Options
Jung, Klaus
Loading...
Preferred name
Jung, Klaus
Official Name
Jung, Klaus
Alternative Name
Jung, K.
Now showing 1 - 10 of 126
2012Journal Article [["dc.bibliographiccitation.firstpage","574"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","American Journal of Orthodontics and Dentofacial Orthopedics"],["dc.bibliographiccitation.lastpage","582"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Bojes, Mariana"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Ziebolz, Dirk"],["dc.date.accessioned","2018-11-07T09:10:45Z"],["dc.date.available","2018-11-07T09:10:45Z"],["dc.date.issued","2012"],["dc.description.abstract","Introduction: There is a paucity of information with regard to the susceptibility of iatrogenic white spot lesion formation after inattentive, surplus orthodontic etching with 30% phosphoric acid and the subsequent provision or absence of adequate oral hygiene. Methods: Ninety sound enamel specimens were randomly allocated to 6 trial groups (n = 15 each) for etching with 30% phosphoric acid for either 15 seconds and standardized daily enamel brushing or no brushing, etching for 30 seconds with daily brushing or no brushing, or nonetched controls with brushing or no brushing. Nutritive acidic assaults were simulated by demineralization cycles 3 times per day for 1 hour with interim storage in artificial saliva. Lesion depths in terms of percentage of fluorescence loss (delta F, delta Q) and lesion extension compared with the baseline were assessed by using quantitative light-induced fluorescence after 2, 7, 14, 21, and 42 days. Etching duration, trial time elapse, and oral hygiene, as well as the significance of factor interactions, were analyzed with 3-way analysis of variance (alpha - 5%). Results: The impact of the factors of enamel brushing, trial time elapse, and etching each had a comparably significant effect on lesion progression. The effect of surplus etching on white spot lesion formation was significantly enhanced by the simultaneous absence of enamel brushing and also the progression of trial time. The combination of 30 seconds of surplus etching with inadequate oral hygiene was especially detrimental. Conclusions: Excessive surplus orthodontic etching of the complete labial enamel surface, instead of the bracket bases only, must be avoided to prevent iatrogenic white spot lesions. Etching times not exceeding 15 seconds are favorable. (Am J Orthod Dentofacial Orthop 2012;141:574-82)"],["dc.identifier.doi","10.1016/j.ajodo.2011.11.017"],["dc.identifier.isi","000303606100019"],["dc.identifier.pmid","22554751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26563"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","0889-5406"],["dc.title","Increased susceptibility for white spot lesions by surplus orthodontic etching exceeding bracket base area"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2013Conference Paper [["dc.bibliographiccitation.firstpage","9"],["dc.bibliographiccitation.lastpage","100"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Beißbarth, Tim"],["dc.date.accessioned","2020-04-02T10:43:45Z"],["dc.date.available","2020-04-02T10:43:45Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.4230/OASIcs.GCB.2013.90"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63516"],["dc.relation.eisbn","978-3-939897-59-0"],["dc.relation.eventlocation","Dagstuhl"],["dc.relation.eventstart","2013"],["dc.relation.ispartof","German Conference on Bioinformatics 2013"],["dc.title","Utilization of ordinal response structures in classification with high-dimensional expression data"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]Details DOI2009Journal Article [["dc.bibliographiccitation.firstpage","747"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","754"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Gripp-Rudolph, Liliam"],["dc.contributor.author","Attin, Thomas"],["dc.contributor.author","Attin, Rengin"],["dc.contributor.author","Sadat-Khonsari, Reza"],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Bauss, Oskar"],["dc.date.accessioned","2018-11-07T08:27:55Z"],["dc.date.available","2018-11-07T08:27:55Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: To test the null hypothesis that third-order measurements are not correlated to lingual incisor features seen on radiographs. Material and Methods: The lateral headfilms of 38 untreated, norm-occlusion subjects without incisor abrasions or restorations were used for third-order measurements of upper and lower central incisors and assessment of the inclination of four sites suitable for lingual bracket placement with reference to the occlusal plane perpendicular. Lingual sections were determined by the tangents at the incisal fossa (S1), at the transition plateau between incisal fossa and the cingulum (S2), by a constructed line reaching from the incisal tip to the cingulum (S3), and by a tangent at the cingulum convexity (S4). Third-order angles were also assessed on corresponding dental casts using an incisor inclination gauge. Regression analysis was performed using the third-order measurements of both methods as the dependent variables and the inclination of the lingual enamel sections (S1, S2, S3, S4) as the independent variables. Results: The null hypothesis was rejected. For the most common bracket application sites located on the lingual shovel (S1 and S2), third-order inclination changes of 0.4-0.7 degrees are expected for each degree of change in the inclination of the lingual surface. The impact of bracket placement errors on third-order angulation is similar between sections S1 and S2 and the cingulum convexity (S4). Section S3 proved to be least affected by interindividual variation. Conclusion: The third-order measurements are correlated to lingual incisor features. Accordingly, third-order changes resulting from variation in lingual bracket placement can be individually predicted from radiographic assessments. (Angle Orthod. 2009;79:747-754.)"],["dc.identifier.doi","10.2319/072308-385.1"],["dc.identifier.isi","000267712600019"],["dc.identifier.pmid","19537870"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5790"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16306"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","E H Angle Education Research Foundation, Inc"],["dc.relation.issn","0003-3219"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Changes in Incisor Third-Order Inclination Resulting from Vertical Variation in Lingual Bracket Placement"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2013Journal Article [["dc.bibliographiccitation.firstpage","900"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Leukemia Research"],["dc.bibliographiccitation.lastpage","906"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Schanz, Julie"],["dc.contributor.author","Götze, Katharina S."],["dc.contributor.author","Müller-Thomas, Catharina"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Germing, Ulrich"],["dc.contributor.author","Brümmendorf, Tim H."],["dc.contributor.author","Bug, Gesine"],["dc.contributor.author","Ottmann, Oliver G."],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Stadler, Michael"],["dc.contributor.author","Hofmann, Wolf-Karsten"],["dc.contributor.author","Schafhausen, Philippe"],["dc.contributor.author","Lübbert, Michael"],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Blau, Igor W."],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Metz, Michael"],["dc.contributor.author","Detken, Sven"],["dc.contributor.author","Seraphin, Jörg"],["dc.contributor.author","Jentsch-Ullrich, Kathleen"],["dc.contributor.author","Böhme, Angelika"],["dc.contributor.author","Schmidt, Burkhard C."],["dc.contributor.author","Trümper, Lorenz"],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T09:22:10Z"],["dc.date.available","2018-11-07T09:22:10Z"],["dc.date.issued","2013"],["dc.description.abstract","The gold standard of cytogenetic analysis in myelodysplastic syndromes (MDS) is conventional chromosome banding (CCB) analysis of bone marrow (BM) metaphases. Most aberrations can also be detected by fluorescence-in situ-hybridization (FISH). For this prospective multicenter German diagnostic study (www.clinicaltrials.gov: #NCT01355913) 360 patients, as yet, were followed up to 3 years by sequential FISH analyses of immunomagnetically enriched CD34+ peripheral blood (PB) cells using comprehensive FISH probe panels, resulting in a total number of 19,516 FISH analyses. We demonstrate that CD34+ PB FISH correlates significantly with CCB analysis and represents a feasible method for a reliable non-invasive cytogenetic monitoring from PB. (C) 2013 Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","Celgene(R) Germany"],["dc.identifier.doi","10.1016/j.leukres.2013.03.019"],["dc.identifier.isi","000321111900012"],["dc.identifier.pmid","23623559"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29278"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0145-2126"],["dc.title","Molecular cytogenetic monitoring from CD34+peripheral blood cells in myelodysplastic syndromes: First results from a prospective multicenter German diagnostic study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2009Journal Article [["dc.bibliographiccitation.firstpage","454"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","461"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Attin, Thomas"],["dc.contributor.author","Engelke, Wilfried G. H."],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Gripp-Rudolph, Liliam"],["dc.contributor.author","Attin, Rengin"],["dc.date.accessioned","2018-11-07T08:30:05Z"],["dc.date.available","2018-11-07T08:30:05Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: To evaluate the significance of crown-root angles (CRAs) by testing the null hypothesis that there are no significant differences in deviations of third-order angles to axial inclination values between Angle Class II division 2 incisors and a neutral occlusion control sample. Materials and Methods: The study group comprised n(total) = 130 whites with either Angle Class II division 2 (n(1) = 62; group A) or neutral (n(2) = 68; control group B) occlusal relationships. Upper central incisor inclination (U1) was assessed with reference to the cephalometric lines NA and palatal plane (U1NA/deg, U1PP/deg). Craniofacial sagittal and vertical relations were classified using angles SNA, SNB, ANB, and NSL-PP. Third-order angles were derived from corresponding dental cast pairs using an incisor inclination gauge. Welch's two-sample t-tests (alpha-level:.05) were used to test the null hypothesis. Single linear regression was applied to determine third-order angle values as a function of axial inclination values (U1NA, U1PP) or sagittal craniofacial structures (ANB angle), separately for group A and B. Results: The discrepancy between axial inclination (U1NA, U1PP) and third-order angles is significantly different (P <.001) between groups A and B. Regression analysis revealed a simply moderate correlation between third-order measurements and axial inclinations or sagittal craniofacial structures. Conclusion: The hypothesis is rejected. The results of this study warn against the use of identical third-order angles irrespective of diminished CRAs typical for Angle Class II division 2 subjects. Routine CRA assessment may be considered in orthodontic treatment planning of Angle Class II division 2 cases. (Angle Orthod. 2009;79:454-461.)"],["dc.identifier.doi","10.2319/042508-234"],["dc.identifier.isi","000266052200008"],["dc.identifier.pmid","19413389"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16807"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0003-3219"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","On the Interaction between Incisor Crown-Root Morphology and Third-Order Angulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2010Review [["dc.bibliographiccitation.firstpage","3"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Allergologie"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Kleine-Tebbe, Joerg"],["dc.contributor.author","Bufe, Albrecht"],["dc.contributor.author","Ebner, C."],["dc.contributor.author","Eigenmann, P."],["dc.contributor.author","Friedrichs, F."],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Huttegger, Isidor"],["dc.contributor.author","Jung, K."],["dc.contributor.author","Klimek, L."],["dc.contributor.author","Kopp, M."],["dc.contributor.author","Laessig, W."],["dc.contributor.author","Merk, Hans F"],["dc.contributor.author","Niggemann, B."],["dc.contributor.author","Rabe, U."],["dc.contributor.author","Saloga, Joachim"],["dc.contributor.author","Schmid-Grendelmeier, P."],["dc.contributor.author","Sitter, H."],["dc.contributor.author","Virchow, J. C."],["dc.contributor.author","Wagenmann, M."],["dc.contributor.author","Wedi, Bettina"],["dc.contributor.author","Worm, Margitta"],["dc.contributor.author","Hering, Thomas"],["dc.contributor.author","Koch, A."],["dc.contributor.author","Lenders, H."],["dc.contributor.author","Muesken, H."],["dc.contributor.author","Schnitzer, Stefan A."],["dc.contributor.author","Stuck, B. A."],["dc.contributor.author","Voigtmann, I."],["dc.contributor.author","Wehrmann, W."],["dc.contributor.author","Kaul, S."],["dc.contributor.author","Luther, B."],["dc.contributor.author","Schwalfenberg, A."],["dc.date.accessioned","2018-11-07T08:46:53Z"],["dc.date.available","2018-11-07T08:46:53Z"],["dc.date.issued","2010"],["dc.identifier.isi","000274075300002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20807"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dustri-verlag Dr Karl Feistle"],["dc.relation.issn","0344-5062"],["dc.title","Specific immunotherapy (hyposensitization) for IgE-mediated allergic diseases"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2011Journal Article [["dc.bibliographiccitation.firstpage","532"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","539"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Jung, Klaus"],["dc.date.accessioned","2018-11-07T08:56:38Z"],["dc.date.available","2018-11-07T08:56:38Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: To assess the informational value, intention, source, and bias of videos related to orthodontics screened by the video-sharing Internet platform You Tube. Methods: You Tube (www.youtube.com) was scanned in July 2010 for orthodontics-related videos using an adequately defined search term. Each of the first 30 search results of the scan was categorized with the system-generated sorts \"by relevance\" and \"most viewed\" (total: 60). These were rated independently by three assessors, who completed a questionnaire for each video. The data were analyzed statistically using Friedman's test for dependent samples, Kendall's tau, and Fleiss's kappa. Results: The You Tube scan produced 5140 results. There was a wide variety of information about orthodontics available on You Tube, and the highest proportion of videos was found to originate from orthodontic patients. These videos were also the most viewed ones. The informational content of most of the videos was generally judged to be low, with a rather poor to inadequate representation of the orthodontic profession, although a moderately pro-orthodontics stance prevailed. It was noticeable that the majority of contributions of orthodontists to You Tube constituted advertising. This tendency was not viewed positively by the majority of You Tube users, as was evident in the divergence in the proportions when sorting by \"relevance\" and \"most viewed.\" Conclusion: In the light of the very large number of people using the Internet as their primary source of information, orthodontists should recognize the importance of You Tube and similar social media Web sites in the opinion-forming process, especially in the case of adolescents. (Angle Orthod. 2011;81:532-539.)"],["dc.identifier.doi","10.2319/091710-541.1"],["dc.identifier.isi","000289761800025"],["dc.identifier.pmid","21261492"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23198"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","E H Angle Education Research Foundation, Inc"],["dc.relation.issn","0003-3219"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Informational value and bias of videos related to orthodontics screened on a video-sharing Web site"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2011Journal Article [["dc.bibliographiccitation.firstpage","76"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","81"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Cuneo, A."],["dc.contributor.author","Haertel, D."],["dc.contributor.author","Jung, K."],["dc.contributor.author","Witteck, C.-H."],["dc.contributor.author","Hoegel, R."],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Bramlage, Peter"],["dc.contributor.author","Tebbe, Ulrich"],["dc.date.accessioned","2018-11-07T09:01:06Z"],["dc.date.available","2018-11-07T09:01:06Z"],["dc.date.issued","2011"],["dc.description.abstract","Background and objective: Angioplasty in patients with renal artery stenosis aims at reducing blood pressure and at improving kidney function. Its efficacy has however been questioned by recent published data. It was the aim of this retrospective study to compare angioplasty with medical treatment in an unselected patient population. Methods: Data on 109 patients were retrospectively anlysed. This cohort included all those patients admitted to the Lippe-Detmold Hospital between 1992 and 2008 for renal artery stenosis. The data included blood pressure, creatinine-based calculated glomerular filtration rate (cGFR), any renal dialysis, cardiovascular risk factors, events and survival time after transluminal renal angioplasty or drug treatment, respectively. Results: Patients who had undergone angioplasty were younger (p = 0.04), had less cardiovascular co-morbidity (p < 0.01), but a higher degree of stenosis (p < 0.01). After a median follow-up of 32.5 (angioplasty) and 36.0 months (drug treatment), respectively, a significant decrease of cGFR was recorded in drug treated patients (- 16.2 ml/min, 95%, CI - 25.7 to - 6.7) but not in the angioplasty group (- 4.5 ml/min, 95%, CI - 13.5 to 4.5). There were no other significant differences were not observed. Conclusion: Younger patients with a high degree of renal artery stenosis but without generalized atherosclerosis more frequently underwent angioplasty in clinical practice. The smaller post-angioplasty reduction in the loss of renal function in this group needs to be validated in a prospective, randomized study."],["dc.identifier.doi","10.1055/s-0030-1269442"],["dc.identifier.isi","000286135500002"],["dc.identifier.pmid","21225553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24334"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0012-0472"],["dc.title","Renal artery stenosis: angioplasty or drug treatment?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2011Journal Article [["dc.bibliographiccitation.firstpage","1467"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","International Journal of Radiation Oncology*Biology*Physics"],["dc.bibliographiccitation.lastpage","1478"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Raus, Ismene"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Schueler, Phillip"],["dc.contributor.author","Herrmann, Markus Karl"],["dc.contributor.author","Hennies, Steffen"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T08:57:35Z"],["dc.date.available","2018-11-07T08:57:35Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose: To test for a possible correlation between high-grade acute organ toxicity during primary radiochemo-therapy and treatment outcome for patients with anal carcinoma. Methods and Materials: From 1991 to 2009, 72 patients with anal carcinoma were treated at our department (10 patients had stage I, 28 patients had stage II, 11 patients had stage IIIA, and 13 patients had stage IIIB cancer [Union Internationale Contre le Cancer criteria]). All patients received normofractionated (1.8 Gy/day, five times/week) whole-pelvis irradiation including iliac and inguinal lymph nodes with a cumulative dose of 50.4 Gy. Concomitant chemotherapy regimen consisted of two cycles of 5-fluorouracil (1,000 mg/m(2)total body surface area (TBSA)/day as continuous intravenous infusion on days 1-4 and 29-32) and mitomycin C (10 mg/m(2)/TBSA, intravenously on days 1 and 29). Toxicity during treatment was monitored weekly, and any incidence of Common Toxicity Criteria (CTC) grade of for skin reaction, cystitis, proctitis, or enteritis was assessed as high-grade acute organ toxicity for later analysis. Results: We found significant correlation between high-grade acute organ toxicity and overall survival, locoregional control, and stoma-free survival, which was independent in multivariate analysis from other possible prognostic factors: patients with a CTC acute organ toxicity grade of >= 3 had a 5-year overall survival rate of 97% compared to 30% in patients without (p < 0.01, multivariate analysis; 97% vs. 48%,p = 0.03 for locoregional control, and 95% vs. 59%, p = 0.05 for stoma-free survival). Conclusions: Our data indicate that normal tissue and tumor tissue may behave similarly with respect to treatment response, since high-grade acute organ toxicity during radiochemotherapy showed itself to be an independent prognostic marker in our patient population. This hypothesis should be further analyzed by using biomolecular and clinical levels in future clinical trials. (c) 2011 Elsevier Inc."],["dc.identifier.doi","10.1016/j.ijrobp.2010.01.010"],["dc.identifier.isi","000288980100027"],["dc.identifier.pmid","20605354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23433"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1879-355X"],["dc.relation.issn","0360-3016"],["dc.title","HIGH-GRADE ACUTE ORGAN TOXICITY AS A POSITIVE PROGNOSTIC FACTOR IN PRIMARY RADIOCHEMOTHERAPY FOR ANAL CARCINOMA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2012Conference Abstract [["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Mueller-Thomas, Catharina"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Jung, K."],["dc.contributor.author","Metz, M."],["dc.contributor.author","Detken, Sven"],["dc.contributor.author","Seraphn, J."],["dc.contributor.author","Bruemmendorf, Tim Hendrik"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Jentsch-Ullrich, Kathleen"],["dc.contributor.author","Boehme, A."],["dc.contributor.author","Bug, G."],["dc.contributor.author","Ottmann, Oliver G."],["dc.contributor.author","Schafhausen, Philippe"],["dc.contributor.author","Stadler, M."],["dc.contributor.author","Hofmann, W.-K"],["dc.contributor.author","Schmidt, B."],["dc.contributor.author","Lubbert, M."],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Blau, Igor W."],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T09:04:53Z"],["dc.date.available","2018-11-07T09:04:53Z"],["dc.date.issued","2012"],["dc.format.extent","30"],["dc.identifier.isi","000310766700069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Cytogenetic diagnostics of CD34+peripheral blood cells in MDS: Results from the multicenter German prospective diagnostic CD34+FISH study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS