Zeeck, Axel

[["dc.bibliographiccitation.firstpage","144"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Industrial Microbiology & Biotechnology"],["dc.bibliographiccitation.lastpage","148"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Schimana, J."],["dc.contributor.author","Walker, M."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Fiedler, H. P."],["dc.date.accessioned","2018-11-07T08:43:05Z"],["dc.date.available","2018-11-07T08:43:05Z"],["dc.date.issued","2001"],["dc.description.abstract","Simocyclinones, a novel group of angucyclinone antibiotics, are produced by Streptomyces antibioticus Tu 6040. The compounds show antibacterial and antitumor properties. In submerged cultivation, the production of simocyclinones is strongly dependent on the carbon and nitrogen sources used in a chemically defined medium. Productivity of distinct components and diversity of simocyclinone compounds are influenced by the medium composition. Four series of simocyclinone compounds were detected by high-performance liquid chromatography (HPLC) diode array detector (DAD) and HPLC electrospray ionization (ESI) mass spectrometry (MS) analysis, isolated and the structures determined by nuclear magnetic resonance (NMR) techniques. Under optimized conditions, simocyclinone D8 was produced in an amount of 300 mg l(-1) and simocyclinone C4 in a concentration up to 50 mg l(-1)."],["dc.identifier.doi","10.1038/sj.jim.7000024"],["dc.identifier.isi","000171534300003"],["dc.identifier.pmid","11780784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19868"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature America Inc"],["dc.publisher.place","New york"],["dc.relation.conference","6th International Conference on Biotechnology of Microbial Products: Novel Pharamacological and Agrobiological Activities"],["dc.relation.eventlocation","SAN DIEGO, CALIFORNIA"],["dc.relation.issn","1367-5435"],["dc.title","Simocyclinones: diversity of metabolites is dependent on fermentation conditions"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","147"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","FEMS Microbiology Letters"],["dc.bibliographiccitation.lastpage","151"],["dc.bibliographiccitation.volume","196"],["dc.contributor.author","Fiedler, H. P."],["dc.contributor.author","Krastel, P."],["dc.contributor.author","Mueller, J."],["dc.contributor.author","Gebhardt, Klaus"],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2018-11-07T09:16:29Z"],["dc.date.available","2018-11-07T09:16:29Z"],["dc.date.issued","2001"],["dc.description.abstract","Enterobactin is described in the literature as the typical iron-chelating compound (siderophore) produced by bacteria of the family Enterobacteriaceae. In the course of a HPLC with diode array detection screening programme for detection of novel secondary metabolites, enterobactin, its biosynthetic precursor 2,3-dihydroxy-N-benzoylserine and its linear dimer and trimer condensation products were found to be produced by two Streptomyces strains besides the trihydroxamate-type siderophores desferri-ferrioxamine B and E. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved."],["dc.identifier.doi","10.1016/S0378-1097(01)00053-2"],["dc.identifier.isi","000167748300011"],["dc.identifier.pmid","11267771"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27948"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0378-1097"],["dc.title","Enterobactin: the characteristic catecholate siderophore of Enterobacteriaceae is produced by Streptomyces species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","110"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Stroch, K."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Antal, N."],["dc.contributor.author","Fiedler, H. P."],["dc.date.accessioned","2018-11-07T08:28:28Z"],["dc.date.available","2018-11-07T08:28:28Z"],["dc.date.issued","2005"],["dc.description.abstract","A detailed screening of the secondary metabolite pattern from Micromonospora sp. strain Tu 6368 resulted in the isolation of ten compounds belonging to five different structural families. The structures of the novel compounds 1-(alpha-ribofuranosyl)-lumichrome (3), retymicin (7), galtamycin B (11) and saquayamycin Z (14) were assigned by spectroscopic methods and chemical transformations. This strain fits our hypothesis that the metabolite analysis of biosynthetically talented strains leads readily to novel compounds."],["dc.identifier.isi","000227314000002"],["dc.identifier.pmid","15835722"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiotics Research Assoc"],["dc.relation.issn","0021-8820"],["dc.title","Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp Tu 6368 - II. Structure elucidation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","730"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","736"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Bertasso, M."],["dc.contributor.author","Holzenkampfer, M."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Dall'Antonia, F."],["dc.contributor.author","Fiedler, H. P."],["dc.date.accessioned","2018-11-07T08:42:40Z"],["dc.date.available","2018-11-07T08:42:40Z"],["dc.date.issued","2001"],["dc.description.abstract","Two novel secondary metabolites, bagremycin A (2) and B (3), were detected in the culture filtrate of Streptomyces sp. Tu 4128 by HPLC-diode-array screening. They are phenol esters of 3-amino-4-hydroxybenzoic acid with a derivative of p-coumaric acid and show a moderate activity against Gram-positive bacteria and some fungi."],["dc.identifier.isi","000171258000006"],["dc.identifier.pmid","11714229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19755"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiot Res Assn"],["dc.relation.issn","0021-8820"],["dc.title","Bagremycin A and B, novel antibiotics from Streptomyces sp Tu 4128"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","301"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","307"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Holzenkampfer, M."],["dc.contributor.author","Walker, M."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Schimana, J."],["dc.contributor.author","Fiedler, H. P."],["dc.date.accessioned","2018-11-07T10:31:22Z"],["dc.date.available","2018-11-07T10:31:22Z"],["dc.date.issued","2002"],["dc.description.abstract","The simocyclinones D4 (1) and D8 (2), members of a novel class of antibiotics, were isolated from the mycelial extract of Streptomyces antibioticus Tu 6040 and consist of angucyclinone, deoxysugar, octatetraene dicarboxylate and aminocoumarin structural elements. The structure elucidation was done by one and two dimensional NMR experiments, and other spectroscopic methods in combination with incorporation experiments using C-13 labelled precursors."],["dc.identifier.isi","000174620000009"],["dc.identifier.pmid","12014446"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44094"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiot Res Assn"],["dc.relation.issn","0021-8820"],["dc.title","Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 - II. Structure elucidation and biosynthesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Antal, N."],["dc.contributor.author","Fiedler, H. P."],["dc.contributor.author","Stackebrandt, Erko"],["dc.contributor.author","Beil, W."],["dc.contributor.author","Stroch, K."],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2018-11-07T08:28:23Z"],["dc.date.available","2018-11-07T08:28:23Z"],["dc.date.issued","2005"],["dc.description.abstract","A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tu 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria."],["dc.identifier.isi","000227314000001"],["dc.identifier.pmid","15835721"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16414"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiotics Research Assoc"],["dc.relation.issn","0021-8820"],["dc.title","Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp Tu 6368 - I. Taxonomy, fermentation, isolation and biological activities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","779"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","787"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Schimana, J."],["dc.contributor.author","Fiedler, H. P."],["dc.contributor.author","Groth, I."],["dc.contributor.author","Sussmuth, R."],["dc.contributor.author","Beil, W."],["dc.contributor.author","Walker, M."],["dc.contributor.author","Zeeck, Axel"],["dc.date.accessioned","2018-11-07T10:37:23Z"],["dc.date.available","2018-11-07T10:37:23Z"],["dc.date.issued","2000"],["dc.description.abstract","Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tu 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines."],["dc.identifier.isi","000088975400004"],["dc.identifier.pmid","11079799"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45551"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiot Res Assn"],["dc.relation.issn","0021-8820"],["dc.title","Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I. Taxonomy, fermentation, isolation and biological activities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","364"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","371"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Bertasso, M."],["dc.contributor.author","Holzenkampfer, M."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Stackebrandt, Erko"],["dc.contributor.author","Beil, W."],["dc.contributor.author","Fiedler, H. P."],["dc.date.accessioned","2018-11-07T10:39:46Z"],["dc.date.available","2018-11-07T10:39:46Z"],["dc.date.issued","2003"],["dc.description.abstract","Strain Tu 6239 was isolated from a soil sample collected in Brazil and determined as a new species of the genus Streptomyces. In the course of our HPLC-diode array screening program three metabolites were detected in the culture filtrate and mycelium extracts of strain Tu 6239. They were characterised as members of the macrolactam group, the new compound ripromycin (1), the previously described ikarugamycin (2) and a new derivative of it, ikarugamycin epoxide (3). They show antibiotic activities against Gram-positive bacteria and cytostatic effects to various human tumor cell lines."],["dc.identifier.isi","000182565800005"],["dc.identifier.pmid","12817810"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46131"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiot Res Assn"],["dc.relation.issn","0021-8820"],["dc.title","Ripromycin and other polycyclic macrolactams from Streptomyces sp Tu 6239: Taxonomy, fermentation, isolation and biological properties"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","794"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","800"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Gebhardt, Klaus"],["dc.contributor.author","Schimana, J."],["dc.contributor.author","Krastel, P."],["dc.contributor.author","Dettner, K."],["dc.contributor.author","Rheinheimer, J."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Fiedler, H. P."],["dc.date.accessioned","2018-11-07T10:05:51Z"],["dc.date.available","2018-11-07T10:05:51Z"],["dc.date.issued","2002"],["dc.description.abstract","Four new members of the phenazine family, endophenazines Asimilar toD, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC-staining reagents and HPLC-diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed)."],["dc.identifier.isi","000178293400002"],["dc.identifier.pmid","12458768"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38981"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiot Res Assn"],["dc.relation.issn","0021-8820"],["dc.title","Endophenazines A similar to D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus I. Taxonomy, fermentation, isolation and biological activities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","715"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","720"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Holtzel, A."],["dc.contributor.author","Schmid, D. G."],["dc.contributor.author","Nicholson, G. J."],["dc.contributor.author","Krastel, P."],["dc.contributor.author","Zeeck, Axel"],["dc.contributor.author","Gebhardt, Klaus"],["dc.contributor.author","Fiedler, H. P."],["dc.contributor.author","Jung, G."],["dc.date.accessioned","2018-11-07T10:44:20Z"],["dc.date.available","2018-11-07T10:44:20Z"],["dc.date.issued","2004"],["dc.description.abstract","The structures of new cytochalasan fungal metabolites aspochalamins Asimilar toD have been elucidated by ESI-FTICR-MS, NMR spectroscopy, and chiral amino acid analysis. Aspochalamins Asimilar toD consist of different aspochalasin skeletons connected at position C-19 to the N terminus of the tripeptidic moiety amide anthranoyl-L-alanine-E-didehydrotryptamide. Furthermore, the structure of a new aspochalasin analog, aspochalasin Z, was derived from its molecular mass and NMR data as 10-isopropyl-14-methyl[11]-cytochalasa-6Z, 13E, 19E-triene-1,21-dione."],["dc.identifier.isi","000225409000002"],["dc.identifier.pmid","15712665"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47247"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiotics Research Assoc"],["dc.relation.issn","0021-8820"],["dc.title","Aspochalamins A similar to D and aspochalasin Z produced by the endosymbiotic fungus Aspergillus niveus LU 9575 II. Structure elucidation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]