El Shafie, Rami

[["dc.bibliographiccitation.firstpage","253"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","260"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Paul, Angela"],["dc.contributor.author","Bernhardt, Denise"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","Welzel, Thomas"],["dc.contributor.author","Sprave, Tanja"],["dc.contributor.author","Hommertgen, Adriane"],["dc.contributor.author","Krisam, Johannes"],["dc.contributor.author","Schmitt, Daniela"],["dc.contributor.author","Klüter, Sebastian"],["dc.contributor.author","Schubert, Kai"],["dc.contributor.author","Klose, Christina"],["dc.contributor.author","Kieser, Meinhard"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Rieken, Stefan"],["dc.date.accessioned","2020-07-16T09:11:12Z"],["dc.date.available","2020-07-16T09:11:12Z"],["dc.date.issued","2019"],["dc.description.abstract","Stereotactic radiosurgery (SRS) of brain metastases (BM) is recommended in oligometastatic scenarios as a less toxic treatment alternative to whole-brain radiotherapy. Recent findings support SRS for patients with multiple (>3) BM. Furthermore, advances in MR imaging have facilitated the detection of very small BM, as advances in SRS technology have facilitated the highly conformal and simultaneous treatment of multiple target lesions."],["dc.identifier.doi","10.1093/neuros/nyy026"],["dc.identifier.pmid","29554321"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67096"],["dc.language.iso","en"],["dc.relation.eissn","1524-4040"],["dc.relation.issn","0148-396X"],["dc.title","Robotic Radiosurgery for Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence (CYBER-SPACE)-A Single-Center Prospective Randomized Trial"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","641"],["dc.bibliographiccitation.journal","Frontiers in Oncology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Böhm, Karina"],["dc.contributor.author","Weber, Dorothea"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","Schlaich, Fabian"],["dc.contributor.author","Adeberg, Sebastian"],["dc.contributor.author","Paul, Angela"],["dc.contributor.author","Haefner, Matthias F."],["dc.contributor.author","Katayama, Sonja"],["dc.contributor.author","Hörner-Rieber, Juliane"],["dc.contributor.author","Hoegen, Philipp"],["dc.contributor.author","Löw, Sarah"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Rieken, Stefan"],["dc.contributor.author","Bernhardt, Denise"],["dc.date.accessioned","2020-07-16T10:33:04Z"],["dc.date.available","2020-07-16T10:33:04Z"],["dc.date.issued","2018"],["dc.description.abstract","Introduction: The purpose of this article is to report our institution's 10-year experience on palliative radiotherapy for the treatment of leptomeningeal carcinomatosis (LC), assessing survival, neurologic outcome, and prognostic factors. Patients and methods: We retrospectively analyzed 110 patients who received palliative radiotherapy for LC between 2008 and 2018. The most common histologies were breast cancer (n = 43, 39.1%) and non-small cell lung cancer (NSCLC) (n = 31, 28.2%). Radiotherapy was administered as whole-brain radiotherapy (WBRT) (n = 51, 46.4%), focal spinal RT (n = 11, 10.0%) or both (n = 47, 42.7%). Twenty-five patients (22.7%) were selected for craniospinal irradiation. Clinical performance and neurologic function were quantified on the neurologic function scale (NFS) before and in response to therapy. A Cox Proportional Hazards model with univariate and multivariate analysis was fitted for survival. Results: Ninety-eight patients (89.1%) died and 12 (10.9%) were alive at the time of analysis. Median OS from LC diagnosis and from the beginning of RT was 13.9 weeks (IQR: 7.1-34.0) and 9.9 weeks (IQR: 5.3-26.3), respectively. In univariate analysis, prognostic of longer OS were a Karnofsky performance scale index (KPI) of ≥70% (HR 0.20, 95%-CI: [0.13; 0.32], p < 0.001), initially moderate neurological deficits (NFS ≤2) (HR 0.32, 95% CI: [0.19; 0.52], p < 0.001), symptom response to RT (HR 0.41, 95%-CI: [0.26; 0.67], p < 0.001) and the administration of systemic therapy (HR 0.51, 95%-CI: [0.33; 0.78], p = 0.002). Prognostic of inferior OS were high-grade myelosuppression (HR 1.78, 95% CI: [1.06; 3.00], p = 0.03) and serum LDH levels >500 U/l (HR 3.62, 95% CI: [1.76; 7.44], p < 0.001). Clinical performance, symptom response and serum LDH stayed independently prognostic for survival in multivariate analysis. RT was well-tolerated and except for grade III myelosuppression in 19 cases (17.3%), no high-grade acute toxicities were observed. Neurologic symptom stabilization was achieved in 83 cases (75.5%) and a sizeable improvement in 39 cases (35.5%). Conclusion: Radiotherapy is a well-tolerated and efficacious means of providing symptom palliation for patients with LC, delaying neurologic deterioration while probably not directly influencing survival. Prognostic factors such as clinical performance, neurologic response and serum LDH can be used for patient stratification to facilitate treatment decisions."],["dc.identifier.doi","10.3389/fonc.2018.00641"],["dc.identifier.pmid","30671384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67172"],["dc.language.iso","en"],["dc.relation.issn","2234-943X"],["dc.title","Palliative Radiotherapy for Leptomeningeal Carcinomatosis-Analysis of Outcome, Prognostic Factors, and Symptom Response"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","El Shafie, Rami"],["dc.contributor.author","Schmitt, Daniela"],["dc.contributor.author","Bougatf, Nina"],["dc.contributor.author","Klüter, Sebastian"],["dc.contributor.author","Rieken, Stefan"],["dc.contributor.author","Debus, J."],["dc.contributor.author","Paul, A."],["dc.date.accessioned","2020-07-10T07:20:48Z"],["dc.date.available","2020-07-10T07:20:48Z"],["dc.date.issued","2017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66975"],["dc.title","Robotic radiosurgery using „Cyberknife M6“ at Heidelberg University Hospital – initial clinical experience in the first 145 patients"],["dc.type","report"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1309"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Der Urologe. Ausgabe A"],["dc.bibliographiccitation.lastpage","1315"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Rieken, S."],["dc.contributor.author","El Shafie, Rami"],["dc.date.accessioned","2020-07-10T08:21:05Z"],["dc.date.available","2020-07-10T08:21:05Z"],["dc.date.issued","2018-11"],["dc.description.abstract","Photon radiotherapy has repeatedly been described to elicit effects beyond mere inhibition of tumor cell clonogenicity: immunomodulatory phenomena including radiation-induced expression of tumor-associated antigens, increased recruitment and functioning of immunocompetent cells and secretion of immunomodulatory messengers have been described to explain the radiation responses of tumor lesions outside of irradiated volumes (\"abscopal effect\") in both preclinical models and clinical cases. With radiotherapy only, the abscopal effect is only rarely observed, but several trials have suggested combining modern immunotherapy with radiation to increase both frequency and intensity of the abscopal effect. Urological malignancies are commonly described as immunogenic malignancies. Both radiotherapy and immunotherapy are typical components of modern treatment regimes. Combining both modalities is expected to result in increased efficacy within and beyond irradiated lesions. However, prospective clinical trials have not yet provided mature results for oncological efficacy and toxicity of combined modality treatments in urological malignancies. This review details the preclinical rationale for combining photon radiotherapy with immunotherapy, summarizes early clinical experience, and provides a perspective for potential, future innovative combination treatments."],["dc.description.abstract","Die Bestrahlung mit Photonen ruft jenseits ihres zytotoxischen Effekts auf die Klonogenität von Tumorzellen Immunmodulationen hervor, die mit der vermehrten Expression tumorassoziierter Antigene, der erhöhten Rekrutierung und Funktionalität immunkompetenter Zellen sowie dem Freiwerden immunmodulierender Botenstoffe einhergehen. Präklinisch und vereinzelt auch klinisch ist gezeigt worden, dass diese Phänomene zur Strahlenwirkung auch jenseits des bestrahlten Volumens führen können („abscopal effect“). Bei alleiniger Strahlentherapie ist dieser Effekt nur selten zu beobachten, während mehrere Studien nahelegen, dass die kombinierte Gabe einer immunonkologischen Therapie zur Bestrahlung den „abscopal effect“ in seiner Häufigkeit und Intensität steigern kann. Urologische Tumorerkrankungen werden typischerweise zu den immunogenen Tumorentitäten gezählt, und sowohl die Radiotherapie als auch die Immuntherapie gehören aktuell zu den fest etablierten Therapiemodalitäten. Von der Kombination beider Verfahren ist eine gesteigerte Effektivität innerhalb wie außerhalb der Strahlenvolumina zu erwarten und bis dato in kleineren Studien gezeigt worden. Nun ist es größeren, aktuell rekrutierenden Studien vorbehalten, die klinische Effektivität und die Toxizität verschiedenartig kombinierter Therapieregime zu untersuchen. Die vorliegende Arbeit erläutert die präklinische Rationale der Radioimmuntherapie, fasst aktuelle klinische Erfahrungen zusammen und erlaubt einen Ausblick in potentielle, zukünftige und innovative Kombinationstherapien."],["dc.identifier.doi","10.1007/s00120-018-0789-x"],["dc.identifier.pmid","30324394"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66995"],["dc.language.iso","other"],["dc.relation.eissn","1433-0563"],["dc.relation.issn","0340-2592"],["dc.title","Kombinationen von Strahlen- und Immuntherapie für urologische Tumorerkrankungen"],["dc.title.alternative","Combining radiotherapy with immunotherapy for urological malignancies"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.journal","Cancer Management and Research"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Akbaba, Sati"],["dc.contributor.author","Koschny, Ronald"],["dc.contributor.author","Bougatf, Nina"],["dc.contributor.author","Bernhardt, Denise"],["dc.contributor.author","Welte, Stefan E."],["dc.contributor.author","Adeberg, Sebastian"],["dc.contributor.author","Häfner, Matthias"],["dc.contributor.author","Kargus, Steffen"],["dc.contributor.author","Plinkert, Peter K."],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Rieken, Stefan"],["dc.date.accessioned","2020-07-16T10:32:31Z"],["dc.date.available","2020-07-16T10:32:31Z"],["dc.date.issued","2020"],["dc.description.abstract","The primary aim of our study was to evaluate percutaneous endoscopic gastrostomy (PEG) tube placement depending on body weight and body mass index in patients undergoing radiotherapy (RT) for head and neck cancer (HNC). A secondary aim was to evaluate the course of weight change following PEG placement."],["dc.identifier.doi","10.2147/CMAR.S218432"],["dc.identifier.pmid","32021429"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67165"],["dc.language.iso","en"],["dc.relation.issn","1179-1322"],["dc.title","Percutaneous Endoscopic Gastrostomy Tube Placement in Patients with Head and Neck Cancer Treated with Radiotherapy"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.contributor.author","Guhlich, Manuel"],["dc.contributor.author","Maag, Teresa Esther"],["dc.contributor.author","Dröge, Leif Hendrik"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Donath, Sandra"],["dc.contributor.author","Schirmer, Markus Anton"],["dc.contributor.author","Knaus, Olga"],["dc.contributor.author","Nauck, Friedemann"],["dc.contributor.author","Overbeck, Tobias Raphael"],["dc.contributor.author","Rieken, Stefan"],["dc.date.accessioned","2022-06-01T09:39:22Z"],["dc.date.available","2022-06-01T09:39:22Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Purpose Superior vena cava syndrome (SVCS) often results from external vessel compression due to tumor growth. Urgent symptom-guided radiotherapy (RT) remains a major treatment approach in histologically proven, rapidly progressive disease. Despite several publications, recent data concerning symptom relief and oncological outcome as well as potential confounders in treatment response are still scarce. Methods We performed a retrospective single-center analysis of patients receiving urgent RT between 2000 and 2021 at the University Medical Center Göttingen. Symptom relief was evaluated by CTCAE score during the RT course. Effects of variables on symptom relief were assessed by logistic regression. The impact of parameters on overall survival (OS) was evaluated using Kaplan–Meier plot along with the log-rank test and by Cox regression analyses. Statistically significant ( p -value < 0.05) confounders were tested in multivariable analyses. Results A total of 79 patients were included. Symptom relief was achieved in 68.4%. Mean OS was 59 days, 7.6% ( n  = 6) of patients showed long-term survival (> 2 years). Applied RT dose > 39 Gy, clinical target volume (CTV) size < 387 ml, concomitant chemotherapy, and completion of the prescribed RT course were found to be statistically significant for OS; applied RT dose and completion of the prescribed RT course were found to be statistically significant for symptom relief. Conclusion Symptom relief by urgent RT for SVCS was achieved in the majority of patients. RT dose and completion of the RT course were documented as predictors for OS and symptom relief, CTV < 387 ml and concomitant chemotherapy were predictive for OS."],["dc.identifier.doi","10.1007/s00066-022-01952-z"],["dc.identifier.pii","1952"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108456"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1439-099X"],["dc.relation.issn","0179-7158"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Symptom relief, prognostic factors, and outcome in patients receiving urgent radiation therapy for superior vena cava syndrome"],["dc.title.alternative","A single-center retrospective analysis of 21 years’ practice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","803"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Radiation Oncology, Biology, Physics"],["dc.bibliographiccitation.lastpage","811"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Held, Thomas"],["dc.contributor.author","Windisch, Paul"],["dc.contributor.author","Akbaba, Sati"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","El Shafie, Rami"],["dc.contributor.author","Bernhardt, Denise"],["dc.contributor.author","Plinkert, Peter"],["dc.contributor.author","Kargus, Steffen"],["dc.contributor.author","Rieken, Stefan"],["dc.contributor.author","Herfarth, Klaus"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Adeberg, Sebastian"],["dc.date.accessioned","2020-07-10T08:22:49Z"],["dc.date.available","2020-07-10T08:22:49Z"],["dc.date.issued","2019"],["dc.description.abstract","This study aimed to assess the feasibility of carbon ion reirradiation (CIR) for recurrent head and neck cancer (HNC)."],["dc.identifier.doi","10.1016/j.ijrobp.2019.07.021"],["dc.identifier.pmid","31349059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67015"],["dc.language.iso","en"],["dc.relation.eissn","1879-355X"],["dc.relation.issn","0360-3016"],["dc.title","Carbon Ion Reirradiation for Recurrent Head and Neck Cancer: A Single-Institutional Experience"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiation oncology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Czech, Maja"],["dc.contributor.author","Kessel, Kerstin A."],["dc.contributor.author","Habermehl, Daniel"],["dc.contributor.author","Weber, Dorothea"],["dc.contributor.author","Rieken, Stefan"],["dc.contributor.author","Bougatf, Nina"],["dc.contributor.author","Jäkel, Oliver"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Combs, Stephanie E."],["dc.date.accessioned","2020-07-16T10:31:06Z"],["dc.date.available","2020-07-16T10:31:06Z"],["dc.date.issued","2018-05-08"],["dc.description.abstract","With the advance of modern irradiation techniques, the role of radiotherapy (RT) for intracranial meningioma has increased significantly throughout the past years. Despite that tumor's generally favorable outcome with local control rates of up to 90% after ten years, progression after RT does occur. In those cases, re-irradiation is often difficult due to the limited radiation tolerance of the surrounding tissue. The aim of this analysis is to determine the value of particle therapy with its better dose conformity and higher biological efficacy for re-irradiating recurrent intracranial meningioma. It was performed within the framework of the \"clinical research group heavy ion therapy\" and funded by the German Research Council (DFG, KFO 214)."],["dc.identifier.doi","10.1186/s13014-018-1026-x"],["dc.identifier.pmid","29739417"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67146"],["dc.language.iso","en"],["dc.relation.issn","1748-717X"],["dc.title","Evaluation of particle radiotherapy for the re-irradiation of recurrent intracranial meningioma"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","294"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","El Shafie, Rami A."],["dc.contributor.author","Tonndorf-Martini, Eric"],["dc.contributor.author","Schmitt, Daniela"],["dc.contributor.author","Weber, Dorothea"],["dc.contributor.author","Celik, Aylin"],["dc.contributor.author","Dresel, Thorsten"],["dc.contributor.author","Bernhardt, Denise"],["dc.contributor.author","Lang, Kristin"],["dc.contributor.author","Hoegen, Philipp"],["dc.contributor.author","Adeberg, Sebastian"],["dc.contributor.author","Paul, Angela"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Rieken, Stefan"],["dc.date.accessioned","2020-07-16T10:33:44Z"],["dc.date.available","2020-07-16T10:33:44Z"],["dc.date.issued","2019-03-01"],["dc.description.abstract","Pre-operative radiosurgery (SRS) preceding the resection of brain metastases promises to circumvent limitations of post-operative cavity SRS. It minimizes uncertainties regarding delineation and safety margins and could reduce dose exposure of the healthy brain (HB)."],["dc.identifier.doi","10.3390/cancers11030294"],["dc.identifier.pmid","30832257"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67181"],["dc.language.iso","en"],["dc.relation.issn","2072-6694"],["dc.title","Pre-Operative Versus Post-Operative Radiosurgery of Brain Metastases-Volumetric and Dosimetric Impact of Treatment Sequence and Margin Concept"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","El Shafie, Rami"],["dc.contributor.author","Bougatf, Nina"],["dc.contributor.author","Lindel, Katja"],["dc.contributor.author","Hauswald, Henrik"],["dc.contributor.author","Welte, Stefan"],["dc.contributor.author","Debus, Jürgen"],["dc.contributor.author","Rieken, Stefan"],["dc.date.accessioned","2020-07-10T07:20:28Z"],["dc.date.available","2020-07-10T07:20:28Z"],["dc.date.issued","2016"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66970"],["dc.title","Percutaneous endoscopic gastrostomy for patients with craniocervical or thoracic irradiation"],["dc.type","report"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]