Wodarz, Andreas

[["dc.bibliographiccitation.firstpage","dev185421"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Development"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Linnemannstöns, Karen"],["dc.contributor.author","Witte, Leonie"],["dc.contributor.author","Karuna M, Pradhipa"],["dc.contributor.author","Kittel, Jeanette Clarissa"],["dc.contributor.author","Danieli, Adi"],["dc.contributor.author","Müller, Denise"],["dc.contributor.author","Nitsch, Lena"],["dc.contributor.author","Honemann-Capito, Mona"],["dc.contributor.author","Grawe, Ferdinand"],["dc.contributor.author","Wodarz, Andreas"],["dc.contributor.author","Gross, Julia Christina"],["dc.date.accessioned","2021-04-14T08:23:55Z"],["dc.date.available","2021-04-14T08:23:55Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1242/dev.185421"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81097"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1477-9129"],["dc.relation.issn","0950-1991"],["dc.title","Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","R91"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","R92"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Giebel, B."],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T10:18:45Z"],["dc.date.available","2018-11-07T10:18:45Z"],["dc.date.issued","2006"],["dc.description.abstract","Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch."],["dc.identifier.doi","10.1016/j.cub.2006.01.022"],["dc.identifier.isi","000235347400016"],["dc.identifier.pmid","16461271"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41513"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0960-9822"],["dc.title","Tumor suppressors: Control of signaling by endocytosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1016"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Nature Cell Biology"],["dc.bibliographiccitation.lastpage","1024"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Wodarz, Andreas"],["dc.contributor.author","Naethke, Inke"],["dc.date.accessioned","2018-11-07T10:59:16Z"],["dc.date.available","2018-11-07T10:59:16Z"],["dc.date.issued","2007"],["dc.description.abstract","The development of cancer is a multistep process in which the DNA of a single cell accumulates mutations in genes that control essential cellular processes. Loss of cell-cell adhesion and cell polarity is commonly observed in advanced tumours and correlates well with their invasion into adjacent tissues and the formation of metastases. Growing evidence indicates that loss of cell-cell adhesion and cell polarity may also be important in early stages of cancer. The strongest hints in this direction come from studies on tumour suppressor genes in the fruitfly Drosophila melanogaster, which have revealed their importance in the control of apical-basal cell polarity."],["dc.identifier.doi","10.1038/ncb433"],["dc.identifier.isi","000249256500007"],["dc.identifier.pmid","17762893"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50658"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1465-7392"],["dc.title","Cell polarity in development and cancer"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1079"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Cell Biology"],["dc.bibliographiccitation.lastpage","1095"],["dc.bibliographiccitation.volume","217"],["dc.contributor.author","Beati, Hamze"],["dc.contributor.author","Peek, Irina"],["dc.contributor.author","Hordowska, Paulina"],["dc.contributor.author","Honemann-Capito, Mona"],["dc.contributor.author","Glashauser, Jade"],["dc.contributor.author","Renschler, Fabian A."],["dc.contributor.author","Kakanj, Parisa"],["dc.contributor.author","Ramrath, Andreas"],["dc.contributor.author","Leptin, Maria"],["dc.contributor.author","Luschnig, Stefan"],["dc.contributor.author","Wiesner, Silke"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2020-12-10T18:15:35Z"],["dc.date.available","2020-12-10T18:15:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1083/jcb.201610098"],["dc.identifier.eissn","1540-8140"],["dc.identifier.issn","0021-9525"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74893"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The adherens junction–associated LIM domain protein Smallish regulates epithelial morphogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","636"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","642"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Krahn, Michael P."],["dc.contributor.author","Klopfenstein, Dieter Robert"],["dc.contributor.author","Fischer, Nannette"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T08:44:08Z"],["dc.date.available","2018-11-07T08:44:08Z"],["dc.date.issued","2010"],["dc.description.abstract","Cell polarity in higher animals is controlled by evolutionarily conserved protein complexes, which localize to the cytocortex in a polarized manner [1, 2]. The PAR-3/PAR-6/atypical protein kinase C (aPKC) complex is the first to become asymmetrically localized, and it controls the localization of additional complexes functioning further downstream in the regulation of cell polarity [3-9]. The first component of the PAR-3/PAR-6/aPKC complex that is localized to the cortex is Bazooka/PAR-3 (Baz), a large scaffolding protein [10]. In most cell types analyzed, loss of Baz function leads to loss of cell polarity [6, 8, 11]. Here we present a structure-function analysis of Baz focusing on its subcellular localization and function in four different polarized Drosophila cell types: the embryonic ectodermal epidermis, the follicular epithelium, embryonic neuroblasts, and the oocyte. We show that the PDZ domains of Baz are dispensable for its correct localization, whereas a conserved region in the C-terminal part of Baz to which no function had been assigned so far is required and sufficient for membrane localization. This region binds to phosphoinositide membrane lipids and thus mediates cortical localization of Baz by direct interaction with the plasma membrane. Our findings reveal a mechanism for the coupling of plasma membrane polarity and cortical polarity."],["dc.identifier.doi","10.1016/j.cub.2010.01.065"],["dc.identifier.isi","000276753100028"],["dc.identifier.pmid","20303268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20129"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0960-9822"],["dc.title","Membrane Targeting of Bazooka/PAR-3 Is Mediated by Direct Binding to Phosphoinositide Lipids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","823"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Wiley Interdisciplinary Reviews: Developmental Biology"],["dc.bibliographiccitation.lastpage","823"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Hartenstein, Volker"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2021-06-01T10:47:23Z"],["dc.date.available","2021-06-01T10:47:23Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1002/wdev.117"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85585"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","1759-7684"],["dc.title","Initial neurogenesis in Drosophila"],["dc.title.alternative","Initial neurogenesis in\n Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Cell Biology"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Krahn, Michael P."],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T11:17:29Z"],["dc.date.available","2018-11-07T11:17:29Z"],["dc.date.issued","2008"],["dc.format.extent","14"],["dc.identifier.isi","000255316100025"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54816"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","31st Annual Meeting of the German-Society-for-Cell-Biology"],["dc.relation.eventlocation","Marburg, GERMANY"],["dc.relation.issn","0171-9335"],["dc.title","Dephosphorylation of Bazooka by PP2A is required for proper apical-basal polarity in embryonic neuroblasts"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","R133"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","R135"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Giebel, Bernd"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T09:13:23Z"],["dc.date.available","2018-11-07T09:13:23Z"],["dc.date.issued","2012"],["dc.description.abstract","During Drosophila sensory organ precursor cell development, Numb segregates asymmetrically and functions as a cell fate determinant. Recent work now demonstrates in vivo that Numb inactivates Notch by promoting its endocytosis."],["dc.identifier.doi","10.1016/j.cub.2012.01.006"],["dc.identifier.isi","000300595300014"],["dc.identifier.pmid","22361152"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27159"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0960-9822"],["dc.title","Notch Signaling: Numb Makes the Difference"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","535"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.bibliographiccitation.lastpage","545"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Zhang, G."],["dc.contributor.author","Breuer, Manuel"],["dc.contributor.author","Foerster, Ankathrin"],["dc.contributor.author","Egger-Adam, Diane"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T08:32:44Z"],["dc.date.available","2018-11-07T08:32:44Z"],["dc.date.issued","2009"],["dc.description.abstract","The formation of the mitotic spindle is controlled by the microtubule organizing activity of the centrosomes and by the effects of chromatin-associated Ran-GTP on the activities of spindle assembly factors. In this study we show that Mars, a Drosophila protein with sequence similarity to vertebrate hepatoma upregulated protein (HURP), is required for the attachment of the centrosome to the mitotic spindle. More than 80% of embryos derived from mars mutant females do not develop properly due to severe mitotic defects during the rapid nuclear divisions in early embryogenesis. Centrosomes frequently detach from spindles and from the nuclear envelope and nucleate astral microtubules in ectopic positions. Consistent with its function in spindle organization, Mars localizes to nuclei in interphase and associates with the mitotic spindle, in particular with the spindle poles, during mitosis. We propose that Mars is an important linker between the spindle and the centrosomes that is required for proper spindle organization during the rapid mitotic cycles in early embryogenesis."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB 590, TP A2, WO 584/4-1, 42]"],["dc.identifier.doi","10.1242/jcs.040352"],["dc.identifier.isi","000263071700012"],["dc.identifier.pmid","19174464"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17407"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Company Of Biologists Ltd"],["dc.relation.issn","0021-9533"],["dc.title","Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Cell Biology"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Gailite, I."],["dc.contributor.author","Egger-Adam, Diane"],["dc.contributor.author","Wodarz, Andreas"],["dc.date.accessioned","2018-11-07T11:17:30Z"],["dc.date.available","2018-11-07T11:17:30Z"],["dc.date.issued","2008"],["dc.format.extent","51"],["dc.identifier.isi","000255316100130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54821"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","31st Annual Meeting of the German-Society-for-Cell-Biology"],["dc.relation.eventlocation","Marburg, GERMANY"],["dc.relation.issn","0171-9335"],["dc.title","Analysis of CG14782, a new interaction partner of Bazooka, in Drosophila development"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]