Olthoff, Arno

[["dc.bibliographiccitation.firstpage","556"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","NERVENHEILKUNDE"],["dc.bibliographiccitation.lastpage","559"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T08:48:12Z"],["dc.date.available","2018-11-07T08:48:12Z"],["dc.date.issued","2010"],["dc.description.abstract","A focal laryngeal dystonia might cause dysphonia, dysphagia or dyspnea. These dysorders can appear discrete or combined. The treatment with botulinum toxin is a symptomatic off-label-use that has to be repetitive every three to six months to conserve a positive outcome. In case of dysphonia and dyspnea the laryngeal muscles and in case of dysphagia the cricopharyngeal muscle and the salivary glands are injected. For a selective indication an interdisciplinary diagnostic is essential."],["dc.identifier.isi","000282799000008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21153"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0722-1541"],["dc.title","Treatment of dysphonia, dysphagia and dyspnea with botulinum toxin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","918"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The Laryngoscope"],["dc.bibliographiccitation.lastpage","922"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Rodel, RMW"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Tergau, Frithjof"],["dc.contributor.author","Simonyan, K."],["dc.contributor.author","Kraemer, Doris"],["dc.contributor.author","Markus, H."],["dc.contributor.author","Kruse, Eberhard"],["dc.date.accessioned","2018-11-07T10:49:22Z"],["dc.date.available","2018-11-07T10:49:22Z"],["dc.date.issued","2004"],["dc.description.abstract","Objectives: To analyze characteristic features and details on motor-evoked potentials (MEPs) of the cricothyroid and vocalis muscles from single-pulse cortical transcranial magnetic stimulation (TMS) in normal subjects to characterize cortical motor representation of laryngeal muscles. Study Design: Prospective, experimental investigation on healthy volunteers. Method: MEPs of the cricothyroid and vocalis muscles elicited by cortical TMS with a figure-8-shaped coil were investigated in two groups of six healthy subjects each, with special regard to MEP amplitude as a function of the coil position on the head surface along the interaural line. Results: Bilateral reproducible responses of the cricothyroid and the vocalis muscles could be observed in all subjects. For the cricothyroid muscle, maximal responses were obtained at mean stimulus positions of 7.5 +/- 1.4 cm (contralateral) and of 7.3 +/- 1.3 cm (ipsilateral), respectively. For the vocalis muscle, we found maximal responses at mean stimulus positions of 10.3 +/- 1.9 cm (contralateral) and of 9.6 +/- 1.6 cm (ipsilateral), respectively. Despite a considerable overlap of these coil positions, from which reproducible MEPs could be elicited in both groups of the laryngeal muscles, statistically significant separation of the cricothyroid- and vocalis-associated cortical representation areas was possible. Conclusions: Our observations point to two different cortical motor representation areas, with the cricothyroid muscle-related area being located more medially."],["dc.identifier.isi","000221537900026"],["dc.identifier.pmid","15126757"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48414"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","20th Scientific Meeting of the German-Society-of-Phoniatrics-and-Pedaudiology"],["dc.relation.eventlocation","Rostock, GERMANY"],["dc.relation.issn","0023-852X"],["dc.title","Human cortical motor representation of the larynx as assessed by transcranial magnetic stimulation (TMS)"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","450"],["dc.bibliographiccitation.issue","08"],["dc.bibliographiccitation.journal","Fortschritte der Neurologie · Psychiatrie"],["dc.bibliographiccitation.lastpage","462"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Grosheva, Maria"],["dc.contributor.author","Reichel, Gerhard"],["dc.contributor.author","Volk, Gerd Fabian"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2020-12-10T18:12:26Z"],["dc.date.available","2020-12-10T18:12:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-115644"],["dc.identifier.eissn","1439-3522"],["dc.identifier.issn","0720-4299"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74374"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Die Behandlung der laryngealen Dystonie mit Botulinumtoxin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2091"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","The Laryngoscope"],["dc.bibliographiccitation.lastpage","2096"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Kruse, Eberhard"],["dc.contributor.author","Dechent, Peter"],["dc.date.accessioned","2018-11-07T11:09:38Z"],["dc.date.available","2018-11-07T11:09:38Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Verbal communication is a human feature and volitional vocalization is its basis. However, little is known regarding the cortical areas involved in human vocalization. Methods: Therefore, functional magnetic resonance imaging at 3 Tesla was performed in 16 healthy adults to evaluate brain activations related to voice production. The main experiments included tasks involving motor control of laryngeal muscles with and without intonation. In addition, reference mappings of the sensorimotor hand area and the auditory cortices were performed. Results: Related to vocalization, in addition to activation of the most lateral aspect of the primary sensorimotor cortex close to the Sylvian fissure (M1c), we found activations medially (M1a) and laterally (M1b) of the well-known sensorimotor hand area. Moreover, the supplementary motor area and the anterior cingulate cortex were activated. Conclusions: Although M1a could be ascribed to motor control of breathing, M1b has been associated with laryngeal motor control. Consequently, even though M1c represents a laryngeal sensorimotor area, its exclusiveness as suggested previously could not be confirmed. Activations in the supplementary motor area and anterior cingulate cortex were ascribed to \"vocal-motor planning.\" The present data provide the basis for further functional magnetic resonance imaging studies in patients with neurological laryngeal disorders."],["dc.identifier.doi","10.1097/MLG.0b013e31817fd40f"],["dc.identifier.isi","000260874700035"],["dc.identifier.pmid","18758379"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53051"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","22nd Scientific Meeting of the German-Society-of-Phoniatrics-and-Pedaudiology"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0023-852X"],["dc.title","Cortical Sensorimotor Control in Vocalization: A Functional Magnetic Resonance Imaging Study"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1045"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","1050"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Rohrbach, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Giefer, B."],["dc.contributor.author","Gotz, W."],["dc.date.accessioned","2018-11-07T11:25:23Z"],["dc.date.available","2018-11-07T11:25:23Z"],["dc.date.issued","2001"],["dc.description.abstract","Nasal hypersecretion is predominantly caused by overaction of nasal glands, which are mainly under cholinergic control. In this work, we investigated the influence of botulinum toxin A (BTA) on the nasal mucosal tissue of the maxillary sinus turbinates of guinea pigs (n = 10) that were painlessly sacrificed 10 days (short-term group) or 3 months (long-term group) after local treatment with 20 units of BTA (Botox) or 0.2 mL of 0.9% sodium chloride (control). Histologic investigation of the nasal mucosal tissue of the BTA-treated animals (short-term group) showed degeneration of glands and ducts and apoptotic nuclei on TUNEL staining of these structures. The control animals revealed normal glandular tissue and no apoptosis. The animals of the long-term group showed almost normal glandular tissue and only a few apoptotic nuclei, In conclusion, BTA induces temporary apoptosis in the nasal glandular compartment of guinea pigs."],["dc.identifier.isi","000172151800010"],["dc.identifier.pmid","11713916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56607"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.relation.issn","0003-4894"],["dc.title","Botulinum toxin type a induces apoptosis in nasal glands of guinea pigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1123"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The Laryngoscope"],["dc.bibliographiccitation.lastpage","1126"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Woywod, Christina"],["dc.contributor.author","Kruse, Eberhard"],["dc.date.accessioned","2018-11-07T11:02:00Z"],["dc.date.available","2018-11-07T11:02:00Z"],["dc.date.issued","2007"],["dc.description.abstract","Objectives: To evaluate and to compare the diagnostic value of videostroboscopy (VS) and high-speed glottography (HGG) in dysphonic patients. Study Design: Randomized, prospective study. Methods: A total of 162 patients underwent indirect laryngoscopy using both methods (VS and HGG). The resulting 324 films were evaluated by two professionals (laryngologists, MDs) using a standardized protocol containing established criteria to classify vocal fold vibratory movement qualities. Results: The rating \"not assessable\" was mentioned significantly more often in VS than in HGG (P <.001). In HGG, methodologic failures were less frequent, and the length of investigation was shorter. Even if the agreement between the two raters was higher in HGG (54%) compared with VS (42%, both percentage values show a low accordance in diagnostic findings. Conclusions: Regardless of the method used (VS or HGG), perceptive evaluations of vibratory movements of vocal folds revealed a higher variability than assumed. This result supports the need for objective methods to analyze vocal fold vibratory movements. Therefore, realtime imaging of vocal fold vibratory movements using HGG will be necessary."],["dc.identifier.doi","10.1097/MLG.0b013e318041f70c"],["dc.identifier.isi","000246925000033"],["dc.identifier.pmid","17545874"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51281"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0023-852X"],["dc.title","Stroboscopy versus high-speed glottography: A comparative study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","joor.13220"],["dc.bibliographiccitation.firstpage","1044"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Oral Rehabilitation"],["dc.bibliographiccitation.lastpage","1049"],["dc.bibliographiccitation.volume","48"],["dc.contributor.affiliation","Adamske, Deike; 1Department of Oral and Maxillofacial Surgery Charité – University Medical Center Berlin Berlin Germany"],["dc.contributor.affiliation","Heyduck, Adrienne; 2Phoniatrics and Pedaudiology Department of Otorhinolaryngology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Weidenmüller, Matthias; 2Phoniatrics and Pedaudiology Department of Otorhinolaryngology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Göricke, Bettina; 3Department of Neurology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Frank, Tobias; 3Department of Neurology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.author","Adamske, Deike"],["dc.contributor.author","Heyduck, Adrienne"],["dc.contributor.author","Weidenmüller, Matthias"],["dc.contributor.author","Göricke, Bettina"],["dc.contributor.author","Frank, Tobias"],["dc.contributor.author","Olthoff, Arno"],["dc.date.accessioned","2021-08-12T07:45:24Z"],["dc.date.available","2021-08-12T07:45:24Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T11:10:06Z"],["dc.description.abstract","Abstract Background Dysphagia as a sequel and possible early sign of amyotrophic lateral sclerosis (ALS) is caused by progressive impaired bulbar motor function. Objective To evaluate bulbar motor dysfunction in patients suffering from ALS compared to a healthy reference group. Methods A clinical study and prospective group comparison was designed. Patients and healthy volunteers were examined in the outpatient clinic of our university medical center. Ten patients with ALS and 20 healthy volunteers were included. All participants underwent a flexible endoscopic evaluation of swallowing (FEES) and a manometric measurement of the maximal sub‐palatal atmospheric pressure generated by suction as well as of the prevalent pressure during swallowing. Additionally, the Sydney Swallow Questionnaire (SSQ) was completed by all participants to score the self‐rated extent of dysphagia. Results Comparing maximal suction pressures, the group of patients showed significantly lower values (p < .001). There was a significant correlation between reduced pressures and the degree of dysphagia (SSQ score) (r = −0.73). Conclusions As the oral cavity is an easily accessible compartment of the upper digestive tract, manometric measurements might serve as a simple instrument in order to detect or to monitor bulbar motor dysfunction. Oral manometry may facilitate early detection and monitoring of dysphagia in ALS. Larger studies are required to confirm our findings."],["dc.identifier.doi","10.1111/joor.13220"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88456"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1365-2842"],["dc.relation.issn","0305-182X"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.title","Dysphagia in amyotrophic lateral sclerosis: Quantification of bulbar motor dysfunction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","253"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES"],["dc.bibliographiccitation.lastpage","258"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Steuer-Vogt, M. K."],["dc.contributor.author","Licht, K."],["dc.contributor.author","Sauer-Goenen, M."],["dc.contributor.author","Werner, C."],["dc.contributor.author","Ambrosch, Petra"],["dc.date.accessioned","2018-11-07T10:40:30Z"],["dc.date.available","2018-11-07T10:40:30Z"],["dc.date.issued","2006"],["dc.description.abstract","The objective of this study was to evaluate the impact of different surgical treatments as well as of radiotherapy for laryngeal carcinomas on health-related quality of life (QL). In a prospective, randomized multicenter study (five university hospitals in Germany), a total of 146 patients with laryngeal carcinomas (UICC stages: I-IV) underwent different surgical treatments (32 total laryngectomies, 81 CO2 laser microsurgical partial laryngectomies, 33 open partial laryngectomies). Postoperative radiotherapy was performed in 44 patients. QL data were obtained by using the EORTC QLQ-C30 questionnaire (developed by the European Organization for Research and Treatment of Cancer). Impaired QL data were seen after total laryngectomy and after radiotherapy. Radiotherapy seemed to have more impact on QL than surgical treatment. Global QL was not affected by any treatment. In general, the QL data were not as discriminating as presumed. To evaluate coping abilities, objective measures (voice, swallowing, breathing) should be obtained for comparison in further investigations. Copyright (c) 2006 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000093094"],["dc.identifier.isi","000240426000002"],["dc.identifier.pmid","16679811"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46313"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0301-1569"],["dc.title","Quality of life after treatment for laryngeal carcinomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","599"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","604"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Zeiss, D."],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Kruse, Eberhard"],["dc.contributor.author","Steiner, W."],["dc.date.accessioned","2018-11-07T10:56:55Z"],["dc.date.available","2018-11-07T10:56:55Z"],["dc.date.issued","2005"],["dc.description.abstract","Objectives: We performed a prospective study to assess respiratory function and voice quality before and after laser microsurgical bilateral posterior cordectonly performed for chronic airway obstruction in patients with bilateral vocal fold paralysis. Methods: In 17 patients a laser microsurgical posterior cordectomy was performed as an immediate bilateral approach. Roughness, breathiness, hoarseness, and dyspnea were evaluated both subjectively (on a scale from 0 to 3) and objectively (body plethysmography, computerized voice analysis: Gottingen Hoarseness Diagram). Results: After laser surgery, the patients ' respiratory function was significantly increased and was sufficient for all activities of daily living. The body plethysmographic measure of airway resistance had superior descriptive power and correlated significantly with the clinical degree of dyspnea (scale 0 to 3). Pretreatment and posttreatment impairment of voice quality was objectively documented with the Gottingen Hoarseness Diagram; the phonatory results measured with it correlated significantly with the subjective clinical evaluation of hoarseness. Aphonia did not occur. Conclusions: A bilateral approach for laser microsurgical posterior cordectomy combines excellent airway improvement and satisfactory voice preservation. In bilateral vocal fold paralysis, pretreatment and posttreatment clinical data should be evaluated by objective measures."],["dc.identifier.isi","000231228800004"],["dc.identifier.pmid","16190092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50129"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.publisher.place","St louis"],["dc.relation.conference","Annual Scientific Meeting of the German-Society-of-Phoniatrics and Pedaudiology"],["dc.relation.eventlocation","Tubingen, GERMANY"],["dc.relation.issn","0003-4894"],["dc.title","Laser microsurgical bilateral posterior cordectomy for the treatment of bilateral vocal fold paralysis"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","475"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","HNO"],["dc.bibliographiccitation.lastpage","478"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T09:09:48Z"],["dc.date.available","2018-11-07T09:09:48Z"],["dc.date.issued","2012"],["dc.description.abstract","Dystonias of the oral, pharyngeal and laryngeal muscles are potential causes of deglutitive, respiratory and communicative disorders. In addition to functional deficits such as dysphagia, dysarthria and dysphonia, social disadvantages may arise from the visible or audible manifestations. Treatment with botulinum toxin offers symptomatic and temporary therapeutic effects. Examples of applications in oromandibular dystonia, palatoclonus, dysphagia and laryngeal dystonia (e.g., spasmodic dysphonia) are described."],["dc.identifier.doi","10.1007/s00106-011-2477-7"],["dc.identifier.isi","000304876600002"],["dc.identifier.pmid","22669434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26344"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-6192"],["dc.title","The application of botulinum toxin in oromandibular, pharyngeal and laryngeal dystonia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]