Hüther, Gerald

[["dc.bibliographiccitation.firstpage","166"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychotherapeut"],["dc.bibliographiccitation.lastpage","179"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Huether, Gerald"],["dc.contributor.author","Sachsse, Ulrich"],["dc.date.accessioned","2018-11-07T11:03:01Z"],["dc.date.available","2018-11-07T11:03:01Z"],["dc.date.issued","2007"],["dc.description.abstract","Anxiety and stress-induced disorders are used in this contribution as an example to demonstrate how effectively neurobiological research findings can be used to improve psychotherapeutical interventions. The acquisition and facilitation of maladaptive coping strategies is the result of the activation of a cascade of emergency reactions which cannot be halted by the activation of available pro-adaptive coping strategies. Such experiences of uncontrollability and helplessness undermine the most essential resources to deal with stress and pave the way to the manifestation of disturbances at the level of secure attachment, self-efficacy, trust, affect control, self-regulation etc. Psychotherapeutic interventions will be most effective if they focus on the restoration of the resources at the level at which the maladaptive coping pattern became primarily stabilized (relational, emotional, cognitive approaches)."],["dc.identifier.doi","10.1007/s00278-007-0545-y"],["dc.identifier.isi","000246521400001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51521"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0935-6185"],["dc.title","Anxiety and stress-induced disorders. Towards a neurobiologically based psychotherapy"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","487"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","ZEITSCHRIFT FUR PADAGOGIK"],["dc.bibliographiccitation.lastpage","495"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Huther, G."],["dc.date.accessioned","2018-11-07T10:48:00Z"],["dc.date.available","2018-11-07T10:48:00Z"],["dc.date.issued","2004"],["dc.description.abstract","The formation of all those connections between nerve cells in the human brain, which are linked after birth, depends on experiences and use. The decisive experiences which cause children and adolescents to use and, thus, to structure their brain in a certain manner are of a psycho-social nature, i.e. experiences connected with relationships. The author gives a summary of the insights gained by neuro-biologists during the last few years relating to the \"social construction\" of the human brain and, from this, deduces the kind of experiences children and adolescents should make in their relationships with educators and teachers in order to be able to put the school's learning offers to the best possible use."],["dc.identifier.isi","000222996400003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48096"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Verlag Julius Beltz"],["dc.relation.issn","0044-3247"],["dc.title","The significance of social experiences for the structuring of the human brain - Which social relations do students and teachers need?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","42"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","ZEITSCHRIFT FUR PSYCHOSOMATISCHE MEDIZIN UND PSYCHOTHERAPIE"],["dc.bibliographiccitation.lastpage","57"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Doering, Stefan"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Pilz, J."],["dc.contributor.author","Bandelow, Borwin"],["dc.contributor.author","Adler, L."],["dc.contributor.author","Huether, Gerald"],["dc.date.accessioned","2018-11-07T09:41:12Z"],["dc.date.available","2018-11-07T09:41:12Z"],["dc.date.issued","2001"],["dc.description.abstract","Cortisol is one of the major parameters investigated in psychoneuroendocrinological research, but the methods employed for sample collecting are often unsatisfactory, A suitable method of sample collection should allow for the integrative assessment of long-term changes of the HPA-system, should be non-invasive, and should not exceed the subject's compliance. The assessment of cortisol in night-urine fulfils these demands; although this method has been occasionally employed, it has not yet been described systematically, For the first time a detailed description is given here that allows for a standardized replication. In ten previous studies and three investigations of our own this method has been successfully applied to detect changes in the cortisol excretion of patients with endocrinological and psychiatric disorders as well as in subjects under conditions of psychosocial stress. The determination of cortisol in night-urine represents an ideal method for the assessment of changes in the basal HPA-activity in numerous areas of psychoneuroendocrinological research, e.g. field and screening studies in natural environment, clinical studies in psychiatry and especially follow-up studies in psychotherapy research."],["dc.identifier.isi","000166985000003"],["dc.identifier.pmid","11593453"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33678"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Vandenhoeck & Ruprecht"],["dc.relation.issn","1438-3608"],["dc.title","Cortisol in night-urine: Introduction of a research method in psychoneuroendocrinology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","65"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Gerontology"],["dc.bibliographiccitation.lastpage","71"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Esselmann, Hermann"],["dc.contributor.author","Maler, Juan Manuel"],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Hüther, Gerald"],["dc.contributor.author","Kornhuber, Johannes"],["dc.date.accessioned","2017-09-07T11:44:43Z"],["dc.date.available","2017-09-07T11:44:43Z"],["dc.date.issued","2001"],["dc.description.abstract","Over the past few years, molecular biological research has considerably deepened our understanding of the pathophysiological basis of Alzheimer’s dementia (AD). Although different genetic origins of the disease have been identified, all of the findings point to a common terminal sequence in familial AD. This consists of an increased production of β-amyloid peptides from β-amyloid precursor protein. For the cases of sporadic AD, which far outweigh the number of cases of familial AD, an impaired catabolism of the β-amyloid peptides may also be pathophysiologically decisive according to the latest findings. Research into the molecular level of AD makes it possible to identify points of attack for rational drug treatment of the disease, while molecular markers of AD are increasingly being used as a part of early and differential neurochemical diagnostics."],["dc.identifier.doi","10.1159/000052775"],["dc.identifier.gro","3151719"],["dc.identifier.pmid","11287729"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8539"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","0304-324X"],["dc.title","Molecular Biology of Alzheimer’s Dementia and Its Clinical Relevance to Early Diagnosis and New Therapeutic Strategies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Meier, A."],["dc.contributor.author","Neumann, A. C."],["dc.contributor.author","Jordan, W."],["dc.contributor.author","Huther, G."],["dc.contributor.author","Rodenbeck, Andrea"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Cohrs, Stefan"],["dc.date.accessioned","2018-11-07T10:56:36Z"],["dc.date.available","2018-11-07T10:56:36Z"],["dc.date.issued","2005"],["dc.format.extent","263"],["dc.identifier.isi","000232591900169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50052"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","24th Symposium of the Arbeitsgemeinschaft-fur-Neuropsychopharmakologie-und-Pharmakopsychiatrie (AGNP)"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Reduced cortisol excretion in healthy subjects under treatment with ziprasidone"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","295"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.lastpage","302"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Himpel, S."],["dc.contributor.author","Bartels, J."],["dc.contributor.author","Zimdars, K."],["dc.contributor.author","Huether, Gerald"],["dc.contributor.author","Adler, L."],["dc.contributor.author","Dawirs, R. R."],["dc.contributor.author","Moll, Gunther H."],["dc.date.accessioned","2018-11-07T10:13:34Z"],["dc.date.available","2018-11-07T10:13:34Z"],["dc.date.issued","2006"],["dc.description.abstract","Persisting alterations in monoaminergic innervation patterns have been observed following various environmental manipulations and neuro-psychopharmacological treatments during fetal or early postnatal life. The present study investigates the question how differences in initial growth conditions at birth might interfere with subsequent development of both serotonergic and noradrenergic innervation in the rat frontal cortex (FC) and brain stem. For this purpose, newborn rat littermates were divided into two groups, a low and a high birth weight group, and the densities of both serotonin (5-HT) and norepinephrine (NE) transporters in the FC and brain stem were analyzed at adulthood. 5-HT transporter density in the FC was significantly higher in the high birth weight group as compared with the low birth weight group. No significant differences were observed between both groups in the density of 5-HT transporters in the brain stem and in the densities of NE transporters in FC and brain stem. It is discussed that differences in birth weight may affect the postnatal development of 5-HT projections to the frontal cortex."],["dc.identifier.doi","10.1007/s00702-005-0330-4"],["dc.identifier.isi","000235114800003"],["dc.identifier.pmid","15997417"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40457"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","1435-1463"],["dc.relation.issn","0300-9564"],["dc.title","Association between body weight of newborn rats and density of serotonin transporters in the frontal cortex at adulthood"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","414"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychopharmacology"],["dc.bibliographiccitation.lastpage","420"],["dc.bibliographiccitation.volume","174"],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Pohlmann, K."],["dc.contributor.author","Guan, Zhenghua"],["dc.contributor.author","Jordan, W."],["dc.contributor.author","Meier, A."],["dc.contributor.author","Huether, Gerald"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Rodenbeck, Andrea"],["dc.date.accessioned","2018-11-07T10:47:56Z"],["dc.date.available","2018-11-07T10:47:56Z"],["dc.date.issued","2004"],["dc.description.abstract","Rationale. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is a frequent finding in psychiatric disorders, including psychotic depression and schizophrenia. Conflicting results exist concerning the influence of antipsychotics on the HPA-axis. Objective. Therefore, this double-blind, placebo-controlled, randomized cross-over study investigated the effect of quetiapine on nocturnal urinary cortisol and melatonin excretion in 13 healthy male subjects under conditions of undisturbed and experimentally disturbed sleep. Methods. Volunteers were studied 3 times for 3 consecutive nights (N0, adaptation; N1, standard sleep conditions; N2, acoustic stress) 4 days apart. Placebo, quetiapine 25 mg or quetiapine 100 mg was administered orally 1 h before bedtime on nights 1 and 2. Urine produced during the 8-h bedtime period was collected for later determination of cortisol and melatonin concentrations by standard radioimmunoassays. Results. MANOVA showed a significant effect for N1 vs. N2 with elevated total amount of cortisol (p<0.005) and melatonin (p<0.05) excretion after acoustic stress. Both quetiapine 25 mg and 100 mg significantly (p<0.0005) reduced the total amount of cortisol excretion in comparison to placebo. No interaction effect of stress condition was observed. There was no effect of quetiapine on melatonin levels. Conclusion. The significant reduction of nocturnal cortisol excretion following quetiapine reflects a decreased activity of the HPA-axis in healthy subjects. This finding may be an important aspect in quetiapine's mode of action in different patient populations."],["dc.identifier.doi","10.1007/s00213-003-1766-6"],["dc.identifier.isi","000222646700013"],["dc.identifier.pmid","14735295"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48081"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0033-3158"],["dc.title","Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","763"],["dc.bibliographiccitation.issue","3-4"],["dc.bibliographiccitation.journal","International Journal of Psychology"],["dc.bibliographiccitation.lastpage","764"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Lackschewitz, Halina"],["dc.contributor.author","Huether, Gerald"],["dc.contributor.author","Kroener-Herwig, Birgit"],["dc.date.accessioned","2018-11-07T11:14:40Z"],["dc.date.available","2018-11-07T11:14:40Z"],["dc.date.issued","2008"],["dc.identifier.isi","000259264309075"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54187"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Psychology Press"],["dc.publisher.place","Hove"],["dc.relation.issn","0020-7594"],["dc.title","Physiological and psychological stress responses in adult patients with Attention-Deficit/Hyperactivity Disorder (ADHD)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","728"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Geburtshilfe und Frauenheilkunde"],["dc.bibliographiccitation.lastpage","733"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Huether, Gerald"],["dc.contributor.author","Adler, L."],["dc.date.accessioned","2018-11-07T11:00:59Z"],["dc.date.available","2018-11-07T11:00:59Z"],["dc.date.issued","2007"],["dc.description.abstract","in gynecological practice, psychoemotional irritation, fear, anxiety and feelings of helplessness are much more often seen and play a much greater role than in may other somatic medical disciplines. Whether or not a certain diagnosis or treatment will trigger a psychoemotional stress response is primarily dependent on the subjective judgment and the appraisal of the situation by the individual patient. This response can only partly be influenced by the medical practitioners. It is governed by the previous experiences made by the individual patient in the course of her life. This contribution describes how such subjective experiences of failure and of success in mastering difficult situations are anchored in the brain. Alternating experiences of the controllability and the uncontrollability of stressors are required for the facilitation and stabilization of neuronal networks and synaptic connections. Based on the current knowledge about the use- and experience-dependent adaptive modification and reorganization of neuronal connectivity, the reasons are discussed which will make certain patients either more vulnerable or more resistant to stressful life events. it is described why the internalized attitudes and views of the individual patient are of uttermost importance for her appraisal. The prerequisites and conditions for the acquisition of resource-strengthening attitudes and views are discussed."],["dc.identifier.doi","10.1055/s-2007-965240"],["dc.identifier.isi","000248403600003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51052"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0016-5751"],["dc.title","Resiliencing in the face of adversity: Causes and consequences of psychoemotional stress, appraisal and coping from a neurobiological perspective"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Psychopharmacology"],["dc.bibliographiccitation.lastpage","18"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Roher, C."],["dc.contributor.author","Jordan, W."],["dc.contributor.author","Meier, A."],["dc.contributor.author","Huether, Gerald"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Rodenbeck, Andrea"],["dc.date.accessioned","2018-11-07T10:16:09Z"],["dc.date.available","2018-11-07T10:16:09Z"],["dc.date.issued","2006"],["dc.description.abstract","Rationale: Increased activity of the hypothalamic-pituitary-adrenal (HPA) axis is an important aspect of the pathophysiology of major depression and schizophrenia. Despite the usefulness of atypical antipsychotics in the treatment of depression and their positive influence on cognitive functioning possibly related to their impact on cortisol, little is known about their effect on HPA axis function. Objective: Therefore, this double-blind, placebo-controlled, randomized cross-over study investigated the influence of the atypical antipsychotics quetiapine and olanzapine in comparison with haloperidol and placebo on plasma adrenocorticotropic hormone (ACTH), cortisol, and prolactin levels. Eleven healthy male volunteers were studied during four sessions one week apart, orally receiving placebo, quetiapine (50 mg), olanzapine (5 mg), or haloperidol (3 mg). Blood samples were taken at hourly intervals from 0900 until 1700 hours. For ACTH, cortisol, and prolactin a significant effect of treatment condition (p <= 0.005; p <= 0.035; p <= 0.0001, respectively) for area under the curve (AUC) was found. In comparison to placebo, quetiapine and olanzapine significantly reduced ACTH (p <= 0.002; p <= 0.05, respectively) and cortisol (p <= 0.005; p <= 0.03, respectively). No effect of haloperidol on AUC of ACTH or cortisol levels was observed. In comparison with placebo, haloperidol (p <= 0.0001) and olanzapine (p <= 0.0001) elevated AUC of prolactin plasma levels, whereas no significant effect was observed for quetiapine as a main effect of treatment condition. The atypical antipsychotics' strong influence on HPA-function with pronounced ACTH and cortisol lowering is possibly related to the atypicals' blockade of serotonergic receptors, but blockade of adrenergic or histaminergic receptors may play a role as well. The observed HPA-axis down-regulation may be clinically important for the atypicals' effects on depressive symptomatology and cognitive functioning."],["dc.identifier.doi","10.1007/s00213-005-0279-x"],["dc.identifier.isi","000235547600002"],["dc.identifier.pmid","16432682"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40980"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0033-3158"],["dc.title","The atypical antipsychotics olanzapine and quetiapine, but not haloperidol, reduce ACTH and cortisol secretion in healthy subjects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]