Dresing, Klaus

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","GMS Medizinische Informatik, Biometrie und Epidemiologie"],["dc.bibliographiccitation.lastpage","7"],["dc.contributor.author","Stürmer, Klaus Michael"],["dc.contributor.author","Wagner, Markus"],["dc.contributor.author","Duwenkamp, Christopher"],["dc.contributor.author","Ahrens, Christoph Alexander"],["dc.contributor.author","Plischke, Maik"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Bott, Oliver Johannes"],["dc.date.accessioned","2019-07-09T11:52:48Z"],["dc.date.available","2019-07-09T11:52:48Z"],["dc.date.issued","2009"],["dc.description.abstract","Hintergrund und Fragestellung: Die durch röntgentechnische Diagnoseverfahren in der Medizin entstehende Strahlenbelastung für Patient und Personal soll laut Strahlenschutzverordnung so gering wie möglich gehalten werden. Um dieses zu erreichen ist ein professioneller und bedachter Umgang mit den Röntgengeräten unabdingbar. Dieses Verhalten kann derzeit jedoch nur theoretisch vermittelt werden, da sich ein Üben mit realer Strahlung von selbst verbietet. Daher stellt sich die Frage wie man die Strahlenschutzausbildung durch eine verbesserte Vermittlung der komplexen Thematik unterstützen kann. Methoden: Das CBT-System (Computer Based Training) virtX, welches das Erlernen der korrekten Handhabung mobiler Röntgengeräte unterstützt, wurde um Aspekte aus dem Bereich des Strahlenschutzes erweitert. Es wurde eine prototypische Visualisierung der entstehenden Streustrahlung sowie die Darstellung des Nutzstrahlenganges integriert. Des Weiteren wurde die Berechnung und Anzeige der virtuellen Einfallsdosis für das durchstrahlte Volumen sowie für den Bereich des Bildverstärkers hinzugefügt. Für die Berechnung und Visualisierung all dieser Komponenten werden die in virtX parametrisierbaren C-Bogen-Einstellungen, z.B. Stellung der Blenden, Positionierung des Röntgengerätes zum durchstrahlten Volumen und Strahlenintensität, herangezogen. Das so erweiterte System wurde auf einem dreitägigen Kurs für OP-Personal mit über 120 Teilnehmern eingesetzt und auf der Basis von Fragebögen evaluiert. Ergebnisse: Von den Teilnehmern gaben 55 einen ausgefüllten Evaluations-Fragebogen ab (Responserate 82%). Das Durchschnittsalter der 39 weiblichen und 15 männlichen Teilnehmer (einer o.A.) lag bei 33±8 Jahren, die Berufserfahrung bei 9,37±7 Jahren. Die Erfahrung mit dem C-Bogen wurde von einem Teilnehmer (2%) mit „Keine oder bisher nur Einführung erhalten“, von acht Teilnehmern (14%) mit „bediene einen C-Bogen gelegentlich“ und von 46 (84%) mit „bediene einen C-Bogen regelmäßig“ angegeben. 45 (92%) der Teilnehmer gaben an, durch die Visualisierung der Streustrahlung etwas Neues zur Vermeidung unnötiger Strahlenbelastung dazugelernt zu haben. Schlussfolgerung: Trotz einer bislang nur prototypischen Visualisierung der Streustrahlung können mit virtX zentrale Aspekte und Verhaltensweisen zur Vermeidung unnötiger Strahlenbelastung erfolgreich vermittelt werden und so Lücken der traditionellen Strahlenschutzausbildung geschlossen werden."],["dc.identifier.doi","10.3205/mibe000081"],["dc.identifier.fs","568165"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5967"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60279"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1860-9171"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","virtX: ein Lehr- und Lernsystem für mobile Röntgengeräte zur Verbesserung der Ausbildung im Strahlenschutz"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","331"],["dc.bibliographiccitation.issue","5-6"],["dc.bibliographiccitation.journal","Journal of Molecular Histology"],["dc.bibliographiccitation.lastpage","341"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Tezval, Mohammad"],["dc.contributor.author","Tezval, Hossein"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Stuermer, Ewa Klara"],["dc.contributor.author","Blaschke, Martina"],["dc.contributor.author","Stuermer, Klaus Michael"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2018-11-07T11:23:52Z"],["dc.date.available","2018-11-07T11:23:52Z"],["dc.date.issued","2009"],["dc.description.abstract","Urocortin-1 (UCN) a corticotropin releasing-factor (CRF) related peptide, has been found to be expressed in many different tissues like the central nervous system, the cardiovascular system, adipose tissue, and skeletal muscle. The effects of UCN are mediated via stimulation of CRF-receptors 1 and 2 (CRFR1 and 2, CRFR's) with a high affinity for CRFR2. It has been shown that the CRF-related peptides and CRFR's are involved in the regulation of stress-related endocrine, autonomic and behavioural responses. Using immunocytochemistry, immunohistochemistry and RT-PCR, we now can show the differentiation dependent expression of UCN mRNA and peptide in human mesenchymal progenitor cells (MSCs) directed to the osteoblastic phenotype for the first time. UCN expression was down regulated by TGF-beta and BMP-2 in the early proliferation phase of osteoblast development, whereas dexamethasone (dex) minimally induced UCN gene expression during matrix maturation after 24 h stimulation. Stimulation of MSCs for 28 days with ascorbate/beta-glycerophosphate (asc/bGp) induced UCN gene expression at day 14. This effect was prevented when using 1,25-vitamin D3 or dex in addition. There was no obvious correlation to osteocalcin (OCN) gene expression in these experiments. In MSCs from patients with metabolic bone disease (n = 9) UCN gene expression was significantly higher compared to MSCs from normal controls (n = 6). Human MSCs did not express any of the CRFR's during differentiation to osteoblasts. Our results indicate that UCN is produced during the development of MSCs to osteoblasts and differentially regulated during culture as well as by differentiation factors. The expression is maximal between proliferation and matrix maturation phase. However, UCN does not seem to act on the osteoblast itself as shown by the missing CRFR's. Our results suggest new perspectives on the role of urocortin in human skeletal tissue in health and disease."],["dc.identifier.doi","10.1007/s10735-009-9244-z"],["dc.identifier.isi","000275443300002"],["dc.identifier.pmid","19949969"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4160"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56279"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1567-2379"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","321"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","341"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Dresing, K."],["dc.date.accessioned","2020-06-09T06:44:38Z"],["dc.date.available","2020-06-09T06:44:38Z"],["dc.date.issued","2018"],["dc.description.abstract","Operationsziel Vollständiges und tiefgehendes Wunddébridement bei akuten Bissverletzungen unter Schonung von Nerven, Gefäßen und Sehnen. Indikationen Akut traumatische und verspätet vorgestellte Bissverletzungen. Kontraindikationen Allgemeine Kontraindikationen gegen Anästhesie und Operation. Operationstechnik Großflächige fächerförmige Lokalanästhesie oder Allgemeinnarkose, Wundspülung mit 0,9 %iger NaCl- oder antiseptischer Lösung, Entfernung avitalen Gewebes, Wunddébridement, Wundrandexzision, erneute ausgiebige Spülung, ggf. Drainage, ggf. Wundverschluss, außer bei älteren oder punktuell tiefgehenden Bissverletzungen, Verband, elastische Wickelung und Ruhigstellung. Gegebenenfalls plastische Deckung verbliebender Defekte. Weiterbehandlung Ruhigstellung mit zunächst täglicher Wundbeurteilung, Entfernung der Drainage oder Lasche am 2. postoperativen Tag, ggf. antibiotische Therapie mit Amoxicillin und Clavulansäure bei Hochrisikowunden (punktuelle Wunden, Gelenk- oder Knochenbeteiligung, ausgedehnte Weichteilquetschung usw.), Entfernung der Nähte am 10.–12. postoperativen Tag. Ergebnisse Bei insgesamt 142 therapierten und retrospektiv betrachteten Bissverletzungen handelte es sich in 46 % der Fälle um Hundebissverletzungen, in 32 % waren Katzen die Verursacher. Die Patienten waren im Durchschnitt 44 Jahre alt, von Hundebissen waren 55 % Frauen betroffen, von Katzenbissen 67 %. In 48 % der Fälle war eine Vollnarkose notwendig. Die postoperative Infektionsrate lag bei 6,3 %."],["dc.description.abstract","Objective Thorough and profound debridement for acute bite injuries while sparing nerves, vessels and tendons. Indications Acute traumatic and late presented bite injuries. Contraindications General contraindication for anesthesia or surgery. Surgical technique Extensive flabellate local anesthesia/general anesthesia, wound irrigation using 0.9% NaCl or antiseptic solutions, removal of avital tissues, wound debridement, wound edge excision, anew extensive irrigation, drainage if necessary, wound closure where applicable (except older or punctual deep injuries), bandage, elastic wrapping and immobilization. If necessary, plastic surgery with coverage of remaining defects. Postoperative management Immobilization with initially daily wound evaluation, removal of drainage/loop on postoperative day 2; if necessary, antibiotic therapy with amoxicillin and clavulanic acid in high-risk wounds (e.g., puncture wounds, joint or bone involvement, extensive soft tissue squeezing), suture removal on day 10–12 after surgery. Results Of 142 bite injuries that were treated and retrospectively evaluated, 46% were caused by dogs and 32% by cats. Patients were on average 44 years old; 55% of all dog bites affected women, but 67% of all cat bites. In 48% of the cases, general anesthesia was necessary. The postoperative infection rate was 6.3%."],["dc.identifier.doi","10.1007/s00064-018-0563-7"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15540"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66207"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0934-6694"],["dc.rights","CC BY 4.0"],["dc.rights","Goescholar"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Chirurgische Behandlung von Bissverletzungen"],["dc.title.alternative","Surgical treatment of bites"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","203"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Pilot and Feasibility Studies"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Fischer, Dagmar-C"],["dc.contributor.author","Sckell, Axel"],["dc.contributor.author","Garkisch, Angelina"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Eisenhauer, Anton"],["dc.contributor.author","Valentini, Luzia"],["dc.contributor.author","Mittlmeier, Thomas"],["dc.date.accessioned","2021-11-23T07:53:48Z"],["dc.date.accessioned","2022-08-16T13:09:25Z"],["dc.date.available","2021-11-23T07:53:48Z"],["dc.date.available","2022-08-16T13:09:25Z"],["dc.date.issued","2021-11-12"],["dc.date.updated","2022-07-29T12:18:52Z"],["dc.description.abstract","Background Edema is commonly seen after surgical fixation of ankle fractures. Rest, ice, compression, and elevation (RICE) is an established combination to prevent swelling but hardly able to stimulate lymphatic resorption. Recently, an epicutaneously applied negative pressure suction apparatus (LymphaTouch®) has been introduced to stimulate lymphatic flow. While postoperative recovery, soft tissue, and osseous healing as well as functional outcome are probably linked to the amount of postoperative swelling, estimates on this relative to prevention (RICE) or prevention + stimulated resorption (RICE+) of fluid are scarce. Methods and analysis This is a single-center, evaluator-blinded randomized pilot trial to investigate postoperative swelling in adults requiring surgical fixation of a closed unilateral ankle fracture. A total of 50 patients will be recruited and randomly assigned to RICE or RICE+ prior to surgery. All patients will undergo evaluator-blinded measurements of the ankle volume the day before surgery and subsequently from the evening of the 2nd postoperative day every 24 h until discharge. RICE will be initiated right after surgery and continued until discharge from the hospital in all patients. Additional application of negative pressure therapy (RICE+) will be initiated on the morning of the 2nd postoperative day and repeated every 24 h until the time of discharge from the hospital. Outcome measures are (i) the relative amount and the time course of the postoperative swelling, (ii) the demand for analgesic therapy (type and amount) together with the perception of pain, (iii) the rate of complications, and (iv) mobility of the ankle joint and the recovery of walking abilities during a 12-weeks follow-up period. Serum and urine samples taken prior to sugery and during postoperative recovery will allow to evaluate the ratio of naturally occurring stable calcium isotopes (δ44/42Ca) as a marker of skeletal calcium accrual. Ethics and dissemination The protocol was approved by the institutional Ethics Committee (Rostock University Medical Center, Rostock, Germany) in accordance with the Declaration of Helsinki (approval number: A 2020-0092). The results of this study will be actively disseminated through scientific publications and conference presentations. Trial registration DRKS, DRKS00023739 . Registered on 14 December 2020"],["dc.identifier.citation","Pilot and Feasibility Studies. 2021 Nov 12;7(1):203"],["dc.identifier.doi","10.1186/s40814-021-00944-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93452"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112766"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Ankle fracture"],["dc.subject","Rest"],["dc.subject","Ice"],["dc.subject","Compression"],["dc.subject","Elevation"],["dc.subject","Edema"],["dc.subject","Postoperative swelling"],["dc.subject","Negative pressure therapy"],["dc.subject","Soft tissue"],["dc.subject","Osseous healing"],["dc.subject","Complications"],["dc.title","Treatment of perioperative swelling by rest, ice, compression, and elevation (RICE) without and with additional application of negative pressure (RICE+) in patients with a unilateral ankle fracture: study protocol for a monocentric, evaluator-blinded randomized controlled pilot trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","253"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","265"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Saul, D."],["dc.contributor.author","Dresing, K."],["dc.date.accessioned","2018-11-07T10:22:20Z"],["dc.date.accessioned","2020-06-10T14:27:11Z"],["dc.date.available","2018-11-07T10:22:20Z"],["dc.date.available","2020-06-10T14:27:11Z"],["dc.date.issued","2017"],["dc.description.abstract","Operationsziel Vollständige Bursektomie am Olekranon nach Wunddébridement unter Schonung von Gefäßen sowie nervalen Strukturen. Risikoadaptierte antibiotische Therapie bei septischer Bursitis und frühfunktionelle Nachbehandlung. Indikationen Akut traumatisch eröffnete Bursa olecrani, therapieresistente Bursitis olecrani. Kontraindikationen Traumatische Bursaverletzung: Allgemeine Kontraindikationen gegen Anästhesie und Operation; chronische Bursitis: nicht verschließbarer Hautdefekt (plastische Deckung erforderlich), hämodynamisch instabiler Patient (z. B. bei Systemic Inflammatory Response Syndrome [SIRS] oder Sepsis), vorbestehende Hautinfektion Operationstechnik Fächerförmige Lokalanästhesie, Wunddébridement, Darstellung der kompletten Bursa olecrani und Exzision, zusätzlich Friedrich-Wundrandexzision, Spülung, Drainage (Redondrainage, Easy-flow-Drainage, Penrose-Lasche). Abschließend Wundverschluss, Verband, elastische Wickelung und Cast-Ruhigstellung. Weiterbehandlung Entfernung der Drainage/Lasche, Wundbeurteilung, frühfunktionelle Nachbehandlung aus der Cast-Schiene heraus, antibiotische Therapie bei septischer Bursitis über 2 Wochen, Maßnahmen nach PRICE-Schema. Entfernung der Nähte am 10.–12. postoperativen Tag. Ergebnisse Von 2011–2016 behandelten wir 138 Fälle einer traumatischen Bursaeröffnung oder chronischen Bursitis olecrani, wobei 82 davon operativ versorgt werden mussten. Bei 10 Patienten war eine Vakuumtherapie („Vacuum Assisted Closure-Therapy“) mit sekundärem Wundverschluss aufgrund ausgedehnter Hautdefekte nötig; in zwei Fällen bildeten sich Fisteln, in zwei weiteren eine Wunddehiszenz. Alle Hautdefekte ließen sich ohne Lappendeckung vollständig verschließen."],["dc.description.abstract","Objective Complete olecranon bursectomy with debridement, protection of veins and nerves. Risk-adapted antibiotic therapy and early functional aftercare. Indications Acute, traumatic laceration of the bursa olecrani, chronic therapy-resistant bursitis olecrani. Contraindications For traumatic bursa injuries: general contraindications for anesthesia and surgery; chronic bursitis: initially not closable skin defect (plastic surgery required), hemodynamically instable patient (e.g. systemic inflammatory response syndrome [SIRS] or sepsis), pre-existing skin infection. Surgical technique Local anesthesia beyond the lesion, careful debridement, identification and removal of the entire bursa, excision of contaminated skin, lavage, drain insertion (Redon, Easy-flow, Penrose). Wound closure, elastic bandage, and splint. Postoperative management Elastic bandage for 2 days, followed by drain removal. Wound assessment, early functional aftercare without splint, antibiotic therapy in septic bursitis for 2 weeks, PRICE scheme. Removal of stitches after 10–12 days. Results Over 5 years, 138 cases of traumatic bursa lesion or chronic bursitis olecrani were treated in our clinic, 82 patients underwent surgery. Ten patients were treated with vacuum-assisted closure therapy and consecutive wound healing; fistulae occurred in two patients and in another two dehiscence developed. All of the defects could be closed without flaps."],["dc.identifier.doi","10.1007/s00064-017-0483-y"],["dc.identifier.isi","000403505900006"],["dc.identifier.pmid","28175943"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14364"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42249"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66224"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1439-0981"],["dc.relation.issn","0934-6694"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Behandlung der traumatisch eröffneten Bursa olecrani und der chronischen Bursitis olecrani"],["dc.title.alternative","Treatment of traumatic lesions of the bursa olecrani and chronic bursitis olecrani"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e000408"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMJ Open Sport & Exercise Medicine"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Krüger, Lara"],["dc.contributor.author","Hohberg, Maike"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Dresing, Klaus"],["dc.date.accessioned","2019-07-09T11:49:39Z"],["dc.date.available","2019-07-09T11:49:39Z"],["dc.date.issued","2018"],["dc.description.abstract","Background/aim: Horse riding is a popular sport, which bears the risk of serious injuries. This study aims to assess whether individual factors influence the risk to sustain major injuries. Methods: Retrospective data were collected from all equine-related accidents at a German Level I Trauma Centre between 2004 and 2014. Logistic regression was used to identify the risk factors for major injures. Results: 770 patients were included (87.9% females). Falling off the horse (67.7%) and being kicked by the horse (16.5%) were the two main injury mechanisms. Men and individuals of higher age showed higher odds for all tested parameters of serious injury. Patients falling off a horse had higher odds for being treated as inpatients, whereas patients who were kicked had higher odds for a surgical therapy (OR 1.7) and intensive care unit/intermediate care unit (ICU/IMC) treatment (OR 1.2). The head was the body region most often injured (32.6%) and operated (32.9%). Patients with head injuries had the highest odds for being hospitalised (OR 6.13). Head or trunk injuries lead to the highest odds for an ICU/IMC treatment (head: OR 4.37; trunk: OR 2.47). Upper and lower limb injuries showed the highest odds for a surgical therapy (upper limb: OR 2.61; lower limb: OR 1.7). Conclusion: Risk prevention programmes should include older individuals and males as target groups. Thus a rethinking of the overall risk assessment is necessary. Not only horseback riding itself, but also handling a horse bears a relevant risk for major injuries. Serious head injures remain frequent, serious and an important issue to be handled in equestrians sports."],["dc.identifier.doi","10.1136/bmjsem-2018-000408"],["dc.identifier.pmid","30364519"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59597"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","610"],["dc.title","Assessing the risk for major injuries in equestrian sports"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]