinatus lesions and to confirm these clinical results with surgical findings, 100 symptomatic patients were clinically examined between October 2018 and November 2019. All 100 patients were evaluated using both the IRO/shift test and Jobe test. A total of 48 of these patients received surgical intervention. Based on these data, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for both the IRO/shift test and Jobe test were calculated. The IRO/shift test had a sensitivity of 96% (95% CI: 82–100%), specificity of 50% (95% CI: 27–73%), PPV of 73% (95% CI: 56–86%), NPV of 91% (95% CI: 59–100%), and an accuracy of 77% (95% CI: 63–88%). The Jobe test had a sensitivity of 89% (95% CI: 72–98%), specificity of 60% (95% CI: 36–81%), PPV of 76% (95% CI: 58–89%), NPV of 80% (95% CI: 52–96%), and an accuracy of 77% (95% CI: 54–81%). These results suggest that the IRO/shift test is comparable to the Jobe test, which is often viewed as the gold standard clinical examination for assessing supraspinatus lesions. This study was approved by the Ethics Commission of the Martin Luther University Halle-Wittenberg (reference number: 2018-05)."],["dc.identifier.doi","10.3390/jpm12091422"],["dc.identifier.pii","jpm12091422"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114337"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.publisher","MDPI"],["dc.relation.eissn","2075-4426"],["dc.rights","Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."],["dc.title","IRO/Shift Test Is Comparable to the Jobe Test for Detection of Supraspinatus Lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0243306"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Frosch, Stephan"],["dc.contributor.author","Buchhorn, Gottfried"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Walde, Tim Alexander"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.editor","de Araújo, Gabriel"],["dc.date.accessioned","2021-04-14T08:31:45Z"],["dc.date.available","2021-04-14T08:31:45Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0243306"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17806"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83704"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Comparison of the double loop knot stitch and Kessler stitch for Achilles tendon repair: A biomechanical cadaver study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","301"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","310"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, L."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Weiser, L."],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0609-5"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16565"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70360"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pedikelsubtraktionsosteotomie zur Korrektur rigider Deformitäten"],["dc.title.alternative","Pedicle subtraction osteotomy to correct rigid deformities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Endocrinological Investigation"],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Büchler, G."],["dc.contributor.author","Böker, K. O."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Roch, P. J."],["dc.contributor.author","Taudien, S."],["dc.contributor.author","Hoffmann, D. B."],["dc.contributor.author","Sehmisch, S."],["dc.date.accessioned","2022-09-01T09:49:26Z"],["dc.date.available","2022-09-01T09:49:26Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Purpose\n Enobosarm (EN), a selective androgen receptor modulator and raloxifene (RAL), a selective estrogen receptor modulator, have been shown to improve bone tissue in osteoporotic males. The present study evaluated the effects of a combination therapy of EN and RAL on bone properties in orchiectomized rats compared to the respective single treatments.\n \n \n Methods\n Eight-month-old male Sprague–Dawley rats were either left intact (Non-Orx) or orchiectomized (Orx). The Orx rats were divided into four groups (n = 15 each): 1) Orx, 2) EN treatment (Orx + EN), 3) RAL treatment (Orx + RAL), 4) combined treatment (Orx + EN + RAL). EN and RAL (0.4 mg and 7 mg/kg body weight/day) were applied immediately after Orx with a soy-free pelleted diet for up to 18 weeks. The lumbar spine and femora were examined by micro-CT, biomechanical, histomorphological, ashing, and gene expression analyses.\n \n \n Results\n EN exhibited an anabolic effect on bone, improving some of its parameters in Orx rats, but did not affect biomechanical properties. RAL exhibited antiresorptive activity, maintaining the biomechanical and trabecular parameters of Orx rats at the levels of Non-Orx rats. EN + RAL exerted a stronger effect than the single treatments, improving most of the bone parameters. Liver weight increased after all treatments; the kidney, prostate, and levator ani muscle weights increased after EN and EN + RAL treatments. BW was reduced due to a decreased food intake in the Orx + RAL group and due a reduced visceral fat weight in the Orx + EN + RAL group.\n \n \n Conclusion\n The EN + RAL treatment appeared to be promising in preventing male osteoporosis, but given the observed side effects on liver, kidney, and prostate weights, it requires further investigation."],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship"," Georg-August-Universität Göttingen 501100003385"],["dc.identifier.doi","10.1007/s40618-022-01865-9"],["dc.identifier.pii","1865"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113421"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1720-8386"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A combined treatment with selective androgen and estrogen receptor modulators prevents bone loss in orchiectomized rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","34S"],["dc.bibliographiccitation.issue","2_suppl"],["dc.bibliographiccitation.journal","Global spine journal"],["dc.bibliographiccitation.lastpage","45S"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Verheyden, Akhil P."],["dc.contributor.author","Spiegl, Ulrich J."],["dc.contributor.author","Ekkerlein, Helmut"],["dc.contributor.author","Gercek, Erol"],["dc.contributor.author","Hauck, Stefan"],["dc.contributor.author","Josten, Christoph"],["dc.contributor.author","Kandziora, Frank"],["dc.contributor.author","Katscher, Sebastian"],["dc.contributor.author","Kobbe, Philipp"],["dc.contributor.author","Knop, Christian"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Meffert, Rainer H."],["dc.contributor.author","Müller, Christian W."],["dc.contributor.author","Partenheimer, Axel"],["dc.contributor.author","Schinkel, Christian"],["dc.contributor.author","Schleicher, Philipp"],["dc.contributor.author","Scholz, Matti"],["dc.contributor.author","Ulrich, Christoph"],["dc.contributor.author","Hoelzl, Alexander"],["dc.date.accessioned","2020-12-10T18:38:40Z"],["dc.date.available","2020-12-10T18:38:40Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1177/2192568218771668"],["dc.identifier.eissn","2192-5690"],["dc.identifier.issn","2192-5682"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77405"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Treatment of Fractures of the Thoracolumbar Spine: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The Spine Journal"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Çelik, Bahar"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Reinhold, Maximilian"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Klockner, Friederike Sophie"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Weiser, Lukas"],["dc.date.accessioned","2022-12-01T08:30:44Z"],["dc.date.available","2022-12-01T08:30:44Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.spinee.2022.10.013"],["dc.identifier.pii","S1529943022009986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117963"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","1529-9430"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Combination of vertebral bone quality scores from different magnetic resonance imaging sequences improves prognostic value for the estimation of osteoporosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","495"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","JSES International"],["dc.bibliographiccitation.lastpage","499"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Fieseler, Georg"],["dc.contributor.author","Laudner, Kevin"],["dc.contributor.author","Sendler, Julia"],["dc.contributor.author","Cornelius, Jakob"],["dc.contributor.author","Schulze, Stephan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hermassi, Souhail"],["dc.contributor.author","Delank, Karl-Stefan"],["dc.contributor.author","Schwesig, René"],["dc.date.accessioned","2022-06-01T09:40:20Z"],["dc.date.available","2022-06-01T09:40:20Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.jseint.2022.01.011"],["dc.identifier.pii","S2666638322000597"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108702"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.issn","2666-6383"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","The internal rotation and shift-test for the detection of superior lesions of the rotator cuff: reliability and clinical performance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Zeitschrift für Orthopädie und Unfallchirurgie"],["dc.contributor.author","von Knoch, Marius"],["dc.contributor.author","Baums, Mike H."],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Frosch, Stephan"],["dc.date.accessioned","2021-06-01T09:41:48Z"],["dc.date.available","2021-06-01T09:41:48Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background The present study used a systematic review to analyse the risk of perioperative injections during arthroscopic reconstruction of the rotator cuff of the shoulder. The questions of interest were whether perioperative local injection increases the infection risk and whether the number of postoperative revisions is increased. Material and Methods A systematic review of the U. S. National Library of Medicine/National Institutes of Health (PubMed) database and the Cochrane Library was performed using the PRISMA checklist. The keywords used were “shoulder” and “arthroscopy” and “injection” and “risk”. In the course of the study, work that was not also primarily concerned with the reconstruction of the rotator cuff was excluded. English original articles and case series were included that contained at least some arthroscopic reconstructions of the rotator cuff. The risk of bias was determined using the Newcastle-Ottawa Scale. The content of the articles relevant to the research questions was analysed. Results 48 hits were primarily generated. 9 articles corresponded to the inclusion criteria and were analysed. In the 6 studies with details on the injected substances, cortisone was used in 98 – 100% of the cases. The reported infection and revision rates based on insurance data were higher with injection than without. The risk of bias in the studies analysed here was rather low based on the Newcastle-Ottawa Score. The risk of infection after a cortisone injection before, during or after surgery was increased. Injection was associated with infection in up to 8% of cases with injections within two weeks of surgery. The risk of infection was increased by up to 11 times with injections within 4 weeks after the operation. Likewise, the risk of revision surgery after injection was increased, with the time intervals between injection and surgery sometimes differing between studies. Discussion Local infections and to a lesser extent revision surgery are associated with perioperative injections (with cortisone) within 3 months preoperatively and 4 weeks postoperatively. However, there were only database studies of insurance data with several studies from a few centres. Thus, no causal relationships could be proven. Currently, however, the following can be recommended using a cautious approach: The interval between injection with cortisone before surgery should be at least 2 weeks, better 3 months. No cortisone injections should be applied intraoperatively. Postoperatively, cortisone should not be injected for at least 4 weeks. If, in exceptional cases, deviations from these time limits are required, patients should be informed about an increased risk of complications."],["dc.description.abstract","Zusammenfassung Hintergrund Die vorliegende Arbeit analysierte durch einen systematischen Review das Risiko von perioperativen Injektionen bei arthroskopischer Rekonstruktion der Rotatorenmanschette der Schulter. Von Interesse war die Frage, ob perioperative lokale Injektionen das Infektionsrisiko erhöhen und ob die Anzahl postoperativer Revisionen erhöht ist. Material und Methoden Es wurde eine systematische Durchsicht der Datenbank der U. S. National Library of Medicine/National Institutes of Health (PubMed) und der Cochrane Library unter Anwendung der PRISMA-Checkliste durchgeführt. Als Suchwörter dienten „shoulder“ und „arthroscopy“ und „injection“ und „risk“. Im Verlauf wurden Arbeiten ausgeschlossen, die sich nicht auch primär mit der Rekonstruktion der Rotatorenmanschette beschäftigten. Englischsprachige Originalarbeiten und Fallserien, die mindestens anteilig arthroskopische Rekonstruktionen der Rotatorenmanschette enthielten, wurden eingeschlossen. Das Verzerrungsrisiko wurde mithilfe der Newcastle-Ottawa Scale ermittelt. Die für die Forschungsfragen relevanten Artikel wurden inhaltlich analysiert. Ergebnisse Es wurden primär 48 Treffer generiert. Neun Artikel entsprachen den Einschlusskriterien und wurden analysiert. In 6 Arbeiten mit näheren Angaben zur injizierten Substanz war in 98 – 100% der Fälle Kortison verwendet worden. Die berichteten Infektions- und Revisionsraten waren mit Injektion höher als ohne. Das Verzerrungsrisiko der hier analysierten Studien war auf Grundlage der Ermittlung der Newcastle-Ottawa Scale eher gering. Das Risiko einer Infektion nach einer Injektion mit Kortison vor, während oder nach einer Operation war erhöht. Innerhalb von 2 Wochen vor Operation war eine Injektion in bis zu 8% der Fälle mit einer Infektion assoziiert. Innerhalb von 4 Wochen nach Operation war das Infektionsrisiko um bis zu 11-fach erhöht. Ebenso war das Risiko einer Revisionsoperation nach Injektion erhöht, wobei die zeitlichen Abstände zwischen Injektion und Operation zwischen den Studien teilweise differierten. Diskussion Lokale Infektionen und in geringerem Maße Revisionsoperationen sind mit perioperativen Injektionen (mit Kortison) innerhalb von 3 Monaten vor und bis 4 Wochen nach Operation assoziiert. Es lagen aber lediglich Datenbankanalysen von Versichertendaten mit mehreren Arbeiten aus wenigen Zentren vor. Somit konnten keine kausalen Zusammenhänge nachgewiesen werden. Aktuell kann aber bei vorsichtiger Herangehensweise Folgendes empfohlen werden: Der zeitliche Abstand zwischen Injektion mit Kortison vor Operation sollte mindestens 2 Wochen, besser 3 Monate betragen. Intraoperative Injektionen mit Kortison sind nicht empfehlenswert. Postoperativ sollte für mindestens 4 Wochen keine Injektion mit Kortison erfolgen. Wenn im Ausnahmefall von diesen zeitlichen Grenzen abgewichen wird, ist eine Aufklärung der Patienten über ein erhöhtes Risiko angezeigt."],["dc.identifier.doi","10.1055/a-1394-6469"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85042"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1864-6743"],["dc.relation.issn","1864-6697"],["dc.title","Risk Analysis of Perioperative Injections in Arthroscopic Reconstruction of the Rotator Cuff of the Shoulder – A Systematic Review"],["dc.title.alternative","Perioperative Injections"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]